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Cognitive deficits in recent-onset and chronic schizophrenia
Open accessAbstract
Although cognitive dysfunction is a primary characteristic of schizophrenia, only recently have investigations begun to pinpoint when the dysfunction develops in the individual afflicted by the disorder. Research to date provides evidence for significant cognitive impairments prior to disorder onset. Less is known about the course of cognitive dysfunction from onset to the chronic phase of schizophrenia. Although longitudinal studies are optimal for assessing stability of cognitive deficits, practice effects often confound assessments, and large and representative subject samples have not been followed over long periods of time. We report results of a cross-sectional study of cognitive deficits early and late in the course of schizophrenia carried out at four different geographic locations to increase sample size and generalizability of findings. We examined a broad set of cognitive functions in 41 recent-onset schizophrenia patients and 106 chronic schizophrenia patients. The study included separate groups of 43 matched controls for the recent-onset sample and 105 matched controls for the chronic schizophrenia sample in order to evaluate the effects of cohort (i.e., age) and diagnosis (i.e., schizophrenia) on cognitive functions. All measures of cognitive function showed effects of diagnosis; however, select time-based measures of problem solving and fine motor dexterity exhibited interactions of diagnosis and cohort indicating that these deficits may progress beyond what is expected with normal aging. Also, worse recall of material in episodic memory was associated with greater length of illness. Nevertheless, findings indicate that nearly all cognitive deficits are comparably impaired across recent-onset and chronic schizophrenia.
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“Larger deficits in working memory have been shown to exist in elderly vs first-episode people with schizophrenia, while worse recall of material in episodic memory, changes in select time-based measures of problem solving and fine motor dexterity have all been associated with greater length of illness.61,62”
From Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far? (2013) · cites this paper as [62]
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“Larger deficits in working memory have been shown to exist in elderly vs first-episode people with schizophrenia, while worse recall of material in episodic memory, changes in select time-based measures of problem solving and fine motor dexterity have all been associated with greater length of illness.61,62”
From Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far? (2013) · cites this paper as [62]
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“Although cognitive impairments are generally stable over relatively short periods of time in the longitudinal course of schizophrenia58–60 cognitive function is age dependent in healthy controls and schizophrenia samples.”
From Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far? (2013) · cites this paper as [62]
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Citations
Cites
VALIDITY OF THE TRAIL MAKING TEST AS AN INDICATOR OF ORGANIC BRAIN DAMAGE
Reitan, R. M. (1958) · Perceptual and Motor Skills · doi:10.2466/pms.1958.8.3.271 · Cited by 8,167
Specific impairments of planning
Shallice, T. (1982) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1982.0082 · Cited by 3,741
Neurocognitive deficit in schizophrenia: A quantitative review of the evidence.
Heinrichs, R. W., & Zakzanis, K. K. (1998) · Neuropsychology · doi:10.1037/0894-4105.12.3.426 · Cited by 2,798
Delis-Kaplan Executive Function System
Delis, D. C., Kaplan, E., & Kramer, J. H. (2012) · PsycTESTS Dataset · doi:10.1037/t15082-000 · Cited by 2,683
A CLASSIFICATION OF HAND PREFERENCE BY ASSOCIATION ANALYSIS
Annett, M. (1970) · British Journal of Psychology · doi:10.1111/j.2044-8295.1970.tb01248.x · Cited by 2,271
Wechsler Adult Intelligence Scale
(2007) · Sage eBooks · doi:10.4135/9781412952644.n478 · Cited by 2,017
Social Class and Mental Illness: A Community Study
Hollingshead, A. B., & Redlich, F. C. (2007) · American Journal of Public Health · doi:10.2105/ajph.97.10.1756 · Cited by 1,846
The hopkins verbal learning test: Development of a new memory test with six equivalent forms
Brandt, J. (1991) · Clinical Neuropsychologist · doi:10.1080/13854049108403297 · Cited by 1,317
Bos, J. (2017) · Sage eBooks · doi:10.4135/9781483365817.n1487 · Cited by 1,262
Neurocognition in first-episode schizophrenia: a meta-analytic review.
