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Extracellular vesicles: The next generation in gene therapy delivery

Cecchin, R., Troyer, Z., Witwer, K. W., & Morris, K. V. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.01.021 · Cited by 196 · see citing works

Exosomes as mediators of immune regulation and immunotherapy in cancer

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Exosomes as natural nanocarrier-based drug delivery system: recent insights and future perspectives

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Enhanced Loading of Functional miRNA Cargo via pH Gradient Modification of Extracellular Vesicles

Jeyaram, A., Lamichhane, T. N., Wang, S., Zou, L., Dahal, E., Kronstadt, S. M., Levy, D. H., Parajuli, B., Knudsen-Palmer, D. R., Chao, W., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.12.007 · Cited by 184 · see citing works

Fat Therapeutics: The Clinical Capacity of Adipose-Derived Stem Cells and Exosomes for Human Disease and Tissue Regeneration

Shukla, L., Yuan, Y., Shayan, R., Greening, D. W., & Karnezis, T. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00158 · Cited by 181 · see citing works

Therapeutic biomaterials based on extracellular vesicles: classification of bio‐engineering and mimetic preparation routes

García‐Manrique, P., Matos, M., Gutiérrez, G., Pazos, C., & Blanco‐López, M. C. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1422676 · Cited by 180 · see citing works

Exosomes as Drug Carriers for Cancer Therapy

Pullan, J. E., Confeld, M. I., Osborn, J., Kim, J., Sarkar, K., & Mallik, S. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00104 · Cited by 179 · see citing works

Nanocarrier‐Mediated Cytosolic Delivery of Biopharmaceuticals

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New advances in exosome-based targeted drug delivery systems

Ferreira, D., Moreira, J. N., & Rodrigues, L. R. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103628 · Cited by 176 · see citing works

Biogenesis, Membrane Trafficking, Functions, and Next Generation Nanotherapeutics Medicine of Extracellular Vesicles

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Cell-derived nanovesicle-mediated drug delivery to the brain: Principles and strategies for vesicle engineering

Liang, Y., Iqbal, Z., Lu, J., Wang, J., Zhang, H., Chen, X., Duan, L., & Xia, J. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2022.10.008 · Cited by 162 · see citing works

Nanostructured particles assembled from natural building blocks for advanced therapies

Ju, Y., Liao, H., Richardson, J. J., Guo, J., & Caruso, F. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00343g · Cited by 157 · see citing works

Methodologies to Isolate and Purify Clinical Grade Extracellular Vesicles for Medical Applications

Akbar, A., Malekian, F., Baghban, N., Kodam, S. P., & Ullah, M. (2022) · Cells · doi:10.3390/cells11020186 · Cited by 154 · see citing works

Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical application

Yang, Q., Li, S., Ou, H., Zhang, Y., Zhu, G., Li, S., & Lei, L. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02298-7 · Cited by 153 · see citing works

A shared, stochastic pathway mediates exosome protein budding along plasma and endosome membranes

Fordjour, F. K., Guo, C., Ai, Y., Daaboul, G. G., & Gould, S. J. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102394 · Cited by 150 · see citing works

Surface functionalization strategies of extracellular vesicles

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Characterization of Urinary Exosomes Purified with Size Exclusion Chromatography and Ultracentrifugation

Guan, S., Yu, H., Yan, G., Gao, M., Sun, W., & Zhang, X. (2020) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00693 · Cited by 147 · see citing works

Exosomes: Cell-Derived Nanoplatforms for the Delivery of Cancer Therapeutics

Kim, H., Kim, E. H., Kwak, G., Chi, S.-G., Kim, S. H., & Yang, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010014 · Cited by 147 · see citing works

Extracellular vesicles: Emerging tools as therapeutic agent carriers

Liu, S., Wu, X., Chandra, S., Lyon, C. J., Ning, B., Jiang, L., Fan, J., & Hu, Y. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.05.002 · Cited by 146 · see citing works

Extracellular vesicles derived from mesenchymal stem/stromal cells: the regenerative impact in liver diseases

Psaraki, A., Ntari, L., Karakostas, C., Korrou‐Karava, D., & Roubelakis, M. G. (2022) · Hepatology · doi:10.1002/hep.32129 · Cited by 145 · see citing works

