The DOI matches its Crossref record; 35 of the 37 references it cites were found in a registry or an index.
Aromatase in endometriosis and uterine leiomyomata
Abstract
Endometrial tissue from uterine disease-free women does not exhibit aromatase activity. In contrast, aromatase enzyme activity and mRNA levels are readily detectable in endometriosis. PGE2 stimulates both aromatase expression and activity in endometriotic stromal cells via promoter II region of the aromatase gene. This results in local production of estradiol, which induces PGE2 formation and establishes a positive feedback cycle. This mechanism seems to contribute to continuous production of estradiol and PGE2. Aromatase mRNA levels and enzyme activity are also present in uterine leiomyomata that are estrogen-dependent benign tumors of the myometrium. Successful treatment of endometriosis and uterine leiomyomata using aromatase inhibitors by recent pilot trials underscores the clinical significance of these molecular studies.
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“The oestrogen can be further produced in the endometrial lesions by aromatase activity [14].”
From 5-Year data analysis of patients following abdominal wall endometrioma surgery (2014) · cites this paper as [14]
Citations
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“…two pathways: first, peripheral adipose tissue converts androstenedione to estrogen via aromatase; and second, the lesion site forms an autocrine positive feedback loop through aberrantly expressed aromatase (CYP19A1) and steroidogenic factor-1 (SF-1), autonomously synthesizing estradiol [18–20].”
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Metadata
- Authors
- Bulun, S. E., Imir, G., Utsunomiya, H., Thung, S., Gurates, B., Tamura, M., & Lin, Z.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Bulun, Serdar E.
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 95
- Issue
- 1-5
- Pages
- 57-62
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W2119512564
- Cited by
- 154
- References
- 37
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 11 · 2013: 3 · 2012: 11
- FWCI
- 10.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD046260, HD-38691, HD46260)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Keywords
- aromatase, endometriosis, uterine fibroids, prostaglandin E2, endometrial stromal cells, estradiol production, positive feedback loop, aromatase inhibitors, estrogen-dependent tumors
- MeSH terms
- Aromatase, Endometriosis, Estrogens, Female, Humans, Leiomyoma, Uterine Neoplasms, Uterus, Aromatase Inhibitors
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