Cited by 123Schizophrenia research and treatmentMental Health and PsychiatryDementia and Cognitive Impairment Research

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Cognitive deficits in recent-onset and chronic schizophrenia

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Sponheim, S.R., Jung, R.E., Seidman, L.J., Mesholam-Gately, R.I., Manoach, D.S., O’Leary, D.S., Ho, B.C., Andreasen, N.C., Lauriello, J., Schulz, S.C.·2010·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2009.09.010PMC PMC3940967

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Abstract

Although cognitive dysfunction is a primary characteristic of schizophrenia, only recently have investigations begun to pinpoint when the dysfunction develops in the individual afflicted by the disorder. Research to date provides evidence for significant cognitive impairments prior to disorder onset. Less is known about the course of cognitive dysfunction from onset to the chronic phase of schizophrenia. Although longitudinal studies are optimal for assessing stability of cognitive deficits, practice effects often confound assessments, and large and representative subject samples have not been followed over long periods of time. We report results of a cross-sectional study of cognitive deficits early and late in the course of schizophrenia carried out at four different geographic locations to increase sample size and generalizability of findings. We examined a broad set of cognitive functions in 41 recent-onset schizophrenia patients and 106 chronic schizophrenia patients. The study included separate groups of 43 matched controls for the recent-onset sample and 105 matched controls for the chronic schizophrenia sample in order to evaluate the effects of cohort (i.e., age) and diagnosis (i.e., schizophrenia) on cognitive functions. All measures of cognitive function showed effects of diagnosis; however, select time-based measures of problem solving and fine motor dexterity exhibited interactions of diagnosis and cohort indicating that these deficits may progress beyond what is expected with normal aging. Also, worse recall of material in episodic memory was associated with greater length of illness. Nevertheless, findings indicate that nearly all cognitive deficits are comparably impaired across recent-onset and chronic schizophrenia.