Achieving the Promise of Therapeutic Extracellular Vesicles: The Devil is in Details of Therapeutic Loading

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Predictive role of GSTP1-containing exosomes in chemotherapy-resistant breast cancer

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Harnessing Exosomes for the Development of Brain Drug Delivery Systems

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Methods for loading therapeutics into extracellular vesicles and generating extracellular vesicles mimetic-nanovesicles

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Strategies for Targeted Delivery of Exosomes to the Brain: Advantages and Challenges

Choi, H., Choi, K., Kim, D., Oh, B.-K., Yim, H. Y., Jo, S., & Choi, C. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030672 · Cited by 136 · see citing works

Designer exosomes enabling tumor targeted efficient chemo/gene/photothermal therapy

Wang, J., Chen, P., Dong, Y., Xie, H., Wang, Y., Soto, F., Ma, P., Feng, X., Du, W., & Liu, B. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121056 · Cited by 135 · see citing works

The Discovery of Extracellular Vesicles and Their Emergence as a Next-Generation Therapy

Rai, A., Claridge, B., Lozano, J., & Greening, D. W. (2024) · Circulation Research · doi:10.1161/circresaha.123.323054 · Cited by 135 · see citing works

Extracellular vesicle-based Nanotherapeutics: Emerging frontiers in anti-inflammatory therapy

Tang, T., Wang, B., Lv, L., & Liu, B. (2020) · Theranostics · doi:10.7150/thno.47865 · Cited by 134 · see citing works

Roles of Exosomes in Ocular Diseases

Liu, J., Jiang, F., Jiang, Y., Wang, Y., Li, Z., Shi, X., Zhu, Y., Wang, H., & Zhang, Z. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s277190 · Cited by 129 · see citing works

Exogenous loading of miRNAs into small extracellular vesicles

de Abreu, R. C., Ramos, C. V., Becher, C., Lino, M. M., Jesus, C., Martins, P. A. D. C., Martins, P. A. T., Moreno, M. J., Fernandes, H., & Ferreira, L. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12111 · Cited by 128 · see citing works

Microfluidic engineering of exosomes: editing cellular messages for precision therapeutics

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State-of-the-art exosome loading and functionalization techniques for enhanced therapeutics: a review

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Engineering Exosomes for Therapeutic Applications: Decoding Biogenesis, Content Modification, and Cargo Loading Strategies

Bahadorani, M., Nasiri, M., Dellinger, K., Aravamudhan, S., & Zadegan, R. M. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s464249 · Cited by 125 · see citing works

Pretreatment of exosomes derived from hUCMSCs with TNF-α ameliorates acute liver failure by inhibiting the activation of NLRP3 in macrophage

Zhang, S., Jiang, L., Hu, H., Wang, H., Wang, X., Jiang, J., Ma, Y., Yang, J., Hou, Y., Xie, D., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117401 · Cited by 123 · see citing works

Engineered Tumor-Derived Extracellular Vesicles: Potentials in Cancer Immunotherapy

Taghikhani, A., Farzaneh, F., Sharifzad, F., Mardpour, S., Ebrahimi, M., & Hassan, Z. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00221 · Cited by 120 · see citing works

Abstract 2167: Efficient and rapid cellular delivery of bioactive proteins using EXPLOR: exosomes engineered for protein loading via optically reversible protein-protein interaction

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Abstract 2150: engEx: A novel exosome engineering platform enabling targeted transfer of pharmacological molecules

Dooley, K., Xu, K., Haupt, S., Lewis, N. D., Harrison, R. A., Martin, S., McCoy, C., Sia, C. L., Jang, S. C., Kirwin, K., et al. (2019) · Experimental and Molecular Therapeutics · doi:10.1158/1538-7445.sabcs18-2150 · Cited by 2 · see citing works

[Construction of engineered exosomes with high loading efficiency of cellular endogenous proteins].

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FedExosomes: Engineering Therapeutic Biological Nanoparticles that Truly Deliver

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Expanding the toolbox of exosome-based modulators of cell functions

Cheng, Q., Dai, Z., Shi, X., Duan, X., Wang, Y., Hou, T., & Zhang, Y. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121129 · Cited by 42 · see citing works