Towards a theory of chronic pain

Apkarian, A. Vania; Baliki, Marwan N.; Geha, Paul Y.

doi:10.1016/j.pneurobio.2008.09.018

Cited by 880Pain Mechanisms and TreatmentsPain Management and TreatmentPain Management and Placebo Effect

Towards a theory of chronic pain

Open access

Apkarian, A. Vania, Baliki, Marwan N., Geha, Paul Y.·2009·Progress in Neurobiology

DOI 10.1016/j.pneurobio.2008.09.018PMC PMC2650821

Open this paper in CoChat — free account

Abstract

In this review, we integrate recent human and animal studies from the viewpoint of chronic pain. First, we briefly review the impact of chronic pain on society and address current pitfalls of its definition and clinical management. Second, we examine pain mechanisms via nociceptive information transmission cephalad and its impact and interaction with the cortex. Third, we present recent discoveries on the active role of the cortex in chronic pain, with findings indicating that the human cortex continuously reorganizes as it lives in chronic pain. We also introduce data emphasizing that distinct chronic pain conditions impact on the cortex in unique patterns. Fourth, animal studies regarding nociceptive transmission, recent evidence for supraspinal reorganization during pain, the necessity of descending modulation for maintenance of neuropathic behavior, and the impact of cortical manipulations on neuropathic pain is also reviewed. We further expound on the notion that chronic pain can be reformulated within the context of learning and memory, and demonstrate the relevance of the idea in the design of novel pharmacotherapies. Lastly, we integrate the human and animal data into a unified working model outlining the mechanism by which acute pain transitions into a chronic state. It incorporates knowledge of underlying brain structures and their reorganization, and also includes specific variations as a function of pain persistence and injury type, thereby providing mechanistic descriptions of several unique chronic pain conditions within a single model.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.pneurobio.2008.09.018