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VALIDITY OF THE TRAIL MAKING TEST AS AN INDICATOR OF ORGANIC BRAIN DAMAGE
Reitan, R. M. (1958) · Perceptual and Motor Skills · doi:10.2466/pms.1958.8.3.271 · Cited by 8,167
Specific impairments of planning
Shallice, T. (1982) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1982.0082 · Cited by 3,741
Neurocognitive deficit in schizophrenia: A quantitative review of the evidence.
Heinrichs, R. W., & Zakzanis, K. K. (1998) · Neuropsychology · doi:10.1037/0894-4105.12.3.426 · Cited by 2,798
Delis-Kaplan Executive Function System
Delis, D. C., Kaplan, E., & Kramer, J. H. (2012) · PsycTESTS Dataset · doi:10.1037/t15082-000 · Cited by 2,683
A CLASSIFICATION OF HAND PREFERENCE BY ASSOCIATION ANALYSIS
Annett, M. (1970) · British Journal of Psychology · doi:10.1111/j.2044-8295.1970.tb01248.x · Cited by 2,271
Wechsler Adult Intelligence Scale
(2007) · Sage eBooks · doi:10.4135/9781412952644.n478 · Cited by 2,017
Social Class and Mental Illness: A Community Study
Hollingshead, A. B., & Redlich, F. C. (2007) · American Journal of Public Health · doi:10.2105/ajph.97.10.1756 · Cited by 1,846
The hopkins verbal learning test: Development of a new memory test with six equivalent forms
Brandt, J. (1991) · Clinical Neuropsychologist · doi:10.1080/13854049108403297 · Cited by 1,317
Wide Range Achievement Test
Bos, J. (2017) · Sage eBooks · doi:10.4135/9781483365817.n1487 · Cited by 1,262
Neurocognition in first-episode schizophrenia: a meta-analytic review.
Mesholam-Gately, R. I., Giuliano, A. J., Goff, K. P., Faraone, S. V., & Seidman, L. J. (2009) · Neuropsychology · doi:10.1037/a0014708 · Cited by 1,130
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Abbott, C., Merideth, F. L., Ruhl, D. A., Yang, Z., Clark, V. P., Calhoun, V. D., Hanlon, F. M., & Mayer, A. R. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.12.011 · Cited by 10
Motor actions across psychiatric disorders: a research domain criteria (RDoC) perspective
Osborne, K. J., Walther, S., & Mittal, V. A. (2024) · Clinical Psychology Review · doi:10.1016/j.cpr.2024.102511 · Cited by 9
Factors Contributing to Risk of Persistence of Positive and Negative Symptoms in Schizophrenia during Hospitalization
Witkowski, G., Januszko, P., Skalski, M., Mach, A., Wawrzyniak, Z. M., Poleszak, E., Ciszek, B., & Radziwoń-Zaleska, M. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20054592 · Cited by 9
Smaller than expected cognitive deficits in schizophrenia patients from the population-representative ABC catchment cohort
Lennertz, L., der Heiden, W. A., Kronacher, R., Schulze‐Rauschenbach, S., Maier, W., Häfner, H., & Wagner, M. (2015) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-015-0625-x · Cited by 9
Early augmentation by using neuromodulation in psychiatric disorder: a kaleidoscopic view
Kar, S. K., & Menon, V. (2021) · CNS Spectrums · doi:10.1017/s1092852921000237 · Cited by 9
The importance of clinical normative data for conceptualizing neuropsychological deficits in people with schizophrenia spectrum disorders
Raudeberg, R., Iverson, G. L., & Hammar, Å. (2019) · Applied Neuropsychology Adult · doi:10.1080/23279095.2019.1699098 · Cited by 8
Influence of empathetic pain processing on cognition in schizophrenia
Hu, K., Lijffijt, M., Beauchaine, T. P., Fan, Z., Shi, H., & He, S. (2014) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0565-x · Cited by 8
Aberrant cortical surface and cognition function in drug-naive first-episode schizophrenia
Wei, Q., Yan, W., Zhang, R., Yang, X., & Xie, S. (2022) · Annals of General Psychiatry · doi:10.1186/s12991-022-00381-7 · Cited by 8
Schizophrenia and accelerated ageing: systematic review and future research directions
Fernández-Egea, E., García‐Rizo, C., & Kirkpatrick, B. W. (2026) · The British Journal of Psychiatry · doi:10.1192/bjp.2026.10606 · Cited by 8
Neurocognition and Social Cognition— Possibilities for Diagnosis and Treatment in Ultra-High Risk for Psychosis State
Rek-Owodziń, K., Tyburski, E. M., Waszczuk, K., Samochowiec, J., & Mak, M. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.765126 · Cited by 7
Figural fluency and immediate visual memory in patients with at‐risk mental state for psychosis: empirical study
Pawełczyk, A., Kotlicka‐Antczak, M., Rabe‐Jabłońska, J., Pawełczyk, T., Ruszpel, A., & Łojek, E. (2015) · Early Intervention in Psychiatry · doi:10.1111/eip.12116 · Cited by 6
Patterns of Emotion Attribution are Affected in Patients with Schizophrenia
Romero-Ferreiro, M. V., Aguado, L., Rodríguez-Torresano, J., Palomo, T., & Rodríguez–Jiménez, R. (2015) · The Spanish Journal of Psychology · doi:10.1017/sjp.2015.60 · Cited by 6
Promoting insight into delusions: Issues and challenges in therapy
Kumar, D. (2020) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651501.2019.1711420 · Cited by 6
Brain subnetworks most sensitive to alterations of functional connectivity in Schizophrenia: a data-driven approach
Keyvanfard, F., Nasab, A. R., & Nasiraei‐Moghaddam, A. (2023) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2023.1175886 · Cited by 5
Stage-specific computational mechanisms of working memory deficits in first-episode and chronic schizophrenia
Zhang, T., Yang, X., Mu, P., Huo, X., & Zhao, X. (2025) · Schizophrenia Research · doi:10.1016/j.schres.2025.06.012 · Cited by 5
Differences in cognitive function and daily living skills between early- and late-stage schizophrenia
Kim, S.-J., Shim, J.-C., Kong, B.-G., Kang, J.-W., Moon, J., Jeon, D.-W., Seo, Y.-S., Oh, M., & Jung, D.-U. (2015) · International Journal of Psychiatry in Clinical Practice · doi:10.3109/13651501.2015.1084328 · Cited by 5
Association of Transferrin Gene Polymorphism with Cognitive Deficits and Psychiatric Symptoms in Patients with Chronic Schizophrenia
Chen, P., Wang, D., Xiu, M., Chen, D., Lackey, B., Wu, H. E., Wang, L., & Zhang, X. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11216414 · Cited by 5
The effect of computerized executive function rehabilitation on the improvement of cognitive functions in patients with schizophrenia
박주현, & Kim, M. (2015) · The Korean Journal of Clinical Psychology · doi:10.15842/kjcp.2015.34.1.003 · Cited by 4
Prediction of patient contacts by cognition in schizophrenia
Nielsen, R. E., Haugaard, C., Jensen, S. O. W., Munk‐Jørgensen, P., & Christensen, T. Ø. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413484093 · Cited by 4
Patterns of Impaired Neurocognitive Performance on the Global Neuropsychological Assessment, and Their Brain Structural Correlates in Recent-onset and Chronic Schizophrenia
Mohan, V., Parekh, P., Lukose, A., Moirangthem, S., Saini, J. S., Schretlen, D. J., & John, J. P. (2023) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2023.21.2.340 · Cited by 4
Processing environmental stimuli in paranoid schizophrenia: recognizing facial emotions and performing executive functions.
Yu, S. H., Zhu, J. P., Xu, Y., Zheng, L., Chai, H., He, W., Liu, W. B., Li, H. C., & Wang, W. (2012) · PubMed · doi:10.3967/0895-3988.2012.06.012 · Cited by 4
Peripheral BDNF Levels in Individuals at Ultra-High Risk for Psychosis: A Systematic Review
Contreras, O., Rivera, C., Villaseca, C., Mas, F., Cartes, B., Castillo-Passi, R. I., & Nieto, R. R. (2025) · Brain Sciences · doi:10.3390/brainsci15090928 · Cited by 3
Selective processing in attention and memory in schizophrenia: A meta-analysis of the negative priming effect
Wang, W., Sun, X., Wong, A. C. ‐., & So, S. H. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.02.041 · Cited by 3
Similarities in cognitive impairment between recent- onset and chronic schizophrenia patients: a consideration for the neurodevelopmental hypothesis.
Mondragón‐Maya, A., Flores-Medina, Y., González-Sánchez, D., & Hernández, E. (2023) · PubMed Central · Cited by 3
Data-driven spatio-temporal dynamic brain connectivity analysis using fALFF: Application to sensorimotor task data
Hossain, K. M., Bhinge, S., Long, Q., Calhoun, V. D., & Adalı, T. (2022) · Conference on Information Sciences and Systems · doi:10.1109/ciss53076.2022.9751190 · Cited by 3
Divergent age-related cognitive impairments in first-episode psychosis
Duan, C., Cao, C., Ju, M., Wei, Y., Tang, X., Xu, L., Cui, H., Tang, Y., Yi, Z., Wei, X., et al. (2025) · Schizophrenia Research Cognition · doi:10.1016/j.scog.2025.100394 · Cited by 2
Clarifying Fundamental Role of Symbol Coding in Cognitive Networks in Schizophrenia and Healthy Controls Leveraging Gaussian Graphical Models and Bayesian Networks
Zhang, Y., Sun, Y., Lu, Z., Zhao, G., Sun, J., Zhang, X., Yang, Y., Kang, Z., Feng, X., Yuan, R., et al. (2025) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaf026 · Cited by 2
‘Two Hit’ Neurodevelopmental Mechanisms in Schizophrenia: Focus on Animal Models and the Role of BDNF
Klug, M., Hill, R., & van den Buuse, M. (2015) · Springer eBooks · doi:10.1007/978-3-319-17103-6_24 · Cited by 2
Schizophrenia, insight and fitness to plead in court and stand trial
Swain, E. (2012) · UCL Discovery (University College London) · Cited by 2
A Case Study on Promoting Neuroplasticity in a Patient With Schizophrenia
Puskar, K. R., Slivka, C., Lee, H., Martin, C. R., & Witt, M. (2015) · Perspectives In Psychiatric Care · doi:10.1111/ppc.12104 · Cited by 3
Are TOPF and WRAT WR Interchangeable Measures among Psychiatric Inpatients?
Rosen, A. S., King, L. C., Kinney, D. I., Nitch, S. R., & Glassmire, D. M. (2021) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acab098 · Cited by 1
Breaking down processing speed: Motor and cognitive insights in first-episode psychosis and unaffected first-degree relatives
Yorca‐Ruiz, Á., Herrero, R. M., de la Foz, V. O., Murillo‐García, N., & Ayesa‐Arriola, R. (2024) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.sjpmh.2024.06.002 · Cited by 1
Psychiatric Rehabilitation in Indian General Hospital Psychiatry Unit Settings
Sivakumar, T., Roy, A., Reddy, K. S., Angothu, H., Jagannathan, A., Muliyala, K. P., Bhola, P., Gandhi, S., & Kumar, D. (2021) · Indian Journal of Social Psychiatry · doi:10.4103/ijsp.ijsp_318_21 · Cited by 1

