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Cited by 210Sexual function and dysfunction studiesDupuytren's Contracture and TreatmentsUrological Disorders and Treatments

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Bother and Distress Associated with Peyronie's Disease: Validation of the Peyronie’s Disease Questionnaire

Hellstrom, Wayne J.G., Feldman, Robert, Rosen, Raymond C., Smith, Ted, Kaufman, Gregory, Tursi, James·2013·Journal of Urology
DOI 10.1016/j.juro.2013.01.090
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Abstract

PURPOSE: We validated the Peyronie's Disease Questionnaire (http://www.auxilium.com/PDQ), a 15-question self-reported survey that measures the impact and severity of Peyronie's disease symptoms in 3 domains, including 1) psychological and physical symptoms, 2) penile pain and 3) symptom bother. MATERIALS AND METHODS: We used baseline data from 2 phase 3 clinical trials (334 and 345 patients, respectively) of collagenase clostridium histolyticum treatment for Peyronie's disease associated penile curvature and bother. Collected data included PDQ domain scores, International Index of Erectile Function scores, objective penile curvature measures and patient reported Peyronie's disease symptom severity. Psychometric analyses included confirmatory factor analysis, inter-item reliability, and tests of convergent and discriminant validity, all related to the overall construct validity of the scale. RESULTS: Confirmatory factor analysis supported the conceptual framework of the PDQ with 3 confirmed subdomains. Each scale showed good consistency, ie internal reliability (each Cronbach α >0.70). Convergent and discriminant validity were noted in the pattern of associations between PDQ domains and other Peyronie's disease measures. PDQ domain scores significantly differed between patients with vs without erectile dysfunction and between patients with vs without Peyronie's disease related symptom distress, further supporting PDQ construct validity. CONCLUSIONS: This study confirms the conceptual framework, factor structure, and convergent and discriminant validity of the PDQ psychological and physical symptoms, penile pain, and symptom bother domains. Used in conjunction with objective penile curvature measurements, the PDQ can serve as a valuable diagnostic tool or outcome measure to assess treatment related improvements in Peyronie's disease symptoms.

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  1. Lipshulz, 2012, Relationship of baseline curvature deformity severity and symptom bother observed in patients with Peyronie's disease, J Sex Med, 9, 203

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Metadata

Authors
Hellstrom, W. J. G., Feldman, R., Rosen, R. C., Smith, T., Kaufman, G., & Tursi, J.
Affiliations
  • Tulane University (US)
  • Connecticut Clinical Research Center and Urology Specialists, Middlebury, Connecticut
  • New England Research Institutes (US)
  • Auxilium Pharmaceuticals, Inc., Chesterbrook, Pennsylvania
ORCID
Hellstrom, Wayne J.G.
Venue
Journal of Urology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2013-08
Volume
190
Issue
2
Pages
627-634
ISSN
  • 0022-5347 (ISSN-L)
  • 1527-3792
DOI
10.1016/j.juro.2013.01.090
OpenAlex
W2003470763
Cited by
210
References
25
Citations by year
2026: 12 · 2025: 13 · 2024: 10 · 2023: 18 · 2022: 18 · 2021: 18 · 2020: 27 · 2019: 7 · 2018: 9 · 2017: 12 · 2016: 24 · 2015: 21 · 2014: 13 · 2013: 7
FWCI
15.28
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Urology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Rheumatology › Dupuytren's Contracture and Treatments
  • Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Keywords
Peyronie's disease, Peyronie's Disease Questionnaire, symptom bother, penile pain, erectile dysfunction, penile curvature, symptom severity, questionnaire validation, psychometric properties, collagenase clostridium histolyticum, patient-reported outcomes
MeSH terms
Adult, Aged, Aged, 80 and over, Analysis of Variance, Microbial Collagenase, Factor Analysis, Statistical, Humans, Male, Middle Aged, Penile Induration, Psychometrics, Surveys and Questionnaires, Severity of Illness Index, Reproducibility of Results, Treatment Outcome, Clinical Trials, Phase III as Topic

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