The DOI matches its Crossref record; 119 of the 120 references it cites were found in a registry or an index.
The role of renal hypoxia in the pathogenesis of diabetic kidney disease: a promising target for newer renoprotective agents including SGLT2 inhibitors?
Open accessAbstract
Diabetic kidney disease is the most common cause of end-stage kidney disease and poses a major global health problem. Finding new, safe, and effective strategies to halt this disease has proven to be challenging. In part that is because the underlying mechanisms are complex and not fully understood. However, in recent years, evidence has accumulated suggesting that chronic hypoxia may be the primary pathophysiological pathway driving diabetic kidney disease and chronic kidney disease of other etiologies and was called the chronic hypoxia hypothesis. Hypoxia is the result of a mismatch between oxygen delivery and oxygen demand. The primary determinant of oxygen delivery is renal perfusion (blood flow per tissue mass), whereas the main driver of oxygen demand is active sodium reabsorption. Diabetes mellitus is thought to compromise the oxygen balance by impairing oxygen delivery owing to hyperglycemia-associated microvascular damage and exacerbate oxygen demand owing to increased sodium reabsorption as a result of sodium-glucose cotransporter upregulation and glomerular hyperfiltration. The resultant hypoxic injury creates a vicious cycle of capillary damage, inflammation, deposition of the extracellular matrix, and, ultimately, fibrosis and nephron loss. This review will frame the role of chronic hypoxia in the pathogenesis of diabetic kidney disease and its prospect as a promising therapeutic target. We will outline the cellular mechanisms of hypoxia and evidence for renal hypoxia in animal and human studies. In addition, we will highlight the promise of newer imaging modalities including blood oxygenation level-dependent magnetic resonance imaging and discuss salutary interventions such as sodium-glucose cotransporter 2 inhibition that (may) protect the kidney through amelioration of renal hypoxia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“First, it may be due to impaired oxygen delivery resulting from microvascular damage. Second, increased oxygen consumption, caused by both glomerular hyperfiltration and inefficient energy generation due to impaired insulin sensitivity, may also contribute (38).”
From GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity (2025) · cites this paper as [38]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
Perkovic, V., Jardine, M. J., Neal, B., Bompoint, S., Heerspink, H. J. L., Charytan, D. M., Edwards, R., Agarwal, R., Bakris, G., Bull, S., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1811744 · Cited by 6,189
Zelniker, T. A., Wiviott, S. D., Raz, I., Im, K., Goodrich, E. L., Bonaca, M. P., Mosenzon, O., Kato, E. T., Cahn, A., Furtado, R. H. M., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(18)32590-x · Cited by 2,845
Cherney, D. Z. I., Perkins, B. A., Soleymanlou, N., Maione, M., Lai, V., Lee, A., Fagan, N. M., Woerle, H. J., Johansen, O. E., Broedl, U. C., et al. (2014) · Circulation · doi:10.1161/circulationaha.113.005081 · Cited by 1,329
Chronic Hypoxia and Tubulointerstitial Injury
Nangaku, M. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005070757 · Cited by 1,146
Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease
de Zeeuw, D., Akizawa, T., Audhya, P., Bakris, G. L., Chin, M. P., Christ‐Schmidt, H., Goldsberry, A., Houser, M. T., Krauth, M., Heerspink, H. J. L., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1306033 · Cited by 1,051
Fuel selection in human skeletal muscle in insulin resistance: a reexamination.