Cites

150 of 150 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The transition from acute to chronic pain entails a transition in the salience of pain, from viewing a painful percept as a sign of external threat to an indication of an internalized disease state.
“As stated by Apkarian et al, 7 the transition from acute to chronic pain entails also a transition in the salience of pain, wherein the condition shifts from viewing a painful percept as a sign of external threat into an indication of an internalized disease state.”
From <p>Pain and Evil: From Local Nociception to Misery Following Social Harm</p> (2020) · cites this paper as [7]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190 · see citing works
Functional connectivity in the motor cortex of resting human brain using echo‐planar mri
Biswal, B., Zerrin Yetkin, F., Haughton, V. M., & Hyde, J. S. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910340409 · Cited by 9,812 · see citing works
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376 · see citing works
Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.
Vlaeyen, J. W. S., & Linton, S. J. (2000) · Pain · doi:10.1016/s0304-3959(99)00242-0 · Cited by 4,931 · see citing works
Neuronal plasticity: Increasing the gain in pain
Woolf, C. J., & Salter, M. W. (2000) · Science · doi:10.1126/science.288.5472.1765 · Cited by 3,781 · cited 1× · see citing works
“Animal models of neuropathic and/or inflammatory injuries that cause a persistent pain condition suggest that peripheral and spinal cord circuitry transmitting nociceptive signals cephalad undergoes dramatic reorganization (Woolf and Salter, 2000, 2006).”
Default-mode network activity distinguishes Alzheimer’s disease from healthy aging: evidence from functional MRI
Greicius, M. D., Srivastava, G., Reiss, A. L., & Menon, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308627101 · Cited by 3,684 · see citing works
Human brain mechanisms of pain perception and regulation in health and disease
Apkarian, A. V., Bushnell, M. C., Treede, R., & Zubieta, J. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.11.001 · Cited by 3,126 · see citing works
Self-citation
Classification of chronic pain
Merskey, H. (1994) · Medical Entomology and Zoology · Cited by 2,952 · see citing works
Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry
Basbaum, A. I., & Fields, H. L. (1984) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.07.030184.001521 · Cited by 2,687 · see citing works
Textbook of pain
Bonica, J. J., Melzack, R., & Wall, P. D. (1999) · Cited by 2,537 · see citing works
Spared nerve injury: an animal model of persistent peripheral neuropathic pain
Décosterd, I., & Woolf, C. J. (2000) · Pain · doi:10.1016/s0304-3959(00)00276-1 · Cited by 2,317 · see citing works
Advances in Pain Research and Therapy
Wang, J. K. (1980) · Anesthesia & Analgesia · doi:10.1213/00000539-198002000-00022 · Cited by 2,263 · see citing works
Resting-State Functional Connectivity in Major Depression: Abnormally Increased Contributions from Subgenual Cingulate Cortex and Thalamus
Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., Reiss, A. L., & Schatzberg, A. F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.020 · Cited by 2,214 · see citing works
Psychological and neural mechanisms of the affective dimension of pain
Price, D. D. (2000) · Science · doi:10.1126/science.288.5472.1769 · Cited by 2,092 · see citing works
Common blood flow changes across visual tasks: II. Decreases in cerebral cortex
Shulman, G. L., Fiez, J. A., Corbetta, M., Buckner, R. L., Miezin, F. M., Raichle, M. E., & Petersen, S. E. (1997) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1997.9.5.648 · Cited by 1,890 · see citing works
A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury
Seltzer, Z., Dubner, R., & Shir, Y. (1990) · Pain · doi:10.1016/0304-3959(90)91074-s · Cited by 1,847 · see citing works
Neurons in medial prefrontal cortex signal memory for fear extinction
Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836 · cited 1× · see citing works
“, 2002) through de novo memory trace formation involving n-methyl-Daspartic acid (NMDA) plasticity (Falls et al., 1992; Milad and Quirk, 2002; Santini et al., 2004).”
The economic burden of back pain in the UK
Maniadakis, N., & Gray, A. (2000) · Pain · doi:10.1016/s0304-3959(99)00187-6 · Cited by 1,510 · see citing works
Scale-Free Brain Functional Networks
Eguı́luz, V. M., Chialvo, D. R., Cecchi, G., Baliki, M. N., & Apkarian, A. V. (2005) · Physical Review Letters · doi:10.1103/physrevlett.94.018102 · Cited by 1,464 · see citing works
Self-citation
Chronic back pain is associated with decreased prefrontal and thalamic gray matter density
Apkarian, A. V., Sosa, Y., Sonty, S., Levy, R. M., Harden, R. N., Parrish, T. B., & Gitelman, D. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2541-04.2004 · Cited by 1,434 · see citing works
Self-citation
Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation
Reynolds, D. V. (1969) · Science · doi:10.1126/science.164.3878.444 · Cited by 1,380 · see citing works
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia
Gracely, R. H., Petzke, F., Wolf, J. M., & Clauw, D. J. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10225 · Cited by 1,263 · see citing works
Back Pain and Sciatica
Frymoyer, J. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198802043180506 · Cited by 1,097 · see citing works
Conceptual Processing during the Conscious Resting State: A Functional MRI Study
Binder, J. R., Frost, J. A., Hammeke, T. A., Bellgowan, P. S. F., Rao, S. M., & Cox, R. W. (1999) · Journal of Cognitive Neuroscience · doi:10.1162/089892999563265 · Cited by 1,066 · see citing works
Neuroanatomy of the pain system and of the pathways that modulate pain
Willis, W. D., & Westlund, K. N. (1997) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199701000-00002 · Cited by 924 · see citing works
Behavioral and Neural Analysis of Extinction
Myers, K. M., & Davis, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)01064-4 · Cited by 918 · see citing works
Musculoskeletal Conditions in the United States
Praemer, A., Furner, S. E., & Rice, D. P. (1992) · Medical Entomology and Zoology · Cited by 910 · see citing works
Physician Office Visits for Low Back Pain
Hart, L. G., Deyo, R. A., & Cherkin, D. C. (1995) · Spine · doi:10.1097/00007632-199501000-00003 · Cited by 889 · see citing works
Beyond Feeling: Chronic Pain Hurts the Brain, Disrupting the Default-Mode Network Dynamics
Baliki, M. N., Geha, P., Apkarian, A. V., & Chialvo, D. R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4123-07.2008 · Cited by 854 · see citing works
Self-citation
Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain
Zubieta, J.-K., Smith, Y. R., Bueller, J. A., Xu, Y., Kilbourn, M. R., Jewett, D. M., Meyer, C. R., Koeppe, R. A., & Stohler, C. S. (2001) · Science · doi:10.1126/science.1060952 · Cited by 842 · see citing works
The adult spine: Principles and practice
Hughes, S. P. F. (1991) · Neuromuscular Disorders · doi:10.1016/0960-8966(91)90115-9 · Cited by 827 · see citing works
Evidence of augmented central pain processing in idiopathic chronic low back pain
Giesecke, T., Gracely, R. H., Grant, M. A. B., NACHEMSON, A. L., Petzke, F. W., Williams, D. A., & Clauw, D. J. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20063 · Cited by 816 · see citing works
Facilitation of Conditioned Fear Extinction by Systemic Administration or Intra-Amygdala Infusions of d-Cycloserine as Assessed with Fear-Potentiated Startle in Rats
Walker, D. L., Ressler, K. J., Lu, K.-T., & Davis, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02343.2002 · Cited by 815 · see citing works
Interactions among the medial prefrontal cortex, hippocampus and midline thalamus in emotional and cognitive processing in the rat
Vertes, R. P. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.06.027 · Cited by 811 · see citing works
Chronic pain and the emotional brain: specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain
Baliki, M. N., Chialvo, D. R., Geha, P. Y., Levy, R. M., Harden, R. N., Parrish, T. B., & Apkarian, A. V. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3576-06.2006 · Cited by 756 · see citing works
Self-citation
THE SKIN SENSES
Marshall, N. J. (1969) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.32.6.639 · Cited by 743 · see citing works
Default-Mode Activity during a Passive Sensory Task: Uncoupled from Deactivation but Impacting Activation
Greicius, M. D., & Menon, V. (2004) · Journal of Cognitive Neuroscience · doi:10.1162/0898929042568532 · Cited by 684 · see citing works
Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala
Falls, W., Miserendino, M., & Davis, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-03-00854.1992 · Cited by 673 · see citing works
Autotomy following peripheral nerve lesions: experimental anesthesia dolorosa
