Nonocclusive mesenteric infarction after cardiac surgery: potential biomarkers
Open accessAbstract
Background Nonocclusive mesenteric ischemia can cause intestinal infarction but the diagnosis is challenging. This prospective study evaluated three plasma biomarkers of intestinal infarction after cardiac surgery.Materials and methods Patients were recruited after cardiac surgery if they required laparotomy (with or without intestinal resection) for suspected nonocclusive mesenteric ischemia. Plasma levels of D-lactate, intestinal fatty acid-binding protein (i-FABP), and smooth muscle actin (SMA) before laparotomy were measured.Results Twenty patients were recruited (68 ± 9 y, EuroSCORE: 8.7 ± 2.8, mortality 70%). A positive laparotomy (n = 13) was associated with no change in D-lactate (P = 0.95), decreased i-FABP (P = 0.007), and increased SMA (P = 0.01). All patients with high SMA had a positive laparotomy. A subgroup analysis was undertaken in the eight patients who required multiple laparotomies. D-lactate increased between the two laparotomies in nonsurvivors (n = 4). Plasma i-FABP (P = 0.008) and SMA (P = 0.036) significantly decreased after the bowel resection, regardless of survival outcome.Conclusions None of the biomarkers were accurate enough to reliably diagnose intestinal infarction. However, all patients with high values of SMA developed intestinal infarction, thus warranting further investigation. An increasing D-lactate after intestinal resection suggests impending death.
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Serum smooth muscle actin had sensitivity 54% and specificity 100% in a single study.
“Serum smooth muscle actin (54 and 100%) [40].”
From Diagnostic accuracy of biomarkers to detect acute mesenteric ischaemia in adult patients: a systematic review and meta-analysis (2023) · cites this paper as [40]
The predictive-properties table reports SMA sensitivity of 0.54 and specificity of 1.00. However, the Biomarker Assays section says the study tested plasma, not serum, so the specimen type in the claim is unsupported. (LLM, conf=0.88)
Experimental — accuracy not yet measuredNewer studies assessing intestinal fatty acid-binding protein have been published but do not confirm the initial enthusiasm.
“Newer studies assessing I-FABP have been published, but do not confirm the initial enthusiasm [21, 40, 56, 64, 68].”
From Diagnostic accuracy of biomarkers to detect acute mesenteric ischaemia in adult patients: a systematic review and meta-analysis (2023) · cites this paper as [40]
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Cites
Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine
ZWEIG, M. H., & Campbell, G. (1993) · Clinical Chemistry · doi:10.1093/clinchem/39.4.561 · Cited by 6,528 · see citing works
Acute Mesenteric Ischemia: A Clinical Review
Oldenburg, W. A., Lau, L. L., Rodenberg, T. J., Edmonds, H. J., & Burger, C. D. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.10.1054 · Cited by 714 · see citing works
Identification and characterization of multiple forms of actin
Garrels, J. I. (1976) · Cell · doi:10.1016/0092-8674(76)90142-2 · Cited by 532 · see citing works
Systematic review of survival after acute mesenteric ischaemia according to disease aetiology
Schoots, I. G., Koffeman, G. I., Legemate, D. A., Levi, M., & van Gulik, T. M. (2004) · Journal of British Surgery · doi:10.1002/bjs.4459 · Cited by 502 · see citing works
Fatty acid-binding proteins as plasma markers of tissue injury
Pelsers, M. M. A. L., Hermens, W. T., & Glatz, J. F. C. (2004) · Clinica Chimica Acta · doi:10.1016/j.cccn.2004.09.001 · Cited by 488 · see citing works
D-Lactate in Human and Ruminant Metabolism
Ewaschuk, J. B., Naylor, J. Μ., & Zello, G. A. (2005) · Journal of Nutrition · doi:10.1093/jn/135.7.1619 · Cited by 422 · see citing works
Non-occlusive mesenteric ischemia: etiology, diagnosis, and interventional therapy
Trompeter, M., Brazda, T., Remy, C. T., Vestring, T., & Reimer, P. (2002) · European Radiology · doi:10.1007/s00330-001-1220-2 · Cited by 378 · see citing works
Pelsers, M. M. A. L., Namiot, Z., Kisielewski, W., Namiot, A., Januszkiewicz, M., Hermens, W. T., & Glatz, J. F. C. (2003) · Clinical Biochemistry · doi:10.1016/s0009-9120(03)00096-1 · Cited by 377 · see citing works
Kanda, T., Fujii, H., Tani, T., Murakami, H., Suda, T., Sakai, Y., Ono, T., & Hatakeyama, K. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8566578 · Cited by 283 · see citing works
Infarction of the Bowel in Cardiac Failure
Ende, N. (1958) · New England Journal of Medicine · doi:10.1056/nejm195805012581804 · Cited by 272 · see citing works
Evennett, N. J., Petrov, M. S., Mittal, A., & Windsor, J. A. (2009) · World Journal of Surgery · doi:10.1007/s00268-009-0074-7 · Cited by 270 · see citing works
Self-citationActin and tropomyosin variants in smooth muscles. Dependence on tissue type.