Kelley, D. E., & Mandarino, L. J. (2000) · Diabetes · doi:10.2337/diabetes.49.5.677 · Cited by 1,017
Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes
Pergola, P. E., Raskin, P., Toto, R. D., Meyer, C. J., Huff, J. W., Grossman, E. B., Krauth, M., Ruiz, S., Audhya, P., Christ-Schmidt, H., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1105351 · Cited by 890
Glomerular hyperfiltration in diabetes: mechanisms, clinical significance, and treatment
Tonneijck, L., Muskiet, M. H. A., Smits, M. M., van Bommel, E. J., Heerspink, H. J. L., van Raalte, D. H., & Joles, J. A. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016060666 · Cited by 887
Inzucchi, S. E., Zinman, B., Fitchett, D., Wanner, C., Ferrannini, E., Schumacher, M., Schmoor, C., Ohneberg, K., Johansen, O. E., George, J. T., et al. (2018) · Diabetes Care · doi:10.2337/dc17-1096 · Cited by 740
Vallon, V., & Thomson, S. C. (2017) · Diabetologia · doi:10.1007/s00125-016-4157-3 · Cited by 635
Self-citationRoxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis
Chen, N., Hao, C., Liu, B., Lin, H., Wang, C., Xing, C., Liang, X., Jiang, G., Liu, Z., Li, X., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1901713 · Cited by 630
The role of fatty acids in insulin resistance
Sears, B., & Perry, M. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0123-1 · Cited by 589
Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis
Chen, N., Hao, C., Peng, X., Lin, H., Yin, A., Hao, L., Tao, Y., Liang, X., Liu, Z., Xing, C., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1813599 · Cited by 582
Physiological and pathological responses to hypoxia
Michiels, C. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63747-9 · Cited by 559
Fine, L. G., & Norman, J. T. (2008) · Kidney International · doi:10.1038/ki.2008.350 · Cited by 515
The tubular hypothesis of nephron filtration and diabetic kidney disease
Vallon, V., & Thomson, S. C. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-020-0256-y · Cited by 465
Self-citationStructural-functional correlations in renal disease
Schainuck, L. I., Striker, G. E., Cutler, R. E., et al. (1970) · Human Pathology · doi:10.1016/s0046-8177(70)80061-2 · Cited by 462
Noninvasive Evaluation of Intrarenal Oxygenation With BOLD MRI
Prasad, P. V., Edelman, R. R., & Epstein, F. H. (1996) · Circulation · doi:10.1161/01.cir.94.12.3271 · Cited by 398
Self-citationHypoxia signaling in human diseases and therapeutic targets
Lee, J. W., Ko, J., Ju, C., & Eltzschig, H. K. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0235-1 · Cited by 384
mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1
Morita, M., Prudent, J., Basu, K., Goyon, V., Katsumura, S., Hulea, L., Pearl, D., Siddiqui, N., Strack, S., McGuirk, S., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.08.013 · Cited by 381
Mitochondria are impaired in the adipocytes of type 2 diabetic mice.
Choo, H.-J., Kim, J.-H., Kwon, O.-B., Lee, C. S., Mun, J. Y., Han, S. S., Yoon, Y.-S., Yoon, G., Choi, K.-M., & Ko, Y.-G. (2006) · Diabetologia · doi:10.1007/s00125-006-0170-2 · Cited by 365
Glomerular Hyperfiltration in Experimental Diabetes Mellitus
Vallon, V., Richter, K., Blantz, R. C., Thomson, S. C., & Oßwald, H. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v10122569 · Cited by 356
Self-citationHypoxia promotes fibrogenesis in human renal fibroblasts
Norman, J. T., Clark, I. M., & García, P. L. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00419.x · Cited by 352
Noninvasive Evaluation of Kidney Hypoxia and Fibrosis Using Magnetic Resonance Imaging
