Inhibiting NF-κB activation by small molecules as a therapeutic strategy
Open accessAbstract
Because nuclear factor-κB (NF-κB) is a ubiquitously expressed proinflammatory transcription factor that regulates the expression of over 500 genes involved in cellular transformation, survival, proliferation, invasion, angiogenesis, metastasis, and inflammation, the NF-κB signaling pathway has become a potential target for pharmacological intervention. A wide variety of agents can activate NF-κB through canonical and noncanonical pathways. Canonical pathway involves various steps including the phosphorylation, ubiquitination, and degradation of the inhibitor of NF-κB (IκBα), which leads to the nuclear translocation of the p50-p65 subunits of NF-κB followed by p65 phosphorylation, acetylation and methylation, DNA binding, and gene transcription. Thus, agents that can inhibit protein kinases, protein phosphatases, proteasomes, ubiquitination, acetylation, methylation, and DNA binding steps have been identified as NF-κB inhibitors. Because of the critical role of NF-κB in cancer and various chronic diseases, numerous inhibitors of NF-κB have been identified. In this review, however, we describe only small molecules that suppress NF-κB activation, and the mechanism by which they block this pathway.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
NF-KB is expressed in all cell types, is involved in the oxidative stress mechanism by expression of numerous genes such as cytokines, and plays a major role in the pathology of inflammatory disease.
“NF-kappB (NF-KB) has been studied for more than 25 years and is known to be expressed in all cell types, where it is involved in the oxidative stress mechanism by the expression of numerous genes, such as the cytokines, and plays a major role in the pathology of inflammatory disease [104,105].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2 retracted
Rosato, R. R., Kolla, S. S., Hock, S. K., Almenara, J. A., Patel, A. K., Amin, S., Atadja, P. W., Fisher, P. B., Dent, P., & Grant, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.095208 · Cited by 64 · see citing works
RetractedD’Acquisto, F., Ialenti, A., Ianaro, A., Vaio, R. D., & Carnuccio, R. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301295 · Cited by 64 · see citing works
RetractedNF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
Ghosh, S., May, M. J., & Kopp, E. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.225 · Cited by 5,182 · see citing works
Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842 · see citing works
Activators and target genes of Rel/NF-κB transcription factors
Pahl, H. L. (1999) · Oncogene · doi:10.1038/sj.onc.1203239 · Cited by 3,727 · see citing works
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638 · cited 1× · see citing works
“In resting cells, NF-κB proteins are kept in the cytoplasm in association with inhibitory IkB proteins including IκBα, IκBβ, and IκBε [15] among which IκBα is the most abundant.”
Activators and Target Genes of Rel/NF-кB Transcription Factors
Loop, T., & Pahl, H. L. (2003) · Springer eBooks · doi:10.1007/978-94-010-0163-2_1 · Cited by 3,179 · see citing works
NF-κB: linking inflammation and immunity to cancer development and progression
Karin, M., & Greten, F. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1703 · Cited by 3,091 · see citing works
Multiple nuclear factors interact with the immunoglobulin enhancer sequences
Sen, R., & Baltimore, D. (1986) · Cell · doi:10.1016/0092-8674(86)90346-6 · Cited by 2,754 · see citing works
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750 · see citing works
Suppression of TNF-α-Induced Apoptosis by NF-κB
Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581 · see citing works
TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB
Wang, C.-Y., Mayo, M. W., & Baldwin, A. S. (1996) · Science · doi:10.1126/science.274.5288.784 · Cited by 2,581 · see citing works
NF-κB in cancer: from innocent bystander to major culprit
Karin, M., Cao, Y., Greten, F. R., & Li, Z. (2002) · Nature reviews. Cancer · doi:10.1038/nrc780 · Cited by 2,476 · see citing works
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., & Karin, M. (1997) · Nature · doi:10.1038/41493 · Cited by 2,125 · see citing works
IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J. W., Young, D. B., Barbosa, M. S., Mann, M., Manning, A. M., et al. (1997) · Science · doi:10.1126/science.278.5339.860 · Cited by 2,042 · see citing works
Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884 · see citing works
Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M., & Karin, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80406-7 · Cited by 1,814 · see citing works
Smoldering and polarized inflammation in the initiation and promotion of malignant disease
Balkwill, F., Charles, K. A., & Mantovani, A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.02.013 · Cited by 1,769 · see citing works
Inhibition of NF-κB by Sodium Salicylate and Aspirin
Kopp, E. B., & Ghosh, S. (1994) · Science · doi:10.1126/science.8052854 · Cited by 1,765 · see citing works
Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625 · see citing works
The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β
Yin, M.-J., Yamamoto, Y., & Gaynor, R. B. (1998) · Nature · doi:10.1038/23948 · Cited by 1,596 · see citing works
NF-κB activation by reactive oxygen species: Fifteen years later
Gloire, G., Legrand-Poels, S., & Piette, J. G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.04.011 · Cited by 1,540 · see citing works
Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation
Viatour, P., Merville, M., Bours, V., & Chariot, A. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.11.009 · Cited by 1,497 · see citing works
The IKK NF-κB system: a treasure trove for drug development
Karin, M., Yamamoto, Y., & Wang, Q. M. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1279 · Cited by 1,364 · see citing works
Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway
Senftleben, U., Cao, Y., Xiao, G., Greten, F. R., Krähn, G. M., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S., et al. (2001) · Science · doi:10.1126/science.1062677 · Cited by 1,361 · see citing works
Nuclear factor-κB: The enemy within
Aggarwal, B. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.003 · Cited by 1,289 · see citing works
Self-citationDuration of Nuclear NF-κB Action Regulated by Reversible Acetylation
Chen, L., Fischle, W., Verdin, E. M., & Greene, W. C. (2001) · Science · doi:10.1126/science.1062374 · Cited by 1,231 · see citing works
Shaping the nuclear action of NF-κB
Chen, L., & Greene, W. C. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1368 · Cited by 1,219 · see citing works
IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK
Woronicz, J. D., Gao, X., Cao, Z., Rothe, M., & Goeddel, D. V. (1997) · Science · doi:10.1126/science.278.5339.866 · Cited by 1,183 · see citing works
Identification and Characterization of an IκB Kinase
Régnier, C. H., Song, H. Y., Gao, X., Goeddel, D. V., Cao, Z., & Rothe, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80344-x · Cited by 1,176 · see citing works
Natarajan, K., Singh, S., Burke, T. R., Grünberger, D., & Aggarwal, B. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9090 · Cited by 1,140 · see citing works
Self-citationWang, C.-Y., Cusack, J., Liu, R., & Baldwin, A. (1999) · Nature Medicine · doi:10.1038/7410 · Cited by 1,088 · see citing works
The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling
Karin, M., & Delhase, M. (2000) · Seminars in Immunology · doi:10.1006/smim.2000.0210 · Cited by 957 · see citing works
Staal, F. J. T., Roederer, M., Herzenberg, L. A., & Herzenberg, L. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9943 · Cited by 956 · see citing works
How NF-κB is activated: the role of the IκB kinase (IKK) complex
Karin, M. (1999) · Oncogene · doi:10.1038/sj.onc.1203219 · Cited by 935 · see citing works
The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways
Dejardin, E., Droin, N. M., Delhase, M., Haas, E., Cao, Y., Makris, C., Li, Z., Karin, M., Ware, C. F., & Green, D. R. (2002) · Immunity · doi:10.1016/s1074-7613(02)00423-5 · Cited by 923 · see citing works
Lin, Y.-Z., Yao, S., Veach, R. A., Torgerson, T. R., & Hawiger, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.24.14255 · Cited by 919 · see citing works
