Steroid sulfatase inhibitors for estrogen- and androgen-dependent cancers
Open accessAbstract
Estrogens and androgens are instrumental in the maturation of many hormone-dependent cancers. Consequently, the enzymes involved in their synthesis are cancer therapy targets. One such enzyme, steroid sulfatase (STS), hydrolyses estrone sulfate, and dehydroepiandrosterone sulfate to estrone and dehydroepiandrosterone respectively. These are the precursors to the formation of biologically active estradiol and androstenediol. This review focuses on three aspects of STS inhibitors: 1) chemical development, 2) biological activity, and 3) clinical trials. The aim is to discuss the importance of estrogens and androgens in many cancers, the developmental history of STS inhibitor synthesis, the potency of these compounds in vitro and in vivo and where we currently stand in regards to clinical trials for these drugs. STS inhibitors are likely to play an important future role in the treatment of hormone-dependent cancers. Novel in vivo models have been developed that allow pre-clinical testing of inhibitors and the identification of lead clinical candidates. Phase I/II clinical trials in postmenopausal women with breast cancer have been completed and other trials in patients with hormone-dependent prostate and endometrial cancer are currently active. Potent STS inhibitors should become therapeutically valuable in hormone-dependent cancers and other non-oncological conditions.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
STX64 is effective in blocking synthesis in endometrial cancer cells in vitro.
“including STX64, which was effective in blocking synthesis in endometrial cancer cells in vitro.”
From Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders (2018) · cites this paper as [107]
The “Maltais” section identifies STX64 as an effective steroid sulfatase inhibitor, supporting its ability to interfere with steroid synthesis. But the reported in vitro test used placental microsomes, not endometrial cancer cells; the “667 COUMATE and beyond” section discusses endometrial cancer only in an in vivo mouse model involving STX213. Our copy does not establish the claimed in vitro result for STX64. (LLM, conf=0.85)
Experimental — accuracy not yet measuredThe potential of STS inhibition has been evaluated in promising clinical trials.
“The potential of STS inhibition has been evaluated in promising clinical trials (Geisler et al., 2011, Purohit and Foster, 2012, Thomas and Potter, 2015).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Purohit and Foster, 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Abiraterone and Increased Survival in Metastatic Prostate Cancer
de Bono, J. S., Logothetis, C. J., Molina, A., Fizazi, K., North, S., Chu, L., Chi, K. N., Jones, R. J., Goodman, O. B., Saad, F., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1014618 · Cited by 4,407 · cited 1× · see citing works
“…breast, prostate, and endometrial, initially rely on steroid production for growth: only later in development do they usually become steroid-independent with the exception of prostate cancer which can remain androgen dependent even at late-stage (Knudsen & Penning 2010, de Bono et al. 2011).”
Horder, & Harnett, W. L. (1941) · BMJ · doi:10.1136/bmj.1.4186.493 · Cited by 1,319 · see citing works
Designed Multiple Ligands. An Emerging Drug Discovery Paradigm
Morphy, R., & Ranković, Z. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm058225d · Cited by 1,237 · see citing works
Endogenous Hormones and Breast Cancer Risk
Bernstein, L., & Ross, R. K. (1993) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036116 · Cited by 697 · see citing works
Environmental causes of cancer: endocrine disruptors as carcinogens
Soto, A. M., & Sonnenschein, C. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.87 · Cited by 574 · see citing works
Steroid sulfatase: molecular biology, regulation, and inhibition
Reed, M. J., Purohit, A., Woo, L. W. L., Newman, S. P., & Potter, B. V. L. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0003 · Cited by 524 · see citing works
Self-citationKroboth, P. D., Salek, F. S., Pittenger, A. L., Fabian, T. J., & Frye, R. F. (1999) · The Journal of Clinical Pharmacology · doi:10.1177/00912709922007903 · Cited by 523 · see citing works
Sulfonation and molecular action
Strott, C. A. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0040 · Cited by 487 · see citing works
van Landeghem, A. A. J., Poortman, J., Nabuurs, M., & Thijssen, J. H. H. (1985) · PubMed · Cited by 448 · see citing works
MacDonald, P. C., Edman, C. D., Hemsell, D. L., Porter, J. C., & Siiteri, P. K. (1978) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(78)90287-9 · Cited by 440 · see citing works
Pasqualini, J. R., Chetrite, G. S., Blacker, C., Feinstein, M. C., Delalonde, L., Talbi, M., & Maloche, C. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636351 · Cited by 433 · see citing works
Santner, S. J., Feil, P. D., & Santen, R. J. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-1-29 · Cited by 407 · see citing works
Inhibition of Human Estrogen Synthetase (Aromatase) by Flavones
Kellis, J. T., & Vickery, L. E. (1984) · Science · doi:10.1126/science.6474163 · Cited by 310 · see citing works
Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer
Knudsen, K. E., & Penning, T. M. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.01.002 · Cited by 291 · see citing works
Estrone Sulfate: Production Rate and Metabolism in Man
Ruder, H. J., LORIAUX, L. D., & LIPSETT, M. B. (1972) · Journal of Clinical Investigation · doi:10.1172/jci106862 · Cited by 257 · see citing works
Stanway, S. J., Purohit, A., Woo, L. W. L., Sufi, S., Vigushin, D. M., Ward, R. E., Wilson, R. H., Stanczyk, F. Z., Dobbs, N. A., Kulinskaya, E., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1996 · Cited by 240 · see citing works
Self-citationImportance of estrogen sulfates in breast cancer
Pasqualini, J. R., Gelly, C., Nguyen, B. ‐., & Vella, C. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90077-0 · Cited by 227 · see citing works
