Cited by 55Estrogen and related hormone effectsBreast Cancer Treatment StudiesCancer, Lipids, and Metabolism

Steroid sulfatase inhibitors: promising new tools for breast cancer therapy?

Geisler, Jürgen, Sasano, Hironobu, Chen, Shiuan, Purohit, Atul·2011·The Journal of Steroid Biochemistry and Molecular Biology

Abstract

Inhibition of aromatase is currently well-established as the major treatment option of hormone-dependent breast cancer in postmenopausal women. However, despite the effects of aromatase inhibitors in both early and metastatic breast cancer, endocrine resistance may cause relapses of the disease and progression of metastasis. Thus, driven by the success of manipulating the steroidogenic enzyme aromatase, several alternative enzymes involved in steroid synthesis and metabolism have recently been investigated as possible drug targets. One of the most promising targets is the steroid sulfatase (STS) which converts steroid sulfates like estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) to estrone (E1) and dehydroepiandrosterone (DHEA), respectively. Estrone and DHEA may thereafter be used for the synthesis of more potent estrogens and androgens that may eventually fuel hormone-sensitive breast cancer cells. The present review summarizes the biology behind steroid sulfatase and its inhibition, the currently available information derived from basic and early clinical trials in breast cancer patients, as well as ongoing research. Article from the Special Issue on Targeted Inhibitors.

Integrity signals

Registry

Crossref · 10.1016/j.jsbmb.2011.02.002

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55 of 55 references verified0 citation errors · 0 not checkable

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  • The potential of STS inhibition has been evaluated in promising clinical trials.

    “The potential of STS inhibition has been evaluated in promising clinical trials (Geisler et al., 2011, Purohit and Foster, 2012, Thomas and Potter, 2015).”

    From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Geisler et al., 2011

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Authors
Geisler, J., Sasano, H., Chen, S., & Purohit, A.
Affiliations
  • University of Oslo (NO)
  • Tohoku University (JP)
  • Beckman Research Institute (US)
  • Hammersmith Hospital (GB)
Corresponding author
Geisler, Jürgen
Venue
The Journal of Steroid Biochemistry and Molecular Biology
Publisher
Elsevier BV
Published
2011-05
Volume
125
Issue
1-2
Pages
39-45
ISSN
0960-0760 (ISSN-L)
OpenAlex
W2044695707
Cited by
55
References
55
Citations by year
2026: 2 · 2024: 1 · 2022: 6 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 6 · 2014: 3 · 2013: 8 · 2012: 3
FWCI
0.64
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords
steroid sulfatase inhibitors, steroid sulfatase, breast cancer, endocrine therapy resistance, aromatase inhibitors, estrone sulfate, dehydroepiandrosterone sulfate, steroid metabolism, hormone-dependent breast cancer, targeted therapy
MeSH terms
Androgens, Breast Neoplasms, Clinical Trials as Topic, Enzyme Inhibitors, Estrogens, Female, Humans, Molecular Structure, Steryl-Sulfatase, Aromatase Inhibitors

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