Mitochondria are impaired in the adipocytes of type 2 diabetic mice.
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Aims/hypothesis The aim of this study was to confirm a link between mitochondrial dysfunction and type 2 diabetes.Materials and methods Cellular levels of mitochondrial proteins, cellular mitochondrial DNA content, and mitochondrial function and morphology were assessed by MitoTracker staining and electron microscopy, in white adipose tissue of 12-week-old male wild-type, obese (ob/ob), and diabetic (db/db) mice.Results Levels of mitochondrial proteins were found to be very similar in the livers and muscles of all the mice studied. However, levels were greatly decreased in the adipocytes of db/db mice, but not in those of the wild-type and ob/ob mice. Levels of mitochondrial DNA were also found to be considerably reduced in the adipocytes of db/db mice. MitoTracker staining and under electron microscopy revealed that the number of mitochondria was reduced in adipocytes of db/db mice. Respiration and fatty acid oxidation studies indicated mitochondrial dysfunction in adipocytes of db/db mice. Interestingly, there was an increase in mitochondria and mitochondrial protein production in adipocytes of db/db mice treated with rosiglitazone, an agent that enhances insulin sensitivity.Conclusions/interpretation Taken together, these data indicate that mitochondrial loss in adipose tissue is correlated with the development of type 2 diabetes.
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Mitochondrial function (respiration, fatty acid oxidation) is decreased in db/db mice.
“Mitochondrial function, as indicated by respiration and fatty acid oxidation, were reported to be decreased in db/db mice, a leptin receptor–deficient obese model of type 2 diabetes (61).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [61]
White adipocyte mitochondrial content is decreased in both rodent and human obesity and correlates with insulin resistance that accompanies obesity.
“White adipocyte mitochondrial content is decreased in both rodent and human obesity (177, 188 -191) and correlates with insulin resistance that accompanies obesity.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [188]
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Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238 · see citing works
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139 · see citing works
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630 · see citing works
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546 · see citing works
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321 · see citing works
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193 · see citing works
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107 · see citing works
PPARs and the complex journey to obesity
Evans, R. M., Barish, G. D., & Wang, Y.-X. (2004) · Nature Medicine · doi:10.1038/nm1025 · Cited by 1,621 · see citing works
Ahima, R. S., & Flier, J. S. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.413 · Cited by 1,428 · see citing works
Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis
Lehman, J. J., Barger, P. M., Kovacs, A., Saffitz, J. E., Medeiros, D. M., & Kelly, D. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10268 · Cited by 1,285 · see citing works
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
Abel, E. D., Peroni, O. D., Kim, J. K., Kim, Y., Boss, O., Hadro, E., Minnemann, T., Shulman, G. I., & Kahn, B. B. (2001) · Nature · doi:10.1038/35055575 · Cited by 1,253 · see citing works
Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice
Lin, J., Wu, P.-H., Tarr, P. T., Lindenberg, K. S., St-Pierre, J., Zhang, C.-Y., Mootha, V. K., Jäger, S., Vianna, C. R., Reznick, R. M., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.013 · Cited by 1,162 · see citing works
New drug targets for type 2 diabetes and the metabolic syndrome
Moller, D. E. (2001) · Nature · doi:10.1038/414821a · Cited by 1,009 · see citing works
Increased Risk of Type 2 Diabetes in Alzheimer Disease
Janson, J., Laedtke, T., Parisi, J. E., O’Brien, P., Petersen, R. C., & Butler, P. C. (2004) · Diabetes · doi:10.2337/diabetes.53.2.474 · Cited by 950 · see citing works
Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes
Ritov, V. B., Menshikova, E. V., He, J., Ferrell, R. E., Goodpaster, B. H., & Kelley, D. E. (2005) · Diabetes · doi:10.2337/diabetes.54.1.8 · Cited by 887 · see citing works
Regulation of Fasted Blood Glucose by Resistin
Banerjee, R. R., Rangwala, S. M., Shapiro, J. S., Rich, A. S., Rhoades, B., Qi, Y., Wang, J., Rajala, M. W., Pocai, A., Scherer, P. E., et al. (2004) · Science · doi:10.1126/science.1092341 · Cited by 727 · see citing works
Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.
Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M. A., Chui, P. C., Leszyk, J., Straubhaar, J., Czech, M. P., & Corvera, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21752 · Cited by 616 · see citing works
Regulation of adipocytokines and insulin resistance
Faßhauer, M., & Paschke, R. (2003) · Diabetologia · doi:10.1007/s00125-003-1228-z · Cited by 543 · see citing works
Wilson-Fritch, L., Burkart, A., Bell, G., Mendelson, K., Leszyk, J., Nicoloro, S., Czech, M., & Corvera, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.1085-1094.2003 · Cited by 459 · see citing works
Oxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes
Schrauwen, P., & Hesselink, M. K. C. (2004) · Diabetes · doi:10.2337/diabetes.53.6.1412 · Cited by 408 · see citing works
Højlund, K., Wrzesinski, K., Larsen, P. M., Fey, S. J., Roepstorff, P., Handberg, A., Dela, F., Vinten, J., McCormack, J. G., Reynet, C., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212881200 · Cited by 221 · see citing works
Antonická, H., Ogilvie, I. M., Taivassalo, T., Anitori, R. P., Haller, R. G., Vissing, J., Kennaway, N. G., & Shoubridge, E. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304998200 · Cited by 174 · see citing works
Unraveling the Causes of Diabetes
Marx, J. L. (2002) · Science · doi:10.1126/science.296.5568.686 · Cited by 161 · see citing works
Extracellular ATP is generated by ATP synthase complex in adipocyte lipid rafts.
Kim, B.-W., Choo, H.-J., Lee, J.-W., Kim, J.-H., & Ko, Y.-G. (2004) · Experimental & Molecular Medicine · doi:10.1038/emm.2004.60 · Cited by 128 · cited 1× · see citing works
“Indeed, mitochondria are generated at very high levels when preadipocyte 3T3-L1 cells are differentiated into adipocytes [18, 19].”
BackgroundGenetic dissection of ``OLETF'', a rat model for non-insulin-dependent diabetes mellitus
Kanemoto, N., Hishigaki, H., Mizoguchi‐Miyakita, A., Oga, K., Okuno, S., Tsuji, A. B., Takagi, T., Takahashi, E.-I., Nakamura, Y., & Watanabe, T. (1998) · Mammalian Genome · doi:10.1007/s003359900789 · Cited by 82 · see citing works
Role of Leptin in Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Expression1
Kakuma, T., Wang, Z.-W., Pan, W., Unger, R. H., & Zhou, Y.-T. (2000) · Endocrinology · doi:10.1210/endo.141.12.7804 · Cited by 76 · see citing works
Causation of Type 2 Diabetes — The Gordian Knot Unravels
Taylor, R. (2004) · New England Journal of Medicine · doi:10.1056/nejmp038239 · Cited by 53 · see citing works
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Bhatti, J. S., Bhatti, G. K., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.010 · Cited by 1,655 · see citing works
Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
Zatterale, F., Longo, M., Naderi, J., Raciti, G. A., Desiderio, A., Miele, C., & Beguinot, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01607 · Cited by 1,180 · see citing works
Bonnard, C., Durand, A., Peyrol, S., Chanseaume, E., Chauvin, M.-A., Morio, B., Vidal, H., & Rieusset, J. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32601 · Cited by 819 · see citing works
Sivitz, W. I., & Yorek, M. A. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2531 · Cited by 742 · see citing works
Targeting adipose tissue in the treatment of obesity-associated diabetes
Kusminski, C. M., Bickel, P. E., & Scherer, P. E. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.75 · Cited by 678 · see citing works
PGC-1 α , Inflammation, and Oxidative Stress: An Integrative View in Metabolism
Rius‐Pérez, S., Torres-Cuevas, I., Millán, I., Ortega, Á., & Pérez, S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1452696 · Cited by 648 · see citing works
Transcriptional Control of Mitochondrial Biogenesis and Function
Hock, M. B., & Kralli, A. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163119 · Cited by 616 · see citing works
Adipokines as novel biomarkers and regulators of the metabolic syndrome
