Weight Loss Prevents Urinary Incontinence in Women With Type 2 Diabetes: Results From the Look AHEAD Trial
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PURPOSE: We determined the effect of weight loss on the prevalence, incidence and resolution of weekly or more frequent urinary incontinence in overweight/obese women with type 2 diabetes after 1 year of intervention in the Look AHEAD (Action for Health in Diabetes) trial. MATERIALS AND METHODS: Women in this substudy (2,739, mean ± SD age 57.9 ± 6.8 years, body mass index 36.5 ± 6.1 kg/m(2)) were randomized into an intensive lifestyle weight loss intervention or a diabetes support and education control condition. RESULTS: At baseline 27% of participants reported urinary incontinence on a validated questionnaire (no significant difference by intensive lifestyle intervention vs diabetes support and education). After 1 year of intervention the intensive lifestyle intervention group in this substudy lost 7.7 ± 7.0 vs 0.7 ± 5.0 kg in the diabetes support and education group. At 1 year fewer women in the intensive lifestyle intervention group reported urinary incontinence (25.3% vs 28.6% in the diabetes support and education group, p = 0.05). Among participants without urinary incontinence at baseline 10.5% of intensive lifestyle intervention and 14.0% of diabetes support and education participants experienced urinary incontinence after 1 year (p = 0.02). There were no significant group differences in the resolution of urinary incontinence (p >0.17). Each kg of weight lost was associated with a 3% reduction in the odds of urinary incontinence developing (p = 0.01), and weight losses of 5% to 10% reduced these odds by 47% (p = 0.002). CONCLUSIONS: Moderate weight loss reduced the incidence but did not improve the resolution rates of urinary incontinence at 1 year among overweight/obese women with type 2 diabetes. Weight loss interventions should be considered for the prevention of urinary incontinence in overweight/obese women with diabetes.
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Intensive lifestyle intervention has been associated with improvements in urinary incontinence, sleep apnea, depression, quality of life, physical function, and mobility in the early years of the trial.
“Other benefits identified during the early years of the trial have included improvements in urinary incontinence,20 sleep apnea,21 depression,22 quality of life,23 physical function,24 and mobility.”
From Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes (2013) · cites this paper as [20]
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Behavioral Strategies in Weight Management
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AUA Guidelines on Stress Urinary Incontinence: What Is New in the Guidelines?
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Impact of weight loss on the risk of urinary incontinence: the role of sex and body type
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Pelvic floor muscle training program for Egyptian women with neglected urinary incontinence
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- Authors
- Phelan, S., Kanaya, A. M., Subak, L. L., Hogan, P. E., Espeland, M. A., Wing, R. R., Burgio, K. L., DiLillo, V., Gorin, A. A., West, D. S., Brown, J. S., & The Look AHEAD Research Group
- Affiliations
- California Polytechnic State University (US)
- University of California, San Francisco (US)
- Wake Forest University Health Sciences (US)
- Brown University (US)
- University of Alabama at Birmingham (US)
- Ohio Wesleyan University (US)
- University of Connecticut (US)
- University of Arkansas for Medical Sciences (US)
- ORCID
- Venue
- Journal of Urology
- Published
- 2012-03
- Volume
- 187
- Issue
- 3
- Pages
- 939-944
- ISSN
- 0022-5347 (ISSN-L)
- 1527-3792
- PMC
- PMC3646565
- OpenAlex
- W1984430026
- Cited by
- 107
- References
- 18
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 3 · 2018: 7 · 2017: 7 · 2016: 19 · 2015: 14 · 2014: 20 · 2013: 9 · 2012: 1
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Urology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Commons - OWU (Ohio Wesleyan University) (submittedVersion)
- Funders
- National Institutes of Health (5p30dk046204-15)
- U.S. Public Health Service (PA-98-053)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-57171, DK 57136, DK57149, DK 57002, DK57182, DK56990, (DK 046204, DK57008, DK57177, DK 57078, DK57219, U01DK057149, DK-57178, U01DK057151, U01DK057135, U01DK057131, U01DK056990, DK-57135, U01DK057136, DK-56992, DK57154, U01DK057178, U01DK057182, U01DK057078, U01DK057154, U01DK057008, U01DK057171, DK57131, U01DK057002, U01DK057219, K24DK080775, U01DK056992, U01DK057177, P30DK017047, P30DK048520, DK 57151, P30-DK046204, P30-DK 48520)
- National Center for Research Resources (M01-RR-0021140, M01RR-00051, M01RR002719, M01RR000056, M01RR000051, M01RR001066, M0-1-RR-02719, M01RR000211, M01-RR01066)
- Topics
- Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- urinary incontinence, weight loss, type 2 diabetes, women, overweight and obesity, intensive lifestyle intervention, diabetes support and education, Look AHEAD trial, body weight
- MeSH terms
- Analysis of Variance, Diabetes Mellitus, Type 2, Female, Humans, Life Style, Middle Aged, Obesity, United States, Urinary Incontinence, Weight Loss, Incidence, Prevalence, Chi-Square Distribution, Logistic Models, Treatment Outcome
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