Cited by 197Heart Rate Variability and Autonomic ControlBipolar Disorder and TreatmentMental Health Research Topics

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Heart rate variability in bipolar mania and schizophrenia

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Henry, Brook L., Minassian, Arpi, Paulus, Martin P., Geyer, Mark A., Perry, William·2010·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2009.07.011PMC PMC2822123

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Abstract

Background Autonomic nervous system (ANS) dysfunction and reduced heart rate variability (HRV) have been reported in a wide variety of psychiatric disorders, but have not been well characterized in bipolar mania. We recorded cardiac activity and assessed HRV in acutely hospitalized manic bipolar (BD) and schizophrenia (SCZ) patients compared to age- and gender-matched healthy comparison (HC) subjects.Method HRV was assessed using time domain, frequency domain, and nonlinear analyses in 23 manic BD, 14 SCZ, and 23 HC subjects during a 5min rest period. Psychiatric symptoms were assessed by administration of the Brief Psychiatric Rating Scale (BPRS) and the Young Mania Rating Scale (YMRS).Results Manic BD patients demonstrated a significant reduction in HRV, parasympathetic activity, and cardiac entropy compared to HC subjects, while SCZ patients demonstrated a similar, but non-significant, trend towards lower HRV and entropy. Reduction in parasympathetic tone was significantly correlated with higher YMRS scores and the unusual thought content subscale on the BPRS. Decreased entropy was associated with increased aggression and diminished personal hygiene on the YMRS scale.Conclusion Cardiac function in manic BD individuals is characterized by decreased HRV, reduced vagal tone, and a decline in heart rate complexity as assessed by linear and nonlinear methods of analysis. Autonomic dysregulation is associated with more severe psychiatric symptoms, suggesting HRV dysfunction in this disorder may be dependent on the phase of the illness.

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Authors: Henry, B. L., Minassian, A., Paulus, M. P., Geyer, M. A., & Perry, W.
Affiliations: University of California San Diego (US)
Corresponding author: Henry, Brook L.
ORCID: Minassian, Arpi
Paulus, Martin P.
Geyer, Mark A.
Perry, William
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2010-02
Volume: 44
Issue: 3
Pages: 168-176
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2009.07.011
PMC: PMC2822123
OpenAlex: W2055618902
Cited by: 197
References: 80
Citations by year: 2026: 5 · 2025: 11 · 2024: 5 · 2023: 12 · 2022: 10 · 2021: 14 · 2020: 11 · 2019: 17 · 2018: 12 · 2017: 21 · 2016: 19 · 2015: 14 · 2014: 10 · 2013: 15 · 2012: 8
FWCI: 4.53
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH071916)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords: heart rate variability, bipolar mania, schizophrenia, autonomic dysfunction, parasympathetic activity, vagal tone, heart rate complexity, nonlinear HRV analysis, manic symptoms, aggression, personal hygiene
MeSH terms: Adult, Aggression, Bipolar Disorder, Female, Heart, Heart Rate, Humans, Hygiene, Male, Brief Psychiatric Rating Scale, Parasympathetic Nervous System, Schizophrenia, Case-Control Studies

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Heart rate variability in bipolar mania and schizophrenia

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