Antioxidant and cytotoxic activities of essential oil of Ocimum canum Sims. from India
Open accessAbstract
Chemical composition analysis of essential oil isolated from the leaves of Ocimum canum Sims. reported the presence of thirty six compounds. The major compound was camphor (39.77%). In vitro antioxidant activity of the isolated oil showed dose dependent free radical scavenging activity against DPPH (IC50 523.55 ± 0.001 μg/mL) and hydroxyl radicals (491.12 ± 0.002 μg/mL), metal chelating (781.38 ± 0.001 μg/mL) and prevention of deoxyribose degradation (168.50 ± 0.003 μg/mL) activities were also calculated. Antioxidant activity of oil was less observed when compared with positive controls such as ascorbic acid and BHT (12.49 ± 0.002 and 30.14 ± 0.005, respectively). Significant cytotoxicity (IC50 value of 60 μg/mL) and DNA fragmentation was observed in breast cancer cells (MCF-7).
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Linalool is famed for its soothing and floral aroma and is used in the perfume and beauty industries.
“Linalool, famed for its soothing and floral aroma, discover packages withinside the perfume and beauty industries [25,26] .”
From Untargeted metabolomics and targeted approach of essential oils to differentiate five Ocimum species using gas chromatography coupled with mass spectrometry (2024) · cites this paper as [26]
The Chemical composition analysis (section 3.1) describes aromatic Ocimum canum oil, but does not discuss linalool’s scent or its use in perfume or beauty products. Searches for linalool, floral fragrance, perfumery, and cosmetic uses found no passage addressing those claims in our copy. (LLM, conf=0.75)
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Suanarunsawat, T., Devakul Na Ayutthaya, W., Songsak, T., Thirawarapan, S., & Poungshompoo, S. (2009) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.09-52 · Cited by 75 · see citing works
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Diversity, phytochemical and medicinal potential of the genus Ocimum L. (Lamiaceae)
Zahran, E. M., Abdelmohsen, U. R., Khalil, H. E., Desoukey, S. Y., Fouad, M. A., & Kamel, M. S. (2020) · Phytochemistry Reviews · doi:10.1007/s11101-020-09690-9 · Cited by 90 · see citing works
Gurav, T. P., Dholakia, B. B., & Giri, A. P. (2022) · Phytochemistry Reviews · doi:10.1007/s11101-021-09767-z · Cited by 87 · see citing works
Tyagi, A., Yadav, A. K., Yadav, A., Saini, L., Kumar, V., Jain, P., Mohammad, I., Ansari, M. J., El Enshasy, H. A., Abdel-Gawad, F. K., et al. (2022) · Journal of King Saud University: Science · doi:10.1016/j.jksus.2022.102355 · Cited by 17 · see citing works
Jaiswal, R. P., Pasrija, A., Mishra, B., Gupta, P. K., & Mitra, R. (2024) · The Journal of Phytopharmacology · doi:10.31254/phyto.2024.13602 · Cited by 2 · see citing works
- Authors
- Tamil Selvi, M., Thirugnanasampandan, R., & Sundarammal, S.
- Affiliations
- Kongunadu Arts and Science College (IN)
- Corresponding author
- Thirugnanasampandan, R.
- Venue
- Journal of Saudi Chemical Society
- Published
- 2015-01
- Volume
- 19
- Issue
- 1
- Pages
- 97-100
- ISSN
- 1319-6103 (ISSN-L)
- OpenAlex
- W2061464673
- Cited by
- 65
- References
- 1
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 8 · 2021: 4 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 3
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Saudi Chemical Society (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Ocimum canum, essential oils, camphor, antioxidant activity, cytotoxicity, free radical scavenging, metal chelating activity, DNA fragmentation, MCF-7 cells, leaf chemical composition
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