Epigenetic regulation in psychiatric disorders

Translating the Histone Code

Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756 · see citing works

Epigenetic programming by maternal behavior

Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177 · see citing works

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics · doi:10.1038/13810 · Cited by 4,990 · see citing works

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051 · see citing works

Neural systems of reinforcement for drug addiction: from actions to habits to compulsion

Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785 · see citing works

Neurobiology of Depression

Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works

NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory

Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647 · see citing works

Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells

Lee, T. I., Jenner, R. G., Boyer, L. A., Guenther, M. G., Levine, S. S., Kumar, R., Chevalier, B. S., Johnstone, S. E., Cole, M. F., Isono, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.043 · Cited by 2,238 · see citing works

Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works

Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780 · see citing works

New approaches to antidepressant drug discovery: beyond monoamines

Berton, O., & Nestler, E. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1846 · Cited by 1,589 · see citing works

Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism

Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561 · see citing works

Cooperation between Complexes that Regulate Chromatin Structure and Transcription

Narlikar, G. J., Fan, H.-Y., & Kingston, R. E. (2002) · Cell · doi:10.1016/s0092-8674(02)00654-2 · Cited by 1,486 · see citing works

Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

Chen, R. Z., Akbarian, S., Tudor, M., & Jaenisch, R. (2001) · Nature Genetics · doi:10.1038/85906 · Cited by 1,275 · see citing works

Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2

Chen, W. G., Chang, Q., Lin, Y., Meissner, A., West, A. E., Griffith, E. C., Jaenisch, R., & Greenberg, M. E. (2003) · Science · doi:10.1126/science.1086446 · Cited by 1,232 · see citing works

Reversal of Neurological Defects in a Mouse Model of Rett Syndrome

Guy, J., Gan, J., Selfridge, J., Cobb, S., & Bird, A. (2007) · Science · doi:10.1126/science.1138389 · Cited by 1,230 · see citing works

Covalent Modification of DNA Regulates Memory Formation

Miller, C. A., & Sweatt, J. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.022 · Cited by 1,180 · see citing works

Controlling the double helix

Felsenfeld, G., & Groudine, M. T. (2003) · Nature · doi:10.1038/nature01411 · Cited by 1,153 · see citing works

Regulation of histone acetylation during memory formation in the hippocampus

Levenson, J. M., O'Riordan, K. J., Brown, K. D., Trinh, M. A., Molfese, D. L., & Sweatt, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402229200 · Cited by 1,131 · see citing works

Variations in maternal care in the rat as a mediating influence for the effects of environment on development

Champagne, F. A., Francis, D. D., Mar, A., & Meaney, M. J. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00149-5 · Cited by 1,021 · see citing works

Chromatin Acetylation, Memory, and LTP Are Impaired in CBP+/− Mice

Alarcón, J. M., Malleret, G., Touzani, K., Vronskaya, S., Ishii, S., Kandel, E. R., & Barco, A. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.021 · Cited by 892 · see citing works

Brain-Specific Phosphorylation of MeCP2 Regulates Activity-Dependent Bdnf Transcription, Dendritic Growth, and Spine Maturation

Zhou, Z., Hong, E. J., Cohen, S., Zhao, W.-N., Ho, H.-Y. H., Schmidt, L., Chen, W. G., Lin, Y., Savner, E., Griffith, E. C., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.037 · Cited by 877 · see citing works

CREB-binding Protein and p300 in Transcriptional Regulation

Vo, N., & Goodman, R. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r000025200 · Cited by 868 · see citing works

Multiple promoters direct tissue-specific expression of the rat BDNF gene

Timmusk, T., Palm, K., Metsis, M., Reintam, T., Paalme, V., Saarma, M., & Persson, H. (1993) · Neuron · doi:10.1016/0896-6273(93)90335-o · Cited by 858 · see citing works

CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation

Korzus, E., Rosenfeld, M. G., & Mayford, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.002 · Cited by 823 · see citing works

The many faces of histone lysine methylation

Lachner, M., & Jenuwein, T. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00335-6 · Cited by 814 · see citing works

Epigenetic mechanisms in memory formation

Levenson, J. M., & Sweatt, J. D. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1604 · Cited by 767 · see citing works

Chromatin Remodeling Is a Key Mechanism Underlying Cocaine-Induced Plasticity in Striatum

Kumar, A., Choi, K.-H., Renthal, W., Tsankova, N. M., Theobald, D. E. H., Truong, H.-T., Russo, S. J., LaPlant, Q., Sasaki, T. S., Whistler, K. N., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.023 · Cited by 764 · see citing works

SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?Preprint

Gill, G. (2004) · Genes & Development · doi:10.1101/gad.1214604 · Cited by 752 · see citing works

Defining the CREB Regulon

Impey, S., McCorkle, S., Cha‐Molstad, H., Dwyer, J. M., Yochum, G. S., Boss, J. M., McWeeney, S. K., Dunn, J. J., Mandel, G., & Goodman, R. H. (2004) · Cell · doi:10.1016/j.cell.2004.10.032 · Cited by 695 · see citing works

Essential role of brain-derived neurotrophic factor in adult hippocampal function

Monteggia, L. M., Barrot, M., Powell, C. M., Berton, O., Galanis, V., Gemelli, T., Meuth, S., Nagy, A., Greene, R. W., & Nestler, E. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402141101 · Cited by 685 · see citing works

Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?

Hassa, P. O., Haenni, S. S., Elser, M., & Hottiger, M. O. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00040-05 · Cited by 682 · see citing works

Maternal care as a model for experience-dependent chromatin plasticity?