Wall, P. D., Devor, M. G., Inbal, R., Scadding, J. W., Schonfeld, D., Seltzer, Z., & TOMKIEWICZ, M. (1979) · Pain · doi:10.1016/0304-3959(79)90002-2 · Cited by 655 · see citing works
Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?
Kuchinad, A., Schweinhardt, P., Seminowicz, D. A., Wood, P. B., Chizh, B. A., & Bushnell, M. C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0098-07.2007 · Cited by 613 · see citing works
Encoding of emotional memories depends on amygdala and hippocampus and their interactions
Richardson, M., Strange, B., & Dolan, R. (2004) · Nature Neuroscience · doi:10.1038/nn1190 · Cited by 591 · see citing works
Chronic pain patients are impaired on an emotional decision-making task
Apkarian, V. A., Sosa, Y., Krauss, B. R., Thomas, S. P., Fredrickson, B. E., Levy, R. E., Harden, N. R., & Chialvo, D. R. (2004) · Pain · doi:10.1016/j.pain.2003.12.015 · Cited by 536 · see citing works
Self-citation
Decreased Central μ-Opioid Receptor Availability in Fibromyalgia
Harris, R. E., Clauw, D. J., Scott, D., McLean, S. A., Gracely, R. H., & Zubieta, J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2849-07.2007 · Cited by 512 · see citing works
Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand‐binding core
Furukawa, H., & Gouaux, E. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg303 · Cited by 510 · see citing works
Memory consolidation of Pavlovian fear conditioning: a cellular and molecular perspective
Schafe, G. E., Nader, K., Blair, H. T., & LeDoux, J. E. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01969-x · Cited by 510 · see citing works
The adult spine : principles and practice
Frymoyer, J. W., & Ducker, T. B. (1991) · Lippincott-Raven eBooks · Cited by 503 · see citing works
Roles of NMDA NR2B Subtype Receptor in Prefrontal Long-Term Potentiation and Contextual Fear Memory
Zhao, M., Toyoda, H., Lee, Y., Wu, L., Ko, S. W., Zhang, X.-H., Jia, Y., Shum, F. W. F., Xu, H., Li, B.-M., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.014 · Cited by 495 · see citing works
Consolidation of Fear Extinction Requires Protein Synthesis in the Medial Prefrontal Cortex
Santini, E., Ge, H., Ren, K., de Ortiz, S. P., & Quirk, G. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0786-04.2004 · Cited by 479 · see citing works
The epidemiology of spinal disorders
Andersson, G. (1997) · Medical Entomology and Zoology · Cited by 447 · see citing works
Cancer pain and its impact on diagnosis, survival and quality of life
Mantyh, P. W. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1914 · Cited by 443 · see citing works
Gray matter decrease in patients with chronic tension type headache
Schmidt‐Wilcke, T., Leinisch, E., Straube, A., Kämpfe, N., Draganski, B., Diener, H., Bogdahn, U., & May, A. (2005) · Neurology · doi:10.1212/01.wnl.0000183067.94400.80 · Cited by 429 · see citing works
Affective components and intensity of pain correlate with structural differences in gray matter in chronic back pain patients
Schmidt-Wilcke, T., Leinisch, E., Gänbauer, S., Draganski, B., Bogdahn, U., Altmeppen, J., & May, A. (2006) · Pain · doi:10.1016/j.pain.2006.05.004 · Cited by 413 · see citing works
Emotional Perseveration: An Update on Prefrontal-Amygdala Interactions in Fear ExtinctionPreprint
Sotres-Bayón, F., Bush, D. E. A., & LeDoux, J. E. (2004) · Learning & Memory · doi:10.1101/lm.79504 · Cited by 407 · see citing works
Epidemiology of back disorders: prevalence, risk factors, and prognosis
Manek, N. J., & MacGregor, A. J. (2005) · Current Opinion in Internal Medicine · doi:10.1097/01.bor.0000154215.08986.06 · Cited by 388 · see citing works
Regulation of Human Affective Responses by Anterior Cingulate and Limbic µ-Opioid Neurotransmission
Zubieta, J., Ketter, T. A., Bueller, J. A., Xu, Y., Kilbourn, M. R., Young, E. A., & Koeppe, R. A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.11.1145 · Cited by 378 · see citing works
Glutamatergic activation of anterior cingulate cortex produces an aversive teaching signal
Johansen, J. P., & Fields, H. L. (2004) · Nature Neuroscience · doi:10.1038/nn1207 · Cited by 365 · see citing works
μ-Opioid Receptor-Mediated Antinociceptive Responses Differ in Men and Women
Zubieta, J.-K., Smith, Y. R., Bueller, J. A., Xu, Y., Kilbourn, M. R., Jewett, D. M., Meyer, C. R., Koeppe, R. A., & Stohler, C. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-12-05100.2002 · Cited by 363 · see citing works
Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex
Jasmin, L., Rabkin, S. D., Granato, A., Boudah, A., & Ohara, P. T. (2003) · Nature · doi:10.1038/nature01808 · Cited by 347 · see citing works
Parallel “Pain” Pathways Arise from Subpopulations of Primary Afferent Nociceptor
Braz, J. M., Nassar, M. A., Wood, J. N., & Basbaum, A. I. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.015 · Cited by 309 · see citing works
Disruption of Attention and Working Memory Traces in Individuals with Chronic Pain
Dick, B. D., & Rashiq, S. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000263280.49786.f5 · Cited by 295 · see citing works
Systematic Review of Antidepressants in the Treatment of Chronic Low Back Pain
Staiger, T. O., Gaster, B., Sullivan, M. D., & Deyo, R. A. (2003) · Spine · doi:10.1097/01.brs.0000092372.73527.ba · Cited by 292 · see citing works
Pain and the Neurosurgeon.
Poser, C. M. (1970) · Archives of Internal Medicine · doi:10.1001/archinte.1970.00310030162023 · Cited by 291 · see citing works
Abnormal brain chemistry in chronic back pain: An in vivo proton magnetic resonance spectroscopy study
Grachev, I. D., Fredrickson, B. E., & Apkarian, V. A. (2000) · Pain · doi:10.1016/s0304-3959(00)00340-7 · Cited by 291 · see citing works
Self-citation
Structural, psychological, and genetic influences on low back and neck pain: A study of adult female twins
MacGregor, A. J., Andrew, T., Sambrook, P. N., & Spector, T. D. (2004) · Arthritis Care & Research · doi:10.1002/art.20236 · Cited by 282 · see citing works
Evaluating the efficacy of graded in vivo exposure for the treatment of fear in patients with chronic back pain: A randomized controlled clinical trial
Woods, M. P., & Asmundson, G. J. G. (2008) · Pain · doi:10.1016/j.pain.2007.06.037 · Cited by 280 · see citing works
An Overview of Neuropathic Pain: Syndromes, Symptoms, Signs, and Several Mechanisms
Dworkin, R. H. (2002) · Clinical Journal of Pain · doi:10.1097/00002508-200211000-00001 · Cited by 278 · see citing works
Emotion-induced changes in human medial prefrontal cortex: I. During cognitive task performance
Simpson, J. R., Snyder, A. Z., Gusnard, D. A., & Raichle, M. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.683 · Cited by 278 · see citing works
Nonsteroidal Anti-Inflammatory Drugs for Low Back Pain
van Tulder, M. W., Scholten, R. J. P. M., Koes, B. W., & Deyo, R. A. (2000) · Spine · doi:10.1097/00007632-200010010-00013 · Cited by 269 · see citing works
Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans
Iannetti, G. D., Zambreanu, L., Wise, R. G., Buchanan, T. J., Huggins, J. P., Smart, T. S., Vennart, W., & Tracey, I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506624102 · Cited by 267 · see citing works
Risk Factors Associated With the Transition From Acute to Chronic Occupational Back Pain
Fransen, M., Woodward, M., Norton, R., Coggan, C. A., Dawe, M., & Sheridan, N. (2002) · Spine · doi:10.1097/00007632-200201010-00022 · Cited by 267 · see citing works
Transition from acute to chronic pain and disability: A model including cognitive, affective, and trauma factors
Casey, C. Y., Greenberg, M. A., Nicassio, P. M., Harpin, E. R., & Hubbard, D. (2007) · Pain · doi:10.1016/j.pain.2007.03.032 · Cited by 267 · see citing works
Spinal and Supraspinal Mechanisms of Neuropathic Pain
Ossipov, M. H., Lai, J. Y., Malan, T. P., & Porreca, F. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06673.x · Cited by 265 · see citing works
Striatal dopamine D1 and D2 receptors in burning mouth syndrome
Hagelberg, N. M., Forssell, H., Rinne, J. O., Scheinin, H., Taiminen, T. J., Aalto, S., Luutonen, S. H., Någren, K., & Jääskeläinen, S. K. (2002) · Pain · doi:10.1016/s0304-3959(02)00323-8 · Cited by 264 · see citing works
Upregulation of Forebrain NMDA NR2B Receptors Contributes to Behavioral Sensitization after Inflammation
Wu, L., Toyoda, H., Zhao, M., Lee, Y., Tang, J., Ko, S. W., Jia, Y. H., Shum, F. W. F., Zerbinatti, C., Bu, G., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1678-05.2005 · Cited by 248 · see citing works
Reduced Presynaptic Dopamine Activity in Fibromyalgia Syndrome Demonstrated With Positron Emission Tomography: A Pilot Study
Wood, P. B., Patterson, J. C., Sunderland, J. J., Tainter, K. H., Glabus, M. F., & Lilien, D. L. (2006) · Journal of Pain · doi:10.1016/j.jpain.2006.05.014 · Cited by 246 · see citing works
THE GATE-CONTROL THEORY OF PAIN
NATHAN, P. W. (1976) · Brain · doi:10.1093/brain/99.1.123 · Cited by 235 · see citing works