Inoue, T., Kozawa, E., Okada, H., et al. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010111143 · Cited by 344
P/O ratios of mitochondrial oxidative phosphorylation
Hinkle, P. C. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2004.09.004 · Cited by 336
Mitochondria-Targeted Peptide Accelerates ATP Recovery and Reduces Ischemic Kidney Injury
Szeto, H. H., Liu, S., Soong, Y., Wu, D., Darrah, S. F., Cheng, F.-Y., Zhao, Z., Ganger, M. T., Tow, C., & Seshan, S. V. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010080808 · Cited by 312
Birk, A., Chao, W. M., Bracken, C., Warren, J. D., & Szeto, H. H. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12468 · Cited by 309
Reactive oxygen species cause diabetes-induced decrease in renal oxygen tension
Palm, F., Cederberg, J., Hansell, P., Liss, P., & Carlsson, P. (2003) · Diabetologia · doi:10.1007/s00125-003-1155-z · Cited by 291
Panchapakesan, U., Pegg, K., Gross, S., Komala, M. G., Mudaliar, H., Forbes, J. M., Pollock, C. A., & Mather, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054442 · Cited by 281
Hansell, P., Welch, W. J., Blantz, R. C., & Palm, F. (2013) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12034 · Cited by 269
Haemodynamic influences on kidney oxygenation: Clinical implications of integrative physiology
Evans, R. G., İnce, C., Joles, J. A., Smith, D. W., May, C. N., O'Connor, P. M., & Gardiner, B. S. (2012) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12031 · Cited by 249
O’Neill, J., Fasching, A., Pihl, L., Patinha, D., Franzén, S., & Palm, F. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00689.2014 · Cited by 234
SGLT2 Inhibition in the Diabetic Kidney—From Mechanisms to Clinical Outcome
van Bommel, E. J. M., Muskiet, M. H. A., Tonneijck, L., Kramer, M. H. H., Nieuwdorp, M., & van Raalte, D. H. (2017) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.06080616 · Cited by 226
Renal diffusion and BOLD MRI in experimental diabetic nephropathy
Ries, M. G., Basseau, F., Tyndal, B., Jones, R., Deminière, C., Catargi, B., Combe, C., MOONEN, C. T. W., & Grenier, N. (2002) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.10224 · Cited by 224
Nephron pO2 and renal oxygen usage in the hypertensive rat kidney
Welch, W. J., Baumgärtl, H., Lübbers, D. W., & Wilcox, C. S. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00483.x · Cited by 213
Adaptation to hypoxia in the diabetic rat kidney
Rosenberger, C., Khamaisi, M., Abassi, Z. A., Shilo, V., Weksler‐Zangen, S., Goldfarb, M., Shina, A., Zibertrest, F., Eckardt, K., Rosen, S., et al. (2007) · Kidney International · doi:10.1038/sj.ki.5002567 · Cited by 208
Zhang, Y., Nakano, D., Guan, Y., Hitomi, H., Uemura, A., Masaki, T., Kobara, H., Sugaya, T., & Nishiyama, A. (2018) · Kidney International · doi:10.1016/j.kint.2018.05.002 · Cited by 203
Mechanisms of Disease: the hypoxic tubular hypothesis of diabetic nephropathy
Singh, D. K., Winocour, P. H., & Farrington, K. (2008) · Nature Reviews Nephrology · doi:10.1038/ncpneph0757 · Cited by 202
Transdifferentiation of cultured tubular cells induced by hypoxia
Manotham, K., Tanaka, T., Matsumoto, M., Ohse, T., Inagi, R., Miyata, T., Kurokawa, K., Fujita, T., Ingelfinger, J. R., & Nangaku, M. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00461.x · Cited by 202
Pruijm, M., Milani, B., Pivin, E., Podhajska, A., Vogt, B., Stuber, M., & Burnier, M. (2018) · Kidney International · doi:10.1016/j.kint.2017.10.020 · Cited by 200
Increased renal metabolism in diabetes. Mechanism and functional implications