Aromatase activity in normal breast and breast tumor tissues: In vivo and in vitro studies
James, V. H. T., McNeill, J. M., Lai, L. C., NEWTON, C. J., Ghilchik, M. W., & Reed, M. J. (1987) · Steroids · doi:10.1016/0039-128x(83)90077-6 · Cited by 219 · see citing works
Estrone sulfamates: potent inhibitors of estrone sulfatase with therapeutic potential
Howarth, N. M., Purohit, A., Reed, M. J., & Potter, B. V. L. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00028a002 · Cited by 218 · see citing works
Self-citationHo, S. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10759 · Cited by 196 · see citing works
Role of estrogens in development of prostate cancer
Härkönen, P. L., & Mäkelä, S. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.10.016 · Cited by 191 · see citing works
Bonney, R. C., Reed, M. J., DAVIDSON, K., Beranek, P. A., & James, V. H. T. (1983) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1983.tb00051.x · Cited by 187 · see citing works
Inactivation of Steroid Sulfatase by an Active Site-Directed Inhibitor, Estrone-3-O-Sulfamate
Purohit, A., Williams, G. J., Howarth, N. M., Potter, B. V. L., & Reed, M. J. (1995) · Biochemistry · doi:10.1021/bi00036a025 · Cited by 171 · see citing works
Self-citation24-Hour Secretory Pattern of Dehydroisoandrosterone and Dehydroisoandrosterone Sulfate
Rosenfeld, R. S., ROSENBERG, B. J., Fukushima, D. K., & HELLMAN, L. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-40-5-850 · Cited by 171 · see citing works
Falany, J. L., & Falany, C. N. (1996) · PubMed · Cited by 165 · see citing works
Aromatase inhibition by flavonoids
Ibrahim, A.-R. S., & Abul‐Hajj, Y. J. (1990) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(90)90335-i · Cited by 160 · see citing works
Davison, S. L., & Davis, S. R. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00204-8 · Cited by 159 · see citing works
Estrogen and prostate cancer: An eclipsed truth in an androgen‐dominated scenario
Carruba, G. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21529 · Cited by 154 · see citing works
Design of enzyme inhibitors as drugs
(1990) · International Journal of Biochemistry · doi:10.1016/0020-711x(90)90152-s · Cited by 152 · see citing works
Steroidal and Nonsteroidal Sulfamates as Potent Inhibitors of Steroid Sulfatase
Woo, L. W. L., Howarth, N. M., Purohit, A., Hejaz, H. A., Reed, M. J., & Potter, B. V. L. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm970527v · Cited by 132 · see citing works
Self-citationHobkirk, R. (1993) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(05)80018-9 · Cited by 113 · see citing works
Elevated steroid sulfatase expression in breast cancers
Utsumi, T., Yoshimura, N., Takeuchi, S., MARUTA, M., Maeda, K., & Harada, N. (2000) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(00)00060-1 · Cited by 108 · see citing works
Estrone and estradiol content in human breast tumors: Relationship to estradiol receptors
Fishman, J., Nisselbaum, J. S., Menendez‐Botet, C. J., & Schwartz, M. K. (1977) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(77)90100-5 · Cited by 105 · see citing works
Lønning, P. E., Dowsett, M., & Powles, T. (1990) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(90)90241-j · Cited by 103 · see citing works
Steroid Sulfatase: A New Target for the Endocrine Therapy of Breast Cancer
Stanway, S. J., Delavault, P., Purohit, A., Woo, L. W. L., Thurieau, C., Potter, B. V. L., & Reed, M. J. (2007) · The Oncologist · doi:10.1634/theoncologist.12-4-370 · Cited by 102 · see citing works
Self-citationEdery, M., Goussard, J., Dehennin, L., Scholler, R., Reiffsteck, J., & Drosdowsky, M. A. (1981) · European Journal of Cancer (1965) · doi:10.1016/0014-2964(81)90220-6 · Cited by 99 · see citing works
Miyoshi, Y., Ando, A., Hasegawa, S., Ishitobi, M., Taguchi, T., Tamaki, Y., & Noguchi, S. (2003) · PubMed · Cited by 99 · see citing works
Purohit, A., Vernon, K. A., Hummelinck, A. E. W., Woo, L. W. L., Hejaz, H. A., Potter, B. V. L., & Reed, M. J. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)00196-9 · Cited by 95 · see citing works
Self-citationNoel, C. T., Reed, M. J., Jacobs, H. S., & James, V. H. T. (1981) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(81)90039-x · Cited by 94 · see citing works
Duncan, L., Purohit, A., Howarth, N. M., Potter, B. V. L., & Reed, M. J. (1993) · PubMed · Cited by 92 · see citing works
Self-citationRegulation of MCF-7 Breast Cancer Cell Growth by β-estradiol Sulfation
Falany, J. L., Macrina, N., & Falany, C. N. (2002) · Breast Cancer Research and Treatment · doi:10.1023/a:1016147004188 · Cited by 92 · see citing works
Purohit, A., Woo, L. W. L., Potter, B. V. L., & Reed, M. J. (2000) · PubMed · Cited by 90 · see citing works
Self-citationvan der Burg, M. E. L. (2001) · Current Treatment Options in Oncology · doi:10.1007/s11864-001-0053-1 · Cited by 86 · see citing works
Prognostic value of breast cancer aromatase
Lipton, A., Santen, R. J., Santner, S. J., Harvey, H. A., Sanders, S. I., & Matthews, Y. L. (1992) · Cancer · doi:10.1002/1097-0142(19921001)70:7 · Cited by 80 · see citing works
Purohit, A., Williams, G. J., Roberts, C. J., et al. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910630119 · Cited by 76 · see citing works
Self-citationFirst Dual Aromatase-Steroid Sulfatase Inhibitors
Woo, L. W. L., Sutcliffe, O. B., Bubert, C., Grasso, A., Chander, S. K., Purohit, A., Reed, M. J., & Potter, B. V. L. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm034033b · Cited by 69 · see citing works
Self-citationSteroid sulphatase inhibitors for breast cancer therapy
Purohit, A., Woo, L. W. L., Chander, S. K., Newman, S. T., Ireson, C. R., Ho, Y., Grasso, A., Leese, M. P., Potter, B. V. L., & Reed, M. J. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00353-4 · Cited by 67 · see citing works
Self-citationEffects of endocrine therapy on steroid-receptor content of breast cancer
Taylor, R., Powles, T. J., Humphreys, J., Bettelheim, R., Dowsett, M., Casey, A., Neville, A. M., & Coombes, R. C. (1982) · British Journal of Cancer · doi:10.1038/bjc.1982.10 · Cited by 67 · see citing works
