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Brain Functional and Anatomical Changes in Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Open accessAbstract
PURPOSE: Research into the pathophysiology of chronic prostatitis/chronic pelvic pain syndrome has primarily focused on markers of peripheral dysfunction. We present the first neuroimaging investigation to our knowledge to characterize brain function and anatomy in chronic prostatitis/chronic pelvic pain syndrome. MATERIALS AND METHODS: We collected data from 19 male patients with chronic prostatitis/chronic pelvic pain syndrome, and 16 healthy age and gender matched controls. Functional magnetic resonance imaging data were obtained from 14 patients with chronic prostatitis/chronic pelvic pain syndrome as they rated spontaneous pain inside the scanner. Group differences (16 patients per group) in gray matter total volume and regional density were evaluated using voxel-based morphometry, and white matter integrity was studied with diffusion tensor imaging to measure fractional anisotropy. Functional and anatomical imaging outcomes were correlated with the clinical characteristics of chronic prostatitis/chronic pelvic pain syndrome. RESULTS: Spontaneous pelvic pain was uniquely characterized by functional activation within the right anterior insula, which correlated with clinical pain intensity. No group differences were found in regional gray matter volume, yet density of gray matter in pain relevant regions (anterior insula and anterior cingulate cortices) positively correlated with pain intensity and extent of pain chronicity. Moreover the correlation between white matter anisotropy and neocortical gray matter volume was disrupted in chronic prostatitis/chronic pelvic pain syndrome. CONCLUSIONS: We provide novel evidence that the pain of chronic prostatitis/chronic pelvic pain syndrome is associated with a chronic pelvic pain syndrome specific pattern of functional brain activation and brain anatomical reorganization. These findings necessitate further investigations into the role of central mechanisms in the initiation and maintenance of chronic prostatitis/chronic pelvic pain syndrome.
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“Guillory and colleagues101 found that a text message-based social support intervention was effective in reducing pain severity and interference and increasing positive affect.”
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Neural systems supporting interoceptive awareness
Critchley, H. D., Wiens, S., Rotshtein, P., Öhman, A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1176 · Cited by 3,406
Human brain mechanisms of pain perception and regulation in health and disease
Apkarian, A. V., Bushnell, M. C., Treede, R., & Zubieta, J. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.11.001 · Cited by 3,126
Self-citationBonica, J. J., Melzack, R., & Wall, P. D. (1999) · Cited by 2,537
Kurth, F., Zilles, K., Fox, P. T., Laird, A. R., & Eickhoff, S. B. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0255-z · Cited by 1,293
Litwin, M. S., McNaughton‐Collins, M., Fowler, F. J., Nickel, J. C., Calhoun, E. A., Pontari, M. A., Alexander, R. B., Farrar, J. T., & O’Leary, M. P. (1999) · The Journal of Urology · doi:10.1016/s0022-5347(05)68562-x · Cited by 943
Towards a theory of chronic pain
Apkarian, A. V., Baliki, M. N., & Geha, P. Y. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.09.018 · Cited by 876
Self-citationDevelopment and preliminary validation of a pain measure specific to neuropathic pain
Galer, B. S., & Jensen, M. (1997) · Neurology · doi:10.1212/wnl.48.2.332 · Cited by 778
Baliki, M. N., Chialvo, D. R., Geha, P. Y., Levy, R. M., Harden, R. N., Parrish, T. B., & Apkarian, A. V. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3576-06.2006 · Cited by 756
Self-citationChronic pain may change the structure of the brain
May, A. (2008) · Pain · doi:10.1016/j.pain.2008.02.034 · Cited by 667
Mertz, H., Morgan, V. L., Tanner, G., Pickens, D. R., Price, R. R., Shyr, Y., & KESSLER, R. M. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70170-3 · Cited by 585
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Ruffle, J. K., Frøkjær, J. B., & Farmer, A. D. (2017) · Springer eBooks · doi:10.1007/978-3-319-48046-6_13 · Cited by 2