Meaney, M. J., & Szyf, M. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.07.006 · Cited by 658 · see citing works

ΔFosB: A sustained molecular switch for addiction

Nestler, E. J., Barrot, M., & Self, D. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191352698 · Cited by 640 · see citing works

Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett Syndrome

Dani, V. S., Chang, Q., Maffei, A., Turrigiano, G. G., Jaenisch, R., & Nelson, S. B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506071102 · Cited by 639 · see citing works

Regulation of gene expression and cocaine reward by CREB and ΔFosB

McClung, C. A., & Nestler, E. J. (2003) · Nature Neuroscience · doi:10.1038/nn1143 · Cited by 625 · see citing works

Evidence That DNA (Cytosine-5) Methyltransferase Regulates Synaptic Plasticity in the Hippocampus

Levenson, J. M., Roth, T. L., Lubin, F. D., Miller, C. A., Huang, I.-C., Desai, P., Malone, L. M., & Sweatt, J. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511767200 · Cited by 615 · see citing works

Depression: a case of neuronal life and death?

Duman, R. S. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.033 · Cited by 612 · see citing works

The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression

Chang, Q., Khare, G., Dani, V., Nelson, S., & Jaenisch, R. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.027 · Cited by 578 · see citing works

Time-Dependent Increases in Brain-Derived Neurotrophic Factor Protein Levels within the Mesolimbic Dopamine System after Withdrawal from Cocaine: Implications for Incubation of Cocaine Craving

Grimm, J. W., Lü, L., Hayashi, T., Hope, B. T., Su, T., & Shaham, Y. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00742.2003 · Cited by 551 · see citing works

Learning and Memory and Synaptic Plasticity Are Impaired in a Mouse Model of Rett Syndrome

Moretti, P., Levenson, J. M., Battaglia, F., Atkinson, R., Teague, R., Antalffy, B., Armstrong, D., Arancio, O., Sweatt, J. D., & Zoghbi, H. Y. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2623-05.2006 · Cited by 545 · see citing works

Antidepressant-Like Effects of the Histone Deacetylase Inhibitor, Sodium Butyrate, in the Mouse

Schroeder, F. A., Lin, C. L., Crusio, W. E., & Akbarian, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.036 · Cited by 541 · see citing works

Role of Neurotrophic Factors in the Etiology and Treatment of Mood Disorders

Duman, R. S. (2004) · NeuroMolecular Medicine · doi:10.1385/nmm:5:1:011 · Cited by 537 · see citing works

Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors

Monteggia, L. M., Luikart, B., Barrot, M., Theobold, D., Malkovska, I., Nef, S., Parada, L. F., & Nestler, E. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.021 · Cited by 502 · see citing works

Integration of Long-Term-Memory-Related Synaptic Plasticity Involves Bidirectional Regulation of Gene Expression and Chromatin Structure

Guan, Z., Giustetto, M., Lomvardas, S., Kim, J.-H., Miniaci, M. C., Schwartz, J. H., Thanos, D., & Kandel, E. R. (2002) · Cell · doi:10.1016/s0092-8674(02)01074-7 · Cited by 497 · see citing works

Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5

Bibb, J. A., Chen, J., Taylor, J. R., Svenningsson, P., Nishi, A., Snyder, G. L., Yan, Z., Sagawa, Z. K., Ouimet, C. C., Nairn, A. C., et al. (2001) · Nature · doi:10.1038/35066591 · Cited by 480 · see citing works

Histone Modifications at Gene Promoter Regions in Rat Hippocampus after Acute and Chronic Electroconvulsive Seizures

Tsankova, N. M., Kumar, A., & Nestler, E. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0589-04.2004 · Cited by 447 · see citing works

The many faces of REST oversee epigenetic programming of neuronal genes

Ballas, N., & Mandel, G. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.08.015 · Cited by 441 · see citing works

Histone H3 Lysine 4 Demethylation Is a Target of Nonselective Antidepressive Medications

Lee, M. G., Wynder, C., Schmidt, D. M., McCafferty, D. G., & Shiekhattar, R. (2006) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.05.004 · Cited by 438 · see citing works

ΔFosB: a molecular switch for long-term adaptation in the brain

McClung, C. A., Ulery, P. G., Perrotti, L. I., Zachariou, V., Berton, O., & Nestler, E. J. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.05.014 · Cited by 398 · see citing works

Pharmacogenetics and Human Molecular Genetics of Opiate and Cocaine Addictions and Their Treatments

Kreek, M. J., Bart, G., Lilly, C., Laforge, K. S., & Nielsen, D. A. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.1.1 · Cited by 391 · see citing works

An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability

Tremolizzo, L., Carboni, G., Ruzicka, W. B., Mitchell, C. P., Sugaya, I., Tueting, P. A., Sharma, R. P., Grayson, D. R., Costa, E., & Guidotti, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262658999 · Cited by 384 · see citing works

Linking the epigenetic ‘language’ of covalent histone modifications to cancer

Hake, S. B., Xiao, A., & Allis, C. D. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601575 · Cited by 384 · see citing works

Identification of PSD-95 as a Regulator of Dopamine-Mediated Synaptic and Behavioral Plasticity

Yao, W., Gainetdinov, R. R., Arbuckle, M. I., Sotnikova, T. D., Cyr, M., Beaulieu, J., Torres, G. E., Grant, S. G. N., & Caron, M. G. (2004) · Neuron · doi:10.1016/s0896-6273(04)00048-0 · Cited by 380 · see citing works

Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function

Zhao, X., Ueba, T., Christie, B. R., Barkho, B. Z., McConnell, M. J., Nakashima, K., Lein, E. S., Eadie, B. D., Willhoite, A. R., Muotri, A. R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1131928100 · Cited by 376 · see citing works

Twin studies of psychiatric illness: an update.