Fatigati, V., & Murphy, R. A. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42610-x · Cited by 241 · see citing works
Mesenteric ischaemia: A multidisciplinary approach
Bradbury, A. W., Brittenden, J., McBride, K., & Ruckley, C. V. (1995) · Journal of British Surgery · doi:10.1002/bjs.1800821105 · Cited by 239 · see citing works
Primer on Medical Decision Analysis: Part 1—Getting Started
Detsky, A. S., Naglie, G., Krahn, M. D., Naimark, D. M. J., & Redelmeier, D. A. (1997) · Medical Decision Making · doi:10.1177/0272989x9701700201 · Cited by 230 · see citing works
Serum D(−)-lactate levels as an aid to diagnosing acute intestinal ischemia
Murray, M. J., Gonze, M. D., Nowak, L. R., & Cobb, C. F. (1994) · The American Journal of Surgery · doi:10.1016/0002-9610(94)90101-5 · Cited by 224 · see citing works
Lieberman, J. M., Sacchettini, J. C., MARKS, C., & Marks, W. H. (1997) · Surgery · doi:10.1016/s0039-6060(97)90363-9 · Cited by 217 · see citing works
Early Diagnosis of Intestinal Ischemia Using Urinary and Plasma Fatty Acid Binding Proteins
Thuijls, G., Wijck, K. V., Grootjans, J., Derikx, J. P. M., van Bijnen, A. A., Heineman, E., Dejong, C. H. C., Buurman, W. A., & Poeze, M. (2011) · Annals of Surgery · doi:10.1097/sla.0b013e318207a767 · Cited by 217 · see citing works
Mitsuyoshi, A., Obama, K., Shinkura, N., Ito, T., & Zaima, M. (2007) · Annals of Surgery · doi:10.1097/01.sla.0000263157.59422.76 · Cited by 202 · see citing works
Angiopathic consequences of saturating the plasma scavenger system for actin.
Haddad, J. G., Harper, K. D., Guoth, M., Pietra, G. G., & Sanger, J. W. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1381 · Cited by 185 · see citing works
Diagnostic accuracy of plasma biomarkers for intestinal ischaemia
Block, T., Nilsson, T. K., Björck, M., & Acosta, S. (2008) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510701646264 · Cited by 172 · see citing works
Role of plasma gelsolin and the vitamin D-binding protein in clearing actin from the circulation.