Deng, Y., & Scherer, P. E. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05875.x · Cited by 558 · see citing works
The role of mitochondria in the pathogenesis of type 2 diabetes
Patti, M.-E., & Corvera, S. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0027 · Cited by 551 · see citing works
The cell biology of fat expansion
Rutkowski, J. M., Stern, J. H., & Scherer, P. E. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201409063 · Cited by 541 · see citing works
Mitochondrial dysfunction in type 2 diabetes mellitus: an organ-based analysis
Pinti, M. V., Fink, G. K., Hathaway, Q. A., Durr, A. J., Kunovac, A., & Hollander, J. M. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00314.2018 · Cited by 432 · see citing works
Mitochondria and ageing: Role in heart, skeletal muscle and adipose tissue
Boengler, K., Kosiol, M., Mayr, M., Schulz, R., & Rohrbach, S. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12178 · Cited by 421 · see citing works
Metabolic adaptation and maladaptation in adipose tissue
Chouchani, E. T., & Kajimura, S. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0021-8 · Cited by 383 · see citing works
Mitochondrial dysfunction in white adipose tissue
Kusminski, C. M., & Scherer, P. E. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.06.004 · Cited by 368 · see citing works
The Physiology of Obese-Hyperglycemic Mice [ob/obMice]
Lindström, P. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.117 · Cited by 353 · see citing works
Lu, Q., Zhu, Y., Deng, C., Liang, Z., Chen, J., Chen, Y., Wang, X., Liu, Y., Tian, Y., & Yang, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01756-w · Cited by 360 · see citing works
Rong, J. X., Qiu, Y., Hansen, M. K., Zhu, L., Zhang, V., Xie, M., Okamoto, Y., Mattie, M. D., Higashiyama, H., Asano, S., et al. (2007) · Diabetes · doi:10.2337/db06-1135 · Cited by 335 · see citing works
Pietiläinen, K. H., Naukkarinen, J., Rissanen, A., Saharinen, J., Ellonen, P., Keränen, H., Suomalainen, A., Götz, A., Suortti, T., Yki‐Järvinen, H., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050051 · Cited by 299 · see citing works
Development of insulin resistance in mice lacking PGC-1α in adipose tissues
Kleiner, S., Mepani, R. J., Laznik, D., Li, Y., Jurczak, M. J., Jornayvaz, F. R., Estall, J. L., Bhowmick, D. C., Shulman, G. I., & Spiegelman, B. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207287109 · Cited by 286 · see citing works
Flachs, P., Rossmeisl, M., Bryhn, M., & Kopecký, J. (2008) · Clinical Science · doi:10.1042/cs20070456 · Cited by 284 · see citing works
Lee, J. H., Park, A., Oh, K., Lee, S. C., Kim, W. K., & Bae, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194924 · Cited by 270 · see citing works
Essential role of mitochondrial function in adiponectin synthesis in adipocytes
Koh, E. H., Park, J.-Y., Park, H.-S., Jeon, M. J., Ryu, J. W., Kim, M., Kim, S. Y., Kim, M.-S., Kim, S.-W., Park, I. S., et al. (2007) · Diabetes · doi:10.2337/db07-0510 · Cited by 275 · see citing works
Vernochet, C., Mourier, A., Bezy, O., Macotela, Y., Boucher, J., Rardin, M. J., An, D., Lee, K. Y., Ilkayeva, O. R., Zingaretti, C. M., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.016 · Cited by 245 · see citing works
White adipose tissue mitochondrial metabolism in health and in obesity
Heinonen, S., Jokinen, R., Rissanen, A., & Pietiläinen, K. H. (2019) · Obesity Reviews · doi:10.1111/obr.12958 · Cited by 243 · see citing works
Yang, J., Chi, Y., Burkhardt, B. R., Guan, Y., & Wolf, B. A. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00282.x · Cited by 235 · see citing works
The Vitamin Nicotinamide: Translating Nutrition into Clinical Care
Maiese, K., Chong, Z. Z., Hou, J., & Shang, Y. C. (2009) · Molecules · doi:10.3390/molecules14093446 · Cited by 240 · see citing works
Lepretti, M., Martucciello, S., Burgos Aceves, M., Putti, R., & Lionetti, L. (2018) · Nutrients · doi:10.3390/nu10030350 · Cited by 232 · see citing works