Kendler, K. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.11.1005 · Cited by 376 · see citing works

DNA Hypomethylation Perturbs the Function and Survival of CNS Neurons in Postnatal Animals

Fan, G., Beard, C., Chen, R. Z., Csankovszki, G., Sun, Y., Siniaia, M. S., Biniszkiewicz, D., Bates, B., Lee, P. P., Kühn, R., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-03-00788.2001 · Cited by 368 · see citing works

A small modulatory dsRNA specifies the fate of adult neural stem cells

Kuwabara, T., Hsieh, J., Nakashima, K., Taira, K., & Gage, F. H. (2004) · Cell · doi:10.1016/s0092-8674(04)00248-x · Cited by 363 · see citing works

Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice

Luikenhuis, S., Giacometti, E., Beard, C., & Jaenisch, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401626101 · Cited by 354 · see citing works

ERK/MAPK regulates hippocampal histone phosphorylation following contextual fear conditioning

Chwang, W. B., O’Riordan, K. J., Levenson, J. M., & Sweatt, J. D. (2006) · Learning & Memory · doi:10.1101/lm.152906 · Cited by 341 · see citing works

Neuronal activity‐dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5

Chawla, S., Vanhoutte, P., Arnold, F. J. L., Huang, C. L.-H., & Bading, H. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01648.x · Cited by 301 · see citing works

Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine

Liu, Q., Lü, L., Zhu, X.-G., Gong, J.-P., Shaham, Y., & Uhl, G. R. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.004 · Cited by 297 · see citing works

Parsing Molecular and Behavioral Effects of Cocaine in Mitogen- and Stress-Activated Protein Kinase-1-Deficient Mice

Brami‐Cherrier, K., Valjent, E., Hervé, D., Darragh, J., Corvol, J., Pagès, C., Simon, A. J., Girault, J., & Caboche, J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1711-05.2005 · Cited by 294 · see citing works

Histone Deacetylase Activity Is Necessary for Oligodendrocyte Lineage Progression

Marin‐Husstege, M., Muggironi, M., Liu, A., & Casaccia-Bonnefil, P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10333.2002 · Cited by 293 · see citing works

Demethylase Activity Is Directed by Histone Acetylation

Cervoni, N., & Szyf, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103921200 · Cited by 293 · see citing works

The Persistence of Long-Term Memory

Bailey, C. H., Kandel, E. R., & Si, K. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.017 · Cited by 277 · see citing works

On the epigenetic regulation of the human reelin promoter

Chen, Y. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf401 · Cited by 274 · see citing works

Altered Histone Acetylation atGlutamate Receptor 2andBrain-Derived Neurotrophic FactorGenes Is an Early Event Triggered by Status Epilepticus

Huang, Y., Doherty, J., & Dingledine, R. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08422.2002 · Cited by 261 · see citing works

Phenotype of schizophrenia: a review and formulation

Tamminga, C. A., & Holcomb, H. H. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001563 · Cited by 261 · see citing works

Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice

Tremolizzo, L., Doueiri, M.-S., Dong, E., Grayson, D. R., Davis, J. M., Pinna, G., Tueting, P. A., Rodriguez‐Menendez, V., Costa, E., & Guidotti, A. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.046 · Cited by 259 · see citing works

CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum

Levine, A. A., Guan, Z., Barco, Á., Xu, S., Kandel, E. R., & Schwartz, J. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509735102 · Cited by 249 · see citing works

Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons

Crosio, C., Heitz, E., Allis, C. D., Borrelli, E., & Sassone‐Corsi, P. (2003) · Journal of Cell Science · doi:10.1242/jcs.00804 · Cited by 242 · see citing works

Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5

Norrholm, S. D., Bibb, J. A., Nestler, E. J., Ouimet, C. C., Taylor, J. R., & Greengard, P. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00560-2 · Cited by 238 · see citing works

Postnatal Loss of Methyl-CpG Binding Protein 2 in the Forebrain is Sufficient to Mediate Behavioral Aspects of Rett Syndrome in Mice

Gemelli, T., Berton, O., Nelson, E. D., Perrotti, L. I., Jaenisch, R., & Monteggia, L. M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.025 · Cited by 237 · see citing works

Effect of Divalproex Combined with Olanzapine or Risperidone in Patients with an Acute Exacerbation of Schizophrenia

Casey, D. E., Daniel, D. G., Wassef, A. A., Tracy, K. A., Wozniak, P., & Sommerville, K. W. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300023 · Cited by 232 · see citing works

Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome

McGill, B. E., Bundle, S. F., Yaylaoglu, M., Carson, J. P., Christina Thaller, B., & Zoghbi, H. Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608702103 · Cited by 229 · see citing works

Chromatin remodeling in neural development and plasticity

Hsieh, J., & Gage, F. H. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.09.002 · Cited by 225 · see citing works

MeCP2-Dependent Transcriptional Repression Regulates Excitatory Neurotransmission

Nelson, E. D., Kavalali, E. T., & Monteggia, L. M. (2006) · Current Biology · doi:10.1016/j.cub.2006.02.062 · Cited by 218 · see citing works

Reelin and glutamic acid decarboxylase 67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia

Dong, E., Agís‐Balboa, R. C., Simonini, M. V., Grayson, D. R., Costa, E., & Guidotti, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505394102 · Cited by 198 · see citing works

Fluoxetine and Cocaine Induce the Epigenetic Factors MeCP2 and MBD1 in Adult Rat Brain

