Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus
Abstract
Stress regulation of brain-derived neurotrophic factor (BDNF) is implicated in the hippocampal damage observed in depression. BDNF has a complex gene structure with four 5' untranslated exons (I-IV) with unique promoters, and a common 3' coding exon (V). To better understand the stress regulation of BDNF, we addressed whether distinct stressors differentially regulate exon-specific BDNF transcripts in the postnatal and adult hippocampus. The early life stress of maternal separation (MS) resulted in a time point-dependent differential upregulation of BDNF transcripts restricted to early postnatal life (P14-BDNF II, P21-BDNF IV, V). In adulthood, distinct stressors regulated BDNF transcripts in a signature manner. Immobilization stress, administered once, decreased all BDNF splice variants but had differing effects on BDNF I/II (increase) and III/IV (decrease) when administered chronically. Although immobilization stress reduced BDNF (V) mRNA, chronic unpredictable stress did not influence total BDNF despite altering specific BDNF transcripts. Furthermore, a prior history of MS altered the signature pattern in which adult-onset stress regulated specific BDNF transcripts. We also examined the expression of cyclic AMP response element-binding protein (CREB), an upstream transcriptional activator of BDNF, and observed a CREB induction in the postnatal hippocampus following MS. As a possible consequence of enhanced CREB and BDNF expression following MS, we examined hippocampal progenitor proliferation and observed a significant increase restricted to early life. These results suggest that alterations in CREB/BDNF may contribute to the generation of individual differences in stress neurocircuitry, providing a substrate for altered vulnerability to depressive disorders.
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Individual stress-system components respond specifically to different challenges, and the physiological stress response profile changes subtly with different stressors.
“At the same time, the individual components of the SRS respond in specific ways to different types of challenges (section 4), and the physiological profile of the stress response has been shown to change subtly with different types of stressors (e.g., Nair et al., 2007; Pacák and Palkovits, 2001; Thrivikraman et al., 2000).”
From The Adaptive Calibration Model of stress responsivity (2011) · cites this paper as Nair et al., 2007
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- Authors
- Nair, A., Vadodaria, K. C., Banerjee, S. B., Benekareddy, M., Dias, B. G., Duman, R. S., & Vaidya, V. A.
- Affiliations
- Tata Institute of Fundamental Research (IN)
- Yale University (US)
- Corresponding author
- Vaidya, Vidita A
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2006-12-13
- Volume
- 32
- Issue
- 7
- Pages
- 1504-1519
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2146976278
- Cited by
- 189
- References
- 65
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 8 · 2020: 3 · 2019: 8 · 2018: 8 · 2017: 6 · 2016: 12 · 2015: 16 · 2014: 14 · 2013: 15 · 2012: 12
- FWCI
- 4.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r03tw006257-03)
- Fogarty International Center (1R03 TW 006257-01)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- brain-derived neurotrophic factor, hippocampus, maternal separation, early life stress, restraint stress, chronic unpredictable mild stress, cyclic AMP response element binding protein, CREB, depression vulnerability, postnatal development
- MeSH terms
- Aging, Animals, Animals, Newborn, Cell Differentiation, Hippocampus, Male, Maternal Deprivation, Neural Pathways, RNA, Messenger, Stem Cells, Stress, Psychological, Transcriptional Activation, Up-Regulation, Rats, Sprague-Dawley, Cyclic AMP Response Element-Binding Protein, Gene Expression Regulation, Developmental, Brain-Derived Neurotrophic Factor, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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