Steroid sulfatase inhibitors: A review covering the promising 2000–2010 decade
Maltais, R., & Poirier, D. (2011) · Steroids · doi:10.1016/j.steroids.2011.03.010 · Cited by 67 · see citing works
Development of steroid sulfatase inhibitors
Woo, L. W. L., Purohit, A., & Potter, B. V. L. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.12.035 · Cited by 66 · see citing works
Self-citationEffects of dehydroepiandrosterone on proliferation, migration, and death of breast cancer cells
López‐Marure, R., Contreras, P. G., & Dillon, J. S. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.03.040 · Cited by 66 · see citing works
Aromatase and Dual Aromatase‐Steroid Sulfatase Inhibitors from the Letrozole and Vorozole Templates
Wood, P. M., Woo, L. W. L., THOMAS, M. P., Mahon, M. F., Purohit, A., & Potter, B. V. L. (2011) · ChemMedChem · doi:10.1002/cmdc.201100145 · Cited by 64 · see citing works
Self-citationThe development of steroid sulphatase inhibitors
Reed, M. J., Purohit, A., Woo, L. W. L., & Potter, B. V. L. (1996) · Endocrine Related Cancer · doi:10.1677/erc.0.0030009 · Cited by 61 · see citing works
Self-citationIntratumoral oestrone sulphatase activity as a prognostic marker in human breast carcinoma
Evans, T., Rowlands, M. G., Law, M. G., & Coombes, R. C. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.101 · Cited by 60 · see citing works
Jackson, T., Woo, L. W. L., Trusselle, M. N., Chander, S. K., Purohit, A., Reed, M. J., & Potter, B. V. L. (2007) · Organic & Biomolecular Chemistry · doi:10.1039/b707768h · Cited by 60 · see citing works
Self-citationSteroid sulfatase and estrogen sulfotransferase in human prostate cancer
Nakamura, Y., Suzuki, T., Fukuda, T., Ito, A., Endo, M., Moriya, T., Arai, Y., & Sasano, H. (2006) · The Prostate · doi:10.1002/pros.20426 · Cited by 59 · see citing works
D-Ring Modified Estrone Derivatives as Novel Potent Inhibitors of Steroid Sulfatase
Fischer, D. S., Woo, L. W. L., Mahon, M. F., Purohit, A., Reed, M. J., & Potter, B. V. L. (2003) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(03)00042-7 · Cited by 58 · see citing works
Self-citationFoster, P., Newman, S. P., Chander, S. K., Stengel, C., Jhalli, R., Woo, L. W. L., Potter, B. V. L., Reed, M. J., & Purohit, A. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0632 · Cited by 56 · see citing works
Self-citationSteroid sulfatase inhibitors: promising new tools for breast cancer therapy?
Geisler, J., Sasano, H., Chen, S., & Purohit, A. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.02.002 · Cited by 55 · see citing works
Self-citationSynthesis and sulfatase inhibitory activities of non-steroidal estrone sulfatase inhibitors
Li, P., Milano, S. K., Kluth, L., & Rhodes, M. E. (1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(96)00093-3 · Cited by 54 · see citing works
Raobaikady, B., Purohit, A., Chander, S. K., Woo, L. W. L., Leese, M. P., Potter, B. V. L., & Reed, M. J. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00049-9 · Cited by 53 · see citing works
Self-citationEstrone sulfate analogs as estrone sulfatase inhibitors
Li, P. (1995) · Steroids · doi:10.1016/0039-128x(94)00048-h · Cited by 53 · see citing works
Purohit, A., Woo, L. W. L., Singh, A., Winterborn, C. J., Potter, B. V. L., & Reed, M. (1996) · PubMed · Cited by 50 · see citing works
Self-citationDevelopment of potent non-estrogenic estrone sulfatase inhibitors
Li, P., Chu, G., Guo, J., Peters, A., & Selcer, K. W. (1998) · Steroids · doi:10.1016/s0039-128x(98)00044-0 · Cited by 50 · see citing works
Lloyd, M. D., Pederick, R. L., NATESH, R., Woo, L. W. L., Purohit, A., Reed, M. J., Acharya, K. R., & Potter, B. V. L. (2005) · Biochemical Journal · doi:10.1042/bj20041037 · Cited by 50 · see citing works
Self-citationNon-steroidal and steroidal sulfamates: new drugs for cancer therapy
Purohit, A., Woo, L. W. L., Barrow, D., Hejaz, H. A., Nicholson, R. I., Potter, B. V. L., & Reed, M. J. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00428-7 · Cited by 49 · see citing works
Self-citationReed, M. J., Hutton, J. D., Baxendale, P. M., James, V. H. T., Jacobs, H. S., & Fisher, R. P. (1979) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(79)90028-1 · Cited by 45 · see citing works
Rasmussen, L. M., Zaveri, N. T., Stenvang, J., Peters, R. H., & Lykkesfeldt, A. E. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9494-y · Cited by 44 · see citing works
Irosustat: a first-generation steroid sulfatase inhibitor in breast cancer
Palmieri, C., Januszewski, A. P., Stanway, S., & Coombes, R. C. (2011) · Expert Review of Anticancer Therapy · doi:10.1586/era.10.201 · Cited by 44 · see citing works
Chanplakorn, N., Chanplakorn, P., Suzuki, T., Ono, K., Chan, M. S. M., Miki, Y., Saji, S., Ueno, T., Toi, M., & Sasano, H. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0785-3 · Cited by 44 · see citing works
Human prostatic dehydroepiandrosterone sulfate sulfatase
Farnsworth, W. E. (1973) · Steroids · doi:10.1016/0039-128x(73)90134-7 · Cited by 43 · see citing works
Fischer, D. S., Chander, S. K., Woo, L. W. L., Fenton, J. C., Purohit, A., Reed, M. J., & Potter, B. V. L. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00048-7 · Cited by 42 · see citing works
Self-citationFoster, P., Woo, L. W. L., Potter, B. V. L., Reed, M. J., & Purohit, A. (2008) · Endocrinology · doi:10.1210/en.2008-0223 · Cited by 42 · see citing works
Self-citationSynthesis and biochemical studies of estrone sulfatase inhibitors
Li, P., Pillai, R., Young, B. L., Bender, W., Martino, D. M., & Lin, F. (1993) · Steroids · doi:10.1016/0039-128x(93)90045-o · Cited by 41 · see citing works
Foster, P., Chander, S. K., Newman, S. P., Woo, L. W. L., Sutcliffe, O. B., Bubert, C., Zhou, D., Chen, S., Potter, B. V. L., Reed, M. J., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1027 · Cited by 41 · see citing works
Self-citationInhibition of estrone sulfatase enzyme in human placenta and human breast carcinoma