Psychosocial factors predictive of occupational low back disability: towards development of a return-to-work model
Schultz, Z. I., Crook, J., Meloche, R. G., Berkowitz, J., MILNER, R. A., Zuberbier, A. O., & Meloche, W. (2003) · Pain · doi:10.1016/j.pain.2003.09.019 · Cited by 233 · see citing works
Striatal dopamine D2 receptors in modulation of pain in humans: a review
Hagelberg, N. M., Jääskeläinen, S. K., Martikainen, I. K., Mansikka, H. T., Forssell, H., Scheinin, H., Hietala, J. A., & Pertovaara, A. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.024 · Cited by 231 · see citing works
Chapter 14 Involvement of the spino-parabrachio -amygdaloid and -hypothalamic pathways in the autonomic and affective emotional aspects of pain
Bernard, J., Bester, H., & Besson, J. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)61868-3 · Cited by 230 · see citing works
Altered dopamine D2 receptor binding in atypical facial pain
Hagelberg, N. M., Forssell, H., Aalto, S., Rinne, J. O., Scheinin, H., Taiminen, T. J., Någren, K., Eskola, O., & Jääskeläinen, S. K. (2003) · Pain · doi:10.1016/s0304-3959(03)00275-6 · Cited by 206 · see citing works
A comparative reappraisal of projections from the superficial laminae of the dorsal horn in the rat: The forebrain
Gauriau, C., & Bernard, J. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10873 · Cited by 205 · see citing works
A role for fMRI in optimizing CNS drug development
Borsook, D., Becerra, L. R., & Hargreaves, R. J. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2027 · Cited by 203 · see citing works
The Pain Genes Database : An interactive web browser of pain-related transgenic knockout studies
LaCroix‐Fralish, M. L., Ledoux, J. B., & Mogil, J. S. (2007) · Pain · doi:10.1016/j.pain.2007.04.041 · Cited by 197 · see citing works
Psychosocial predictors of health-related quality of life and health service utilisation in people with chronic low back pain
Keeley, P., Creed, F. H., Tomenson, B., Todd, C. J., Borglin, G., & Dickens, C. M. (2007) · Pain · doi:10.1016/j.pain.2007.05.015 · Cited by 196 · see citing works
Brain activity for spontaneous pain of postherpetic neuralgia and its modulation by lidocaine patch therapy
Geha, P., Baliki, M. N., Chialvo, D. R., Harden, R. N., Paice, J. A., & Apkarian, A. V. (2006) · Pain · doi:10.1016/j.pain.2006.09.014 · Cited by 190 · see citing works
Self-citation
Chronic non-specific low back pain – sub-groups or a single mechanism?
Wand, B. M., & O'Connell, N. E. (2008) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-9-11 · Cited by 183 · see citing works
Proton magnetic resonance spectroscopy of the thalamus in patients with chronic neuropathic pain after spinal cord injury.
Pattany, P. M., Yezierski, R. P., Widerström-Noga, E. G., Bowen, B. C., Martinez‐Arizala, A., Garcia, B. R., & Quencer, R. M. (2002) · PubMed Central · Cited by 181 · see citing works
Pain enhances functional connectivity of a brain network evoked by performance of a cognitive task
Seminowicz, D. A., & Davis, K. D. (2007) · Journal of Neurophysiology · doi:10.1152/jn.01210.2006 · Cited by 179 · see citing works
Deafferentation hypersensitivity in the rat after dorsal rhizotomy: A possible animal model of chronic pain
Lombard, M., Nashold, B. S., & Albe-Fessard, D. (1979) · Pain · doi:10.1016/0304-3959(79)90123-4 · Cited by 174 · see citing works
Differential involvement of the hippocampus, anterior cingulate cortex, and basolateral amygdala in memory for context and footshock.
Malin, E. L., & McGaugh, J. D. (2006) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0510890103 · Cited by 160 · see citing works
Electrophysiological studies on human pain perception
Kakigi, R., Inui, K., & Tamura, Y. (2005) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.11.016 · Cited by 146 · see citing works
The medullary dorsal reticular nucleus as a pronociceptive centre of the pain control system
Lima, D. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00025-9 · Cited by 145 · see citing works
Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization
Vera–Portocarrero, L. P., Zhang, E.-T., Ossipov, M. H., Xie, J. Y., King, T. E., Lai, J., & Porreca, F. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.03.016 · Cited by 141 · see citing works
Sensitization of Pain-Modulating Neurons in the Rostral Ventromedial Medulla after Peripheral Nerve Injury
Carlson, J. D., Maire, J. J., Martenson, M. E., & Heinricher, M. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3715-07.2007 · Cited by 141 · see citing works
DECONSTRUCTING ENDOGENOUS PAIN MODULATIONS
Mason, P. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00249.2005 · Cited by 140 · see citing works
Neuropsychological assessment of chronic non‐malignant pain patients treated in a multidisciplinary pain centre
Sjøgren, P., Christrup, L. L., Petersen, M. A., & Højsted, J. (2004) · European Journal of Pain · doi:10.1016/j.ejpain.2004.10.005 · Cited by 137 · see citing works
Expression of B7 costimulatory molecules by salivary gland epithelial cells in patients with Sj�gren's syndrome
Manoussakis, M. N., Dimitriou, I. D., Kapsogeorgou, E. K., Xanthou, G., Paikos, S., Polihronis, M., & Moutsopoulos, H. Μ. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199902)42:2 · Cited by 134 · see citing works
Protein kinase A‐dependent enhanced NMDA receptor function in pain‐related synaptic plasticity in rat amygdala neurones
Bird, G. C., Lash, L. L., Han, J. S., Zou, X., Willis, W. D., & Neugebauer, V. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.084780 · Cited by 130 · see citing works
The Updated Cochrane Review of Bed Rest for Low Back Pain and Sciatica
Hagen, K. B., Jamtvedt, G., Hilde, G., & Winnem, M. F. (2005) · Spine · doi:10.1097/01.brs.0000154625.02586.95 · Cited by 130 · see citing works
Radiographic features of lumbar disc degeneration and self-reported back pain.
Pye, S. R., Reid, D. M., Smith, R. F., Adams, J. E., Nelson, K., Silman, A. J., & O’Neill, T. W. (2004) · PubMed · Cited by 129 · see citing works
Plasticity and pain: role of the dorsal horn
Woolf, C. J., & Salter, M. W. (2006) · Elsevier eBooks · doi:10.1016/b0-443-07287-6/50010-2 · Cited by 125 · see citing works
The Impact of Psychosocial Factors on Low Back Pain
Clays, E., Bacquer, D. D., Leynen, F., Kornitzer, M., Kittel, F., & Backer, G. D. (2007) · Spine · doi:10.1097/01.brs.0000251884.94821.c0 · Cited by 124 · see citing works
Low back pain.
Ehrlich, G. E. (2003) · PubMed · Cited by 124 · see citing works
Dynamics of Pain: Fractal Dimension of Temporal Variability of Spontaneous Pain Differentiates Between Pain States
Foss, J. M., Apkarian, A. V., & Chialvo, D. R. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00768.2005 · Cited by 121 · see citing works
Self-citation
MRS shows abnormalities before symptoms in familial Alzheimer disease
Godbolt, A. K., Waldman, A. D., MacManus, D. G., Schott, J. M., Frost, C. D., Cipolotti, L., Fox, N. C., & Rossor, M. N. (2006) · Neurology · doi:10.1212/01.wnl.0000201237.05869.df · Cited by 120 · see citing works
The Pathology of Ligamentum Flavum in Degenerative Lumbar Disease
Okuda, T., Baba, I., Fujimoto, Y., Tanaka, N., Sumida, T., Manabe, H., Hayashi, Y., & Ochi, M. (2004) · Spine · doi:10.1097/01.brs.0000132510.25378.8c · Cited by 117 · see citing works
mGluR1 and mGluR5 antagonists in the amygdala inhibit different components of audible and ultrasonic vocalizations in a model of arthritic pain
Han, J. S., & Neugebauer, V. (2004) · Pain · doi:10.1016/j.pain.2004.10.022 · Cited by 117 · see citing works
d-Cycloserine reduces neuropathic pain behavior through limbic NMDA-mediated circuitry ☆
Millecamps, M., Centeno, M. V., Berra, H. H., Rudick, C. N., Lavarello, S., Tkatch, T., & Apkarian, A. V. (2007) · Pain · doi:10.1016/j.pain.2007.03.003 · Cited by 116 · see citing works
Self-citation
Attenuation of neuropathic pain by segmental and supraspinal activation of the dorsal column system in awake rats
El-Khoury, C., Hawwa, N., Baliki, M., Atweh, S., Jabbur, S. J., & Saadé, N. E. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00111-2 · Cited by 115 · see citing works
Self-citation
Low-Back Pain
Deyo, R. A. (1998) · Scientific American · doi:10.1038/scientificamerican0898-48 · Cited by 114 · see citing works
A comprehensive review of clinical trials on the efficacy and safety of drugs for the treatment of low back pain
Schnitzer, T. J., Ferraro, A., Hunsche, E., & Kong, S. X. (2004) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2003.10.015 · Cited by 112 · see citing works
Workers’ Beliefs and Expectations Affect Return to Work Over 12 Months
Heymans, M. W., de Vet, H. C. W., Knol, D. L., Bongers, P. M., Koes, B. W., & van Mechelen, W. (2006) · Journal of Occupational Rehabilitation · doi:10.1007/s10926-006-9058-8 · Cited by 109 · see citing works
Smoking
