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Cited by 31Posttraumatic Stress Disorder ResearchCardiac Health and Mental HealthSleep and related disorders

Behavioral health mediators of the link between posttraumatic stress disorder and dyslipidemia

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Dennis, Paul A., Ulmer, Christi S., Calhoun, Patrick S., Sherwood, Andrew, Watkins, Lana L., Dennis, Michelle F., Beckham, Jean C.·2014·Journal of Psychosomatic Research
DOI 10.1016/j.jpsychores.2014.05.001PMC PMC4120708
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Abstract

Objectives Posttraumatic stress disorder (PTSD) has been linked to dyslipidemia, which is a major risk factor for coronary artery disease. Although this link is thought to reflect response to heightened stress, behavioral health risks, including smoking, alcohol dependence, and poor sleep quality, may mediate the relationship between PTSD and dyslipidemia. Methods To test this hypothesis, serum lipid levels were collected from 220 young adults (18-39 years old), 103 of whom were diagnosed with PTSD. Results PTSD and associated depressive symptoms were negatively related to high-density lipoprotein cholesterol (HDL-C), p=.04, and positively related to triglyceride (TG) levels, p=.04. Both associations were mediated by cigarette consumption and poor sleep quality, the latter of which accounted for 83% and 93% of the effect of PTSD and depression on HDL-C and TG, respectively. Conclusions These results complement recent findings highlighting the prominence of health behaviors in linking PTSD with cardiovascular risk.

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Sorted by citations

Authors
Dennis, P. A., Ulmer, C. S., Calhoun, P. S., Sherwood, A., Watkins, L. L., Dennis, M. F., & Beckham, J. C.
Affiliations
  • Durham VA Medical Center (US)
  • Durham VA Health Care System (US)
  • Duke Medical Center (US)
Corresponding author
Beckham, Jean C.
ORCID
Venue
Journal of Psychosomatic Research
Publisher
Elsevier BV
Published
2014-07
Volume
77
Issue
1
Pages
45-50
ISSN
0022-3999 (ISSN-L)
DOI
10.1016/j.jpsychores.2014.05.001
PMC
PMC4120708
OpenAlex
W2118377872
Cited by
31
References
6
Citations by year
2025: 4 · 2023: 5 · 2022: 1 · 2021: 4 · 2020: 1 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 2
FWCI
4.73
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Psychosomatic Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R01MH062482)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
post-traumatic stress disorder, dyslipidemia, cigarette smoking, sleep quality, depression, HDL cholesterol, triglycerides, cardiovascular risk, young adults, serum lipids
MeSH terms
Adolescent, Adult, Alcoholism, Depression, Female, Humans, Cholesterol, HDL, Male, Risk Factors, Sleep, Smoking, Stress Disorders, Post-Traumatic, Triglycerides, Health Behavior, Dyslipidemias, Young Adult

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