Evans, T. R. J., Rowlands, M., Jarman, M., & Coombes, R. C. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90243-x · Cited by 41 · see citing works
Estrone Sulfatase: Probing Structural Requirements for Substrate and Inhibitor Recognition
Anderson, C., Freeman, J. C., Lucas, L. H., Farley, M., Dalhoumi, H., & Widlanski, T. S. (1997) · Biochemistry · doi:10.1021/bi961536t · Cited by 40 · see citing works
Steroid sulfatase and estrogen sulfotransferase in human carcinomas
Suzuki, T., Miki, Y., Nakamura, Y., Ito, K., & Sasano, H. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.001 · Cited by 39 · see citing works
Estrone sulfonates as inhibitors of estrone sulfatase
Howarth, N. M., Purohit, A., Reed, M. J., & Potter, B. V. L. (1997) · Steroids · doi:10.1016/s0039-128x(96)00243-7 · Cited by 38 · see citing works
Self-citationRecent advances in the development of steroid sulphatase inhibitors
Purohit, A., Hejaz, H. A., Woo, L. W. L., van Strien, A. E., Potter, B. V. L., & Reed, M. J. (1999) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(99)00039-4 · Cited by 36 · see citing works
Self-citationPrognostic significance of aromatase and estrone sulfatase enzymes in human breast cancer
Evans, T. R. J., Rowlands, M., Silva, M. C., Law, M. G., & Coombes, R. C. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90263-v · Cited by 34 · see citing works
Regulation and Inhibition of Steroid Sulfatase Activity in Breast Cancer a
Purohit, A., Reed, M. J., Morris, N., WILLIAMS, G. J., & Potter, B. V. L. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb16226.x · Cited by 34 · see citing works
Self-citationBonney, R. C., Scanlon, M. J., Reed, M. J., Jones, D. L., Beranek, P. A., & James, V. H. T. (1984) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(84)90261-9 · Cited by 34 · see citing works
Estrone sulfate (E1S), a prognosis marker for tumor aggressiveness in prostate cancer (PCa)
Giton, F., TAILLE, A. D. L., Allory, Y., Galons, H., Vacherot, F., Soyeux, P., Abbou, C.-C., Loric, S., Cussenot, O., Raynaud, J., et al. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.10.005 · Cited by 34 · see citing works
Aspinall, S. R., Stamp, S., Davison, A., Shenton, B. K., & Lennard, T. W. J. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2003.10.011 · Cited by 34 · see citing works
Foster, P., Chander, S. K., Parsons, M. F. C., Newman, S. P., Woo, L. W. L., Potter, B. V. L., Reed, M. J., & Purohit, A. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9769-3 · Cited by 34 · see citing works
Self-citationJames, M. R., Skaar, T. C., Lee, R. Y., MacPherson, A., Zwiebel, J. A., Ahluwalia, B. S., Ampy, F. R., & Clarke, R. C. (2001) · Endocrinology · doi:10.1210/endo.142.4.8091 · Cited by 33 · see citing works
New Developments in Intracrinology of Human Breast Cancer
Sasano, H., Nagasaki, S., Miki, Y., & Suzuki, T. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03683.x · Cited by 32 · see citing works
Ishida, H., Nakata, T., Suzuki, M., Shiotsu, Y., Tanaka, H., Sato, N., Terasaki, Y., Takebayashi, M., Anazawa, H., Murakata, C., et al. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9495-x · Cited by 31 · see citing works
Sulfate derivatives of 2-phenylindols as novel steroid sulfatase inhibitors
Birnböck, H., & Angerer, E. V. (1990) · Biochemical Pharmacology · doi:10.1016/0006-2952(90)90115-2 · Cited by 30 · see citing works
Inhibition of human placental sterylsulfatase by synthetic analogs of estrone sulfate
DIBBELT, L., Li, P., Pillai, R., & Knüppen, R. (1994) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)90130-9 · Cited by 28 · see citing works
Carlström, K., Döberl, A., Gershagen, S., & Rannevik, G. (1984) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016348409156998 · Cited by 26 · see citing works
Estrone sulfatase activity in patients with advanced ovarian cancer
Chura, J. C., Blomquist, C. H., Ryu, H. S., & Argenta, P. A. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.08.037 · Cited by 26 · see citing works
Wood, P. M., Woo, L. W. L., Labrosse, J., THOMAS, M. P., Mahon, M. F., Chander, S. K., Purohit, A., Reed, M. J., & Potter, B. V. L. (2010) · ChemMedChem · doi:10.1002/cmdc.201000203 · Cited by 25 · see citing works
Self-citationHowarth, N. M., Purohit, A., Robinson, J. J., Vicker, N., Reed, M. J., & Potter, B. V. L. (2002) · Biochemistry · doi:10.1021/bi020543g · Cited by 23 · see citing works
Self-citationIshida, H., Nakata, T., Sato, N., Li, P., Kuwabara, T., & Akinaga, S. (2006) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9404-8 · Cited by 22 · see citing works
Significance of steroid sulfatase expression in human breast cancer
Utsumi, T., Yoshimura, N., MARUTA, M., Takeuchi, S., Ando, J., Maeda, K., & Harada, N. (1999) · Breast Cancer · doi:10.1007/bf02966443 · Cited by 19 · see citing works
Rausch, L. L., Green, C., Steinmetz, K. L., LeValley, S., Catz, P., Zaveri, N. T., Schweikart, K. M., Tomaszewski, J. E., & Mirsalis, J. C. (2010) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-010-1430-x · Cited by 19 · see citing works
Kudoh, M., Susaki, Y., Ideyama, Y., Nanya, T., Okada, M., Shikama, H., & Fujikura, T. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00136-n · Cited by 19 · see citing works
Major impact of hormonal therapy in localized prostate cancer—death can already be an exception
Labrie, F., Cusan, L., Gomez, J., Luu-The, V., Candas, B., Bélanger, A., & Labrie, C. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.10.011 · Cited by 18 · see citing works
Calhoun, K. E. (2003) · Archives of Surgery · doi:10.1001/archsurg.138.8.879 · Cited by 17 · see citing works
Purohit, A., Howarth, N. M., Potter, B. V. L., & Reed, M. J. (1994) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)90203-8 · Cited by 13 · see citing works
Self-citationInactivation of recombinant human steroid sulfatase by KW-2581
Ishida, H., Sato, N., Hosogi, J., Tanaka, H., & Kuwabara, T. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.06.003 · Cited by 8 · see citing works
Endocrine factors concerned in the genesis of experimental mammary carcinoma.