Feldman, D. E., Rossignol, M., Shrier, I., & Abenhaim, L. L. (1999) · Spine · doi:10.1097/00007632-199912010-00011 · Cited by 104 · see citing works
Expression of IL-1β in supraspinal brain regions in rats with neuropathic pain
Apkarian, A. V., Lavarello, S., Randolf, A., Berra, H. H., Chialvo, D. R., Besedovsky, H. O., & del Rey, A. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.08.034 · Cited by 103 · see citing works
Self-citation
Low back pain.
Frank, A. O. (1993) · BMJ · doi:10.1136/bmj.306.6882.901 · Cited by 103 · see citing works
Anterior cingulate cortex contributes to the descending facilitatory modulation of pain via dorsal reticular nucleus
Zhang, L., Zhang, Y., & Zhao, Z. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04302.x · Cited by 101 · see citing works
Disabling Low Back Pain and Depressive Symptoms in the Community-Dwelling Elderly: A Prospective Study
Meyer, T., Cooper, J., & Raspe, H. (2007) · Spine · doi:10.1097/brs.0b013e3181557955 · Cited by 100 · see citing works
Etoricoxib reduced pain and disability and improved quality of life in patients with chronic low back pain: a 3 month, randomized, controlled trial
Pallay, R., Seger, W., Adler, J., Ettlinger, R., Quaidoo, E., Lipetz, R. S., O’Brien, K. M., Mucciola, L. M., Skalky, C. S., Petruschke, R., et al. (2004) · Scandinavian Journal of Rheumatology · doi:10.1080/03009740410005728 · Cited by 99 · see citing works
Psychosocial Variables in Patients With (Sub)Acute Low Back Pain
Heneweer, H., Aufdemkampe, G., van Tulder, M. W., Kiers, H., Stappaerts, K. H., & Vanhees, L. (2007) · Spine · doi:10.1097/01.brs.0000256447.72623.56 · Cited by 98 · see citing works
Spinal Cord Injury: A Model of Central Neuropathic Pain
Yezierski, R. P. (2005) · Neurosignals · doi:10.1159/000087657 · Cited by 94 · see citing works
Nucleus Gracilis: An Integrator for Visceral and Somatic Information
Al–Chaer, E. D., Westlund, K. N., & Willis, W. D. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.1.521 · Cited by 94 · see citing works
Brain dynamics for perception of tactile allodynia (touch-induced pain) in postherpetic neuralgia
Geha, P., Baliki, M. N., Wang, X., Harden, R. N., Paice, J. A., & Apkarian, A. V. (2008) · Pain · doi:10.1016/j.pain.2008.02.021 · Cited by 93 · see citing works
Self-citation
Rostral ventromedial medulla control of spinal sensory processing in normal and pathophysiological states
Bee, L., & Dickenson, A. H. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.05.004 · Cited by 92 · see citing works
Analysis of synchrony demonstrates ‘pain networks’ defined by rapidly switching, task-specific, functional connectivity between pain-related cortical structures
Ohara, S., Crone, N. E., Weiss, N., & Lenz, F. A. (2006) · Pain · doi:10.1016/j.pain.2006.02.012 · Cited by 90 · see citing works
Differences in Metabolites in Pain-Processing Brain Regions in Patients With Diabetes and Painful Neuropathy
Sorensen, L., Siddall, P. J., Trenell, M. I., & Yue, D. K. (2008) · Diabetes Care · doi:10.2337/dc07-2088 · Cited by 90 · see citing works
Why is a treatment aimed at psychosocial factors not effective in patients with (sub)acute low back pain?
Jellema, P., van der Windt, D., van der Horst, H. E., Blankenstein, A. H., Bouter, L. M., & Stalman, W. A. B. (2005) · Pain · doi:10.1016/j.pain.2005.09.002 · Cited by 88 · see citing works
Cardiovascular and Neuronal Responses to Head Stimulation Reflect Central Sensitization and Cutaneous Allodynia in a Rat Model of Migraine
Yamamura, H., Malick, A., Chamberlin, N. L., & Burstein, R. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.2.479 · Cited by 86 · see citing works
Clinical Symptoms in Lumbar Disc Herniations and Their Correlation to the Histological Composition of the Extruded Disc Material
Willburger, R., Ehiosun, U. K., Kuhnen, C., Krämer, J., & Schmid, G. (2004) · Spine · doi:10.1097/01.brs.0000133645.94159.64 · Cited by 82 · see citing works
The Relationship Between Psychological Factors and Disabling Musculoskeletal Pain in Community‐Dwelling Older Persons
Reid, M. C., Williams, C. S., & Gill, T. M. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51357.x · Cited by 81 · see citing works
N-Acetylaspartate concentrations in the thalami of neuropathic pain patients and healthy comparison subjects measured with 1H-MRS
Fukui, S., Matsuno, M., Inubushi, T., & Nosaka, S. (2005) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2005.10.021 · Cited by 79 · see citing works
Effects of valdecoxib in the treatment of chronic low back pain: results of a randomized, placebo-controlled trial
Coats, T. L., BORENSTEIN, D. G., Nangia, N., & Brown, M. (2004) · Clinical Therapeutics · doi:10.1016/s0149-2918(04)80081-x · Cited by 78 · see citing works
Evidence against the use of lumbar spine radiography for low back pain
van den Bosch, M. A. A. J., Hollingworth, W., Kinmonth, A. L., & Dixon, A. K. (2003) · Clinical Radiology · doi:10.1016/j.crad.2003.08.012 · Cited by 76 · see citing works
Electrical Stimulation of the Anterior Cingulate Cortex Reduces Responses of Rat Dorsal Horn Neurons to Mechanical Stimuli
Senapati, A. K., LaGraize, S. C., Huntington, P. J., Wilson, H., Fuchs, P. N., & Peng, Y. B. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00040.2005 · Cited by 71 · see citing works
Pharmacological FMRI in the development of new analgesic compounds
Schweinhardt, P., Bountra, C., & Tracey, I. (2006) · NMR in Biomedicine · doi:10.1002/nbm.1076 · Cited by 59 · see citing works
Genetic and Environmental Contributions to Back Pain in Old Age
Hartvigsen, J., Christensen, K., Frederiksen, H., & Pedersen, H. C. (2004) · Spine · doi:10.1097/00007632-200404150-00015 · Cited by 59 · see citing works
Hello, is this the Web?
Gibbs, W. W. (1998) · Scientific American · doi:10.1038/scientificamerican1298-48 · Cited by 52 · see citing works
Psychosocial Variables in Patients With (Sub)Acute Low Back Pain: An Inception Cohort in Primary Care Physical Therapy in the Netherlands
Aufdemkampe, G., Kiers, H., Stappaerts, K. H., Heneweer, H., & van Tulder, M. W. (2007) · Data Archiving and Networked Services (DANS) · Cited by 51 · see citing works
Factors Associated With Back Pain After Physical Injury
Harris, I. A., Young, J. M., Rae, H., Jalaludin, B. B., & Solomon, M. J. (2007) · Spine · doi:10.1097/brs.0b013e318067dce8 · Cited by 50 · see citing works
Attenuation of neuropathic manifestations by local block of the activities of the ventrolateral orbito-frontal area in the rat
Baliki, M., Al-Amin, H. A., Atweh, S., Jaber, M., Hawwa, N., Jabbur, S. J., Apkarian, A. V., & Saadé, N. E. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00408-1 · Cited by 49 · see citing works
Self-citation
The role of the dorsal columns in neuropathic behavior: evidence for plasticity and non-specificity
Saadé, N. E., Baliki, M., El-Khoury, C., Hawwa, N., Atweh, S., Apkarian, A. V., & Jabbur, S. J. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00417-7 · Cited by 40 · see citing works
Self-citation
Single Subject Pharmacological-MRI (phMRI) Study: Modulation of Brain Activity of Psoriatic Arthritis Pain by Cyclooxygenase-2 Inhibitor
Baliki, M., Katz, J., Chialvo, D. R., & Apkarian, A. V. (2005) · Molecular Pain · doi:10.1186/1744-8069-1-32 · Cited by 37 · see citing works
Self-citation
The lateral ventromedial thalamic nucleus spreads nociceptive signals from the whole body surface to layer I of the frontal cortex
Monconduit, L., & Villanueva, L. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04160.x · Cited by 36 · see citing works
Shared mechanisms between chronic pain and neurodegenerative disease
Apkarian, A. V., & Scholz, J. (2006) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2006.09.006 · Cited by 29 · see citing works
Self-citation
Responsiveness to brightness change in male and female rats following treatment with the partial agonist of the N-methyl-d-aspartate receptor, d-cycloserine
Hughes, R. N. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.10.028 · Cited by 29 · see citing works
Neuropathic low back pain
Audette, J. F., Emenike, E., & Meleger, A. L. (2005) · Current Pain and Headache Reports · doi:10.1007/s11916-005-0058-8 · Cited by 28 · see citing works
Brown-Séquard and His Work on the Spinal Cord
Aminoff, M. J. (1996) · Spine · doi:10.1097/00007632-199601010-00029 · Cited by 26 · see citing works
Pharmacological alternatives for the alleviation of back pain
Bogduk, N. (2004) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.5.10.2091 · Cited by 21 · see citing works
Impaired visual memory in rats reared in isolation is reversed by d-cycloserine in the adult rat
Johannesen, T. S., & Myhrer, T. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01282-7 · Cited by 21 · see citing works
The shadows of pain
Apkarian, A. V., & Chialvo, D. R. (2006) · Pain · doi:10.1016/j.pain.2006.04.028 · Cited by 10 · see citing works
Self-citation
Untitled work
(1996) · doi:10.1002/(sici)1096-9861(19960219)365:4
Self-citation