Xu, Z., Xu, X., Zhong, M., Hotchkiss, I. P., Lewandowski, R. P., Wagner, J. G., Bramble, L. A., Yang, Y., Wang, A., Harkema, J. R., et al. (2011) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-8-20 · Cited by 230 · see citing works
New Insights for Oxidative Stress and Diabetes Mellitus
Maiese, K. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/875961 · Cited by 227 · see citing works
Defective Mitochondrial Biogenesis
Nisoli, E., Clementi, E., Carruba, M. O., & Moncada, S. (2007) · Circulation Research · doi:10.1161/01.res.0000259591.97107.6c · Cited by 224 · see citing works
Goto, T., Lee, J., Teraminami, A., Kim, Y., Hirai, S., Uemura, T., Inoue, H., Takahashi, N., & Kawada, T. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m011320 · Cited by 219 · see citing works
Oxidative Stress Biology and Cell Injury During Type 1 and Type 2 Diabetes Mellitus
Maiese, K., Morhan, S. D., & Chong, Z. Z. (2007) · Current Neurovascular Research · doi:10.2174/156720207779940653 · Cited by 213 · see citing works
Gao, C., Zhu, C., Zhao, Y., Chen, X.-H., Ji, C., Zhang, C., Zhu, J., Xia, Z., Tong, M., & Guo, X. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.01.039 · Cited by 203 · see citing works
Hesp, A. C., Schaub, J. A., Prasad, P. V., Vallon, V., Laverman, G. D., Bjornstad, P., & van Raalte, D. H. (2020) · Kidney International · doi:10.1016/j.kint.2020.02.041 · Cited by 202 · see citing works
Exercise and adrenaline increase PGC‐1α mRNA expression in rat adipose tissue
Sutherland, L., Bomhof, M. R., Capozzi, L., Basaraba, S. A. U., & Wright, D. C. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.165464 · Cited by 201 · see citing works
Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome
Bugger, H., & Abel, E. D. (2008) · Clinical Science · doi:10.1042/cs20070166 · Cited by 195 · see citing works
Mechanistic Insights Into Diabetes Mellitus and Oxidative Stress
Maiese, K., Chong, Z. Z., & Shang, Y. C. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707781058968 · Cited by 185 · see citing works
Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes
Hao, J., Shen, W., Yu, G., Jia, H., Li, X., Feng, Z., Wang, Y., Weber, P., Wertz, K., Sharman, E. H., et al. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.03.012 · Cited by 179 · see citing works
Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization
Sears, D. D., Hsiao, G., Hsiao, A., Yu, J., Courtney, C. H., Ofrecio, J. M., Chapman, J., & Subramaniam, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903032106 · Cited by 177 · see citing works
Gealekman, O., Burkart, A., Chouinard, M., Nicoloro, S. M. C., Straubhaar, J., & Corvera, S. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90345.2008 · Cited by 174 · see citing works
Yang, X., Liu, Q., Li, Y., Tang, Q., Wu, T., Chen, L., Pu, S., Zhao, Y., Zhang, G., Huang, C., et al. (2020) · Adipocyte · doi:10.1080/21623945.2020.1807850 · Cited by 178 · see citing works
Metabolic remodeling of white adipose tissue in obesity
Cummins, T. D., Holden, C. R., Sansbury, B. E., Gibb, A., Shah, J., Zafar, N., Tang, Y., Hellmann, J. L., Rai, S. N., Spite, M. R., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00271.2013 · Cited by 169 · see citing works
The Wnt signaling pathway: Aging gracefully as a protectionist?
Maiese, K., Li, F., Chong, Z. Z., & Shang, Y. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.01.004 · Cited by 170 · see citing works
Xia, W., Veeragandham, P., Cao, Y., Xu, Y., Rhyne, T. E., Qian, J., Hung, C.-W., Zhao, P., Jones, Y., Gao, H., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-00978-0 · Cited by 176 · see citing works
Wang, C., Wang, C., Huang, H., & Wei, Y. (2013) · The FEBS Journal · doi:10.1111/febs.12096 · Cited by 165 · see citing works
Zhu, L., Liu, Z., Feng, Z., Hao, J., Shen, W., Li, X., Sun, L., Sharman, E. H., Wang, Y., Wertz, K., et al. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.09.006 · Cited by 165 · see citing works
Is mitochondrial dysfunction a cause of insulin resistance?
