Lower LINE-1 methylation in first-episode schizophrenia patients with the history of childhood trauma
Open accessAbstract
AIM: We investigated methylation of DNA repetitive sequences (LINE-1 and BAGE) in peripheral blood leukocytes from first-episode schizophrenia (FES) patients and healthy controls (HCs) with respect to childhood adversities. MATERIALS & METHODS: Patients were divided into two subgroups based on the history of childhood trauma - FES(+) and FES(-) subjects. The majority of HCs had a negative history of childhood trauma - HCs(-) subjects. RESULTS: FES(+) patients had significantly lower LINE-1 methylation in comparison with FES(-) patients or HC(-) subjects. Emotional abuse and total trauma score predicted lower LINE-1 methylation in FES patients, while general trauma score was associated with lower BAGE methylation in HCs. CONCLUSION: Childhood adversities might be associated with global DNA hypomethylation in adult FES patients.
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In a 2017 systematic review of epigenetic associations with childhood trauma in first episode psychosis patients and healthy individuals, childhood trauma was associated with global hypomethylation in peripheral blood samples.
“In a 2017 systematic review of epigenetic associations with childhood trauma in first episode psychosis patients and healthy individuals, childhood trauma was associated with global hypomethylation in peripheral blood samples (104, 105).”
From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [105]
The Abstract reports lower LINE-1 methylation in peripheral blood leukocytes of first-episode schizophrenia patients with childhood trauma, and an association between general trauma score and lower BAGE methylation in healthy controls. But this source is a 2015 original study, not a 2017 systematic review, and its conclusion cautiously limits global hypomethylation to adult first-episode schizophrenia patients. (LLM, conf=0.90)
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“In a 2017 systematic review of epigenetic associations with childhood trauma in first episode psychosis patients and healthy individuals, childhood trauma was associated with global hypomethylation in peripheral blood samples (104, 105).”
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- Authors
- Misiak, B., Szmida, E., Karpiński, P., Loska, O., Sąsiadek, M. M., & Frydecka, D.
- Affiliations
- Wroclaw Medical University (PL)
- Department of Genetics, Wroclaw Medical University, 1 Marcinkowski Street, 50-368 Wroclaw, Poland
- Corresponding author
- Misiak, Błażej
- Venue
- Epigenomics
- Publisher
- Informa UK Limited
- Published
- 2015-07-27
- Volume
- 7
- Issue
- 8
- Pages
- 1275-1285
- ISSN
- 1750-1911 (ISSN-L)
- 1750-192X
- OpenAlex
- W2099555944
- Cited by
- 77
- References
- 74
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 1 · 2023: 6 · 2022: 10 · 2021: 16 · 2020: 13 · 2019: 8 · 2018: 7 · 2017: 5 · 2016: 2
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Epigenomics (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Funders
- National Science Centre (DEC-2011/03/N/NZ5/00248)
- START scholarship provided by the Foundation for Polish Science
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- LINE-1 methylation, first-episode schizophrenia, childhood trauma, childhood adversity, DNA hypomethylation, emotional abuse, repetitive DNA, peripheral blood leukocytes, epigenetics
- MeSH terms
- Adult, Antigens, Neoplasm, Female, Humans, Male, Risk Factors, Schizophrenia, Wounds and Injuries, Biomarkers, Case-Control Studies, DNA Methylation, Long Interspersed Nucleotide Elements, Epigenesis, Genetic, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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