Lacassagne, A. (1955) · PubMed · Cited by 6 · see citing works
Jackson, T., Lwl., W., Trusselle, M. N., Chander, S. K., Purohit, A., Reed, M., & Potter, B. V. L. (2007) · Organic & Biomolecular Chemistry · Cited by 6 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- Reed MJ & Murray MAF 1979 The Oestrogens. In Hormones in Blood, edn 3, pp 263-266. Eds CH Gray & VHT James. London: Academic Press.
- Eds M Sandler & HJ Smith. Oxford University Press.
Cited by
Sorted by citations
Thakur, A., Singla, R., & Jaitak, V. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.07.010 · Cited by 491 · see citing works
Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105439 · Cited by 450 · see citing works
“STS activity is upregulated in several steroid-dependent cancers [40] and has been evaluated as drug target [170,171].”
The Regulation of Steroid Action by Sulfation and Desulfation
Mueller, J. W., Gilligan, L. C., Idkowiak, J., Arlt, W., & Foster, P. A. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1036 · Cited by 419 · see citing works
Self-citationAndrogens in pregnancy: roles in parturition
Makieva, S., Saunders, P. T. K., & Norman, J. E. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu008 · Cited by 232 · see citing works
Intracrine androgen biosynthesis, metabolism and action revisited
Schiffer, L., Arlt, W., & Storbeck, K.-H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.08.016 · Cited by 217 · see citing works
“The potential of STS inhibition has been evaluated in promising clinical trials (Geisler et al., 2011; Purohit and Foster, 2012; Thomas and Potter, 2015).”
The structural biology of oestrogen metabolism
THOMAS, M. P., & Potter, B. V. L. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.12.014 · Cited by 181 · see citing works
Estrogen receptors in breast carcinogenesis and endocrine therapy
Huang, B., Warner, M. N., & Gustafsson, J.-Α. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.11.015 · Cited by 165 · see citing works
Estrogen receptor agonists/antagonists in breast cancer therapy: A critical review
Begam, A. J., Selvaraj, J., & Nanjan, M. J. (2017) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2017.02.011 · Cited by 162 · see citing works
Estrogen Biosynthesis and Action in Ovarian Cancer
Mungenast, F., & Thalhammer, T. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00192 · Cited by 158 · see citing works
Molecular Pathways: Inhibiting Steroid Biosynthesis in Prostate Cancer
Ferraldeschi, R., Sharifi, N., Auchus, R. J., & Attard, G. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0931 · Cited by 93 · see citing works
Oostdijk, W., Idkowiak, J., Mueller, J. W., House, P. J., Taylor, A. E., O'Reilly, M. W., Hughes, B. A., de Vries, M. C., Kant, S. G., Santen, G. W. E., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3556 · Cited by 81 · see citing works
Androgens, oestrogens and endometrium: a fine balance between perfection and pathology
Gibson, D. A., Simitsidellis, I., Collins, F., & Saunders, P. T. K. (2020) · Journal of Endocrinology · doi:10.1530/joe-20-0106 · Cited by 76 · see citing works
Estrogen biosynthesis, phase I and phase II metabolism, and action in endometrial cancer
Rižner, T. L. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.07.026 · Cited by 75 · see citing works
Secky, L., Svoboda, M., Klameth, L., Bajna, E., Hamilton, G., Zeillinger, R., Jäger, W. R., & Thalhammer, T. (2013) · Journal of Drug Delivery · doi:10.1155/2013/957605 · Cited by 71 · see citing works
Scherbakov, A. M., Komkov, A. V., Komendantova, A. S., Yastrebova, M. A., Andreeva, O. E., Ширинян, В. З., Hajra, A., Zavarzin, I. V., & Volkova, Y. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00979 · Cited by 66 · see citing works
Konings, G. F. J., Brentjens, L. S., Delvoux, B., Linnanen, T., Cornel, K. M. C., Koskimies, P., Bongers, M. Y., Kruitwagen, R. F. P. M., Xanthoulea, S., & Romano, A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00940 · Cited by 65 · see citing works
Grienke, U., Foster, P., Zwirchmayr, J., Tahir, A., Rollinger, J. M., & Mikros, E. (2019) · Scientific Reports · doi:10.1038/s41598-019-47434-8 · Cited by 63 · see citing works
Self-citationEndometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders
Gibson, D. A., Simitsidellis, I., Collins, F., & Saunders, P. T. K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103276 · Cited by 70 · see citing works
“Several potent STS inhibitors have been developed [107], including STX64, which was effective in blocking synthesis in endometrial cancer cells in vitro.”