Körner, A., Eklöf, A.-C., Celsi, G., & Aperia, A. (1994) · Diabetes · doi:10.2337/diab.43.5.629 · Cited by 185
Activation of Hypoxia-Inducible Factors Prevents Diabetic Nephropathy
Nordquist, L., Friederich‐Persson, M., Fasching, A., Liss, P., Shoji, K., Nangaku, M., Hansell, P., & Palm, F. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013090990 · Cited by 185
SGLT2 inhibition and kidney protection
Nespoux, J., & Vallon, V. (2018) · Clinical Science · doi:10.1042/cs20171298 · Cited by 182
Self-citationChin, M. P., Bakris, G. L., Block, G. A., Chertow, G. M., Goldsberry, A., Inker, L. A., Heerspink, H. J. L., O’Grady, M. L., Pérgola, P. E., Wanner, C., et al. (2018) · American Journal of Nephrology · doi:10.1159/000486398 · Cited by 167
The VHL/HIF oxygen-sensing pathway and its relevance to kidney disease
Haase, V. H. (2006) · Kidney International · doi:10.1038/sj.ki.5000221 · Cited by 166
Tanaka, S., Sugiura, Y., Saito, H., Sugahara, M., Higashijima, Y., Yamaguchi, J., Inagi, R., Suematsu, M., Nangaku, M., & Tanaka, T. (2018) · Kidney International · doi:10.1016/j.kint.2018.04.025 · Cited by 166
Pedersen, M., Dissing, T. H., Merkenborg, J., Stødkilde‐Jørgensen, H., Hansen, L. H., Pedersen, L. B., Grenier, N., & Frekiaer, J. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00334.x · Cited by 165
Bessho, R., Takiyama, Y., Takiyama, T., Kitsunai, H., Takeda, Y., Sakagami, H., & Ota, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-51343-1 · Cited by 165
Chin, M. P., Wrolstad, D., Bakris, G. L., Chertow, G. M., de Zeeuw, D., Goldsberry, A., Linde, P. G., McCullough, P. A., McMurray, J. J. V., Wittes, J. T., et al. (2014) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2014.10.001 · Cited by 164
Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes
Sedeek, M. H., Gutsol, A. A., Montezano, A. C. I., Burger, D. E., Cat, A. N. D., Kennedy, C., Burns, K. D., Cooper, M. E., Jandeleit-Dahm, K. A. M., Page, P., et al. (2012) · Clinical Science · doi:10.1042/cs20120330 · Cited by 164
INTRARENAL OXYGENATION IN CHRONIC RENAL FAILURE
Norman, J. T., & Fine, L. G. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04476.x · Cited by 145
Pruijm, M. T., Mendichovszky, I. A., Liss, P., der Niepen, P. V., Textor, S. C., Lerman, L. O., Krediet, C. T. P., Caroli, A., Burnier, M., & Prasad, P. V. (2018) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfy243 · Cited by 144
Self-citationGallo, L. A., Ward, M. S., Fotheringham, A. K., Zhuang, A., Borg, D. J., Flemming, N., Harvie, B. M., Kinneally, T. L., Yeh, S.-M., McCarthy, D. A., et al. (2016) · Scientific Reports · doi:10.1038/srep26428 · Cited by 143
Self-citationModeling oxygen consumption in the proximal tubule: effects of NHE and SGLT2 inhibition
Layton, A. T., Vallon, V., & Edwards, A. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00007.2015 · Cited by 142
Self-citationEffects of furosemide on medullary oxygenation in younger and older subjects
Epstein, F. H., & Prasad, P. V. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00057.x · Cited by 141
Self-citationLayton, A. T., Vallon, V., & Edwards, A. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00543.2015 · Cited by 141
Self-citationNoninvasive evaluation of renal oxygenation in diabetic nephropathy by BOLD-MRI
Yin, W.-J., Liu, F., Li, X.-M., Yang, L., Zhao, S., Huang, Z.-X., Huang, Y.-Q., & Liu, R.-B. (2012) · European Journal of Radiology · doi:10.1016/j.ejrad.2011.03.045 · Cited by 136
Mechanisms underlying the differential control of blood flow in the renal medulla and cortex