Flagged first, then by citations

1 of the 151 references couldn’t be matched to a known paper.

Sorted by citations

Neuropathic pain: mechanisms and their clinical implications
Cohen, S. P., & Mao, J. (2014) · BMJ · doi:10.1136/bmj.f7656 · Cited by 802 · see citing works
Pain and the brain: specificity and plasticity of the brain in clinical chronic pain
Apkarian, V. A., Hashmi, J. A., & Baliki, M. N. (2011) · Pain · doi:10.1016/j.pain.2010.11.010 · Cited by 782 · see citing works
Self-citation
Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits
Hashmi, J. A., Baliki, M. N., Huang, L., Baria, A. T., Torbey, S., Hermann, K. M., Schnitzer, T. J., & Apkarian, A. V. (2013) · Brain · doi:10.1093/brain/awt211 · Cited by 762 · see citing works
Self-citation
Nociception, pain, negative moods, and behavior selection
Baliki, M. N., & Apkarian, A. V. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.005 · Cited by 731 · see citing works
Self-citation
Phantom percepts: Tinnitus and pain as persisting aversive memory networks
Ridder, D. D., Elgoyhen, A. B., Romo, R., & Langguth, B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018466108 · Cited by 619 · see citing works
Chronic Musculoskeletal Pain and the Occurrence of Falls in an Older Population
Leveille, S. G. (2009) · JAMA · doi:10.1001/jama.2009.1738 · Cited by 567 · see citing works
Getting the pain you expect: mechanisms of placebo, nocebo and reappraisal effects in humans
Tracey, I. (2010) · Nature Medicine · doi:10.1038/nm.2229 · Cited by 553 · see citing works
Predicting Value of Pain and Analgesia: Nucleus Accumbens Response to Noxious Stimuli Changes in the Presence of Chronic Pain
Baliki, M. N., Geha, P., Fields, H. L., & Apkarian, A. V. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.002 · Cited by 549 · see citing works
Self-citation
Brain gray matter decrease in chronic pain is the consequence and not the cause of pain
Rodriguez-Raecke, R., Niemeier, A., Ihle, K., Ruether, W., & May, A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3687-09.2009 · Cited by 527 · see citing works
Abnormalities in Hippocampal Functioning with Persistent Pain
Mutso, A., Radzicki, D., Baliki, M. N., Huang, L. Q., Banisadr, G., Centeno, M. V., Radulović, J., Martina, M., Miller, R. J., & Apkarian, A. V. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0587-12.2012 · Cited by 495 · see citing works
Self-citation
Reward and motivation in pain and pain relief
Navratilova, E., & Porreca, F. (2014) · Nature Neuroscience · doi:10.1038/nn.3811 · Cited by 481 · see citing works
Anterior insula integrates information about salience into perceptual decisions about pain
Wiech, K., Lin, C.-S., Brodersen, K. H., Bingel, U., Ploner, M., & Tracey, I. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2087-10.2010 · Cited by 470 · see citing works
How neuroimaging studies have challenged us to rethink: Is chronic pain a disease?
Tracey, I., & Bushnell, M. C. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.09.001 · Cited by 455 · see citing works
Chronic Pain: Structural and Functional Changes in Brain Structures and Associated Negative Affective States
Yang, S., & Chang, M. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133130 · Cited by 410 · see citing works
Alleviating Neuropathic Pain Hypersensitivity by Inhibiting PKMζ in the Anterior Cingulate Cortex
Li, X., Ko, H., Chen, T., Descalzi, G., Koga, K., Wang, H., Kim, S. S., Shang, Y., Kwak, C., Park, S., et al. (2010) · Science · doi:10.1126/science.1191792 · Cited by 407 · see citing works
Neuroimaging of the periaqueductal gray: State of the field
Linnman, C., Moulton, E. A., Barmettler, G., Becerra, L. R., & Borsook, D. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.095 · Cited by 402 · see citing works
Brain Morphological Signatures for Chronic Pain
Baliki, M. N., Schnitzer, T. J., Bauer, W. R., & Apkarian, A. V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026010 · Cited by 369 · see citing works
Self-citation
Cortical changes in chronic low back pain: Current state of the art and implications for clinical practice
Wand, B. M., Parkitny, L., O'Connell, N. E., Luomajoki, H. A., McAuley, J. H., Thacker, M. A., & Moseley, G. L. (2010) · Manual Therapy · doi:10.1016/j.math.2010.06.008 · Cited by 347 · see citing works
Do people with chronic pain have impaired executive function? A meta-analytical review
Berryman, C. F., Stanton, T. R., Bowering, K. J., Tabor, A., McFARLANE, A. C., & Moseley, G. L. (2014) · Clinical Psychology Review · doi:10.1016/j.cpr.2014.08.003 · Cited by 313 · see citing works
Towards a mechanism-based approach to pain management in osteoarthritis
Malfait, A., & Schnitzer, T. J. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.138 · Cited by 310 · see citing works
Common brain mechanisms of chronic pain and addiction
Elman, I., & Borsook, D. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.027 · Cited by 303 · see citing works
Paradoxes in Acupuncture Research: Strategies for Moving Forward
Langevin, H. M., Wayne, P. M., MacPherson, H., Schnyer, R. N., Milley, R. J., Napadow, V., Lao, L., Park, J., Harris, R. E., Cohen, M. R., et al. (2010) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2011/180805 · Cited by 288 · see citing works
The stress model of chronic pain: evidence from basal cortisol and hippocampal structure and function in humans.
Vachon-Presseau, É., Roy, M., Martel, M., Caron, E., Marin, M.-F., Chen, J., Albouy, G., Plante, I., Sullivan, M., Lupien, S., et al. (2013) · Brain : a journal of neurology · doi:10.1093/brain/aws371 · Cited by 285 · see citing works
Gastrointestinal pain
Drewes, A. M., Olesen, A. E., Farmer, A. D., Szigethy, E., Rebours, V., & Olesen, S. S. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0135-7 · Cited by 280 · see citing works
Epigenetic suppression of GAD65 expression mediates persistent pain
Zhang, Z., Cai, Y.-Q., Zou, F., Bie, B., & Pan, Z. Z. (2011) · Nature Medicine · doi:10.1038/nm.2442 · Cited by 278 · see citing works
The anatomy of pain and suffering in the brain and its clinical implications
Ridder, D. D., Adhia, D. B., & Vanneste, S. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.08.013 · Cited by 276 · see citing works
The cannabinoid system and pain
Woodhams, S. G., Chapman, V., Finn, D. P., Hohmann, A. G., & Neugebauer, V. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.015 · Cited by 272 · see citing works
Brain white matter structural properties predict transition to chronic pain
Mansour, A. R., Baliki, M. N., Huang, L., Torbey, S., Herrmann, K. M., Schnitzer, T. J., & Apkarian, A. V. (2013) · Pain · doi:10.1016/j.pain.2013.06.044 · Cited by 263 · see citing works
Self-citation
Her versus his migraine: multiple sex differences in brain function and structure
Maleki, N., Linnman, C., Brawn, J., Burstein, R., Becerra, L. R., & Borsook, D. (2012) · Brain · doi:10.1093/brain/aws175 · Cited by 255 · see citing works
Frontostriatal Gating of Tinnitus and Chronic Pain
Rauschecker, J. P., May, E. S., Maudoux, A., & Ploner, M. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.08.002 · Cited by 251 · see citing works
The Emotional Brain as a Predictor and Amplifier of Chronic Pain
Vachon‐Presseau, É., Centeno, M. V., Ren, W., Berger, S., Tétreault, P., Ghantous, M. E., Baria, A. T., Farmer, M., Baliki, M. N., Schnitzer, T. J., et al. (2016) · Journal of Dental Research · doi:10.1177/0022034516638027 · Cited by 241 · see citing works
Self-citation
Chronic pain: The role of learning and brain plasticity
Mansour, A. R., Farmer, M., Baliki, M. N., & Apkarian, A. V. (2014) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-139003 · Cited by 238 · see citing works
Self-citation
Human Experimental Pain Models for Assessing the Therapeutic Efficacy of Analgesic Drugs
Olesen, A. E., Andresen, T., Staahl, C., & Drewes, A. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005447 · Cited by 238 · see citing works
Minimal acupuncture is not a valid placebo control in randomised controlled trials of acupuncture: a physiologist's perspective
Lund, I., Näslund, J., & Lundeberg, T. (2009) · Chinese Medicine · doi:10.1186/1749-8546-4-1 · Cited by 232 · see citing works
Predicting transition to chronic pain
Apkarian, A. V., Baliki, M. N., & Farmer, M. A. (2013) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32836336ad · Cited by 232 · see citing works
Self-citation
Brain regions associated with psychological pain: implications for a neural network and its relationship to physical pain
Meerwijk, E. L., Ford, J. M., & Weiss, S. J. (2012) · Brain Imaging and Behavior · doi:10.1007/s11682-012-9179-y · Cited by 227 · see citing works
Disrupted functional connectivity of the periaqueductal gray in chronic low back pain
Yu, R., Gollub, R. L., Spaeth, R. B., Napadow, V., Wasan, A. D., & Kong, J. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.08.019 · Cited by 220 · see citing works
A dynamic network perspective of chronic pain
Farmer, M. A., Baliki, M. N., & Apkarian, A. V. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.05.001 · Cited by 216 · see citing works
Self-citation
Quantifying cerebral contributions to pain beyond nociception
Woo, C., Schmidt, L., Krishnan, A., Jepma, M., Roy, M., Lindquist, M. A., Atlas, L. Y., & Wager, T. D. (2017) · Nature Communications · doi:10.1038/ncomms14211 · Cited by 215 · see citing works
Gray matter alterations in chronic pain: A network-oriented meta-analytic approach
Cauda, F., Palermo, S., Costa, T., Torta, R., Duca, S., Vercelli, U., Geminiani, G., & Torta, D. M. E. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2014.04.007 · Cited by 212 · see citing works
Depressive and Anxiety Symptoms as Risk Factors for Temporomandibular Joint Pain: A Prospective Cohort Study in the General Population
Kindler, S., Samietz, S., Houshmand, M., Grabe, H. J., Bernhardt, O., Biffar, R., Kocher, T., Meyer, G. F., Völzke, H., Metelmann, H., et al. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.09.004 · Cited by 212 · see citing works
Brain imaging of pain: state of the art
Morton, D. L., Jones, A. K. P., & Sandhu, J. (2016) · Journal of Pain Research · doi:10.2147/jpr.s60433 · Cited by 211 · see citing works
Rethinking the fear avoidance model: toward a multidimensional framework of pain-related disability
Wideman, T. H., Asmundson, G. G. J., Smeets, R. J. E. M., Zautra, A. J., Simmonds, M. J., Sullivan, M. J. L., Haythornthwaite, J. A., & Edwards, R. R. (2013) · Pain · doi:10.1016/j.pain.2013.06.005 · Cited by 210 · see citing works
Does cognitive functioning predict chronic pain? Results from a prospective surgical cohort
Attal, N., Masselin-Dubois, A., Martinez, V., Jayr, C., Albi, A., Fermanian, J., Bouhassira, D., & Baudic, S. (2014) · Brain · doi:10.1093/brain/awt354 · Cited by 204 · see citing works
Opioids for the Treatment of Chronic Pain: Mistakes Made, Lessons Learned, and Future Directions
Ballantyne, J. C. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002500 · Cited by 203 · see citing works
Is neuroplasticity in the central nervous system the missing link to our understanding of chronic musculoskeletal disorders?
Pelletier, R., Higgins, J., & Bourbonnais, D. (2015) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-015-0480-y · Cited by 202 · see citing works
Fibromyalgia: Moderate and substantial pain intensity reduction predicts improvement in other outcomes and substantial quality of life gain
Moore, A. R., Straube, S., Paine, J., Phillips, C. J., Derry, S., & McQuay, H. J. (2010) · Pain · doi:10.1016/j.pain.2010.02.039 · Cited by 200 · see citing works
Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain
Kim, S. K., Hayashi, H., Ishikawa, T., Shibata, K., Shigetomi, E., Shinozaki, Y., Inada, H., Roh, S. E., Kim, S. J., Lee, G., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci82859 · Cited by 200 · see citing works
Intrinsic functional connectivity of the periaqueductal gray, a resting fMRI study
Kong, J., Tu, P., Zyloney, C. E., & Su, T. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.03.042 · Cited by 198 · see citing works
Animal models of chronic pain: Advances and challenges for clinical translation
Burma, N. E., Leduc‐Pessah, H., Fan, C. Y., & Trang, T. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23768 · Cited by 198 · see citing works
Reward, motivation, and emotion of pain and its relief