BackgroundJayshree, R. S. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.649815 · Cited by 62 · see citing works
Xu, Y., Liu, X., Guo, F., Ning, Y., Zhi, X., Wang, X., Chen, S., Yin, L., & Li, X. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02258.x · Cited by 61 · see citing works
Delvoux, B., D'Hooghe, T., Kyama, C., Koskimies, P., Hermans, R. J. J., Dunselman, G. A., & Romano, A. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2851 · Cited by 59 · see citing works
Wang, Q., Rangiah, K., Mesaros, C., Snyder, N. W., Vachani, A., Song, H., & Blair, I. A. (2015) · Steroids · doi:10.1016/j.steroids.2015.01.014 · Cited by 58 · see citing works
Hanamura, T., & Hayashi, S. (2017) · Breast Cancer · doi:10.1007/s12282-017-0772-1 · Cited by 57 · see citing works
Penning, T. M. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.05.010 · Cited by 55 · see citing works
Sulfatase inhibitors: a patent review
Williams, S. J. (2012) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2013.736965 · Cited by 50 · see citing works
Steroid sulphatase and its inhibitors: past, present, and future
Foster, P. A. (2021) · Molecules · doi:10.3390/molecules26102852 · Cited by 49 · see citing works
Self-citationCirculating steroid hormone variations throughout different stages of prostate cancer
Snaterse, G., Visser, J. A., Arlt, W., & Hofland, J. (2017) · Endocrine Related Cancer · doi:10.1530/erc-17-0155 · Cited by 44 · see citing works
Sulfatase inhibitors for recidivist breast cancer treatment: A chemical review
Shah, R., Singh, J., Singh, D., Jaggi, A. S., & Singh, N. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.02.054 · Cited by 44 · see citing works
Harrelson, J. P., & Lee, M. W. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.07.014 · Cited by 41 · see citing works
Steroid Sulfation in Neurodegenerative Diseases
Vítků, J., Hill, M., Kolátorová, L., Havrdová, E., & Kancheva, R. L. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.839887 · Cited by 40 · see citing works
Heterocyclic steroids: Efficient routes for annulation of pentacyclic steroidal pyrimidines
Monier, M., El‐Mekabaty, A., Abdel-Latif, D. A., Mert, B. D., & Elattar, K. M. (2019) · Steroids · doi:10.1016/j.steroids.2019.108548 · Cited by 40 · see citing works
Shin, S., Im, H.-J., Kwon, Y., Ye, D.-J., Baek, H., Kim, D., Choi, H., & Chun, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.18645 · Cited by 39 · see citing works
Wang, Q., Mesaros, C., & Blair, I. A. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.01.002 · Cited by 38 · see citing works
Steroid metabolism in breast cancer: Where are we and what are we missing?
Africander, D., & Storbeck, K. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.05.016 · Cited by 39 · see citing works
Wang, Q., Bottalico, L. N., Mesaros, C., & Blair, I. A. (2014) · Steroids · doi:10.1016/j.steroids.2014.08.012 · Cited by 37 · see citing works
Local estrogen metabolism (intracrinology) in endometrial cancer: A systematic review
Cornel, K. M. C., Bongers, M. Y., Kruitwagen, R. F. P. M., & Romano, A. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.10.004 · Cited by 37 · see citing works
Sulfamates in drug design and discovery: Pre-clinical and clinical investigations
Zaraei, S., Abduelkarem, A. R., Anbar, H. S., Kobeissi, S., Mohammad, M., Ossama, A., & El-Gamal, M. I. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.06.052 · Cited by 37 · see citing works
Li, W., Yin, S., Gong, X., Xu, W., Yang, R., Wan, Y., Yuan, L., & Zhang, X. (2019) · Chemical Communications · doi:10.1039/c9cc08672b · Cited by 36 · see citing works
El-Gamal, M. I., Semreen, M. H., Foster, P., & Potter, B. V. L. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.04.040 · Cited by 32 · see citing works
Self-citationHanamura, T., Niwa, T., Gohno, T., Kurosumi, M., Takei, H., Yamaguchi, Y., Ito, K.-I., & Hayashi, S.-I. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2788-3 · Cited by 31 · see citing works
Role of OATP transporters in steroid uptake by prostate cancer cells in vivo
Green, S. M., Kaipainen, A., Bullock, K. H., Zhang, A., Lucas, J. M., Matson, C., Banks, W. A., & Mostaghel, E. A. (2016) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2016.42 · Cited by 30 · see citing works
HDL in Endocrine Carcinomas: Biomarker, Drug Carrier, and Potential Therapeutic
Morin, E. E., Li, X., & Schwendeman, A. A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00715 · Cited by 31 · see citing works
Steroid derivatives as inhibitors of steroid sulfatase
Mostafa, Y. A., & Taylor, S. D. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.01.013 · Cited by 30 · see citing works
Clinical implications of estrone sulfate measurement in laboratory medicine
Rezvanpour, A., & Don-Wauchope, A. (2016) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2016.1252310 · Cited by 28 · see citing works
Induction of Integrin Signaling by Steroid Sulfatase in Human Cervical Cancer Cells
Ye, D.-J., Kwon, Y., Shin, S., Baek, H., Shin, D.-W., & Chun, Y.-J. (2016) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2016.155 · Cited by 28 · see citing works
Salah, M., Abdelsamie, A. S., & Frotscher, M. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00062 · Cited by 28 · see citing works
Konkoľová, E., Hudáčová, M., Hamuľaková, S., Jendželovský, R., Vargová, J., Ševc, J., Fedoročko, P., & Kožurková, M. (2021) · Molecules · doi:10.3390/molecules26041133 · Cited by 28 · see citing works
Davies, W., Humby, T., Trent, S., Eddy, J. B., Ojarikre, O. A., & Wilkinson, L. S. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.115 · Cited by 27 · see citing works
Bjerregaard‐Olesen, C., Ghisari, M., & Bonefeld‐Jørgensen, E. C. (2016) · Environmental Research · doi:10.1016/j.envres.2016.07.001 · Cited by 27 · see citing works
Estrogen sulfotransferase and sulfatase in steroid homeostasis, metabolic disease, and cancer
Wang, J., Feng, Y., Liu, B., & Xie, W. (2023) · Steroids · doi:10.1016/j.steroids.2023.109335 · Cited by 27 · see citing works
Sex-Dependent Role of Estrogen Sulfotransferase and Steroid Sulfatase in Metabolic Homeostasis
Garbacz, W. G., Jiang, M., & Xie, W. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_21 · Cited by 25 · see citing works
Pohl, O., Bestel, E., & Gotteland, J. (2014) · Reproductive Sciences · doi:10.1177/1933719114522526 · Cited by 24 · see citing works
Bjerregaard‐Olesen, C., Ghisari, M., Kjeldsen, L. S., Wielsøe, M., & Bonefeld‐Jørgensen, E. C. (2015) · Steroids · doi:10.1016/j.steroids.2015.11.009 · Cited by 22 · see citing works