Cassel, S. L., Carouge, D., Gensburger, C., Anglard, P., Burgun, C., Dietrich, J., Aunis, D., & Zwiller, J. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.022301 · Cited by 194 · see citing works

The Oncoprotein Set/TAF-1β, an Inhibitor of Histone Acetyltransferase, Inhibits Active Demethylation of DNA, Integrating DNA Methylation and Transcriptional Silencing

Cervoni, N., Detich, N., Seo, S., Chakravarti, D., & Moshe Szyf, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202256200 · Cited by 175 · see citing works

Control of MEF2 Transcriptional Activity by Coordinated Phosphorylation and Sumoylation

Grégoire, S., Tremblay, A., Xiao, L., Yang, Q., Ma, K., Nie, J., Mao, Z., Wu, Z., Giguère, V., & Yang, X. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509471200 · Cited by 171 · see citing works

DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism

nsch, D. B., Lenz, B., Kornhuber, J., & Bleich, S. (2005) · Neuroreport · doi:10.1097/00001756-200502080-00020 · Cited by 163 · see citing works

Regulation of Gene Expression by Chronic Morphine and Morphine Withdrawal in the Locus Ceruleus and Ventral Tegmental Area

McClung, C. A., Nestler, E. J., & Zachariou, V. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0062-05.2005 · Cited by 163 · see citing works

Imprinted gene expression in the brain

Davies, W., Isles, A. R., & Wilkinson, L. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.11.007 · Cited by 158 · see citing works

Dopamine D2‐like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP‐protein kinase A and NMDA receptor signaling

Li, J., Guo, Y., Schroeder, F. A., Youngs, R. M., Schmidt, T. W., Ferris, C. F., Konradi, C. L., & Akbarian, S. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02569.x · Cited by 151 · see citing works

ACUTE IN VIVO EFFECT OF ETHANOL (BINGE DRINKING) ON HISTONE H3 MODIFICATIONS IN RAT TISSUES

KIM, J.-S., & Shukla, S. D. (2005) · Alcohol and Alcoholism · doi:10.1093/alcalc/agh248 · Cited by 147 · see citing works

The human reelin gene: Transcription factors (+), repressors (−) and the methylation switch (+/−) in schizophrenia

Grayson, D. R., Chen, Y., Costa, E., Dong, E., Guidotti, A., Kundaković, M., & Sharma, R. P. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.01.007 · Cited by 139 · see citing works

Epigenetic Mechanisms and Gene Networks in the Nervous System

Colvis, C. M., Pollock, J. D., Goodman, R. H., Impey, S., Dunn, J. J., Mandel, G., Champagne, F. A., Mayford, M. R., Korzus, E., Kumar, A., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4119-05.2005 · Cited by 139 · see citing works

Mitogen-Regulated RSK2-CBP Interaction Controls Their Kinase and Acetylase Activities

Mérienne, K., Pannetier, S., Harel‐Bellan, A., & Sassone‐Corsi, P. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.20.7089-7096.2001 · Cited by 132 · see citing works

The molecular foundations of psychiatry

(1993) · Choice Reviews Online · doi:10.5860/choice.30-4099 · Cited by 129 · see citing works

Inactivation of the Myocyte Enhancer Factor-2 Repressor Histone Deacetylase-5 by Endogenous Ca2//Calmodulin-dependent Kinase II Promotes Depolarization-mediated Cerebellar Granule Neuron Survival

Linseman, D. A., Bartley, C. M., Le, S. S., Laessig, T. A., Bouchard, R. J., Meintzer, M. K., Li, M., & Heidenreich, K. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307245200 · Cited by 124 · see citing works

MeCP2 Dysfunction in Humans and Mice

Zoghbi, H. Y. (2005) · Journal of Child Neurology · doi:10.1177/08830738050200090701 · Cited by 90 · see citing works

Syndromes of disordered chromatin remodeling

Ausió, J., Levin, D., Amorim, G. D., Bakker, S., & Macleod, P. (2003) · Clinical Genetics · doi:10.1034/j.1399-0004.2003.00124.x · Cited by 90 · see citing works

The effects of L-methionine (without MAOI) in schizophrenia

Antun, F., Burnett, G. B., Cooper, A. J., Daly, R. J., Smythies, J., & Zealley, A. K. (1971) · Journal of Psychiatric Research · doi:10.1016/0022-3956(71)90009-4 · Cited by 80 · see citing works

Cocaine-responsive gene expression changes in rat hippocampus

Freeman, W. M., Brebner, K., Lynch, W. J., Robertson, D. J., Roberts, D. C. S., & Vrana, K. E. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00432-8 · Cited by 73 · see citing works

Inducible Covalent Posttranslational Modification of Histone H3

Bode, A. M., & Dong, Z. (2005) · Science s STKE · doi:10.1126/stke.2812005re4 · Cited by 73 · see citing works

Changes in rat frontal cortex gene expression following chronic cocaine

Freeman, W. M., Brebner, K., Lynch, W. J., Patel, K. M., Robertson, D. J., Roberts, D. C. S., & Vrana, K. E. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00197-3 · Cited by 58 · see citing works

The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal‐like cultures

Korutla, L., Wang, P. J., & Mackler, S. A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03206.x · Cited by 54 · see citing works

Molecular Genetics of Human Cognition

Weeber, E. J. (2002) · Molecular Interventions · doi:10.1124/mi.2.6.376 · Cited by 48 · see citing works

Cdk5/p35 Phosphorylates mSds3 and Regulates mSds3-mediated Repression of Transcription