Evans, R. G., Eppel, G. A., Anderson, W. P., et al. (2004) · Journal of Hypertension · doi:10.1097/01.hjh.0000133744.85490.9d · Cited by 132
Layton, A. T., & Vallon, V. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00551.2017 · Cited by 132
Self-citationdos Santos, E. A., Li, L., Ji, L., & Prasad, P. V. (2007) · Investigative Radiology · doi:10.1097/01.rli.0000252492.96709.36 · Cited by 124
Self-citationMiyamoto, S., Hsu, C., Hamm, G. R., Darshi, M., Diamond-Stanic, M. K., Declèves, A., Slater, L., Pennathur, S., Stauber, J., Dorrestein, P. C., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.03.033 · Cited by 123
Hypoxia, HIF, and Associated Signaling Networks in Chronic Kidney Disease
Liu, J., Wei, Q., Guo, C., Dong, G., Liu, Y., Tang, C., & Dong, Z. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18050950 · Cited by 118
BOLD-MRI for the assessment of renal oxygenation in humans: Acute effect of nephrotoxic xenobiotics
Hofmann, L., Simon‐Zoula, S. C., Nowak, A., Giger, A., Vock, P., Boesch, C., Frey, F. J., & Vogt, B. (2006) · Kidney International · doi:10.1038/sj.ki.5000418 · Cited by 112
Friederich, M., Fasching, A., Hansell, P., Nordquist, L., & Palm, F. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.03.030 · Cited by 111
Wang, C., Li, L., Liu, S., Liao, G., Li, L., Chen, Y., Cheng, J., Lu, Y., & Liu, J. (2018) · PLOS ONE · doi:10.1371/journal.pone.0193473 · Cited by 110
Leong, C.-L., Anderson, W. P., O'Connor, P. M., & Evans, R. G. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00436.2006 · Cited by 108
Mitochondria–Power Players in Kidney Function?
Forbes, J. M. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.05.002 · Cited by 106
Podocyte protection by darbepoetin: preservation of the cytoskeleton and nephrin expression
Eto, N., Wada, T., Inagi, R., et al. (2007) · Kidney International · doi:10.1038/sj.ki.5002311 · Cited by 103
Milani, B., Ansaloni, A., Sousa-Guimaraes, S., Vakilzadeh, N., Piskunowicz, M., Vogt, B., Stuber, M., Burnier, M., & Pruijm, M. T. (2016) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfw362 · Cited by 100
Targeting Mitochondria and Reactive Oxygen Species-Driven Pathogenesis in Diabetic Nephropathy
Lindblom, R. S. J., Higgins, G. C., Coughlan, M. T., & de Haan, J. B. (2015) · The Review of Diabetic Studies · doi:10.1900/rds.2015.12.134 · Cited by 99
Arterial spin labeling MRI is able to detect early hemodynamic changes in diabetic nephropathy
Mora‐Gutiérrez, J. M., Garcı́a-Fernández, N., Roblero, M. F. S., Páramo, J. A., Escalada, J., Wang, D. J. J., Benito, A., & Fernández‐Seara, M. A. (2017) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.25717 · Cited by 98
Pruijm, M. T., Hofmann, L., Piskunowicz, M., Muller, M.-E., Zweiacker, C., Bassi, I., Vogt, B., Stuber, M., & Burnier, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095895 · Cited by 97
Lipotoxicity in Diabetic Nephropathy
Murea, M., Freedman, B. I., Parks, J. S., Antinozzi, P. A., Elbein, S. C., & Ma, L. (2010) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.08160910 · Cited by 89
Li, L., Tan, H., Thacker, J., et al. (2016) · Kidney International Reports · doi:10.1016/j.ekir.2016.09.003 · Cited by 88
Self-citationRenal oxygenation in clinical acute kidney injury
Ricksten, S., Bragadottir, G., & Redfors, B. (2013) · Critical Care · doi:10.1186/cc12530 · Cited by 87
Renal hemodynamics and plasma and kidney angiotensin II in established diabetes mellitus in rats
Vallon, V., Wead, L. M., & Blantz, R. C. (1995) · Journal of the American Society of Nephrology · doi:10.1681/asn.v5101761 · Cited by 86
Self-citationTubular Hypermetabolism as a Factor in the Progression of Chronic Renal Failure