IKK/NF- B signaling: balancing life and death - a new approach to cancer therapy
Luo, J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26322 · Cited by 879 · see citing works
Zhong, H., Suyang, H., Erdjument‐Bromage, H., Tempst, P., & Ghosh, S. (1997) · Cell · doi:10.1016/s0092-8674(00)80222-6 · Cited by 828 · see citing works
Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF‐κB
Chen, L., Mu, Y., & Greene, W. C. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf660 · Cited by 827 · see citing works
Madrid, L. V., Mayo, M. W., Reuther, J. Y., & Baldwin, A. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101103200 · Cited by 777 · see citing works
Vermeulen, L., Wilde, G. D., Damme, P. V., Berghe, W. V., & Haegeman, G. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg139 · Cited by 760 · see citing works
Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation
Grilli, M., Pizzi, M., Memo, M., & Spano, P. (1996) · Science · doi:10.1126/science.274.5291.1383 · Cited by 751 · see citing works
Role of NF-κB in p53-mediated programmed cell death
Ryan, K. M., Ernst, M. K., Rice, N. R., & Vousden, K. H. (2000) · Nature · doi:10.1038/35009130 · Cited by 735 · see citing works
Recognition and Signaling by Toll-Like Receptors
West, A. P., Koblansky, A. A., & Ghosh, S. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.122303.115827 · Cited by 718 · see citing works
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy
Tovar, C., Rosinski, J., Filipovic, Z., Higgins, B., Kolinsky, K., Hilton, H., Zhao, X., Vu, B. T., Qing, W., Packman, K., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507493103 · Cited by 708 · see citing works
Berghe, W. V., Plaisance, S., Boone, E., Bosscher, K. D., Schmitz, M. L., Fiers, W., & Haegeman, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3285 · Cited by 679 · see citing works
May, M. J., D’Acquisto, F., Madge, L. A., Glöckner, J., Pober, J. S., & Ghosh, S. (2000) · Science · doi:10.1126/science.289.5484.1550 · Cited by 678 · see citing works
Perkins, N. D. (2006) · Oncogene · doi:10.1038/sj.onc.1209937 · Cited by 674 · see citing works
Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α
Imbert, V., Rupec, R. A., Livolsi, A., Pahl, H. L., Traenckner, E. B.-M., Mueller‐Dieckmann, C., Farahifar, D., Rossi, B., Auberger, P., Baeuerle, P. A., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80153-1 · Cited by 660 · see citing works
IκB kinase complexes: gateways to NF-κB activation and transcription
Scheidereit, C. (2006) · Oncogene · doi:10.1038/sj.onc.1209934 · Cited by 652 · see citing works
Sizemore, N., Leung, S., & Stark, G. R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4798 · Cited by 650 · see citing works
Inhibition of NF-κB Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes
Shembade, N., Ma, A. I., & Harhaj, E. W. (2010) · Science · doi:10.1126/science.1182364 · Cited by 644 · see citing works
Transcriptional Cross Talk between NF-κB and p53
Webster, G. A., & Perkins, N. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3485 · Cited by 598 · see citing works
Morishita, R., Sugimoto, T., Aoki, M., Kida, I., Tomita, N., Moriguchi, A., Maeda, K., Sawa, Y., Kaneda, Y., Higaki, J., et al. (1997) · Nature Medicine · doi:10.1038/nm0897-894 · Cited by 584 · see citing works
Schulze‐Osthoff, K., Beyaert, R., Vandevoorde, V., Haegeman, G., & Fiers, W. C. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05978.x · Cited by 577 · see citing works
Manna, S. K., Zhang, H. J., Yan, T., Oberley, L. W., & Aggarwal, B. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.13245 · Cited by 563 · see citing works
Self-citationBurke, J. R., Pattoli, M. A., Gregor, K. R., Brassil, P. J., MacMaster, J. F., McIntyre, K. W., Yang, X., Iotzova, V. S., Clarke, W., Strnad, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209677200 · Cited by 550 · see citing works
Post-activation Turn-off of NF-κB-dependent Transcription Is Regulated by Acetylation of p65
Kiernan, R. E., Brès, V., Ng, R. W. M., Coudart, M.-P., Messaoudi, S. E., Sardet, C., Jin, D., Emiliani, S., & Benkirane, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209572200 · Cited by 536 · see citing works
NF-κB, chemokine gene transcription and tumour growth
