Cited by 109Epigenetics and DNA MethylationSchizophrenia research and treatmentTryptophan and brain disorders

Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: A potential link between epigenetics and schizophrenia

Shimabukuro, Morihiro, Sasaki, Tsukasa, Imamura, Akira, Tsujita, Takahiro, Fuke, Chiaki, Umekage, Tadashi, Tochigi, Mamoru, Hiramatsu, Kennichi +5 more·2007·Journal of Psychiatric Research

Abstract

Genetic and epigenetic factors can potentially alter susceptibility to psychiatric disorders such as schizophrenia. In order to explore the effect of epigenetics on the pathogenesis of schizophrenia, we examined the global methylation level of leukocyte DNA from 210 patients with schizophrenia (124 males and 86 females) and 237 healthy subjects (108 males and 129 females). Methylated deoxycytidine (mC) content in peripheral leukocyte DNA was measured by high performance liquid chromatography (HPLC). We confirmed in the healthy subjects our previous finding that there are sex-dependent differences in mC content (males>females; beta=0.319, p<0.001), in addition to the effect of age (beta=-0.141, p=0.022). We therefore used multiple regression to analyze the data from all subjects by sex, with age as a co-variant. In males, a tendency was observed toward lower mC content in patients than in controls (beta=-0.115, p=0.075), with a significant effect of age (beta=-0.212, p<0.001). This difference was more prominent in younger individuals. In females, no effect of age or disease status on mC content was observed. These results established that there is significant sex-dependent difference in the mC content of human peripheral leukocyte DNA, and raise the possibility that alterations in DNA methylation state are present in patients with schizophrenia.

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Crossref · 10.1016/j.jpsychires.2006.08.006

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  • In both human and animal models, treatment with haloperidol induces sex-specific DNA methylation differences.

    “In both human and animal models, it has been observed treatment with haloperidol induces sex-specific DNA methylation differences [71, 72].”

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Authors
Shimabukuro, M., Sasaki, T., Imamura, A., Tsujita, T., Fuke, C., Umekage, T., Tochigi, M., Hiramatsu, K., Miyazaki, T., Oda, T., Sugimoto, J., Jinno, Y., & Okazaki, Y.
Affiliations
  • University of the Ryukyus (JP)
  • The University of Tokyo (JP)
  • Nagasaki University (JP)
  • Mie University (JP)
Corresponding author
Jinno, Yoshihiro
Venue
Journal of Psychiatric Research
Publisher
Elsevier BV
Published
2007-12
Volume
41
Issue
12
Pages
1042-1046
ISSN
0022-3956 (ISSN-L)
OpenAlex
W2148944032
Cited by
108
References
40
Citations by year
2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 10 · 2015: 7 · 2014: 8 · 2013: 5 · 2012: 14
FWCI
2.44
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Psychiatric Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
schizophrenia, DNA methylation, global hypomethylation, peripheral blood leukocytes, epigenetics, sex differences, age effects
MeSH terms
Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Chromatography, High Pressure Liquid, Female, Humans, Leukocytes, Male, Middle Aged, Schizophrenia, Sex Factors, DNA Methylation, Epigenesis, Genetic

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