Schrier, R. W., Harris, D. C. H., Chan, L. K., et al. (1988) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(88)80130-6 · Cited by 84
Hypoxia-Induced Changes in Extracellular Matrix Metabolism in Renal Cells
Norman, J. T., Orphanides, C., Garcia, P., & Fine, L. G. (1999) · Nephron Experimental Nephrology · doi:10.1159/000020625 · Cited by 82
Factors that render the kidney susceptible to tissue hypoxia in hypoxemia
Evans, R. G., Goddard, D., Eppel, G. A., & O'Connor, P. M. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00552.2010 · Cited by 79
Understanding EMPA-REG OUTCOME
Muskiet, M. H. A., van Raalte, D. H., van Bommel, E. J. M., Smits, M. M., & Tonneijck, L. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00424-6 · Cited by 79
Bragadottir, G., Redfors, B., Nygren, A., Sellgren, J., & Ricksten, S.-E. (2009) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2009.02037.x · Cited by 78
Li, H., Satriano, J. A., Thomas, J. L., Miyamoto, S., Sharma, K., Pastor‐Soler, N. M., Hallows, K. R., & Singh, P. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00463.2014 · Cited by 78
Direct Activation of ENaC by Angiotensin II: Recent Advances and New Insights
Zaika, O., Mamenko, M., Staruschenko, A., & Pochynyuk, O. M. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0316-1 · Cited by 77
How Do Kidneys Adapt to a Deficit or Loss in Nephron Number?
Fattah, H., Layton, A. T., & Vallon, V. (2019) · Physiology · doi:10.1152/physiol.00052.2018 · Cited by 74
Self-citationEffect of Sodium Loading/Depletion on Renal Oxygenation in Young Normotensive and Hypertensive Men
Pruijm, M. T., Hofmann, L., Maillard, M. P., Tremblay, S., Glatz, N., Wuerzner, G., Burnier, M., & Vogt, B. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.149682 · Cited by 74
Vasopressin regulation of sodium transport in the distal nephron and collecting duct
Kortenoeven, M. L. A., Pedersen, N. B., Rosenbæk, L. L., & Fenton, R. A. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00093.2015 · Cited by 73
Cherney, D. Z. I., Miller, J., Scholey, J. W., Nasrallah, R., Hébert, R., Dekker, M. G., Slorach, C., Sochett, E. B., & Bradley, T. J. (2010) · Diabetes Care · doi:10.2337/dc09-2340 · Cited by 72
Multi-Parametric Evaluation of Chronic Kidney Disease by MRI: A Preliminary Cross-Sectional Study
Prasad, P. V., Thacker, J., Li, L.-P., Haque, M. E., Li, W., Koenigs, H., Zhou, Y., & Sprague, S. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139661 · Cited by 72
Self-citationRole of Renal Oxygenation and Mitochondrial Function in the Pathophysiology of Acute Kidney Injury
Nourbakhsh, N., & Singh, P. (2014) · Nephron Clinical Practice · doi:10.1159/000363545 · Cited by 67
Mitochondrial Reactive Oxygen Species and Kidney Hypoxia in the Development of Diabetic Nephropathy
Schiffer, T. A., & Friederich‐Persson, M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00211 · Cited by 66
Zhang, J. L., Morrell, G., Rusinek, H., Warner, L., Vivier, P.-H., Cheung, A. K., Lerman, L. O., & Lee, V. S. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00575.2013 · Cited by 63
Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation
Fujiki, T., Ando, F., Murakami, K., Isobe, K., Mori, T., Susa, K., Nomura, N., Sohara, E., Rai, T., & Uchida, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-45539-8 · Cited by 63
Diffusion of oxygen from arterial to venous segments of renal capillaries
Levy, M. N., & Sauceda, G. (1959) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1959.196.6.1336 · Cited by 63
Nrf2 activator for the treatment of kidney diseases