Porreca, F., & Navratilova, E. (2017) · Pain · doi:10.1097/j.pain.0000000000000798 · Cited by 198 · see citing works
Contributions of psychology to the understanding and treatment of people with chronic pain: Why it matters to ALL psychologists
Jensen, M. P., & Turk, D. C. (2014) · American Psychologist · doi:10.1037/a0035641 · Cited by 196 · see citing works
Chronic myofascial temporomandibular pain is associated with neural abnormalities in the trigeminal and limbic systems
Younger, J., Shen, Y. F., Goddard, G., & Mackey, S. (2010) · Pain · doi:10.1016/j.pain.2010.01.006 · Cited by 193 · see citing works
Reorganization of hippocampal functional connectivity with transition to chronic back pain
Mutso, A., Petre, B., Huang, L. Q., Baliki, M. N., Torbey, S., Herrmann, K. M., Schnitzer, T. J., & Apkarian, A. V. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00611.2013 · Cited by 188 · see citing works
Self-citation
Cortico-limbic pain mechanisms
Thompson, J. M., & Neugebauer, V. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.11.037 · Cited by 183 · see citing works
Patients with Chronic Pain After Abdominal Surgery Show Less Preoperative Endogenous Pain Inhibition and More Postoperative Hyperalgesia: A Pilot Study
Wilder‐Smith, O. H. G., Schreyer, T., Scheffer, G. J., & Arendt‐Nielsen, L. (2010) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.3109/15360281003706069 · Cited by 177 · see citing works
Abnormal thalamocortical activity in patients with Complex Regional Pain Syndrome (CRPS) Type I
Walton, K. D., Dubois, M. Y., & Llinás, R. R. (2010) · Pain · doi:10.1016/j.pain.2010.02.023 · Cited by 176 · see citing works
Contribution of chronic pain and neuroticism to abnormal forebrain gray matter in patients with temporomandibular disorder
Moayedi, M., Weissman‐Fogel, I., Crawley, A. P., Goldberg, M. B., Freeman, B. V., Tenenbaum, H. C., & Davis, K. D. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.12.013 · Cited by 176 · see citing works
Roles of the hippocampal formation in pain information processing
Liu, M., & Chen, J. (2009) · Neuroscience Bulletin · doi:10.1007/s12264-009-0905-4 · Cited by 175 · see citing works
Central Nervous System Reorganization in a Variety of Chronic Pain States: A Review
Henry, D. E., Chiodo, A. E., & Yang, W. (2011) · PM&R · doi:10.1016/j.pmrj.2011.05.018 · Cited by 172 · see citing works
The NG2 chondroitin sulfate proteoglycan: a multifunctional proteoglycan associated with immature cells.
Levine, J., & Nishiyama, A. (1996) · PubMed · Cited by 171 · see citing works
A comprehensive literature review of chronic pain and memory
Mazza, S., Frot, M., & Rey, A. E. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.08.006 · Cited by 170 · see citing works
A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity
Tan, L. L., Pelzer, P., Heinl, C., Tang, W., Gangadharan, V., Flor, H., Sprengel, R., Kuner, T., & Kuner, R. (2017) · Nature Neuroscience · doi:10.1038/nn.4645 · Cited by 170 · see citing works
Can neuroimaging studies identify pain endophenotypes in humans?
Tracey, I. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.4 · Cited by 166 · see citing works
Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network
Clemens, J. Q., Mullins, C. E., Ackerman, A. L., Bavendam, T. G., van Bokhoven, A., Ellingson, B. M., Harte, S. E., Kutch, J. J., Lai, H. H., Martucci, K. T., et al. (2018) · Nature Reviews Urology · doi:10.1038/s41585-018-0135-5 · Cited by 166 · see citing works
Supervised exercise, spinal manipulation, and home exercise for chronic low back pain: a randomized clinical trial
Brønfort, G., Maiers, M., Evans, R., Schulz, C. A., Bracha, Y., Svendsen, K. H., Grimm, R. H., Owens, E. F., Garvey, T. A., & Transfeldt, E. E. (2011) · The Spine Journal · doi:10.1016/j.spinee.2011.01.036 · Cited by 164 · see citing works
Brain activations during pain
Jensen, K. B., Regenbogen, C., Ohse, M. C., Frasnelli, J., Freiherr, J., & Lundström, J. N. (2016) · Pain · doi:10.1097/j.pain.0000000000000517 · Cited by 161 · see citing works
Nerve Injury-Induced Neuropathic Pain Causes Disinhibition of the Anterior Cingulate Cortex
Blom, S. M., Pfister, J.-P., Santello, M., Senn, W., & Nevian, T. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3667-13.2014 · Cited by 160 · see citing works
Depression and Pain: Use of Antidepressants
Bonilla-Jaime, H., Sánchez-Salcedo, J. A., Estevez-Cabrera, M. M., Molina‐Jiménez, T., Cortes-Altamirano, J. L., & Alfaro-Rodríguez, A. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210609161447 · Cited by 159 · see citing works
Common and specific large-scale brain changes in major depressive disorder, anxiety disorders, and chronic pain: a transdiagnostic multimodal meta-analysis of structural and functional MRI studies
Brandl, F., Weise, B., Bratec, S. M., Jassim, N., Ayala, D. H., Bertram, T., Ploner, M., & Sorg, C. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01271-y · Cited by 153 · see citing works
Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA A receptors
Ji, G., & Neugebauer, V. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00461.2011 · Cited by 150 · see citing works
A prognostic risk score for development and spread of chronic pain
Tanguay-Sabourin, C., Fillingim, M., Guglietti, G. V., Zare, A., Parisien, M., Norman, J., Sweatman, H., Da‐ano, R., Heikkala, E., Breitner, J. C. S., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02430-4 · Cited by 162 · see citing works
Chronic Back Pain Is Associated With Decreased Prefrontal and Anterior Insular Gray Matter: Results From a Population-Based Cohort Study
Fritz, H.-C., McAuley, J. H., Wittfeld, K., Hegenscheid, K., Schmidt, C. O., Langner, S., & Lotze, M. (2015) · Journal of Pain · doi:10.1016/j.jpain.2015.10.003 · Cited by 144 · see citing works
Dynamic Oscillatory Signatures of Central Neuropathic Pain in Spinal Cord Injury
Vučković, A., Hasan, M., Fraser, M. H., Conway, B., Nasseroleslami, B., & Allan, D. (2014) · Journal of Pain · doi:10.1016/j.jpain.2014.02.005 · Cited by 115 · see citing works
Sodium Channels in Human Pain Disorders: Genetics and Pharmacogenomics
Dib‐Hajj, S. D., & Waxman, S. G. (2019) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070918-050144 · Cited by 144 · see citing works
Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception
Tan, L. L., Oswald, M. J., Heinl, C., Romero, O. A. R., Kaushalya, S. K., Monyer, H., & Kuner, R. (2019) · Nature Communications · doi:10.1038/s41467-019-08873-z · Cited by 144 · see citing works
Etiology and Treatment of Pain and Psychosocial Issues in Patients With Inflammatory Bowel Diseases
Regueiro, M., Greer, J. B., & Szigethy, E. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.036 · Cited by 142 · see citing works
Structural brain changes in chronic pain reflect probably neither damage nor atrophy
Rodriguez-Raecke, R., Niemeier, A., Ihle, K., Ruether, W., & May, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054475 · Cited by 141 · see citing works
S1 is Associated with Chronic Low Back Pain: A Functional and Structural MRI Study
Kong, J., Spaeth, B., Wey, H., Cheetham, A., Cook, A. H., Jensen, K. B., Tan, Y. H. V., Liu, H., Wang, D., Loggia, M. L., et al. (2013) · Molecular Pain · doi:10.1186/1744-8069-9-43 · Cited by 140 · see citing works
Improvement of Pain, Sleep, and Quality of Life in Chronic Pain Patients With Vitamin D Supplementation
Huang, W., Shah, S. P., Long, Q., Crankshaw, A. K., & Tangpricha, V. (2012) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e318255655d · Cited by 138 · see citing works
Immunological Mechanisms Underlying Chronic Pelvic Pain and Prostate Inflammation in Chronic Pelvic Pain Syndrome
Breser, M. L., Salazar, F. C., Rivero, V. E., & Motrich, R. D. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00898 · Cited by 134 · see citing works
Modulation of medial prefrontal cortical activity using in vivo recordings and optogenetics
Ji, G., & Neugebauer, V. (2012) · Molecular Brain · doi:10.1186/1756-6606-5-36 · Cited by 130 · see citing works
Neuropathic Pain and Spinal Cord Injury: Phenotypes and Pharmacological Management
Widerström-Noga, E. G. (2017) · Drugs · doi:10.1007/s40265-017-0747-8 · Cited by 128 · see citing works
Brain functional and anatomical changes in chronic prostatitis/chronic pelvic pain syndrome
Farmer, M. A., Chanda, M. L., Parks, E. L., Baliki, M. N., Apkarian, A. V., & Schaeffer, A. J. (2011) · Journal of Urology · doi:10.1016/j.juro.2011.03.027 · Cited by 126 · see citing works
Self-citation
Is Placebo Acupuncture What It Is Intended to Be?
Lundeberg, T., Lund, I., Sing, A., & Näslund, J. (2009) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nep049 · Cited by 126 · see citing works
Long-Term Outcomes of Spinal Cord Stimulation With Paddle Leads in the Treatment of Complex Regional Pain Syndrome and Failed Back Surgery Syndrome
Sears, N. C., Machado, A. G., Nagel, S. J., Deogaonkar, M. S., Stanton-Hicks, M. D., Rezai, A. R., & Henderson, J. M. (2011) · Neuromodulation Technology at the Neural Interface · doi:10.1111/j.1525-1403.2011.00372.x · Cited by 123 · see citing works
Alexithymia in Chronic Pain Disorders
Tella, M. D., & Castelli, L. (2016) · Current Rheumatology Reports · doi:10.1007/s11926-016-0592-x · Cited by 122 · see citing works
Rescue of Impaired mGluR5-Driven Endocannabinoid Signaling Restores Prefrontal Cortical Output to Inhibit Pain in Arthritic Rats
Kiritoshi, T., Ji, G., & Neugebauer, V. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4047-15.2016 · Cited by 121 · see citing works
Abnormal medial prefrontal cortex functional connectivity and its association with clinical symptoms in chronic low back pain
Tu, Y., Jung, M., Gollub, R. L., Napadow, V., Gerber, J. A., Ortiz, A., Lang, C., Mawla, I., Shen, W., Chan, S., et al. (2019) · Pain · doi:10.1097/j.pain.0000000000001507 · Cited by 121 · see citing works
Chronic neuropathic pain-like behavior correlates with IL-1β expression and disrupts cytokine interactions in the hippocampus
del Rey, A., Yau, H., Randolf, A., Centeno, M. V., Wildmann, J., Martina, M., Besedovsky, H. O., & Apkarian, A. V. (2011) · Pain · doi:10.1016/j.pain.2011.09.013 · Cited by 118 · see citing works
Self-citation
Dysfunction of Cortical Dendritic Integration in Neuropathic Pain Reversed by Serotoninergic Neuromodulation
Santello, M., & Nevian, T. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.003 · Cited by 118 · see citing works
Brain Circuits Mediating Opposing Effects on Emotion and Pain
Cai, Y.-Q., Wang, W., Paulucci-Holthauzen, A., & Pan, Z.-Z. Z. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2780-17.2018 · Cited by 100 · see citing works
Modulating the pain network—neurostimulation for central poststroke pain
Hosomi, K., Seymour, B., & Saitoh, Y. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.58 · Cited by 118 · see citing works
Influence of transcranial direct current stimulation of the dorsolateral prefrontal cortex on pain related emotions: A study using electroencephalographic power spectrum analysis
Maeoka, H., Matsuo, A., Hiyamizu, M., Morioka, S., & Ando, H. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.01.037 · Cited by 117 · see citing works
Associative fear learning and perceptual discrimination: A perceptual pathway in the development of chronic pain
Zaman, J., Vlaeyen, J. W. S., Oudenhove, L. V., Wiech, K., & Diest, I. V. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.01.009 · Cited by 116 · see citing works
The Missing P in Psychiatric Training
Elman, I., Zubieta, J.-K., & Borsook, D. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.174 · Cited by 115 · see citing works
Placebo 2.0: the impact of expectations on analgesic treatment outcome
Bingel, U. (2020) · Pain · doi:10.1097/j.pain.0000000000001981 · Cited by 113 · see citing works
Effects of stress on the corticolimbic system: implications for chronic pain
Vachon‐Presseau, É. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.10.014 · Cited by 113 · see citing works
Toward a theoretical model for mindfulness-based pain management
Day, M. A., Jensen, M. P., Ehde, D. M., & Thorn, B. E. (2014) · The Journal of Pain · doi:10.1016/j.jpain.2014.03.003 · Cited by 112 · see citing works
Lost but making progress—Where will new analgesic drugs come from?
Borsook, D., Hargreaves, R. J., Bountra, C., & Porreca, F. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008320 · Cited by 112 · see citing works