Lind, S. E., Smith, D. B., Janmey, P. A., et al. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112634 · Cited by 157 · see citing works
Current theories of pathogenesis and treatment of nonocclusive mesenteric ischemia
Wilcox, M. G., Howard, T. J., Plaskon, L. A., Unthank, J. L., & Madura, J. A. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02064966 · Cited by 142 · see citing works
Colonic lactate metabolism andd-lactic acidosis
Hove, H., & Mortensen, P. B. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02065417 · Cited by 127 · see citing works
Fatal nonocclusive mesenteric ischaemia: population‐based incidence and risk factors
ACOSTA, S., ÖGREN, M., STERNBY, N. ‐., BERGQVIST, D., & BJÖRCK, M. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01613.x · Cited by 124 · see citing works
Non-occlusive mesenteric ischaemia: a common disorder in gastroenterology and intensive care
Kolkman, J. J., & Mensink, P. (2003) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/s1521-6918(03)00021-0 · Cited by 116 · see citing works
Barja, F., Coughlin, C., Belin, D., et al. (1986) · PubMed · Cited by 115 · see citing works
Knowles, C., Silk, D., Darzi, A., Veress, B., Feakins, R., Raimundo, A., Crompton, T., Browning, E., Lindberg, G., & Martin, J. E. (2004) · Gut · doi:10.1136/gut.2003.037275 · Cited by 114 · see citing works
Risk factors for nonocclusive mesenteric ischemia after elective cardiac surgery
Groesdonk, H. V., Klingele, M., Schlempp, S., Bomberg, H., Schmied, W., Minko, P., & Schäfers, H.-J. (2013) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2012.11.022 · Cited by 110 · see citing works
Poeze, M., Froon, A. H. M., Greve, J.-W. M., & Ramsay, G. (1998) · British journal of surgery · doi:10.1046/j.1365-2168.1998.00837.x · Cited by 106 · see citing works
Cronk, D. R., Houseworth, T. P., Cuadrado, D. G., Herbert, G. S., McNutt, P. M., & Azarow, K. S. (2006) · Current Surgery · doi:10.1016/j.cursur.2006.05.006 · Cited by 105 · see citing works
Woodhams, R., Nishimaki, H., Fujii, K., Kakita, S., & Hayakawa, K. (2009) · European Journal of Radiology · doi:10.1016/j.ejrad.2009.05.012 · Cited by 103 · see citing works
Bowel Infarction as a Cause of Death in Dialysis Patients
Diamond, S. M. (1986) · JAMA · doi:10.1001/jama.1986.03380180107028 · Cited by 74 · see citing works
Plasma d-Lactate as a Potential Early Marker for Colon Ischaemia After Open Aortic Reconstruction
Assadian, A., Assadian, O., Senekowitsch, C., Rotter, R., Bahrami, S., Fürst, W., Jaksch, W., Hagmüller, G. W., & Hübl, W. (2005) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2005.10.031 · Cited by 68 · see citing works
van der Voort, P. H., Westra, B., Wester, J. P., Bosman, R. J., van Stijn, I., Haagen, I.-A., Loupatty, F. J., & Rijkenberg, S. (2014) · BMC Anesthesiology · doi:10.1186/1471-2253-14-111 · Cited by 59 · see citing works
Masumoto, K., Suita, S., Nada, O., et al. (1999) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(99)90104-5 · Cited by 57 · see citing works
Measures Derived from a 2 x 2 Table for an Accuracy of a Diagnostic Test
Shaikh, S. A. (2011) · Journal of Biometrics & Biostatistics · doi:10.4172/2155-6180.1000128 · Cited by 57 · see citing works
Detection of patients at high risk for non-occlusive mesenteric ischemia in hemodialysis
Quiroga, B., Verde, E., Abad, S., Vega, A., Goicoechea, M., Reque, J., López–Gómez, J. M., & Luño, J. (2012) · Journal of Surgical Research · doi:10.1016/j.jss.2012.10.008 · Cited by 52 · see citing works
Elevated Procalcitonin in Patients After Cardiac Surgery: A Hint to Nonocclusive Mesenteric Ischemia
Klingele, M., Bomberg, H., Poppleton, A., Minko, P., Speer, T., Schäfers, H., & Groesdonk, H. V. (2015) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2014.10.064 · Cited by 42 · see citing works
Serum Markers and Intestinal Mucosal Injury in Chronic Gastrointestinal Ischemia
van Noord, D., Mensink, P., de Knegt, R. J., Ouwendijk, M., Francke, J., van Vuuren, A. J., Hansen, B. E., & Kuipers, E. J. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1303-5 · Cited by 39 · see citing works
Elevated endothelin-1 level is a risk factor for nonocclusive mesenteric ischemia