Geha, P., Schulman, B. R. M., Dib‐Hajj, S. D., & Waxman, S. G. (2018) · Neurobiology of Pain · doi:10.1016/j.ynpai.2018.01.002 · Cited by 2
CNS changes in interstitial cystitis/painful bladder syndrome
Khavari, R., & Boone, T. B. (2015) · Nature Reviews Urology · doi:10.1038/nrurol.2015.142 · Cited by 2
Functional brain imaging in bowel and bladder control
Franco, I. (2015) · doi:10.1002/9781118814789.ch3 · Cited by 2
What has brain diffusion MRI taught us about chronic pain: a narrative reviewPreprint
Bautin, P., Fortier, M.-A., Sean, M., Little, G. E., Martel, M., Descoteaux, M., Léonard, G., & Tétreault, P. (2023) · medRxiv · doi:10.1101/2023.03.03.23286579 · Cited by 2
Pang, S., Liu, Y., Shi, K., Yi, B., Wang, S., Bi, Y., & Wang, J. (2026) · iScience · doi:10.1016/j.isci.2026.116935 · Cited by 1
Microstructural brain reorganization in chronic gastrointestinal disorders
Zhou, Q., & Verne, G. N. (2013) · Pain · doi:10.1016/j.pain.2013.05.046 · Cited by 1
The importance of treating pain in endometriosis
Morelli, M., Venturella, R., & Zullo, F. (2013) · Expert Review of Obstetrics & Gynecology · doi:10.1586/17474108.2013.825467 · Cited by 1
Schaeffer, A. J. (2011) · European Urology · doi:10.1016/j.eururo.2011.11.024
Self-citationSutton, K. S. (2013) · QSpace (Queen's University Library)
Montironia, R., Antonio Lopez-beltran, B., Liang Cheng, C., & Scarpelli, M. (2012)
MRI reveals altered brain activity and anatomy in men with CP/CPPS
Warde, N. (2011) · Nature Reviews Urology · doi:10.1038/nrurol.2011.93
Логвиненко, В. В., Shen, N. P., Leashenko, A. N., & Rahmatullin, R. M. (2013) · CyberLeninK (CyberLeninka)
Kucyi, A. (2014) · TSpace (University of Toronto)
Bantel, C. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732783304.793553564
Zubelić, A., Vuletić, J., Ašćerić, M., Rašić-Marković, A., Stanojlović, O. P., Šutulović, N., & Hrnčić, D. (2022) · Medicinski podmladak · doi:10.5937/mp73-34860
Executive Functioning in Females Living With Chronic Pelvic Pain: A Pilot Study
Guitar, N. A., Connelly, D. M., Murray, L. L., & Hunter, S. W. (2023) · Journal of Women s & Pelvic Health Physical Therapy · doi:10.1097/jwh.0000000000000281
Spontaneous pain dynamics characterized by stochasticity in awake human LFP with chronic painPreprint
Ryu, J., Kao, J. C., & Bari, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.22.581655
Sudhakar, T. D., Bogić, M., Elliott, J. E., Lim, M. M., Buchwald, D., Strachan, E. D., & Levendovszky, S. R. (2024) · medRxiv · doi:10.1101/2024.12.04.24317355
Zhang, K., Dong, H., & Bian, T.-S. (2025) · Systems Biology in Reproductive Medicine · doi:10.1080/19396368.2025.2586609
Ren, H., Bai, W., Ye, G., Hong, N., Li, S., Zhang, K., Su, H., Luo, X., Liu, J., Yin, F., et al. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1765343
Luan, J., Gu, Q., Yu, M., Chen, D., Xu, C., Zhang, J., Yang, J., & Song, N. (2026) · The Journal of Sexual Medicine · doi:10.1093/jsxmed/qdag160
Liu, X., Mo, J., Sun, Z., Liu, M., & Yang, Z. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1966858
Metadata
- Authors
- Farmer, M. A., Chanda, M. L., Parks, E. L., Baliki, M. N., Apkarian, A. V., & Schaeffer, A. J.
- Affiliations
- Northwestern University (US)
- Venue
- Journal of Urology
- Published
- 2011-07
- Volume
- 186
- Issue
- 1
- Pages
- 117-124
- ISSN
- 0022-5347 (ISSN-L)
- 1527-3792
- PMC
- PMC4889821
- OpenAlex
- W2118252411
- Cited by
- 126
- References
- 23
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 9 · 2016: 13 · 2015: 12 · 2014: 13 · 2013: 22 · 2012: 9
- FWCI
- 18.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Urology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK65277, U01DK065277)
- National Institute of Neurological Disorders and Stroke (R01NS035115)
- Topics
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- chronic prostatitis, brain activation, anterior insula, anterior cingulate cortex, gray matter density, white matter integrity, fractional anisotropy, spontaneous pain, pain intensity, central sensitization, neuroimaging
- MeSH terms
- Adult, Brain, Brain Mapping, Humans, Magnetic Resonance Imaging, Male, Prostatitis
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