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Cited by 292Circadian rhythm and melatoninBipolar Disorder and TreatmentTreatment of Major Depression

Melatonin in mood disorders

Srinivasan, Venkataramanujan, Smits, Marcel, Spence, Warren, Lowe, Alan D., Kayumov, Leonid, Pandi-Perumal, Seithikurippu R., Parry, Barbara, Cardinali, Daniel P.·2006·The World Journal of Biological Psychiatry
DOI 10.1080/15622970600571822
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Abstract

The cyclic nature of depressive illness, the diurnal variations in its symptomatology and the existence of disturbed sleep-wake and core body temperature rhythms, all suggest that dysfunction of the circadian time keeping system may underlie the pathophysiology of depression. As a rhythm-regulating factor, the study of melatonin in various depressive illnesses has gained attention. Melatonin can be both a 'state marker' and a 'trait marker' of mood disorders. Measurement of melatonin either in saliva or plasma, or of its main metabolite 6-sulfatoxymelatonin in urine, have documented significant alterations in melatonin secretion in depressive patients during the acute phase of illness. Not only the levels but also the timing of melatonin secretion is altered in bipolar affective disorder and in patients with seasonal affective disorder (SAD). A phase delay of melatonin secretion takes place in SAD, as well as changes in the onset, duration and offset of melatonin secretion. Bright light treatment, that suppresses melatonin production, is effective in treating bipolar affective disorder and SAD, winter type. This review discusses the role of melatonin in the pathophysiology of bipolar disorder and SAD.

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Crossref · 10.1080/15622970600571822

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158 of 158 references verified0 citation errors · 0 not checkable

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  • There is evidence of a correlation between evening chronotype and mood disorders, most notably seasonal affective disorder, depression, and worsening of bipolar disorder episodes.

    “There is also evidence of a correlation between evening chronotype and mood disorders, most notably seasonal affective disorder, depression, and worsening of bipolar disorder episodes (Srinivasan et al. 2006; Kivelä et al. 2018; Taylor and Hasler 2018).”

    From Archaic Introgression Shaped Human Circadian Traits (2023) · cites this paper as Srinivasan et al. 2006

  • The major findings regarding altered hormone patterns in PMDD include decreased melatonin secretion (AUC and amplitude).

    “The major findings regarding altered hormone patterns in PMDD include decreased melatonin secretion (AUC and amplitude) (Table 2), which is reminiscent of findings in patients with major depressive disorder (MDD) [107].”

    From Sleep, hormones, and circadian rhythms throughout the menstrual cycle in healthy women and women with premenstrual dysphoric disorder (2010) · cites this paper as [107]

  • Decreased melatonin secretion in PMDD is reminiscent of findings in patients with major depressive disorder (MDD).

    “The major findings regarding altered hormone patterns in PMDD include decreased melatonin secretion (AUC and amplitude) (Table 2), which is reminiscent of findings in patients with major depressive disorder (MDD) [107].”

    From Sleep, hormones, and circadian rhythms throughout the menstrual cycle in healthy women and women with premenstrual dysphoric disorder (2010) · cites this paper as [107]

  • Additional abnormalities in melatonin secretion in SAD patients, such as phase delays over twenty-four hours, have been reported; however, other studies have reported no differences in circadian melatonin levels or rhythms in SAD patients.

    “Additional abnormalities in melatonin secretion in SAD patients, such as phase delays over twenty-four hours, have also been reported; however, other studies have reported no differences in circadian melatonin levels or rhythms in SAD patients (Checkley et al., 1993; Srinivasan et al., 2006).”

    From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Srinivasan et al., 2006

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Authors
Srinivasan, V., Smits, M., Spence, W., Lowe, A. D., Kayumov, L., Pandi-Perumal, S. R., Parry, B., & Cardinali, D. P.
Affiliations
  • Universiti Sains Malaysia (MY)
  • Ziekenhuis Gelderse Vallei (NL)
  • Scarborough Health Network (CA)
  • Mount Sinai Hospital (US)
  • University of California San Diego (US)
  • Universidad de Buenos Aires (AR)
Corresponding author
Cardinali, Daniel P.
ORCID
Venue
The World Journal of Biological Psychiatry
Publisher
Informa UK Limited
Published
2006-01
Volume
7
Issue
3
Pages
138-151
ISSN
  • 1562-2975 (ISSN-L)
  • 1814-1412
DOI
10.1080/15622970600571822
OpenAlex
W1992860227
Cited by
292
References
158
Citations by year
2026: 9 · 2025: 5 · 2024: 13 · 2023: 9 · 2022: 14 · 2021: 12 · 2020: 9 · 2019: 9 · 2018: 8 · 2017: 15 · 2016: 15 · 2015: 12 · 2014: 22 · 2013: 21 · 2012: 22
FWCI
7.56
Type
journal article
Language
en
Open access
closed
Locations
  • The World Journal of Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
melatonin, depression, bipolar disorder, seasonal affective disorder, circadian rhythm, 6-sulfatoxymelatonin, bright light therapy, sleep-wake cycle, mood disorders
MeSH terms
Antidepressive Agents, Bipolar Disorder, Circadian Rhythm, Major Depressive Disorder, Depressive Disorder, Humans, Melatonin, Phototherapy, Biomarkers, Seasonal Affective Disorder, Treatment Outcome, Sleep Disorders, Circadian Rhythm

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