Turner, N. A., & Heilbronn, L. K. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.08.001 · Cited by 163 · see citing works
Insulin Resistance and Mitochondrial Dysfunction
González-Franquesa, A., & Patti, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_25 · Cited by 154 · see citing works
Flachs, P., Rossmeisl, M., Kuda, O., & Kopecký, J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.02.003 · Cited by 149 · see citing works
Energy metabolism of white adipose tissue and insulin resistance in humans
Bódis, K. B., & Roden, M. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.13017 · Cited by 147 · see citing works
Sutherland, L. N., Capozzi, L. C., Turchinsky, N. J., Bell, R. C., & Wright, D. C. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90408.2008 · Cited by 147 · see citing works
Mitochondrial function/dysfunction in white adipose tissue
Boudina, S., & Graham, T. E. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.081414 · Cited by 146 · see citing works
Holmström, M. H., Iglesias-Gutierrez, E., Zierath, J. R., & Garcia-Roves, P. M. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00159.2011 · Cited by 137 · see citing works
Oxygenation of adipose tissue: A human perspective
Lempesis, I. G., van Meijel, R. L. J., Manolopoulos, K. N., & Goossens, G. H. (2019) · Acta Physiologica · doi:10.1111/apha.13298 · Cited by 138 · see citing works
Perrone, C. E., Mattocks, D. A. L., Jarvis-Morar, M., Plummer, J. D., & Orentreich, N. (2010) · Metabolism · doi:10.1016/j.metabol.2009.10.023 · Cited by 136 · see citing works
Weight loss is a critical factor to reduce inflammation
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Crosstalk between mitochondrial (dys)function and mitochondrial abundance
Michel, S., Wanet, A., Pauw, A. D., Rommelaere, G., Arnould, T., & Renard, P. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.23021 · Cited by 132 · see citing works
Apelin Attenuates Oxidative Stress in Human Adipocytes
Than, A., Zhang, X., Leow, M. K., Poh, C. L., Chong, S. K., & Chen, P. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.526210 · Cited by 126 · see citing works
Liu, J., Shen, W., Zhao, B., Wang, Y., Wertz, K., Weber, P., & Zhang, P. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.06.007 · Cited by 129 · see citing works
Lipidomics as a Principal Tool for Advancing Biomedical Research
Lam, S. M., & Shui, G. (2013) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2013.06.007 · Cited by 128 · see citing works
Sakamoto, T., Takahashi, N., Sawaragi, Y., Naknukool, S., Yu, R., Goto, T., & Kawada, T. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00312.2012 · Cited by 128 · see citing works
Mitochondrial Dysfunction in Adipocytes as a Primary Cause of Adipose Tissue Inflammation
Woo, C.-Y., Jang, J. E., Lee, S. E., Koh, E. H., & Lee, K. (2019) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2018.0221 · Cited by 126 · see citing works
Ceramides and mitochondrial fatty acid oxidation in obesity
Fucho, R., Casals, N., Serra, D., & Herrero, L. (2016) · The FASEB Journal · doi:10.1096/fj.201601156r · Cited by 124 · see citing works
Succination of Protein Thiols during Adipocyte Maturation
Nagai, R., Brock, J. W. C., Blatnik, M., Baatz, J. E., Bethard, J. R., Walla, M. D., Thorpe, S. R., Baynes, J., & Frizzell, N. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703551200 · Cited by 122 · see citing works
Proinflammatory cytokine interleukin-1β suppresses cold-induced thermogenesis in adipocytes
Goto, T., Naknukool, S., Yoshitake, R., Hanafusa, Y., Tokiwa, S., Li, Y., Sakamoto, T., Nitta, T., Kim, M., Takahashi, N., et al. (2015) · Cytokine · doi:10.1016/j.cyto.2015.11.001 · Cited by 120 · see citing works
Wang, C., Ching-chū, W., & Wei, Y. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05625.x · Cited by 117 · see citing works