Yamawaki, K., Kanda, H., & Shimazaki, R. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.09.030 · Cited by 62
Sugiyama, K., Inoue, T., Kozawa, E., Ishikawa, M., Shimada, A., Kobayashi, N., Tanaka, J., & Okada, H. (2018) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfy324 · Cited by 62
Cree‐Green, M., Gupta, A., Coe, G. V., Baumgartner, A., Pyle, L. L., Reusch, J. E. B., Brown, M. S., Newcomer, B. R., & Nadeau, K. J. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.10.014 · Cited by 57
Renin-angiotensin-aldosterone system activation in long-standing type 1 diabetes
Lovshin, J. A., Boulet, G., Lytvyn, Y., Lovblom, L. E., Bjornstad, P., Farooqi, M. A., LAI, V. S., Cham, L., TSE, J. M., Orszag, A., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.96968 · Cited by 57
Self-citationPronounced kidney hypoxia precedes albuminuria in type 1 diabetic mice
Franzén, S., Pihl, L., Khan, N. I., Gustafsson, H., & Palm, F. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00049.2016 · Cited by 56
Prasad, P. V., Li, L., Thacker, J., Li, W., Hack, B. K., Kohn, O. F., & Sprague, S. M. (2019) · American Journal of Nephrology · doi:10.1159/000496161 · Cited by 49
Self-citationLi, L., Lin, J., SANTOS, E. A. D., Dunkle, E. E., Pierchala, L., & Prasad, P. V. (2009) · Investigative Radiology · doi:10.1097/rli.0b013e3181900975 · Cited by 48
Self-citationHaddock, B., Larsson, H. B. W., Francis, S., & Andersen, U. B. (2019) · Acta Physiologica · doi:10.1111/apha.13292 · Cited by 46
Renal tubular Na(+)-K(+)-ATPase in diabetes mellitus: relationship to metabolic abnormality
Wald, H., Scherzer, P., Rasch, R., & Popovtzer, M. M. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.1.e96 · Cited by 46
Bjornstad, P., Maahs, D. M., Jensen, T., et al. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.04.012 · Cited by 42
Self-citationModeling glucose metabolism and lactate production in the kidney
Chen, Y., Fry, B. C., & Layton, A. T. (2017) · Mathematical Biosciences · doi:10.1016/j.mbs.2017.04.008 · Cited by 36
Renal Hypoxia: An Important Prognostic Marker in Patients with Chronic Kidney Disease
Zhou, H., Yang, M., Jiang, Z., Ding, J., Di, J., & Cui, L. (2018) · American Journal of Nephrology · doi:10.1159/000491551 · Cited by 33
Intrarenal red cell and plasma volumes in the non-diuretic rat
Rasmussen, S. N. (1973) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00593250 · Cited by 31
Manotham, K., Ongvilawan, B., Urusopone, P., Chetsurakarn, S., Tanamai, J., Limkuansuwan, P., Tungsanga, K., & Eiam‐Ong, S. (2011) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2011.02610.x · Cited by 29
Hypoxia and hypoxia-inducible factors in chronic kidney disease
Tanaka, S., Tanaka, T., & Nangaku, M. (2016) · Renal Replacement Therapy · doi:10.1186/s41100-016-0038-y · Cited by 28
Chen, F., Li, S., & Sun, D. (2018) · Kidney & Blood Pressure Research · doi:10.1159/000488072 · Cited by 25
Sällström, J., Eriksson, T., Fredholm, B. B., Persson, A. E. G., & Palm, F. (2013) · Acta Physiologica · doi:10.1111/apha.12152 · Cited by 23
Prasad, P. V. (2018) · Kidney International · doi:10.1016/j.kint.2017.11.029 · Cited by 23
Self-citationEndogenous vasopressin regulates Na-K-ATPase and Na+-K+-Cl−cotransporterrbsc-1in rat outer medulla
Bertuccio, C. A., Ibarra, F. R., Toledo, J. E., et al. (2002) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00354.2000 · Cited by 21
Pohlmann, A., Cantow, K., Huelnhagen, T., et al. (2017) · Tomography · doi:10.18383/j.tom.2017.00012 · Cited by 18
Blot‐Chabaud, M., Djelidi, S., Coutry, N., et al. (2001) · PubMed · Cited by 17