Richmond, A. J. (2002) · Nature reviews. Immunology · doi:10.1038/nri887 · Cited by 523 · see citing works
Kwok, B. H. B., Koh, B. D., Ndubuisi, M. I., Elofsson, M., & Crews, C. M. (2001) · Chemistry & Biology · doi:10.1016/s1074-5521(01)00049-7 · Cited by 516 · see citing works
Molecular Linkage Between the Kinase ATM and NF-κB Signaling in Response to Genotoxic Stimuli
Wu, Z., Shi, Y., Tibbetts, R. S., & Miyamoto, S. (2006) · Science · doi:10.1126/science.1121513 · Cited by 515 · see citing works
Takada, Y., Mukhopadhyay, A., Kundu, G. C., Mahabeleshwar, G. H., Singh, S., & Aggarwal, B. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212389200 · Cited by 495 · see citing works
Self-citationAt the Crossroads of Inflammation and Cancer
Clevers, H. C. (2004) · Cell · doi:10.1016/j.cell.2004.09.005 · Cited by 494 · see citing works
Sulindac Inhibits Activation of the NF-κB Pathway
Yamamoto, Y., Yin, M.-J., Lin, K.-M., & Gaynor, R. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.38.27307 · Cited by 493 · see citing works
Sunwoo, J. B., Chen, Z., Dong, G., Yeh, N. T., Bancroft, C. C., Sausville, E. A., Adams, J., Elliott, P. J., & Waes, C. V. (2001) · PubMed · Cited by 473 · see citing works
Wang, D., Westerheide, S. D., Ostrander, J. H., & Baldwin, A. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001358200 · Cited by 454 · see citing works
Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms
Li, N., & Karin, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13012 · Cited by 429 · see citing works
Lymphoid Malignancies: the dark side of B-cell differentiation
Shaffer, A. L., Rosenwald, A., & Staudt, L. M. (2002) · Nature reviews. Immunology · doi:10.1038/nri953 · Cited by 420 · see citing works
Nuclear Factor-κB Activation: From Bench to Bedside
Sethi, G., Sung, B., & Aggarwal, B. B. (2008) · Experimental Biology and Medicine · doi:10.3181/0707-mr-196 · Cited by 417 · see citing works
Self-citationCysteine 38 in p65/NF-κB Plays a Crucial Role in DNA Binding Inhibition by Sesquiterpene Lactones
García‐Piñeres, A., Castro, V., MORA, G. A., Schmidt, T. J., Strunck, E., Pahl, H. L., & Merfort, I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101985200 · Cited by 408 · see citing works
Wang, Z., Boudjelal, M., Kang, S., Voorhees, J. J., & Fisher, G. J. (1999) · Nature Medicine · doi:10.1038/10577 · Cited by 404 · see citing works
Inhibition of the Mitogen-Activated Protein Kinase Kinase Superfamily by a Yersinia Effector
Orth, K., Palmer, L. E., Bao, Z., Stewart, S., Rudolph, A. E., Bliska, J. B., & Dixon, J. E. (1999) · Science · doi:10.1126/science.285.5435.1920 · Cited by 402 · see citing works
Bubici, C., Papa, S., Dean, K., & Franzoso, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209936 · Cited by 399 · see citing works
Sizemore, N., Lerner, N., Dombrowski, N., Sakurai, H., & Stark, G. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110572200 · Cited by 391 · see citing works
Transcription factor cross-talk: the estrogen receptor and NF-κB
Kalaitzidis, D., & Gilmore, T. D. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.01.004 · Cited by 388 · see citing works
Anti-Cancer Potential of Sesquiterpene Lactones: Bioactivity and Molecular Mechanisms
Zhang, S., Won, Y.-K., Ong, C. N., & Shen, H. (2005) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1568011053765976 · Cited by 383 · see citing works
Evidence that reactive oxygen species do not mediate NF‐κB activation
Hayakawa, M., Miyashita, H., Sakamoto, I., Kitagawa, M., Tanaka, H., Yasuda, H., Karin, M., & Kikugawa, K. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg332 · Cited by 381 · see citing works
Arbibe, L., Kim, D. W., Batsché, É., Pédron, T., Mateescu, B., Muchardt, C., Parsot, C., & Sansonetti, P. J. (2006) · Nature Immunology · doi:10.1038/ni1423 · Cited by 376 · see citing works
Kapahi, P., Takahashi, T., Natoli, G., Adams, S., Chen, Y., Tsien, R. Y., & Karin, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007204200 · Cited by 359 · see citing works
Dejardin, E. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.08.007 · Cited by 348 · see citing works
Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF‐kappa B.
