The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Exosome-based delivery of super-repressor IκBα ameliorates kidney ischemia-reperfusion injury
Open accessAbstract
Ischemia-reperfusion injury is a major cause of acute kidney injury. Recent studies on the pathophysiology of ischemia-reperfusion-induced acute kidney injury showed that immunologic responses significantly affect kidney ischemia-reperfusion injury and repair. Nuclear factor (NF)-ĸB signaling, which controls cytokine production and cell survival, is significantly involved in ischemia-reperfusion-induced acute kidney injury, and its inhibition can ameliorate ischemic acute kidney injury. Using EXPLOR, a novel, optogenetically engineered exosome technology, we successfully delivered the exosomal super-repressor inhibitor of NF-ĸB (Exo-srIĸB) into B6 wild type mice before/after kidney ischemia-reperfusion surgery, and compared outcomes with those of a control exosome (Exo-Naïve)-injected group. Exo-srIĸB treatment resulted in lower levels of serum blood urea nitrogen, creatinine, and neutrophil gelatinase-associated lipocalin in post-ischemic mice than in the Exo-Naïve treatment group. Systemic delivery of Exo-srIĸB decreased NF-ĸB activity in post-ischemic kidneys and reduced apoptosis. Post-ischemic kidneys showed decreased gene expression of pro-inflammatory cytokines and adhesion molecules with Exo-srIĸB treatment as compared with the control. Intravital imaging confirmed the uptake of exosomes in neutrophils and macrophages. Exo-srIĸB treatment also significantly affected post-ischemic kidney immune cell populations, lowering neutrophil, monocyte/macrophage, and T cell frequencies than those in the control. Thus, modulation of NF-ĸB signaling through exosomal delivery can be used as a novel therapeutic method for ischemia-reperfusion-induced acute kidney injury.
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“Compared with the control group, the results confirmed it could improve renal injury significantly by regulating different biological components [99].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [99]
Citations
Cites
Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer
Yamamoto, Y., & Gaynor, R. B. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11914 · Cited by 1,593
Current Mechanistic Concepts in Ischemia and Reperfusion Injury
Wu, M., Yiang, G.-T., Liao, W.-T., Tsai, A. P., Cheng, Y., Cheng, P., Li, C.-Y., & Li, C. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000489241 · Cited by 1,401
Extracellular vesicles for drug delivery.
Vader, P., Mol, E. A., Pasterkamp, G., & Schiffelers, R. M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.02.006 · Cited by 1,319
Wang, C.-Y., Cusack, J. C., Liu, R., & Baldwin, A. S. (1999) · Nature Medicine · doi:10.1038/7410 · Cited by 986
Recent Advances in the Pathophysiology of Ischemic Acute Renal Failure
Bonventre, J. V., & Weinberg, J. M. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000079785.13922.f6 · Cited by 766
Inhibiting NF-κB activation by small molecules as a therapeutic strategy
Gupta, S. C., Sundaram, C., Reuter, S., & Aggarwal, B. B. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.05.004 · Cited by 762
Exosomes in bodily fluids are a highly stable resource of disease biomarkers
Boukouris, S., & Mathivanan, S. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201400114 · Cited by 600
Sanz, A. B., Sánchez-Niño, M. D., Ramos, A. M., Moreno, J. A., Santamaria, B., Ruiz‐Ortega, M., Egido, J., & Ortíz, A. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010020218 · Cited by 581
Yim, N., Ryu, S.-W., Choi, K., Lee, K. R., Lee, S., Choi, H., Kim, J., Shaker, M. R., Sun, W., Park, J.-H., et al. (2016) · Nature Communications · doi:10.1038/ncomms12277 · Cited by 578
Self-citationAdenovirus vectors for gene therapy, vaccination and cancer gene therapy
Wold, W., & Toth, K. (2014) · Current Gene Therapy · doi:10.2174/1566523213666131125095046 · Cited by 555
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Wang, S., Shaukat, A., Al‐Rasheed, M., Tareen, A. M., Arain, M. A., & Luo, C. (2026) · Food Science of Animal Resources · doi:10.1007/s44463-026-00104-6
Metadata
- Authors
- Kim, S., Lee, S. A., Yoon, H., Kim, M. Y., Yoo, J.-K., Ahn, S.-H., Park, C. H., Park, J., Nam, B. Y., Park, J. T., Han, S. H., Kang, S.-W., Kim, N. H., Kim, H. S., Han, D., Yook, J. I., Choi, C., & Yoo, T.-H.
- Affiliations
- Yonsei University (KR)
- Korea Advanced Institute of Science and Technology (KR)
- Corresponding author
- Yook, Jong In
- Choi, Chulhee
- Yoo, Tae-Hyun
- ORCID
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2021-09
- Volume
- 100
- Issue
- 3
- Pages
- 570-584
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W3164860351
- Cited by
- 100
- References
- 52
- Citations by year
- 2026: 15 · 2025: 23 · 2024: 23 · 2023: 27 · 2022: 9 · 2021: 3
- FWCI
- 10.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- National Research Foundation of Korea
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- exosomes, NF-κB signaling, renal ischemia-reperfusion injury, acute kidney injury, exosome delivery, neutrophil gelatinase-associated lipocalin, apoptosis, inflammatory cytokines, neutrophils, macrophages, T cells, intravital imaging
- MeSH terms
- NF-KappaB Inhibitor alpha, Animals, Kidney, Mice, Inbred C57BL, Reperfusion Injury, Mice, Exosomes, Acute Kidney Injury
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