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Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment
Open accessAbstract
Chronic unpredictable stress (CUS) is a widely used animal model of depression. The present study was undertaken to investigate behavioral, physiological and molecular effects of CUS and/or chronic antidepressant treatment (venlafaxine or imipramine) in the same set of animals. Anhedonia, a core symptom of depression, was assessed by measuring consumption of a palatable solution. Exposure to CUS reduced intake of a palatable solution and this effect was prevented by chronic antidepressant treatment. Moreover, chronic antidepressant treatment decreased depressive-like behavior in a modified forced swim test in stressed rats. Present evidence suggests a role for brain-derived neurotrophic factor (BDNF) in depression. BDNF mRNA levels in the ventral and dorsal hippocampus were assessed by in situ hybridization. Exposure to CUS was not correlated with a decrease but rather with an increase in BDNF mRNA expression in both the dentate gyrus of the dorsal hippocampus and the CA3 region of the ventral hippocampus indicating that there is no simple link between depression-like behaviors per se and brain BDNF levels in rats. However, a significant increase in BDNF mRNA levels in the dentate gyrus of the dorsal hippocampus correlated with chronic antidepressant treatment emphasizing a role for BDNF in the mechanisms underlying antidepressant activity.
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“Both MDD patients [57–59] and animal models of depression [60, 61] show a remarkable reduction in serum BDNF levels.”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [61]
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217
Behavioural despair in rats: A new model sensitive to antidepressant treatments
Porsolt, R. D., Anton, G., Blavet, N., & Jalfre, M. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90118-8 · Cited by 3,138
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889
Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,241 · cited 1×
“The precise neuroanatomical basis of depression is still poorly understood, but strong evidence indicates that the hippocampus is one of the brain regions that play a central role in many aspects of depression (Drevets et al., 2008; Duman and Monteggia, 2006).”
BackgroundNibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109
Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654
Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605
Detke, M. J., Rickels, M. R., & Lucki, I. (1995) · Psychopharmacology · doi:10.1007/bf02245592 · Cited by 1,466
Regional dissociations within the hippocampus-memory and anxiety
Bannerman, D. M., Rawlins, J. N. P., McHugh, S. B., Deacon, R. M. J., Yee, B. K., Bast, T., Zhang, W.-N., Pothuizen, H. H. J., & Feldon, J. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.004 · Cited by 1,462
Smith, M., Makino, S., Květňanský, R., & Post, R. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01768.1995 · Cited by 1,449
Brunoni, A. R., Lopes, M., & Fregni, F. (2008) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009309 · Cited by 972
Moser, E., Moser, M. ‐., & Andersen, P. N. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03916.1993 · Cited by 953
Reduced fear expression after lesions of the ventral hippocampus
Kjelstrup, K. G., Tuvnes, F. A., Steffenach, H.-A., Murison, R., Moser, E. I., & Moser, M.-B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152112399 · Cited by 912
Antidepressant-like effect of brain-derived neurotrophic factor (BDNF)
Siuciak, J. A., Lewis, D. R., Wiegand, S. J., & Lindsay, R. M. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00169-4 · Cited by 841
Saarelainen, T., Hendolin, P., Lucas, G., Koponen, E., Sairanen, M., MacDonald, E., Agerman, K., Haapasalo, A., Nawa, H., Aloyz, R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00349.2003 · Cited by 800
Essential role of brain-derived neurotrophic factor in adult hippocampal function
Monteggia, L. M., Barrot, M., Powell, C. M., Berton, O., Galanis, V., Gemelli, T., Meuth, S., Nagy, A., Greene, R. W., & Nestler, E. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402141101 · Cited by 685
Role of neurotrophic factors in depression
CASTREN, E., VOIKAR, V, & RANTAMAKI, T. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.08.009 · Cited by 667
Stress-Induced Anhedonia in Mice is Associated with Deficits in Forced Swimming and Exploration
Strekalova, T. V., Spanagel, R., Bartsch, D., Henn, F. A., & Gass, P. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300532 · Cited by 584
Stress, depression, and anhedonia: caveats concerning animal models
Anisman, H., & Matheson, K. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.007 · Cited by 569
