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Brain Functional and Anatomical Changes in Chronic Prostatitis/Chronic Pelvic Pain Syndrome
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PURPOSE: Research into the pathophysiology of chronic prostatitis/chronic pelvic pain syndrome has primarily focused on markers of peripheral dysfunction. We present the first neuroimaging investigation to our knowledge to characterize brain function and anatomy in chronic prostatitis/chronic pelvic pain syndrome. MATERIALS AND METHODS: We collected data from 19 male patients with chronic prostatitis/chronic pelvic pain syndrome, and 16 healthy age and gender matched controls. Functional magnetic resonance imaging data were obtained from 14 patients with chronic prostatitis/chronic pelvic pain syndrome as they rated spontaneous pain inside the scanner. Group differences (16 patients per group) in gray matter total volume and regional density were evaluated using voxel-based morphometry, and white matter integrity was studied with diffusion tensor imaging to measure fractional anisotropy. Functional and anatomical imaging outcomes were correlated with the clinical characteristics of chronic prostatitis/chronic pelvic pain syndrome. RESULTS: Spontaneous pelvic pain was uniquely characterized by functional activation within the right anterior insula, which correlated with clinical pain intensity. No group differences were found in regional gray matter volume, yet density of gray matter in pain relevant regions (anterior insula and anterior cingulate cortices) positively correlated with pain intensity and extent of pain chronicity. Moreover the correlation between white matter anisotropy and neocortical gray matter volume was disrupted in chronic prostatitis/chronic pelvic pain syndrome. CONCLUSIONS: We provide novel evidence that the pain of chronic prostatitis/chronic pelvic pain syndrome is associated with a chronic pelvic pain syndrome specific pattern of functional brain activation and brain anatomical reorganization. These findings necessitate further investigations into the role of central mechanisms in the initiation and maintenance of chronic prostatitis/chronic pelvic pain syndrome.
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“Guillory and colleagues101 found that a text message-based social support intervention was effective in reducing pain severity and interference and increasing positive affect.”
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Metadata
- Authors
- Farmer, M. A., Chanda, M. L., Parks, E. L., Baliki, M. N., Apkarian, A. V., & Schaeffer, A. J.
- Affiliations
- Northwestern University (US)
- Venue
- Journal of Urology
- Published
- 2011-07
- Volume
- 186
- Issue
- 1
- Pages
- 117-124
- ISSN
- 0022-5347 (ISSN-L)
- 1527-3792
- PMC
- PMC4889821
- OpenAlex
- W2118252411
- Cited by
- 126
- References
- 23
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 9 · 2016: 13 · 2015: 12 · 2014: 13 · 2013: 22 · 2012: 9
- FWCI
- 18.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Urology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK65277, U01DK065277)
- National Institute of Neurological Disorders and Stroke (R01NS035115)
- Topics
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- chronic prostatitis, brain activation, anterior insula, anterior cingulate cortex, gray matter density, white matter integrity, fractional anisotropy, spontaneous pain, pain intensity, central sensitization, neuroimaging
- MeSH terms
- Adult, Brain, Brain Mapping, Humans, Magnetic Resonance Imaging, Male, Prostatitis
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