The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Innate and adaptive immunity at mucosal surfaces of the female reproductive tract: stratification and integration of immune protection against the transmission of sexually transmitted infections
Open accessAbstract
This review examines the multiple levels of pre-existing immunity in the upper and lower female reproductive tract. In addition, we highlight the need for further research of innate and adaptive immune protection of mucosal surfaces in the female reproductive tract. Innate mechanisms include the mucus lining, a tight epithelial barrier and the secretion of antimicrobial peptides and cytokines by epithelial and innate immune cells. Stimulation of the innate immune system also serves to bridge the adaptive arm resulting in the generation of pathogen-specific humoral and cell-mediated immunity. Less understood are the multiple components that act in a coordinated way to provide a network of ongoing protection. Innate and adaptive immunity in the human female reproductive tract are influenced by the stage of menstrual cycle and are directly regulated by the sex steroid hormones, progesterone and estradiol. Furthermore, the effect of hormones on immunity is mediated both directly on immune and epithelial cells and indirectly by stimulating growth factor secretion from stromal cells. The goal of this review is to focus on the diverse aspects of the innate and adaptive immune systems that contribute to a unique network of protection throughout the female reproductive tract.
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Cites
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
REVIEW ARTICLE: The Immune System in Pregnancy: A Unique Complexity
Mor, G., & Cardenas, I. (2010) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2010.00836.x · Cited by 1,431
Cited by
Verstraelen, H., Vilchez-Vargas, R., Desimpel, F., Jauregui, R., Vankeirsbilck, N., Weyers, S., Verhelst, R., De Sutter, P., Pieper, D. H., & Van De Wiele, T. (2016) · PeerJ · doi:10.7717/peerj.1602 · Cited by 307
Trichomonas vaginalis Exosomes Deliver Cargo to Host Cells and Mediate Host∶Parasite Interactions
Twu, O., de Miguel, N., Lustig, G., Stevens, G. C., Vashisht, A. A., Wohlschlegel, J. A., & Johnson, P. J. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003482 · Cited by 276
The Immune System in Menopause: Pros and Cons of Hormone Therapy
Ghosh, M., Rodriguez-Garcia, M., & Wira, C. R. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.09.003 · Cited by 119
Self-citationWessels, J. M., Felker, A. M., Dupont, H. A., & Kaushic, C. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.035147 · Cited by 102
Antifungal Activity of Plant Secondary Metabolites on Candida albicans: An Updated Review
Khan, A., Moni, S. S., Ali, M., Mohan, S., Jan, H., Rasool, S., Kamal, M. A., Alshahrani, S., Halawi, M., & Alhazmi, H. A. (2023) · Current Molecular Pharmacology · doi:10.2174/1874467215666220304143332 · Cited by 17
Metadata
- Authors
- Hickey, D. K., Patel, M. V., Fahey, J. V., & Wira, C. R.
- Venue
- Journal of Reproductive Immunology
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 88
- Issue
- 2
- Pages
- 185-194
- ISSN
- 0165-0378 (ISSN-L)
- OpenAlex
- W1541628524
- Cited by
- 238
- References
- 2
- FWCI
- 17.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Hickey, D. K., Patel, M. V., Fahey, J. V., & Wira, C. R. (2011). Innate and adaptive immunity at mucosal surfaces of the female reproductive tract: stratification and integration of immune protection against the transmission of sexually transmitted infections. Journal of Reproductive Immunology. https://doi.org/10.1016/j.jri.2011.01.005
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