Castrén, E. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1629 · Cited by 563
Monteggia, L. M., Luikart, B., Barrot, M., Theobold, D., Malkovska, I., Nef, S., Parada, L. F., & Nestler, E. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.021 · Cited by 502
Kendler, K. S., Thornton, L. M., & Gardner, C. O. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.4.582 · Cited by 480
Effect of treatment on serum brain–derived neurotrophic factor levels in depressed patients
Gonul, A. S., Akdeniz, F., Taneli, F., Donat, O., Eker, Ç., & Vahip, S. (2005) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-005-0578-6 · Cited by 375
Jayatissa, M. N., Bisgaard, C. F., Tingström, A., Papp, M., & Wiborg, O. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301041 · Cited by 361
Li, S., Wang, C., Wang, M., Murakami, Y., & Matsumoto, K. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.01.004 · Cited by 346
Aydemır, Ö., Deveci, A., & Taneli, F. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.009 · Cited by 329
Schumacher, J. H., Jamra, R. A., Becker, T., Ohlraun, S., Klopp, N., Binder, E. B., Schulze, T. G., Deschner, M., Schmäl, C., Höfels, S., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.006 · Cited by 313
Bekris, S., Antoniou, K., Daskas, S., & Papadopoulou-Daifoti, Z. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.01.005 · Cited by 281
Rasmusson, A. M. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00286-5 · Cited by 265
Aguilera, M., Arias, B., Wichers, M., Barrantes-Vidal, N., Moya, J., Villa, H., van Os, J., Ibáñez, M. I., Ruipérez, M. A., Ortet, G., et al. (2009) · Psychological Medicine · doi:10.1017/s0033291709005248 · Cited by 265
Grønli, J., Bramham, C., Murison, R., Kanhema, T., Fiske, E., Bjorvatn, B., Ursin, R., & Portas, C. M. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.11.021 · Cited by 260
de Foubert, G., Carney, S. L., Robinson, C. S., Destexhe, E. J., Tomlinson, R., Hicks, C. A., Murray, T. K., Gaillard, J. P., Deville, C., Xhenseval, V., et al. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.054 · Cited by 249
Bi-phasic change in BDNF gene expression following antidepressant drug treatment
Coppell, A., Pei, Q., & Zetterström, T. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00077-7 · Cited by 244
From high anxiety trait to depression: a neurocognitive hypothesis
Sandi, C., & Richter‐Levin, G. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.02.004 · Cited by 240
Self-citationRepeated stress increases catalytic TrkB mRNA in rat hippocampus
Nibuya, M., Takahashi, M., Russell, D., & Duman, R. S. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00335-3 · Cited by 236
Suppression of sucrose drinking by chronic mild unpredictable stress: A methodological analysis
Muscat, R., & Willner, P. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80192-7 · Cited by 233
Brain-derived neurotrophic factor (BDNF) changes in the serum of depressed women
Aydemir, Ç., Yalçın, E. S., Aksaray, S., Kısa, C., Yildirim, S. G., Uzbay, T. I., & Göka, E. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.03.025 · Cited by 214
Konkle, A. T. M., Baker, S. L., Kentner, A. C., Barbagallo, L. S.-M., Merali, Z., & Bielajew, C. H. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.047 · Cited by 208
Pharmacological validation of the chronic mild stress model of depression
Papp, M., Moryl, E., & Willner, P. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00697-4 · Cited by 205
Bergström, A., Jayatissa, M. N., Mørk, A., & Wiborg, O. (2007) · Brain Research · doi:10.1016/j.brainres.2007.12.025 · Cited by 205
Gervasoni, N., Aubry, J., Bondolfi, G., Osiek, C., Schwald, M., Bertschy, G., & Karege, F. (2005) · Neuropsychobiology · doi:10.1159/000085725 · Cited by 204
Herrero, A. I., Sandi, C., & Venero, C. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.02.001 · Cited by 196
Self-citationTrivedi, M. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.02.005 · Cited by 191
Nair, A., Vadodaria, K. C., Banerjee, S. B., Benekareddy, M., Dias, B. G., Duman, R. S., & Vaidya, V. A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301276 · Cited by 189
Lee, K. J., Kim, S.-J., Kim, S.-W., Choi, S.-H., Shin, Y.-C., Park, S.-H., Moon, B., Cho, E., Lee, M.-S., Choi, S.-H., et al. (2006) · Experimental & Molecular Medicine · doi:10.1038/emm.2006.6 · Cited by 139
Jordan, S., Kramer, G. L., Zukas, P. K., Moeller, M., & Petty, F. (1994) · Synapse · doi:10.1002/syn.890180404 · Cited by 137
KAP1-Mediated Epigenetic Repression in the Forebrain Modulates Behavioral Vulnerability to Stress
Jakobsson, J., Cordero, M. I., Bisaz, R., Groner, A. C., Busskamp, V., Bensadoun, J., Cammas, F. M., Losson, R., Mansuy, I. M., Sandi, C., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.036 · Cited by 134
Self-citationWichers, M., Kenis, G., Jacobs, N., Mengelers, R., Derom, C., Vlietinck, R., & van Os, J. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30576 · Cited by 127