Mesholam-Gately, R. I., Giuliano, A. J., Goff, K. P., Faraone, S. V., & Seidman, L. J. (2009) · Neuropsychology · doi:10.1037/a0014708 · Cited by 1,130
Self-citationVALIDITY OF THE TRAIL MAKING TEST AS AN INDICATOR OF ORGANIC BRAIN DAMAGE
Reitan, R. M. (1958) · Perceptual and Motor Skills · doi:10.2466/pms.8.7.271-276 · Cited by 1,088
Neuropsychology of First-Episode Schizophrenia: Initial Characterization and Clinical Correlates
Bilder, R. M., Goldman, R. S., Robinson, D. G., Reiter, G., Bell, L., Bates, J. A., Pappadopulos, E. A., Willson, D. F., Alvir, J., Woerner, M. G., et al. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.4.549 · Cited by 906
Premorbid IQ in Schizophrenia: A Meta-Analytic Review
Woodberry, K. A., Giuliano, A. J., & Seidman, L. J. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07081242 · Cited by 570
Self-citationRuff, R. M., & Parker, S. B. (1993) · Perceptual and Motor Skills · doi:10.2466/pms.1993.76.3c.1219 · Cited by 490
Caplan, B. (2018) · Springer eBooks · doi:10.1007/978-3-319-56782-2_3000-2 · Cited by 426
Goldberg, T. E., GOLDMAN, R. S., Burdick, K. E., Malhotra, A. K., Lencz, T., Patel, R. C., Woerner, M. G., Schooler, N. R., Kane, J. M., & Robinson, D. G. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.10.1115 · Cited by 396
Hulshoff Pol, H. E., & Kahn, R. S. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm168 · Cited by 364
Longitudinal Neuropsychological Follow-Up Study of Patients With First-Episode Schizophrenia
Hoff, A. L., Sakuma, M., Wieneke, M. H., Horon, R., Kushner, M., & DeLisi, L. E. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.9.1336 · Cited by 363
Cirillo, M. A., & Seidman, L. J. (2003) · Neuropsychology Review · doi:10.1023/a:1023870821631 · Cited by 355
Self-citationFuller, R. L. M., Nopoulos, P., Arndt, S. V., OʼLeary, D. S., Ho, B., & Andreasen, N. C. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1183 · Cited by 338
Self-citationLongitudinal studies of cognition in schizophrenia: Meta-analysis
Szöke, A., Trandafir, A., Dupont, M.-E., Méary, A., Schürhoff, F., & Leboyer, M. (2008) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.029009 · Cited by 331
Keefe, R. S. E., Seidman, L. J., Christensen, B. K., Hamer, R. M., Sharma, T., Sitskoorn, M. M., Lewine, R. R. J., Yurgelun-Todd, D. A., Gur, R. C., Tohen, M., et al. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.6.985 · Cited by 314
Self-citationLongitudinal Study of Cognitive Function in First-Episode and Recent-Onset Schizophrenia
Gold, S. M., Arndt, S. V., Nopoulos, P., OʼLeary, D. S., & Andreasen, N. C. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.9.1342 · Cited by 296
Self-citationvan Haren, N. E. M., Pol, H. E. H., Schnack, H. G., Cahn, W., Brans, R. G. H., Carati, I., Rais, M., & Kahn, R. S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.01.004 · Cited by 278
Hoff, A. L., Svetina, C., Shields, G. W., Stewart, J., & DeLisi, L. E. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.05.010 · Cited by 259
Friedman, J. I., Harvey, P. D., Coleman, T. M., Moriarty, P. J., Bowie, C. R., Parrella, M., White, L., Adler, D. A., & Davis, K. L. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.9.1441 · Cited by 249
Neurocognitive impairment across the lifespan in schizophrenia: an update
Kurtz, M. J. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.07.005 · Cited by 243
Harvey, P. D., Silverman, J. M., Mohs, R. C., Parrella, M. J., White, L., Powchik, P., Davidson, M., & Davis, K. L. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00273-x · Cited by 234
Stirling, J. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00014-8 · Cited by 218
Caspi, A. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00056-2 · Cited by 201
Wood, S. J., Pantelis, C., Velakoulis, D., Yücel, M., Fornito, A., & McGorry, P. D. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm149 · Cited by 195
Lawrie, S. M., McIntosh, A. M., Hall, J., Owens, D. G. C., & Johnstone, E. C. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm158 · Cited by 194
Fucetola, R. P., Seidman, L. J., Kremen, W. S., Faraone, S. V., Goldstein, J. M., & Tsuang, M. T. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00240-7 · Cited by 165
Self-citationAddington, J., Saeedi, H., & Addington, D. E. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.05.008 · Cited by 153
Rund, B. R., Melle, I. S., Friis, S., Johannessen, J. O., Larsen, T. K., Midbøe, L. J., Opjordsmoen, S., Simonsen, E. H., Vaglum, P., & McGlashan, T. H. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2006.11.030 · Cited by 137
Seidman, L. J., Buka, S. L., Goldstein, J. M., & Tsuang, M. T. (2006) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390500360471 · Cited by 130
Self-citationAlbus, M., Hubmann, W., Mohr, F., Tiedemann, T. V., Pechler, S., Drießlein, D., & Küchenhoff, H. (2019) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-019-01030-z · Cited by 121
Long-Term Neurocognitive Effects of Olanzapine or Low-Dose Haloperidol in First-Episode Psychosis
Keefe, R. S. E., Seidman, L. J., Christensen, B. K., Hamer, R. M., Sharma, T., Sitskoorn, M. M., Rock, S. L., Woolson, S., Tohen, M. F., Tollefson, G. D., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.022 · Cited by 120