Li, Z., David, G., Hung, K.-W., DePinho, R. A., Fu, A. K. Y., & Ip, N. Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411002200 · Cited by 41 · see citing works

Communication between levels of transcriptional control improves robustness and adaptivity

Tsankov, A. M., Brown, C. R., Yu, M. C., Win, M. Z., Silver, P. A., & Casolari, J. M. (2006) · Molecular Systems Biology · doi:10.1038/msb4100106 · Cited by 32 · see citing works

Effect of Ethanol on Chromatin and Nonhistone Nuclear Proteins in Rat Brain

Mahadev, K., & Vemuri, M. C. (1998) · Neurochemical Research · doi:10.1023/a:1020778018149 · Cited by 21 · see citing works

Genome‐Wide Analysis of Epigenetics in Cancer

Lee, M. P. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb05965.x · Cited by 21 · see citing works

Regulating fragile X gene transcription in the brain and beyond

Lim, J. H., Booker, A. B., & Fallon, J. R. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20401 · Cited by 21 · see citing works

The Molecular Foundations of Psychiatry

(1992) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550176 · Cited by 13 · see citing works

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works

The molecular neurobiology of depression

Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889 · see citing works

Major depressive disorder

Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166 · see citing works

Untitled work

(2009)

Synaptic plasticity and addiction

Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397 · see citing works

Mechanisms of stress in the brain

McEwen, B. S., Bowles, N. P., Gray, J. D., Hill, M. N., Hunter, R. G., Karatsoreos, I. N., & Nasca, C. (2015) · Nature Neuroscience · doi:10.1038/nn.4086 · Cited by 1,386 · see citing works

Brain foods: The effects of nutrients on brain function.

Gómez-Pinilla, F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2421 · Cited by 1,372 · see citing works

Lasting epigenetic influence of early-life adversity on the BDNF gene

Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.028 · Cited by 1,273 · see citing works

Psychobiology and molecular genetics of resilience

Feder, A., Nestler, E. J., & Charney, D. S. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2649 · Cited by 1,272 · see citing works

Epigenetics and the biological definition of gene×environment interactions

Meaney, M. J. (2010) · Child Development · doi:10.1111/j.1467-8624.2009.01381.x · Cited by 1,239 · see citing works

<p>Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics</p>

Tiwari, S., Atluri, V., Kaushik, A., Yndart, A., & Nair, M. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s200490 · Cited by 1,308 · see citing works

Dynamic DNA methylation programs persistent adverse effects of early-life stress

Murgatroyd, C., Patchev, A. V., Wu, Y., Micale, V., Bockmühl, Y., Fischer, D., Holsboer, F., Wotjak, C. T., Almeida, O. F. X., & Spengler, D. (2009) · Nature Neuroscience · doi:10.1038/nn.2436 · Cited by 1,162 · see citing works

Epigenetic transmission of the impact of early stress across generations

Franklin, T. B., Russig, H., Weiss, I. C., Gräff, J., Linder, N., Michalon, A., Vizi, S., & Mansuy, I. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.036 · Cited by 1,125 · see citing works

Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons

Feng, J., Zhou, Y., Campbell, S. L., Le, T., Li, E., Sweatt, J. D., Silva, A. J., & Fan, G. (2010) · Nature Neuroscience · doi:10.1038/nn.2514 · Cited by 1,019 · see citing works

Sex-Specific Programming of Offspring Emotionality after Stress Early in Pregnancy

Mueller, B. R., & Bale, T. L. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1424-08.2008 · Cited by 988 · see citing works

Early Life Programming and Neurodevelopmental Disorders

Bale, T. L., Baram, T. Z., Brown, A. S., Goldstein, J. M., Insel, T. R., McCarthy, M. M., Nemeroff, C. B., Reyes, T. M., Simerly, R. B., Susser, E. S., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.028 · Cited by 961 · see citing works

Perceiving the epigenetic landscape through histone readers

Musselman, C. A., Lalonde, M., Côté, J., & Kutateladze, T. G. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2436 · Cited by 840 · see citing works

Epigenetic Regulation of <i>bdnf</i> Gene Transcription in the Consolidation of Fear Memory

Lubin, F. D., Roth, T. L., & Sweatt, J. D. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1786-08.2008 · Cited by 793 · see citing works

Interaction between BDNF and Serotonin: Role in Mood Disorders

Martinowich, K., & Lu, B. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301571 · Cited by 793 · see citing works

Understanding resilience

Wu, G., Feder, A., Cohen, H., Kim, J. J., Calderon, S., Charney, D. S., & Mathé, A. A. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00010 · Cited by 780 · see citing works

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

Kazantsev, A. G., & Thompson, L. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2681 · Cited by 715 · see citing works

Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects

Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.009 · Cited by 694 · see citing works

Histone acetylation: molecular mnemonics on the chromatin

Gräff, J., & Tsai, L.-H. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3427 · Cited by 680 · see citing works

Neuronal activity modifies the DNA methylation landscape in the adult brain

Guo, J. U., Ma, D. K., Mo, H., Ball, M. P., Jang, M.-H., Bonaguidi, M. A., Balazer, J. A., Eaves, H. L., Xie, B., Ford, E., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2900 · Cited by 669 · see citing works

Linking Molecules to Mood: New Insight Into the Biology of Depression

Krishnan, V., & Nestler, E. J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.10030434 · Cited by 643 · see citing works

Alcoholism: A Systems Approach From Molecular Physiology to Addictive Behavior

Spanagel, R. (2009) · Physiological Reviews · doi:10.1152/physrev.00013.2008 · Cited by 636 · see citing works