Jensen, T., Bjornstad, P., Johnson, R. J., Sippl, R., Rewers, M., & Snell‐Bergeon, J. K. (2018) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2018.03.006 · Cited by 17
Self-citationMuller, M.-E., Pruijm, M. T., Bonny, O., Burnier, M., & Zanchi, A. (2018) · Advances in Therapy · doi:10.1007/s12325-018-0708-y · Cited by 16
Aizawa, K., Takeda, S., Tashiro, Y., et al. (2012) · American Journal of Nephrology · doi:10.1159/000343493 · Cited by 15
Bjornstad, P., Johnson, R. J., Snell‐Bergeon, J. K., Pyle, L., Davis, A. K., Foster, N. C., Cherney, D. Z. I., & Maahs, D. M. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.11.015 · Cited by 15
Self-citationSerizawa, K., Yogo, K., Tashiro, Y., Aizawa, K., Kawasaki, R., Hirata, M., & Endo, K. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.09.034 · Cited by 13
Cited by
Sorted by citations
Diabetic vascular diseases: molecular mechanisms and therapeutic strategies
Li, Y., Liu, Y., Liu, S., Gao, M., Wang, W., Chen, K., Huang, L., & Liu, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01400-z · Cited by 799
Chronic Inflammation in Chronic Kidney Disease Progression: Role of Nrf2
Stenvinkel, P., Chertow, G. M., Devarajan, P., Levin, A., Andreoli, S. P., Bangalore, S., & Warady, B. A. (2021) · Kidney International Reports · doi:10.1016/j.ekir.2021.04.023 · Cited by 327
Diabetes mellitus—Progress and opportunities in the evolving epidemic
Abel, E. D., Gloyn, A. L., Evans‐Molina, C., Joseph, J. J., Misra, S., Pajvani, U. B., Simcox, J., Suszták, K., & Drucker, D. J. (2024) · Cell · doi:10.1016/j.cell.2024.06.029 · Cited by 350
An Overview of the Cardiorenal Protective Mechanisms of SGLT2 Inhibitors
Salvatore, T., Galiero, R., Caturano, A., Rinaldi, L., Martino, A. D., Albanese, G., Salvo, J. D., Epifani, R., Marfella, R., Docimo, G., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073651 · Cited by 279
Inflammation and Oxidative Stress in Chronic Kidney Disease and Dialysis Patients
Ebert, T., Neytchev, O., Witasp, A., Kublickiene, K. R., Stenvinkel, P., & Shiels, P. G. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8184 · Cited by 197
Metadata
- Authors
- Hesp, A. C., Schaub, J. A., Prasad, P. V., Vallon, V., Laverman, G. D., Bjornstad, P., & van Raalte, D. H.
- Affiliations
- Amsterdam University Medical Centers (NL)
- University of Michigan (US)
- Endeavor Health (US)
- University of California San Diego (US)
- Ziekenhuis Groep Twente (NL)
- University of Colorado Anschutz (US)
- Corresponding author
- Hesp, Anne C.
- ORCID
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 98
- Issue
- 3
- Pages
- 579-589
- ISSN
- 0085-2538 (ISSN-L)
- PMC
- PMC8397597
- OpenAlex
- W3020088156
- Cited by
- 202
- References
- 120
- Citations by year
- 2026: 30 · 2025: 34 · 2024: 25 · 2023: 38 · 2022: 40 · 2021: 32 · 2020: 3
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK106557)
- National Institutes of Health (R01DK112042, R01DK106102, R01HL142814, RF1AG061296)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- diabetic nephropathy, renal hypoxia, oxygen delivery, oxygen requirement, sodium-glucose cotransporter 2 inhibition, SGLT2 inhibitors, renal perfusion, glomerular hyperfiltration, sodium reabsorption, renal fibrosis, extracellular matrix deposition, BOLD MRI, renal protection, end-stage renal disease
- MeSH terms
- Sodium-Glucose Transporter 2 Inhibitors, Animals, Hypoxia, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Humans, Hyperglycemia, Hypoglycemic Agents, Kidney
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
