REVIEW ARTICLE: The Immune System in Pregnancy: A Unique Complexity
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Citation Mor G, Cardenas I. The immune system in pregnancy: a unique complexity. Am J Reprod Immunol 2010 Placental immune response and its tropism for specific viruses and pathogens affect the outcome of the pregnant woman’s susceptibility to and severity of certain infectious diseases. The generalization of pregnancy as a condition of immune suppression or increased risk is misleading and prevents the determination of adequate guidelines for treating pregnant women during pandemics. There is a need to evaluate the interaction of each specific pathogen with the fetal/placental unit and its responses to design the adequate prophylaxis or therapy. The complexity of the immunology of pregnancy and the focus, for many years, on the concept of immunology of pregnancy as an organ transplantation have complicated the field and delayed the development of new guidelines with clinical implications that could help to answer these and other relevant questions. Our challenge as scientists and clinicians interested in the field of reproductive immunology is to evaluate many of the ‘classical concepts’ to define new approaches for a better understanding of the immunology of pregnancy that will benefit mothers and fetuses in different clinical scenarios.
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There is evidence that the mother changes the balance of her T-cell responses to Th2 rather than Th1.
“There is evidence that the mother changes the balance of her T-cell responses to Th2 rather than Th1 [68].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [68]
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Immunity and Inflammation in the Uterus
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Pregnancy, Viral Infection, and COVID-19
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Ashraf, M. A., Keshavarz, P., Hosseinpour, P., Erfani, A., Roshanshad, A., Pourdast, A., Nowrouzi‐Sohrabi, P., Chaichian, S., & Poordast, T. (2020) · PubMed Central · Cited by 99 · see citing works
- Authors
- Mor, G., & Cardenas, I.
- Affiliations
- Yale University (US)
- Corresponding author
- Mor, Gil
- Venue
- American Journal of Reproductive Immunology
- Publisher
- Wiley
- Published
- 2010-05-10
- Volume
- 63
- Issue
- 6
- Pages
- 425-433
- ISSN
- 0271-7352 (ISSN-L)
- 1046-7408
- 1600-0897
- PMC
- PMC3025805
- OpenAlex
- W49611453
- Cited by
- 1,431
- References
- 55
- Citations by year
- 2026: 143 · 2025: 94 · 2024: 133 · 2023: 123 · 2022: 136 · 2021: 140 · 2020: 154 · 2019: 79 · 2018: 87 · 2017: 71 · 2016: 61 · 2015: 55 · 2014: 54 · 2013: 43 · 2012: 30
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Reproductive Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (N01 HD023342, P01HD054713)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Obstetrics and Gynecology › COVID-19 Impact on Reproduction
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Keywords
- pregnancy immunology, placental immunity, reproductive immunology
- MeSH terms
- Female, Humans, Immune System, Placenta, Pregnancy, Pregnancy Complications, Infectious, Virus Diseases
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