Cortical excitation and chronic pain
Zhuo, M. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.01.003 · Cited by 534 · see citing works
Pain Pathways and Nervous System Plasticity: Learning and Memory in Pain
McCarberg, B. H., & Peppin, J. F. (2019) · Pain Medicine · doi:10.1093/pm/pnz017 · Cited by 176 · see citing works
Chronic Pain-Related Remodeling of Cerebral Cortex – ‘Pain Memory‘: A Possible Target for Treatment of Chronic Pain
Lithwick, A., Lev, S., & Binshtok, A. M. (2012) · Pain Management · doi:10.2217/pmt.12.74 · Cited by 388 · see citing works
Structural plasticity and reorganisation in chronic pain
Kuner, R., & Flor, H. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.162 · Cited by 700 · see citing works
Plasticity and Cortical Reorganization Associated With Pain
Weiß, T. (2016) · Zeitschrift für Psychologie · doi:10.1027/2151-2604/a000241 · Cited by 18 · see citing works

Authors: Apkarian, A. V., Baliki, M. N., & Geha, P. Y.
Affiliations: Northwestern University (US)
Corresponding author: Apkarian, A. Vania
ORCID: Apkarian, A. Vania
Baliki, Marwan N.
Geha, Paul Y.
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 2009-02
Volume: 87
Issue: 2
Pages: 81-97
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/j.pneurobio.2008.09.018
PMC: PMC2650821
OpenAlex: W1995458911
Cited by: 876
References: 151
Citations by year: 2026: 62 · 2025: 57 · 2024: 41 · 2023: 28 · 2022: 35 · 2021: 51 · 2020: 46 · 2019: 53 · 2018: 48 · 2017: 65 · 2016: 55 · 2015: 47 · 2014: 68 · 2013: 57 · 2012: 59
FWCI: 3.69
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neurobiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS 57704, R21NS053602, NS35115, NS53602, R01NS057704, R01NS035115)
Topics: Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords: chronic pain, nociception, descending pain modulation, neuropathic pain, cortical reorganization, acute to chronic pain transition, pain mechanisms, pharmacological pain management
MeSH terms: Animals, Brain, Brain Mapping, Chronic Disease, Humans, Pain, Pain Management

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Towards a theory of chronic pain

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks