The DOI matches its Crossref record; 178 of the 178 references it cites were found in a registry or an index.
Functional brain imaging of tobacco use and dependence
Open accessAbstract
While most cigarette smokers endorse a desire to quit smoking, only about 14% to 49% will achieve abstinence after 6 months or more of treatment. A greater understanding of the effects of smoking on brain function may (in conjunction with other lines of research) result in improved pharmacological (and behavioral) interventions. Many research groups have examined the effects of acute and chronic nicotine/cigarette exposure on brain activity using functional imaging; the purpose of this paper is to synthesize findings from such studies and present a coherent model of brain function in smokers. Responses to acute administration of nicotine/smoking include: a reduction in global brain activity; activation of the prefrontal cortex, thalamus, and visual system; activation of the thalamus and visual cortex during visual cognitive tasks; and increased dopamine (DA) concentration in the ventral striatum/nucleus accumbens. Responses to chronic nicotine/cigarette exposure include decreased monoamine oxidase (MAO) A and B activity in the basal ganglia and a reduction in alpha4beta2 nicotinic acetylcholine receptor (nAChR) availability in the thalamus and putamen. Taken together, these findings indicate that smoking enhances neurotransmission through cortico-basal ganglia-thalamic circuits either by direct stimulation of nAChRs, indirect stimulation via DA release or MAO inhibition, or a combination of these factors. Activation of this circuitry may be responsible for the effects of smoking seen in tobacco dependent subjects, such as improvements in attentional performance, mood, anxiety, and irritability.
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“Brain imaging studies have demonstrated that nicotine acutely increases the activity in the visual system, PFC, and thalamus which are consistent with activation of the corticobasal ganglia-thalamic brain circuits”
From Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits (2023) · cites this paper as [24]
In the citing paper
“Heavy nicotine use in the form of smoking tobacco has been linked to neuropathy (Brody, 2006), often manifesting as prefrontal gray matter atrophy (Gallinat et al., 2006; Zhang et al., 2011).”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Brody, 2006
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Cites
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Items 201–207 of 207
Marin, M. D. C. G. (2012) · theses.fr (ABES) · doi:10.70675/95b129bbz91cdz4c63zbd7dz07f9fc210c7a
Diversité des effets de la nicotine sur les neurones dopaminergiques de l’aire tegmentale ventrale
Nguyen, C. (2020) · theses.fr (ABES) · doi:10.70675/57dc4740z36f1z4ee7z87e7z960af8c4a43e
Approche thérapeutique et cognitive chez les patients souffrant d'une addiction au tabac
Vanderkam, P. (2023) · theses.fr (ABES) · doi:10.70675/307f9e53z9985z46a6z8c9dz1701c02f2849
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Metadata
- Authors
- BRODY, A.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- BRODY, A
- ORCID
- BRODY, A
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 40
- Issue
- 5
- Pages
- 404-418
- ISSN
- 0022-3956 (ISSN-L)
- PMC
- PMC2876087
- OpenAlex
- W2047492603
- Cited by
- 207
- References
- 178
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 9 · 2023: 9 · 2022: 2 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 11 · 2017: 6 · 2016: 8 · 2015: 15 · 2014: 12 · 2013: 14 · 2012: 12
- FWCI
- 7.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institute on Drug Abuse (R01DA020872, R01 DA 15059, R01DA015059)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- tobacco dependence, smoking, nicotine, brain function, prefrontal cortex, thalamus, visual cortex, dopamine, nucleus accumbens, monoamine oxidase, nicotinic acetylcholine receptors, alpha4beta2 receptor, basal ganglia, attention, mood, anxiety, irritability
- MeSH terms
- Animals, Brain, Brain Mapping, Cognition, Dopamine, Humans, Personality, Receptors, Nicotinic, Smoking, Tobacco Use Disorder
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