Gray, B. R., Steyn, F. J., Davies, P. S. W., & Vitetta, L. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.197 · Cited by 115 · see citing works
The role of mitochondria in the aetiology of insulin resistance and type 2 diabetes
Martin, S. D., & McGee, S. L. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.09.019 · Cited by 112 · see citing works
A “FOXO” in sight: Targeting Foxo proteins from conception to cancer
Maiese, K., Chong, Z. Z., Shang, Y., & Hou, J. (2008) · Medicinal Research Reviews · doi:10.1002/med.20139 · Cited by 112 · see citing works
Erythropoietin: Elucidating new cellular targets that broaden therapeutic strategies
Maiese, K., Chong, Z. Z., Li, F., & Shang, Y. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.02.002 · Cited by 111 · see citing works
Zhou, Z., Moore, T. M., Drew, B. G., Ribas, V., Wanagat, J., Civelek, M., Segawa, M., Wolf, D. M., Norheim, F., Seldin, M. M., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax8096 · Cited by 108 · see citing works
Kobori, M., Takahashi, Y., Sakurai, M., Akimoto, Y., Tsushida, T., Oike, H., & Ippoushi, K. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500595 · Cited by 111 · see citing works
Jokinen, R., Pirnes-Karhu, S., Pietiläinen, K. H., & Pirinen, E. (2017) · Redox Biology · doi:10.1016/j.redox.2017.02.011 · Cited by 103 · see citing works
Shen, W., Liu, K., Tian, C., Yang, L., Li, X., Ren, J., Packer, L., Cotman, C. W., & Liu, J. (2007) · Diabetologia · doi:10.1007/s00125-007-0852-4 · Cited by 102 · see citing works
Succination of Thiol Groups in Adipose Tissue Proteins in Diabetes
Frizzell, N., Rajesh, M. P., Jepson, M. J., Nagai, R., Carson, J. A., Thorpe, S. R., & Baynes, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.019257 · Cited by 99 · see citing works
Ji, C., Chen, X., Gao, C., Jiao, L., Wang, J., Xu, G., Fu, H., Guo, X., & Zhao, Y. (2011) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-011-9361-8 · Cited by 99 · see citing works
Mercader, J., Palou, A., & Bonet, M. L. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.07.007 · Cited by 95 · see citing works
Wang, C., & Wei, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155266 · Cited by 95 · see citing works
Heinonen, S., Muniandy, M., Buzková, J., Mardinoğlu, A., Rodrı́guez, A., Frühbeck, G., Hakkarainen, A., Lundbom, J., Lundbom, N. M. I., Kaprio, J. A., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-4121-2 · Cited by 94 · see citing works
Alam, M. A., & Rahman, M. (2014) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/2251-6581-13-60 · Cited by 92 · see citing works
Leucine in Obesity: Therapeutic Prospects
Yao, K., Duan, Y., Li, F., Tan, B., Hou, Y., Wu, G., & Yin, Y. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.05.004 · Cited by 89 · see citing works
Adipose Tissue Biology and Cardiomyopathy
Turer, A. T., Hill, J. A., Elmquist, J. K., & Scherer, P. E. (2012) · Circulation Research · doi:10.1161/circresaha.111.262493 · Cited by 89 · see citing works
Mitochondrial oxidative injury: a key player in nonalcoholic fatty liver disease
Dornas, W. C., & Schuppan, D. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00121.2020 · Cited by 90 · see citing works
Pardo, R., Enguix, N., Lasheras, J., Felíu, J. E., Kralli, A., & Villena, J. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026989 · Cited by 85 · see citing works
Role of Mitochondrial Complex IV in Age-Dependent Obesity
Soro-Arnáiz, I., Li, Q. O. Y., Torres‐Capelli, M., Meléndez‐Rodríguez, F., Veiga, S. R., Veys, K., Sebastián, D., Elorza, A., Tello, D., Hernansanz‐Agustín, P., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.041 · Cited by 83 · see citing works
Laye, M. J., Rector, R. S., Warner, S. O., Naples, S. P., Perretta, A. L., Uptergrove, G. M., Laughlin, M. H., Thyfault, J. P., Booth, F. W., & Ibdah, J. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.172601 · Cited by 82 · see citing works