Ibargüen-Vargas, Y., Surget, A., Vourc’h, P., Leman, S., Andres, C. R., Gardier, A. M., & Belzung, C. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.040 · Cited by 112
Fendt, M., & Endres, T. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.05.010 · Cited by 107
Sillaber, I., Panhuysen, M., Henniger, M. S. H., Ohl, F., Kühne, C., Pütz, B., Pohl, T., Deussing, J. M., Páez-Pereda, M., & Holsboer, F. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1232-6 · Cited by 95
Sandi, C., Cordero, M. I., Ugolini, A., Varea, E., Caberlotto, L., & Large, C. H. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06451.x · Cited by 85
Self-citationLarsen, M. H., Hay‐Schmidt, A., Rønn, L. C. B., & Mikkelsen, J. D. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.08.050 · Cited by 76
Self-citationVitale, G., Ruggieri, V., Filaferro, M., Frigeri, C., Alboni, S., Tascedda, F., Brunello, N., Guerrini, R., Cifani, C., & Massi, M. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1646-9 · Cited by 76
Cordero, M. I., Rodríguez, J. J., Davies, H. A., Peddie, C. J., Sandi, C., & Stewart, M. G. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.046 · Cited by 73
Self-citationRogóż, Z., Skuza, G., & Legutko, B. (2005) · PubMed · Cited by 72
Dawson, L. A., Nguyen, H. Q., & Geiger, A. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00052-0 · Cited by 71
Xu, H., Luo, C., Richardson, J. S., & Li, X.-M. (2004) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500265 · Cited by 71
Varea, E., Castillo-Gómez, E., Gómez‐Climent, M. Á., Blasco‐Ibáñez, J. M., Crespo, C., Martinez-Guijarro, F. J., & Nácher, J. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.01.001 · Cited by 62
Lucca, G., Comim, C. M., Valvassori, S. S., Pereira, J. G., Stertz, L., Gavioli, E. C., Kapczinski, F. P., & Quevedo, J. (2008) · Current Neurovascular Research · doi:10.2174/156720208786413406 · Cited by 53
Schulte‐Herbrüggen, O., Fuchs, E., Abumaria, N., Ziegler, A. M., Danker‐Hopfe, H., Hiemke, C., & Hellweg, R. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22080 · Cited by 51
Allaman, I., Papp, M., Kraftsik, R., Fiumelli, H., Magistretti, P. J., & Martin, J. (2008) · PubMed · Cited by 40
Larsen, M., Olesen, M. V., Woldbye, D. P. D., Hay‐Schmidt, A., Hansen, H. H., Rønn, L. C. B., & Mikkelsen, J. D. (2005) · Brain Research · doi:10.1016/j.brainres.2005.09.039 · Cited by 37
Self-citationEffects of chronic imipramine on exploration, locomotion, and food/water intake in rats
Mogensen, J., Pedersen, T. K., & Holm, S. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90139-2 · Cited by 25
Chronic imipramine effects on exploratory behavior in rats
Hughes, R. N., & Pither, J. M. (1987) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(87)90581-8 · Cited by 16
Adding complexity to emotion-cognition interactions: the stressed individual
Sandi, C. (2008) · Frontiers in Neuroscience · doi:10.3389/neuro.01.042.2008 · Cited by 5
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Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects
Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.009 · Cited by 694
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Hill, M. N., Hellemans, K. G. C., Verma, P., Gorzalka, B. B., & Weinberg, J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.001 · Cited by 420
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Metadata
- Authors
- Larsen, M. H., Mikkelsen, J. D., Hay-Schmidt, A., & Sandi, C.
- Affiliations
- University of Copenhagen (DK)
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Larsen, Marianne H.
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 44
- Issue
- 13
- Pages
- 808-816
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2078116925
- Cited by
- 165
- References
- 71
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 6 · 2021: 14 · 2020: 7 · 2019: 10 · 2018: 11 · 2017: 5 · 2016: 6 · 2015: 17 · 2014: 15 · 2013: 10 · 2012: 16
- FWCI
- 12.67
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (FP7-HEALTH-F2M-2007-201600, 120791)
- FP7 Health
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- brain-derived neurotrophic factor, chronic unpredictable mild stress, depression, anhedonia, antidepressant treatment, venlafaxine, imipramine, hippocampus, dentate gyrus, CA3 region, BDNF mRNA expression, forced swim test
- MeSH terms
- Venlafaxine Hydrochloride, Animals, Antidepressive Agents, Cyclohexanols, Disease Models, Animal, Food Preferences, Hippocampus, Imipramine, Locomotion, Male, RNA, Messenger, Saccharin, Stress, Psychological, Sweetening Agents, Swimming, Time Factors, Rats, Sprague-Dawley, In Situ Hybridization, Maze Learning, Dentate Gyrus, Brain-Derived Neurotrophic Factor, Rats, CA3 Region, Hippocampal
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