A new series of aryl sulfamate derivatives: Design, synthesis, and biological evaluation
El-Gamal, M. I., Zaraei, S., Foster, P., Anbar, H. S., El‐Gamal, R., El‐Awady, R., & Potter, B. V. L. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115406 · Cited by 22 · see citing works
Self-citationLu, X., Ma, P., Shi, Y., Yao, M., Hou, L., Zhang, P., & Jiang, L. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.11.016 · Cited by 22 · see citing works
Ouellet, C., Maltais, R., Ouellet, É., Barbeau, X., Lagüe, P., & Poirier, D. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.04.044 · Cited by 22 · see citing works
Defective DNA repair systems and the development of breast and prostate cancer
Kitagishi, Y., Kobayashi, M., & Matsuda, S. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1696 · Cited by 22 · see citing works
Kozak, W., Daśko, M., Masłyk, M., Pieczykolan, J., Gielniewski, B., Rachoń, J., & Demkowicz, S. (2014) · RSC Advances · doi:10.1039/c4ra07135b · Cited by 21 · see citing works
In touch with your feminine side: how oestrogen metabolism impacts prostate cancer
Rahman, H. P., Hofland, J., & Foster, P. (2016) · Endocrine Related Cancer · doi:10.1530/erc-16-0118 · Cited by 21 · see citing works
Self-citationQuest for steroidomimetics: Amino acids derived steroidal and nonsteroidal architectures
Shagufta, S., Ahmad, I., & Panda, G. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.03.054 · Cited by 21 · see citing works
Davies, W. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0219 · Cited by 18 · see citing works
Armstrong, C. M., Liu, C., Liu, L., Yang, J. C., Lou, W., Zhao, R., Ning, S., Lombard, A. P., Zhao, J., D'Abronzo, L. S., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-1682 · Cited by 20 · see citing works
Demkowicz, S., Daśko, M., Kozak, W., Krawczyk, K., Witt, D., Masłyk, M., Kubiński, K., & Rachoń, J. (2015) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12652 · Cited by 20 · see citing works
Waihenya, S., Şenel, P., Osonga, F. J., Erdoğan, T., Altay, F., Gölcü, A., & Sadik, O. A. (2021) · ACS Omega · doi:10.1021/acsomega.0c02612 · Cited by 19 · see citing works
Läsche, M., Gallwas, J. K. S., & Gründker, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095050 · Cited by 19 · see citing works
Li, S., Xie, L., Du, M., Xu, K., Zhu, L., Chu, H., Chen, J., Wang, M., Zhang, Z., & Gu, D. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2195-y · Cited by 19 · see citing works
Daśko, M., Demkowicz, S., Biernacki, K. A., Ciupak, O., Kozak, W., Masłyk, M., & Rachoń, J. (2020) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2020.1758692 · Cited by 19 · see citing works
The Biological Roles of Steroid Sulfonation
Anthony, P. (2012) · InTech eBooks · doi:10.5772/52714 · Cited by 18 · see citing works
Steroid Hormones and Other Lipid Molecules Involved in Human Reproduction
Strauss, J. F., & FitzGerald, G. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00004-4 · Cited by 18 · see citing works
Wu, Y., Tang, L., Azabdaftari, G., POP, E. A., & Smith, G. J. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.02.018 · Cited by 17 · see citing works
Grienke, U., Kaserer, T., Kirchweger, B., Lambrinidis, G., Kandel, R. T., Foster, P., Schuster, D., Mikros, E., & Rollinger, J. M. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103495 · Cited by 17 · see citing works
Self-citationPoirier, D., Roy, J., & Maltais, R. (2021) · Cancers · doi:10.3390/cancers13081841 · Cited by 19 · see citing works
Im, H.-J., Park, N.-H., Kwon, Y., Shin, S., Kim, D., & Chun, Y. (2012) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2012.20.6.556 · Cited by 16 · see citing works
Biernacki, K. A., Ciupak, O., Daśko, M., Rachoń, J., Kozak, W., Rak, J., Kubiński, K., Masłyk, M., Martyna, A., Śliwka‐Kaszyńska, M., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c02220 · Cited by 16 · see citing works
Phase Two Steroid Metabolism and Its Roles in Breast and Prostate Cancer Patients
McNamara, K. M., Nakamura, Y., Miki, Y., & Sasano, H. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00116 · Cited by 14 · see citing works
Design and synthesis of dansyl-labeled inhibitors of steroid sulfatase for optical imaging
Maltais, R., Ngueta, A. D., Roy, J., Barbeau, X., Lambert, J., & Poirier, D. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115368 · Cited by 14 · see citing works
Secosteroidal hydrazides: Promising scaffolds for anti-breast cancer agents
Ilovaisky, A. I., Merkulova, V. M., Chernoburova, E. I., Shchetinina, M. A., Salnikova, D. I., Scherbakov, A. M., Zavarzin, I. V., & Terent'ev, A. O. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.106000 · Cited by 13 · see citing works
Enzyme-Responsive Polymeric Materials with Anticancer and Antibacterial Activities
Ghosh, D., Bag, S., & De, P. (2025) · Biomacromolecules · doi:10.1021/acs.biomac.5c01944 · Cited by 12 · see citing works
SULFATION PATHWAYS: Contribution of intracrine oestrogens to the aetiology of endometriosis
Piccinato, C. D. A., Malvezzi, H., Gibson, D. A., & Saunders, P. T. K. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0297 · Cited by 12 · see citing works
The sulfatase pathway as estrogen supply in endometrial cancer
Cornel, K. M. C., Delvoux, B., Saya, T., Xanthoulea, S., Konings, G. F. J., Kruitwagen, R. F. P. M., Bongers, M. Y., Kooreman, L. F. S., & Romano, A. (2018) · Steroids · doi:10.1016/j.steroids.2018.09.002 · Cited by 12 · see citing works
Abdelsamie, A. S., Bey, E., Hanke, N., Empting, M., Hartmann, R. W., & Frotscher, M. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.05.074 · Cited by 11 · see citing works
Mohamed, A., Salah, M., Tahoun, M., Hawner, M., Abdelsamie, A. S., & Frotscher, M. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00589 · Cited by 11 · see citing works
Sung, C.-H., Im, H.-J., Park, N., Kwon, Y., Shin, S., Ye, D.-J., Cho, N.-H., Park, Y.-S., Choi, H., Kim, D., et al. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.09.006 · Cited by 11 · see citing works
Antisulfatase, Osteogenic, and Anticancer Activities of Steroid Sulfatase Inhibitor EO-33 in Mice
Poirier, D., Roy, J., Maltais, R., & Ayan, D. P. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00382 · Cited by 11 · see citing works
Wehner, G., & Schweikert, H. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2607 · Cited by 11 · see citing works
Hanamura, T., Ito, T., Kanai, T., Maeno, K., Shimojo, Y., Uehara, T., Suzuki, T., Hayashi, S., & Ito, K. (2016) · Cancer Medicine · doi:10.1002/cam4.708 · Cited by 11 · see citing works
Steroid sulfatase inhibitors: promising new therapy for breast cancer.
