The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder
Open accessAbstract
Epigenetic alterations of the brain-derived neurotrophic factor (Bdnf) gene have been linked with memory, stress, and neuropsychiatric disorders. Here we examined whether there was a link between an established rat model of post-traumatic stress disorder (PTSD) and BdnfDNA methylation. Adult male Sprague-Dawley rats were given psychosocial stress composed of two acute cat exposures in conjunction with 31 days of daily social instability. These manipulations have been shown previously to produce physiological and behavioral sequelae in rats that are comparable to symptoms observed in traumatized people with PTSD. We then assessed BdnfDNA methylation patterns (at exon IV) and gene expression. We have found here that the psychosocial stress regimen significantly increased BdnfDNA methylation in the dorsal hippocampus, with the most robust hypermethylation detected in the dorsal CA1 subregion. Conversely, the psychosocial stress regimen significantly decreased methylation in the ventral hippocampus (CA3). No changes in BdnfDNA methylation were detected in the medial prefrontal cortex or basolateral amygdala. In addition, there were decreased levels of BdnfmRNA in both the dorsal and ventral CA1. These results provide evidence that traumatic stress occurring in adulthood can induce CNS gene methylation, and specifically, support the hypothesis that epigenetic marking of the Bdnfgene may underlie hippocampal dysfunction in response to traumatic stress. Furthermore, this work provides support for the speculative notion that altered hippocampal BdnfDNA methylation is a cellular mechanism underlying the persistent cognitive deficits which are prominent features of the pathophysiology of PTSD.
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DNA methylation patterns and epigenetic memory
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Self-citationDNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation
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Lasting epigenetic influence of early-life adversity on the BDNF gene
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“Moreover, a series of studies has demonstrated isoform-specific epigenetic marking, including methylation of Bdnf DNA, in rats exposed to either early developmental stress or fear conditioning in adulthood (Lubin et al., 2008; Roth et al., 2009a).”
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Biological studies of post-traumatic stress disorder
Pitman, R. K., Rasmusson, A. M., Koenen, K. C., Shin, L. M., Orr, S. P., Gilbertson, M. W., Milad, M. R., & Liberzon, I. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3339 · Cited by 1,529
Genome-wide epigenetic regulation by early-life trauma
Labonté, B., Suderman, M., Maussion, G., Navaro, L., Yerko, V., Mahar, I., Bureau, A., Mechawar, N., Szyf, M., Meaney, M. J., et al. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2287 · Cited by 488
Faulk, C., & Dolinoy, D. C. (2011) · Epigenetics · doi:10.4161/epi.6.7.16209 · Cited by 386
Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene
Perroud, N., Salzmann, A., Prada, P., Nicastro, R., Hoeppli, M.-E., Furrer, S., Ardu, S., Krejci, I., Karege, F., & Malafosse, A. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.140 · Cited by 320
The neurodevelopmental origins of suicidal behavior
Turecki, G., Ernst, C., Jollant, F., Labonté, B., & Mechawar, N. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.008 · Cited by 299
Metadata
- Authors
- Roth, T. L., Zoladz, P. R., Sweatt, J. D., & Diamond, D. M.
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 45
- Issue
- 7
- Pages
- 919-926
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2160621075
- Cited by
- 323
- References
- 26
- FWCI
- 39.32
- Type
- journal article
- Language
- en
- Open access
- green
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