Antidepressant Actions of Histone Deacetylase Inhibitors

Covington, H. E., Maze, I., LaPlant, Q. C., Vialou, V. F., Ohnishi, Y. N., Berton, O., Fass, D. M., Renthal, W., Rush, A. J., Wu, E. Y., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1758-09.2009 · Cited by 624 · see citing works

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens

LaPlant, Q., Vialou, V., Covington, H. E., Dumitriu, D., Feng, J., Warren, B. L., Maze, I., Dietz, D. M., Watts, E. L., Iñiguez, S. D., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2619 · Cited by 612 · see citing works

Fluorogenic probes for disease-relevant enzymes

Zhang, J., Chai, X., He, X., Kim, H.-J., Yoon, J., & Tian, H. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00907k · Cited by 606 · see citing works

Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli

Renthal, W., Maze, I., Krishnan, V., Covington, H. E., Xiao, G., Kumar, A., Russo, S. J., Graham, A., Tsankova, N., Kippin, T. E., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.032 · Cited by 599 · see citing works

Research Review: The neurobiology and genetics of maltreatment and adversity

McCrory, E., De Brito, S. A., & Viding, E. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02271.x · Cited by 598 · see citing works

Epigenetics and the environmental regulation of the genome and its function

Zhang, T.-Y., & Meaney, M. J. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163625 · Cited by 565 · see citing works

Decoding the Epigenetic Language of Neuronal Plasticity

Borrelli, E., Nestler, E. J., Allis, C. D., & Sassone‐Corsi, P. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.012 · Cited by 529 · see citing works

The Emerging Field of Human Social Genomics

Slavich, G. M., & Cole, S. W. (2013) · Clinical Psychological Science · doi:10.1177/2167702613478594 · Cited by 523 · see citing works

Epigenetic and transgenerational reprogramming of brain development

Bale, T. L. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3818 · Cited by 505 · see citing works

Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders

Abel, T. G., & Zukin, R. S. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.12.002 · Cited by 495 · see citing works

Oxidative stress in schizophrenia: An integrated approach

Bitanihirwe, B. K. Y., & Woo, T.-U. W. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.008 · Cited by 474 · see citing works

Stress Hormone Regulation: Biological Role and Translation into Therapy

Holsboer, F., & Ising, M. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100321 · Cited by 473 · see citing works

Neurobiological mechanisms in major depressive disorder

Rot, M. A. H., Mathew, S. J., & Charney, D. S. (2009) · Canadian Medical Association Journal · doi:10.1503/cmaj.080697 · Cited by 473 · see citing works

Protein methyltransferases as a target class for drug discovery

Copeland, R. A., Solomon, M. E., & Richon, V. M. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2974 · Cited by 467 · see citing works

Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder

Dempster, E. L., Pidsley, R., Schalkwyk, L. C., Owens, S., Georgiades, A., Kane, F., Kalidindi, S., Picchioni, M., Kravariti, E., Toulopoulou, T., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr416 · Cited by 460 · see citing works

Epigenetic mechanisms of drug addiction

Nestler, E. J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.004 · Cited by 458 · see citing works

Sex differences in neural mechanisms mediating reward and addiction

Becker, J. B., & Chartoff, E. H. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0125-6 · Cited by 455 · see citing works

Mood and gut feelings

Forsythe, P., Sudo, N., Dinan, T., Taylor, V. H., & Bienenstock, J. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.05.058 · Cited by 429 · see citing works

Long non-coding RNAs in nervous system function and disease

Qureshi, I., Mattick, J. S., & Mehler, M. F. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.110 · Cited by 426 · see citing works

Influence of gut microbiota on neuropsychiatric disorders

Cénit, M. C., Sanz, Y., & Codoñer‐Franch, P. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i30.5486 · Cited by 418 · see citing works

The Role of MeCP2 in the Brain

Guy, J., Cheval, H., Selfridge, J., & Bird, A. P. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154121 · Cited by 414 · see citing works

Epigenetic programming of the stress response in male and female rats by prenatal restraint stress

Darnaudéry, M., & Maccari, S. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.11.004 · Cited by 412 · see citing works

DNA Methylation in the Human Cerebral Cortex Is Dynamically Regulated throughout the Life Span and Involves Differentiated Neurons

Siegmund, K. D., Connor, C., Campan, M., Long, T. I., Weisenberger, D. J., Biniszkiewicz, D., Jaenisch, R., Laird, P. W., & Akbarian, S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000895 · Cited by 411 · see citing works

The genetics of bipolar disorder

Barnett, J. H., & Smoller, J. W. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.03.080 · Cited by 407 · see citing works

Communication Between the Synapse and the Nucleus in Neuronal Development, Plasticity, and Disease

Cohen, S., & Greenberg, M. E. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175235 · Cited by 400 · see citing works

Epigenetic Status of Gdnf in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events

Uchida, S., Hara, K., Kobayashi, A., Otsuki, K., Yamagata, H., Hobara, T., Suzuki, T., Miyata, N., & Watanabe, Y. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.023 · Cited by 398 · see citing works

Transcriptional mechanisms of addiction: role of ΔFosB

Nestler, E. J. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0067 · Cited by 392 · see citing works

Epigenetic control

Delcuve, G. P., Rastegar, M., & Davie, J. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21678 · Cited by 392 · see citing works

Epigenetic mechanisms in drug addiction

Renthal, W. R., & Nestler, E. J. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.06.004 · Cited by 383 · see citing works

Increased BDNF Promoter Methylation in the Wernicke Area of Suicide Subjects

Keller, S., Sarchiapone, M., Zarrilli, F., Videtič, A., Ferraro, A., Carli, V., Sacchetti, S., Lembo, F., Angiolillo, A., Jovanovic, N., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.9 · Cited by 379 · see citing works

Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2

Verma, S. K., Tian, X., LaFrance, L. V., Duquenne, C., Suarez, D., Newlander, K. A., Romeril, S. P., Burgess, J. L., Grant, S. W., Brackley, J. A., et al. (2012) · ACS Medicinal Chemistry Letters · doi:10.1021/ml3003346 · Cited by 374 · see citing works

Brain Chromatin Remodeling: A Novel Mechanism of Alcoholism

Pandey, S. C., Ugale, R. R., Zhang, H., Tang, L., & Prakash, A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5731-07.2008 · Cited by 374 · see citing works

Epigenetic regulation of gene expression in physiological and pathological brain processes

Gräff, J., Kim, D., Dobbin, M. M., & Tsai, L.-H. (2011) · Physiological Reviews · doi:10.1152/physrev.00012.2010 · Cited by 373 · see citing works

Activating positive memory engrams suppresses depression-like behaviour

Ramirez, S., Liu, X., MacDonald, C. J., Moffa, A., Zhou, J. Y., Redondo, R. L., & Tonegawa, S. (2015) · Nature · doi:10.1038/nature14514 · Cited by 373 · see citing works

Genomic imprinting effects on brain development and function

Wilkinson, L. S., Davies, W., & Isles, A. R. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2235 · Cited by 373 · see citing works

Promoter-Wide Hypermethylation of the Ribosomal RNA Gene Promoter in the Suicide Brain

McGowan, P. O., Sasaki, A., Huang, T. C. T., Unterberger, A., Suderman, M. J., Ernst, C., Meaney, M. J., Turecki, G., & Moshe Szyf, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002085 · Cited by 372 · see citing works

Targeting the correct HDAC(s) to treat cognitive disorders

Fischer, A., Sananbenesi, F., Mungenast, A. E., & Tsai, L. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.09.003 · Cited by 355 · see citing works

Epigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions

Klengel, T., & Binder, E. B. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.036 · Cited by 353 · see citing works

Prefrontal Dysfunction in Schizophrenia Involves Mixed-Lineage Leukemia 1-Regulated Histone Methylation at GABAergic Gene Promoters

Huang, H.-S., Matevossian, A., Whittle, C., Kim, S. Y., Schumacher, A., Baker, S. P., & Akbarian, S. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3272-07.2007 · Cited by 352 · see citing works

The emerging field of epigenetics in neurodegeneration and neuroprotection

Hwang, J.-Y., Aromolaran, K. A., & Zukin, R. S. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.46 · Cited by 343 · see citing works

CREB regulation of nucleus accumbens excitability mediates social isolation–induced behavioral deficits

Wallace, D. L., Han, M.-H., Graham, D. L., Green, T. A., Vialou, V., Iñiguez, S. D., Cao, J.-L., Kirk, A., Chakravarty, S., Kumar, A., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2257 · Cited by 342 · see citing works

Epigenetic basis of mental illness

Nestler, E. J., Peña, C. J., Kundakovic, M., Mitchell, A., & Akbarian, S. (2016) · The Neuroscientist · doi:10.1177/1073858415608147 · Cited by 342 · see citing works

Prenatal Restraint Stress Generates Two Distinct Behavioral and Neurochemical Profiles in Male and Female Rats

Zuena, A. R., Mairesse, J., Casolini, P., Cinque, C., Alemà, G., Morley‐Fletcher, S., Chiodi, V., Spagnoli, L. G., Gradini, R., Catalani, A., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002170 · Cited by 339 · see citing works

Clustering of depression and inflammation in adolescents previously exposed to childhood adversity

Miller, G. E., & Cole, S. W. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.02.034 · Cited by 331 · see citing works

The Impact of Childhood Maltreatment: A Review of Neurobiological and Genetic Factors

McCrory, E., De Brito, S. A., & Viding, E. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00048 · Cited by 329 · see citing works

Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder

Roth, T. L., Zoladz, P. R., Sweatt, J. D., & Diamond, D. M. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.01.013 · Cited by 321 · see citing works

A Review of the Fetal Brain Cytokine Imbalance Hypothesis of Schizophrenia

Meyer, U., Feldon, J., & Yee, B. K. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn022 · Cited by 318 · see citing works

Molecular and cellular basis of epileptogenesis in symptomatic epilepsy

Pitkänen, A., & Łukasiuk, K. (2008) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2008.09.023 · Cited by 316 · see citing works

Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents

Uchida, S., Hara, K., Kobayashi, A., Funato, H., Hobara, T., Otsuki, K., Yamagata, H., McEwen, B. S., & Watanabe, Y. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1436-10.2010 · Cited by 310 · see citing works

The role of DNA methylation in stress-related psychiatric disorders

Klengel, T., Pape, J., Binder, E. B., & Mehta, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.013 · Cited by 309 · see citing works

Epigenetic codes in cognition and behaviour

Gräff, J., & Mansuy, I. M. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.01.021 · Cited by 307 · see citing works

Does the Concept of "Sensitization" Provide a Plausible Mechanism for the Putative Link Between the Environment and Schizophrenia?