Self-citationNeurocognitive functioning in patients with first-episode schizophrenia
Albus, M., Hubmann, W., Mohr, F., Hecht, S., Hinterberger-Weber, P., Seitz, N.-N., & Küchenhoff, H. (2006) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-006-0667-1 · Cited by 111
The Visual Retention Test as a Constructional Praxis Task
Benton, A. L. (2007) · Confinia Neurologica · doi:10.1159/000104348 · Cited by 104
Cognitive Impairment in Adolescents With Schizophrenia
Kenny, J. T., Friedman, L., Findling, R. L., Swales, T. P., Strauss, M. E., Jesberger, J. A., & Schulz, S. C. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.11.1613 · Cited by 97
Self-citationCervellione, K. L., Burdick, K. E., Cottone, J. G., Rhinewine, J. P., & Kumra, S. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318054678d · Cited by 89
Hawkins, K. A., Keefe, R. S. E., Christensen, B. K., Addington, J., Woods, S. W., Callahan, J. L., Zipursky, R. B., Perkins, D. O., Tohen, M. F., Breier, A. F., et al. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.07.008 · Cited by 87
Basic neuropsychological dimensions in schizophrenia
Jaeger, J. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00052-5 · Cited by 75
Hurlemann, R., Jessen, F., Wagner, M., Frommann, I., Ruhrmann, S., Brockhaus, A., Picker, H., Scheef, L., Block, W., Schild, H. H., et al. (2008) · Psychological Medicine · doi:10.1017/s0033291708003279 · Cited by 70
Granholm, E. L., Morris, S., Asarnow, R. F., Chock, D., & Jeste, D. V. (2000) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617700611049 · Cited by 58
Bowie, C. R., Reichenberg, A., McClure, M. M., Leung, W. L., & Harvey, P. D. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.10.026 · Cited by 45
Zipparo, L., Whitford, T. J., Hodge, M. A., Lucas, S. K., Farrow, T. F. D., Brennan, J., Gomes, L. J., Williams, L. M., & Harris, A. W. F. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.10.011 · Cited by 44
First- and second-generation antipsychotic medication and cognitive processing in schizophrenia
Weickert, T. W., & Goldberg, T. E. (2005) · Current Psychiatry Reports · doi:10.1007/s11920-005-0085-5 · Cited by 41
Social Class and Mental Illness: A Community Study.
Goldhamer, H., Hollingshead, A. B., & Redlich, F. C. (1959) · American Sociological Review · doi:10.2307/2089549 · Cited by 38
Premkumar, P., Kumari, V., Corr, P. J., Fannon, D. G., & Sharma, T. (2008) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.08.005 · Cited by 32
Neurocognitive Function in Schizophrenia at a 10-Year Follow-Up: A Preliminary Investigation
Kurtz, M. M., Seltzer, J. C., Ferrand, J. L., & Wexler, B. E. (2005) · CNS Spectrums · doi:10.1017/s1092852900022598 · Cited by 28
Cited by
Sorted by citations
Carbon, M., & Correll, C. U. (2014) · CNS Spectrums · doi:10.1017/s1092852914000601 · Cited by 281
BDNF and Schizophrenia: From Neurodevelopment to Neuronal Plasticity, Learning, and Memory
Nieto, R. R., Manuel Kukuljan, P., & Silva, H. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00045 · Cited by 219
Gollub, R. L., Shoemaker, J. M., King, M. D., White, T. J. H., Ehrlich, S., Sponheim, S. R., Clark, V. P., Turner, J. A., Mueller, B. A., Magnotta, V. A., et al. (2013) · Neuroinformatics · doi:10.1007/s12021-013-9184-3 · Cited by 212
Self-citationAssociations of Cortical Thickness and Cognition in Patients With Schizophrenia and Healthy Controls
Ehrlich, S., Brauns, S., Yendiki, A., Ho, B., Calhoun, V. D., Schulz, S. C., Gollub, R. L., & Sponheim, S. R. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr018 · Cited by 166
Self-citationPedrini, M., Massuda, R., Fries, G. R., Pasquali, M. A. D. B., Schnorr, C. E., Moreira, J. C. F., Teixeira, A. L., Lobato, M. I. R., Walz, J. C., Belmonte-de-Abreu, P. S., et al. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.03.019 · Cited by 142
Metadata
- Authors
- Sponheim, S. R., Jung, R. E., Seidman, L. J., Mesholam-Gately, R. I., Manoach, D. S., O’Leary, D. S., Ho, B. C., Andreasen, N. C., Lauriello, J., & Schulz, S. C.
- Affiliations
- Minneapolis VA Health Care System (US)
- Mind Research Network (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- University of Iowa (US)
- University of New Mexico (US)
- Corresponding author
- Sponheim, S.R.
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 44
- Issue
- 7
- Pages
- 421-428
- ISSN
- 0022-3956 (ISSN-L)
- PMC
- PMC3940967
- OpenAlex
- W2140536737
- Cited by
- 123
- References
- 52
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 5 · 2023: 8 · 2022: 15 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 2 · 2016: 2 · 2015: 11 · 2014: 11 · 2013: 12 · 2012: 8
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH040856, K23MH068380)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- schizophrenia, cognitive impairment, recent-onset schizophrenia, chronic schizophrenia, clinical course, problem solving, fine motor dexterity, episodic memory, memory retrieval, length of illness, aging, practice effects
- MeSH terms
- Adult, Analysis of Variance, Chronic Disease, Cognition Disorders, Cross-Sectional Studies, Female, Humans, Male, Neuropsychological Tests, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology, Case-Control Studies, Disease Progression, Young Adult
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