Sadozai, H. (2013) · PubMed · Cited by 10 · see citing works
Schuler, G. C., Sánchez‐Guijo, A., Hartmann, M. F., & Wudy, S. A. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.10.006 · Cited by 9 · see citing works
A novel fluorescent probe for rapid detection of sulfatase in vitro and in living cells
Chen, J., Peng, Z., Ji, M., & Wang, P. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106655 · Cited by 9 · see citing works
Kucera, H., Puschner, B., Conley, A. J., & Berger, T. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215390 · Cited by 9 · see citing works
Anticancer Drugs That Modulate Hormone Action
Avendaño, C., & Menéndez, J. C. (2015) · Elsevier eBooks · doi:10.1016/b978-0-444-62649-3.00003-x · Cited by 9 · see citing works
Lespérance, M., Roy, J., Ngueta, A. D., Maltais, R., & Poirier, D. (2021) · Steroids · doi:10.1016/j.steroids.2021.108856 · Cited by 9 · see citing works
Ilovaisky, A. I., Scherbakov, A. M., Chernoburova, E. I., Povarov, A. A., Shchetinina, M. A., Merkulova, V. M., Salnikova, D. I., Sorokin, D. V., Bozhenko, E. I., Zavarzin, I. V., et al. (2023) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2023.106386 · Cited by 8 · see citing works
Daśko, M., Masłyk, M., Kubiński, K., Aszyk, J., Rachoń, J., & Demkowicz, S. (2016) · MedChemComm · doi:10.1039/c6md00113k · Cited by 8 · see citing works
Swanepoel, A. C., Naidoo, P., Nielsen, V. G., & Pretorius, E. (2017) · Microscopy Research and Technique · doi:10.1002/jemt.22854 · Cited by 8 · see citing works
A Potent Inhibitor of Steroid Sulfatase (EM-1913) Blocks Tumor Growth in Nude Mice (MCF-7 Xenograft)
Poirier, D., Roy, J., Maltais, R., & Ayan, D. P. (2015) · Current Enzyme Inhibition · doi:10.2174/157340801101150707124626 · Cited by 8 · see citing works
Secosteroid diacylhydrazines as novel effective agents against hormone-dependent breast cancer cells
Ilovaisky, A. I., Scherbakov, A. M., Chernoburova, E. I., Shchetinina, M. A., Merkulova, V. M., Bogdanov, F. B., Sorokin, D. V., Salnikova, D. I., Bozhenko, E. I., Zavarzin, I. V., et al. (2024) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2024.106597 · Cited by 7 · see citing works
New potent STS inhibitors based on fluorinated 4-(1-phenyl-1H-[1,2,3]triazol-4-yl)-phenyl sulfamates
Daśko, M., Demkowicz, S., Rachoń, J., Biernacki, K. A., Aszyk, J., Kozak, W., Masłyk, M., & Kubiński, K. (2019) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2019.1680642 · Cited by 7 · see citing works
The Synthesis and Metabolism of Steroid Hormones
Strauss, J. F. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-2758-2.00004-4 · Cited by 7 · see citing works
New structural insights provide a different angle on steroid sulfatase action
Foster, P., & Mueller, J. W. (2023) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2023.106353 · Cited by 6 · see citing works
Self-citation
- Authors
- Purohit, A., & Foster, P. A.
- Affiliations
- Hammersmith Hospital (GB)
- ORCID
- Foster, Paul A
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2011-08-22
- Volume
- 212
- Issue
- 2
- Pages
- 99-110
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2143089038
- Cited by
- 126
- References
- 105
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 12 · 2018: 11 · 2017: 11 · 2016: 14 · 2015: 12 · 2014: 16 · 2013: 11 · 2012: 6
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Ipsen
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Keywords
- steroid sulfatase inhibitors, steroid sulfatase, estrone sulfate, dehydroepiandrosterone sulfate, hormone-dependent tumors, breast cancer, prostate cancer, endometrial cancer, estrogen metabolism, androgen metabolism, drug development, clinical trials, postmenopausal women
- MeSH terms
- Androgens, Animals, Breast Neoplasms, Enzyme Inhibitors, Estrogens, Female, Humans, Male, Neoplasm Proteins, Neoplasms, Hormone-Dependent, Prostatic Neoplasms, Receptors, Androgen, Receptors, Estrogen, Antineoplastic Agents, Hormonal, Steryl-Sulfatase, Aromatase Inhibitors, Molecular Targeted Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