Mammalian cardiolipin biosynthesis
Mejia, E. M., Nguyen, H., & Hatch, G. M. (2013) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2013.10.001 · Cited by 82 · see citing works
Maassen, J. A., Romijn, J. A., & Heine, R. J. (2007) · Diabetologia · doi:10.1007/s00125-007-0776-z · Cited by 82 · see citing works
Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR
Maiese, K. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.179032 · Cited by 78 · see citing works
Laye, M. J., Rector, R. S., Borengasser, S. J., Naples, S. P., Uptergrove, G. M., Ibdah, J. A., Booth, F. W., & Thyfault, J. P. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91186.2008 · Cited by 77 · see citing works
Schöttl, T., Kappler, L., Fromme, T., & Klingenspor, M. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.07.001 · Cited by 75 · see citing works
Moreno‐Navarrete, J. M., Ortega, F. J., Moreno, M., Ricart, W., & Fernández‐Real, J. M. (2014) · Diabetologia · doi:10.1007/s00125-014-3298-5 · Cited by 77 · see citing works
Liu, H., Kao, H.-H., & Wu, C.-H. (2019) · Nutrition & Metabolism · doi:10.1186/s12986-019-0349-4 · Cited by 77 · see citing works
Keuper, M., Jastroch, M., Yi, C., Fischer‐Posovszky, P., Wabitsch, M., Tschöp, M. H., & Hofmann, S. M. (2013) · The FASEB Journal · doi:10.1096/fj.13-238725 · Cited by 75 · see citing works
Melatonin promotes adipogenesis and mitochondrial biogenesis in 3T3‐L1 preadipocytes
Kato, H., Tanaka, G., Masuda, S., Ogasawara, J., Sakurai, T., Kizaki, T., Ohno, H., & Izawa, T. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12259 · Cited by 72 · see citing works
Maiese, K. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.01.009 · Cited by 75 · see citing works
Lipodystrophy in HIV 1-infected patients: lessons for obesity research
Villarroya, F., Domingo, P., & Giralt, M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803698 · Cited by 74 · see citing works
Mráček, T., Gao, D., Tzanavari, T., Bao, Y., Xiao, X., Stocker, C. J., Trayhurn, P., & Bing, C. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0299 · Cited by 74 · see citing works
M., M., Chen, J. L., Wang, G. G., Wang, H., Lu, Y., Li, J. F., Yi, J., Yuan, Y. J., Zhang, Q. W., Mi, J., et al. (2007) · Diabetologia · doi:10.1007/s00125-006-0589-5 · Cited by 73 · see citing works
Beaudoin, M., Snook, L. A., Arkell, A. M., Simpson, J. A., Holloway, G. P., & Wright, D. C. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00200.2013 · Cited by 72 · see citing works
- Authors
- Choo, H.-J., Kim, J.-H., Kwon, O.-B., Lee, C. S., Mun, J. Y., Han, S. S., Yoon, Y.-S., Yoon, G., Choi, K.-M., & Ko, Y.-G.
- Affiliations
- Korea University (KR)
- Ajou University (KR)
- Corresponding author
- Ko, Y.-G.
- Venue
- Diabetologia
- Published
- 2006-02-25
- Volume
- 49
- Issue
- 4
- Pages
- 784-791
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2051674591
- Cited by
- 365
- References
- 27
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 17 · 2023: 16 · 2022: 13 · 2021: 14 · 2020: 25 · 2019: 17 · 2018: 14 · 2017: 18 · 2016: 23 · 2015: 20 · 2014: 24 · 2013: 26 · 2012: 19
- FWCI
- 14.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- AJOU Open Repository (Ajou University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- mitochondrial dysfunction, type 2 diabetes, adipocytes, white adipose tissue, mitochondrial DNA, mitochondrial respiration, fatty acid oxidation, rosiglitazone, insulin sensitivity, db/db mice, ob/ob mice, mitochondrial loss
- MeSH terms
- Rosiglitazone, Animals, Diabetes Mellitus, Type 2, DNA, Mitochondrial, Female, Male, Microscopy, Electron, Mitochondria, Adipocytes, Mitochondrial Proteins, Thiazolidinediones, Mice, Rats
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