Collip, D., Myin-Germeys, I., & Van Os, J. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm163 · Cited by 305 · see citing works

Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients

Rao, J. S., Keleshian, V. L., Klein, S. L., & Рапопорт, С. И. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.55 · Cited by 305 · see citing works

The Potential of HDAC Inhibitors as Cognitive Enhancers

Gräff, J., & Tsai, L. (2013) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140216 · Cited by 297 · see citing works

Epigenetic principles and mechanisms underlying nervous system functions in health and disease

Mehler, M. F. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.10.001 · Cited by 292 · see citing works

Regulation of hippocampal H3 histone methylation by acute and chronic stress

Hunter, R. G., McCarthy, K. J., Milne, T. A., Pfaff, D. W., & McEwen, B. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911143106 · Cited by 290 · see citing works

A Role for Repressive Histone Methylation in Cocaine-Induced Vulnerability to Stress

Covington, H. E., Maze, I., Sun, H., Bomze, H. M., DeMaio, K. D., Wu, E. Y., Dietz, D. M., Lobo, M. K., Ghose, S., Mouzon, E., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.007 · Cited by 289 · see citing works

Epigenetic Regulation of the BDNF Gene: Implications for Psychiatric Disorders

Boulle, F., van den Hove, D. L. A., Jakob, S. B., Rutten, B. P., Hamon, M., van Os, J., Lesch, K.-P., Lanfumey, L., Steinbusch, H. W., & Kenis, G. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.107 · Cited by 282 · see citing works

Epigenetic suppression of GAD65 expression mediates persistent pain

Zhang, Z., Cai, Y.-Q., Zou, F., Bie, B., & Pan, Z. Z. (2011) · Nature Medicine · doi:10.1038/nm.2442 · Cited by 278 · see citing works

HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity

Kurita, M., Holloway, T. D., García‐Bea, A., Kozlenkov, A., Friedman, A. K., Moreno, J. L., Heshmati, M., Golden, S. A., Kennedy, P., Takahashi, N., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3181 · Cited by 278 · see citing works

Epigenetic Mechanisms of Depression and Antidepressant Action

Vialou, V., Feng, J., Robison, A. J., & Nestler, E. J. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134540 · Cited by 277 · see citing works

The epigenetics of social adversity in early life: Implications for mental health outcomes

McGowan, P. O., & Szyf, M. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.12.026 · Cited by 272 · see citing works

Social Defeat as an Animal Model for Depression

Hollis, F., & Kabbaj, M. (2014) · ILAR Journal · doi:10.1093/ilar/ilu002 · Cited by 270 · see citing works

Genetic Inactivation of Dopamine D1 but Not D2 Receptors Inhibits L-DOPA–Induced Dyskinesia and Histone Activation

Darmopil, S., Martín, A. B., Ruiz‐DeDiego, I., Ares‐Santos, S., & Moratalla, R. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.025 · Cited by 267 · see citing works

Molecular Determinants of Dysregulated GABAergic Gene Expression in the Prefrontal Cortex of Subjects with Schizophrenia

Mellios, N., Huang, H.-S., Baker, S. P., Galdzicka, M., Ginns, E., & Akbarian, S. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.019 · Cited by 266 · see citing works

Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers

Monick, M. M., Beach, S. R. H., Plume, J., Sears, R., Gerrard, M., Brody, G. H., & Philibert, R. A. (2012) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32021 · Cited by 264 · see citing works

Long‐lasting depression‐like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury

Onishchenko, N. R., Karpova, N. N., Sabri, F., Ċastrén, E., & Ceccatelli, S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05484.x · Cited by 263 · see citing works

Personalized medicine in psychiatry: problems and promises

Ozomaro, U., Wahlestedt, C., & Nemeroff, C. B. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-132 · Cited by 237 · see citing works

Prevention and treatment of drug addiction by environmental enrichment

Solinas, M., Thiriet, N., Chauvet, C., & Jaber, M. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.08.002 · Cited by 256 · see citing works

Association of SLC6A4 methylation with early adversity, characteristics and outcomes in depression

Kang, H.-J., Kim, J.-M., Stewart, R., Kim, S.-Y., Bae, K.-Y., Kim, S.-W., Shin, I.-S., Shin, M.-G., & Yoon, J.-S. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.01.006 · Cited by 254 · see citing works

Annual research review: Epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development

Roth, T. L., & David Sweatt, J. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02282.x · Cited by 246 · see citing works

Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression

Márquez, C., Poirier, G. L., Cordero, M. I., Larsen, M. H., Groner, A., Marquis, J., Magistretti, P. J., Trono, D., & Sandi, C. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.144 · Cited by 245 · see citing works

Genetic approaches to addiction: genes and alcohol

Ducci, F., & Goldman, D. A. (2008) · Addiction · doi:10.1111/j.1360-0443.2008.02203.x · Cited by 245 · see citing works

The human BDNF gene: peripheral gene expression and protein levels as biomarkers for psychiatric disorders

Cattaneo, A., Cattane, N., Begni, V, Pariante, C. M., & Riva, M. A. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.214 · Cited by 244 · see citing works

Psikiyatrik Hastal›klar›n Gelifliminde Epigenetik Mekanizmalar

Erol, D., Elyas, Z., & Ünal, S. (2010)

Hidden Switches in the Mind

Nestler, E. J. (2011) · Scientific American · doi:10.1038/scientificamerican1211-76 · Cited by 36 · see citing works

Epigenetic of Drug Resistance in Neuropsychiatric Diseases

Shaikh, Z. P., & Bhise, S. B. (2025) · IGI Global eBooks · doi:10.4018/979-8-3693-5464-3.ch003

Epigenetic and genetic complexity of psychosis: invited commentary on 'why schizophrenia genetics needs epigenetics'.

Adžić, M. (2012) · PubMed

Epigenetic Signaling in Psychiatric Disorders

Peña, C. J., Bagot, R. C., Labonté, B., & Nestler, E. J. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.03.016 · Cited by 163 · see citing works