Groesdonk, H. V., Raffel, M., Speer, T., Bomberg, H., Schmied, W., Klingele, M., & Schäfers, H.-J. (2015) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2014.12.019 · Cited by 33 · see citing works
Minko, P., Stroeder, J., Groesdonk, H. V., Graeber, S. M., Klingele, M., Buecker, A., Schäfers, H., & Katoh, M. (2014) · CardioVascular and Interventional Radiology · doi:10.1007/s00270-014-0844-y · Cited by 30 · see citing works
Evennett, N. J., Cerigioni, E., Hall, N. J., Pierro, A., & Eaton, S. D. (2014) · Journal of Surgical Research · doi:10.1016/j.jss.2014.04.020 · Cited by 27 · see citing works
Self-citationElimination of Low Molecular Weight Proteins During Hemofiltration
Röckel, A., Gilge, U., Liewald, A., et al. (1982) · Artificial Organs · doi:10.1111/j.1525-1594.1982.tb01678.x · Cited by 27 · see citing works
Kazui, T., Yamasaki, M., Abe, K., Watanabe, S., & Kawazoe, K. (2011) · Annals of Thoracic and Cardiovascular Surgery · doi:10.5761/atcs.cr.10.01654 · Cited by 26 · see citing works
Intestinal proteome changes during infant necrotizing enterocolitis
Jiang, P., Smith, B., Qvist, N., Nielsen, C., Wan, J. M., Sit, W., Jensen, T. K., Wang, H., & Sangild, P. T. (2012) · Pediatric Research · doi:10.1038/pr.2012.182 · Cited by 23 · see citing works
Gelsolin is Depleted in Post-Shock Mesenteric Lymph
Jordan, J. R., Moore, E. E., Damle, S. S., et al. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2007.04.017 · Cited by 23 · see citing works
Kwok, H. C. K., Dirkzwager, I., Duncan, D., Gillham, M. J., & Milne, D. G. (2014) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)01463-1 · Cited by 17 · see citing works
Self-citationAltered expression of alpha-smooth muscle isoactin in Hirschsprung's disease.
Fromont, G., Lafer, D., & Masood, S. (1996) · PubMed · Cited by 12 · see citing works
Brener, Z. Z., Bergman, M., Ohm, H. K., & Winchester, J. F. (2008) · Cases Journal · doi:10.1186/1757-1626-1-217 · Cited by 7 · see citing works
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“Newer studies assessing I-FABP have been published, but do not confirm the initial enthusiasm [21, 40, 56, 64, 68].”
BackgroundDiagnostic accuracy of hematological parameters in Acute mesenteric ischemia-A systematic review
Khan, S. M., Emile, S. H., Wang, Z., & Agha, M. A. (2019) · International Journal of Surgery · doi:10.1016/j.ijsu.2019.04.005 · Cited by 51 · see citing works
Zogheib, E., Cosse, C., Sabbagh, C., Marx, S., Caus, T., Henry, M., Nader, J., Fumery, M., Bernasinski, M., Besserve, P., et al. (2018) · Annals of Intensive Care · doi:10.1186/s13613-018-0395-5 · Cited by 30 · see citing works
- Authors
- Hong, J., Gilder, E., Blenkiron, C., Jiang, Y., Evennett, N. J., Petrov, M. S., Phillips, A. R. J., Windsor, J. A., & Gillham, M.
- Affiliations
- University of Auckland (NZ)
- Auckland City Hospital (NZ)
- Corresponding author
- Hong, Jiwon
- ORCID
- Venue
- Journal of Surgical Research
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 211
- Pages
- 21-29
- ISSN
- 0022-4804 (ISSN-L)
- OpenAlex
- W2560707786
- Cited by
- 27
- References
- 49
- Citations by year
- 2025: 1 · 2024: 9 · 2023: 5 · 2022: 2 · 2021: 3 · 2019: 5 · 2018: 2
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Surgical Research (publishedVersion)
- PubMed (publishedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Funders
- Auckland Medical Research (1109025)
- Trust Research (SPG-1006-003 4773)
- Green Lane Research and Educational Fund (13/39/4095)
- Topics
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Keywords
- nonocclusive mesenteric ischemia, intestinal infarction, cardiac surgery complications, plasma biomarkers, D-lactate, intestinal fatty acid binding protein, smooth muscle actin, laparotomy, bowel resection, postoperative mortality
- MeSH terms
- Actins, Aged, Aged, 80 and over, Female, Cardiac Surgical Procedures, Humans, Infarction, Intestines, Laparotomy, Male, Middle Aged, Pilot Projects, Postoperative Complications, Prospective Studies, ROC Curve, Biomarkers, Lactic Acid, Fatty Acid-Binding Proteins, Mesenteric Ischemia
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