Authors: Sponheim, S. R., Jung, R. E., Seidman, L. J., Mesholam-Gately, R. I., Manoach, D. S., O’Leary, D. S., Ho, B. C., Andreasen, N. C., Lauriello, J., & Schulz, S. C.
Affiliations: Minneapolis VA Health Care System (US)
Mind Research Network (US)
Beth Israel Deaconess Medical Center (US)
Harvard University (US)
University of Iowa (US)
University of New Mexico (US)
Corresponding author: Sponheim, S.R.
ORCID: Sponheim, S.R.
Jung, R.E.
Seidman, L.J.
Manoach, D.S.
Ho, B.C.
Andreasen, N.C.
Schulz, S.C.
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2010-05
Volume: 44
Issue: 7
Pages: 421-428
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2009.09.010
PMC: PMC3940967
OpenAlex: W2140536737
Cited by: 123
References: 52
Citations by year: 2026: 3 · 2025: 8 · 2024: 5 · 2023: 8 · 2022: 15 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 2 · 2016: 2 · 2015: 11 · 2014: 11 · 2013: 12 · 2012: 8
FWCI: 4.12
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH040856, K23MH068380)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: schizophrenia, cognitive impairment, recent-onset schizophrenia, chronic schizophrenia, clinical course, problem solving, fine motor dexterity, episodic memory, memory retrieval, length of illness, aging, practice effects
MeSH terms: Adult, Analysis of Variance, Chronic Disease, Cognition Disorders, Cross-Sectional Studies, Female, Humans, Male, Neuropsychological Tests, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology, Case-Control Studies, Disease Progression, Young Adult

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