Daily rhythm of serum melatonin in patients with dementia of the degenerate type

Uchida, Katsuhisa; Okamoto, Norio; Ohara, Kenshiro; Morita, Yukitomo

doi:10.1016/0006-8993(96)00086-8

Cited by 139Circadian rhythm and melatoninDementia and Cognitive Impairment ResearchSleep and Work-Related Fatigue

Daily rhythm of serum melatonin in patients with dementia of the degenerate type

Uchida, Katsuhisa, Okamoto, Norio, Ohara, Kenshiro, Morita, Yukitomo·1996·Brain Research

DOI 10.1016/0006-8993(96)00086-8

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Abstract

The daily rhythm in serum melatonin levels was measured in patients with dementia of the degenerate type (Alzheimer's disease, Pick's disease and senile dementia of the Alzheimer type) by radioimmunoassay. Thirteen patients (age: 69.0 +/- 8.0 years, mean +/- S.D.) were studied. All patients were hospitalized at the time of the study and had a history of sleep-wake disturbances, nocturnal wandering and/or delirium. We also studied 13 age-matched healthy control subjects (control group 1), ten young adults (control group 2), and nine hospitalized patients without dementia (control group 3). Two subjects in the control groups showed no measurable changes in melatonin level throughout the day, while the other 30 control subjects exhibited a clear daily rhythm with the peak concentration occurring during the night. On the other hand, four out of the 13 patients with dementia did not show any melatonin rhythm. Two of the demented patients who did not exhibit melatonin rhythm displayed clinical symptoms of rhythm disorders. One out of the nine patients with melatonin rhythm presented with clinical symptoms, such as delirium and sleep-wake disturbance. Our results suggest that the probability of absent melatonin rhythm is higher in demented patients compared with subjects without dementia. However, a lack of melatonin rhythm is not always associated with symptomatic rhythm disorders. Since the melatonin rhythm reflects that of the suprachiasmatic nucleus, it follows that the SCN function of the patients having a history of rhythm disorders was not always severely damaged.

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Compared with healthy aged people, individuals with AD or PD show considerably lower melatonin rhythm amplitudes and excessive sleepiness, as well as other sleep-wake cycle disturbances, such as later sleep onsets.
“Compared with healthy aged people, individuals with AD or PD show considerably lower melatonin rhythm amplitudes and excessive sleepiness, as well as other sleep–wake cycle disturbances, such as later sleep onsets254–258.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [257]

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Authors: Uchida, K., Okamoto, N., Ohara, K., & Morita, Y.
Affiliations: Hamamatsu University (JP)
Venue: Brain Research
Publisher: Elsevier BV
Published: 1996-04
Volume: 717
Issue: 1-2
Pages: 154-159
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(96)00086-8
OpenAlex: W2036215613
Cited by: 138
References: 29
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 8 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 7 · 2014: 5 · 2013: 6 · 2012: 9
FWCI: 1.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology (05455011)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: serum melatonin, circadian rhythm, dementia, Alzheimer's disease, Pick's disease, senile dementia of the Alzheimer type, suprachiasmatic nucleus, sleep-wake disturbances, nocturnal wandering, delirium, circadian rhythm disorders
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Circadian Rhythm, Dementia, Female, Humans, Male, Melatonin, Middle Aged, Radioimmunoassay, Sleep Wake Disorders

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Daily rhythm of serum melatonin in patients with dementia of the degenerate type

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