Frantz, B., Ec, N., Bren, G. D., Steffan, N. M., Paya, C. V., Kincaid, R. L., Tocci, M. J., O’Keefe, S. J., & O’Neill, E. A. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06329.x · Cited by 334 · see citing works
Pahl, H. L., Krauss, B., Schulze‐Osthoff, K., Decker, T., Traenckner, E. B.-M., Vogt, M., Myers, C., Parks, T., Warring, P., Mühlbacher, A., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.4.1829 · Cited by 334 · see citing works
Antigen-Receptor Signaling to Nuclear Factor κB
Schulze‐Luehrmann, J., & Ghosh, S. (2006) · Immunity · doi:10.1016/j.immuni.2006.10.010 · Cited by 330 · see citing works
PIDD Mediates NF-κB Activation in Response to DNA Damage
Janssens, S., Tinel, A., Lippens, S., & Tschopp, J. (2005) · Cell · doi:10.1016/j.cell.2005.09.036 · Cited by 319 · see citing works
CK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV Response
Kato, T., Delhase, M., Hoffmann, A., & Karin, M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00358-7 · Cited by 313 · see citing works
Takada, Y., Bhardwaj, A., Potdar, P. D., & Aggarwal, B. B. (2004) · Oncogene · doi:10.1038/sj.onc.1208169 · Cited by 310 · see citing works
Self-citationSchesser, K., Spiik, A., Dukuzumuremyi, J., Neurath, M. F., Pettersson, S., & Wolf‐Watz, H. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00851.x · Cited by 280 · see citing works
van Hogerlinden, M., Rozell, B., Ährlund‐Richter, L., & Toftgård, R. (1999) · PubMed · Cited by 277 · see citing works
Collier-Hyams, L. S., Zeng, H., Sun, J., Tomlinson, A. D., Bao, Z., Chen, H., Madara, J., Orth, K., & Neish, A. S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.2846 · Cited by 276 · see citing works
Qiu, D., Zhao, G., Aoki, Y., Shi, L., Uyei, A., Nazarian, S., Ng, J. C.-H., & Kao, P. N. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13443 · Cited by 269 · see citing works
Inflammation-associated cancer: NF-κB is the lynchpin
Li, Q., Withoff, S., & Verma, I. M. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.04.003 · Cited by 268 · see citing works
Gurova, K. V., Hill, J. E., Guo, C., Prokvolit, A., Burdelya, L. G., Samoylova, E. M., Khodyakova, A. V., Ganapathi, R. N., Ganapathi, M. K., Tararova, N. D., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508888102 · Cited by 266 · see citing works
Sung, B., Pandey, M. K., Ahn, K. S., Yi, T., Chaturvedi, M. M., Liu, M., & Aggarwal, B. B. (2008) · Blood · doi:10.1182/blood-2007-10-117994 · Cited by 265 · see citing works
Self-citationDuffey, D. C., Chen, Z., Dong, G., Ondrey, F. G., Wolf, J. S., Brown, K., Siebenlist, U. K., & Waes, C. V. (1999) · PubMed · Cited by 263 · see citing works
Bohuslav, J., Chen, L., Kwon, H., Mu, Y., & Greene, W. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313509200 · Cited by 256 · see citing works
The pro‐ or anti‐apoptotic function of NF‐κB is determined by the nature of the apoptotic stimulus
Kaltschmidt, B., Kaltschmidt, C., Hofmann, T. G., Hehner, S. P., Dröge, W., & Schmitz, M. L. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01421.x · Cited by 252 · see citing works
Inhibition of HIV-1 replication and NF-x B activity by cysteine and cysteine derivatives
Mihm, S., Ennen, J., Pessara, U., Kurth, R., & Dröge, W. (1991) · AIDS · doi:10.1097/00002030-199105000-00004 · Cited by 252 · see citing works
Cross-talk between nuclear receptors and nuclear factor κB
Bosscher, K. D., Berghe, W. V., & Haegeman, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209935 · Cited by 247 · see citing works
Manipulation of the nuclear factor-κB pathway and the innate immune response by viruses
Hiscott, J. B., Nguyen, T.-L. A., Argüello, M., Nakhaei, P., & Paz, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209941 · Cited by 246 · see citing works
Nawrocki, S. T., Carew, J. S., Pino, M. S., Highshaw, R. A., Andtbacka, R. H. I., Dunner, K., Pal, A., Bornmann, W. G., Chiao, P. J., Huang, P., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2961 · Cited by 240 · see citing works
Huang, W., Ju, T.-K., Hung, M., & Chen, C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.02.019 · Cited by 239 · see citing works
Inhibition of NF‐κB cellular function via specific targeting of the IκB‐ubiquitin ligase
Yaron, A., Gonen, H., Alkalay, I., Hatzubai, A., Jung, S., Beyth, S., Mercurio, F., Manning, A. M., Ciechanover, A. J., & Ben‐Neriah, Y. (1997) · The EMBO Journal · doi:10.1093/emboj/16.21.6486 · Cited by 239 · see citing works
Mattioli, I., Sebald, A., Bucher, C., Charles, R., Nakano, H., Doi, T., Kracht, M., & Schmitz, M. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.10.6336 · Cited by 230 · see citing works
Li, J., & Fang, C. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2003.12.014 · Cited by 228 · see citing works
Role of glycogen synthase kinase-3 in TNF-α-induced NF-κB activation and apoptosis in hepatocytes
Schwabe, R. F., & Brenner, D. A. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00016.2002 · Cited by 227 · see citing works
Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-κB activation
Zhou, H., Monack, D. M., Kayagaki, N., Wertz, I. E., Yin, J., Wolf, B. B., & Dixit, V. M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051194 · Cited by 226 · see citing works
Rodríguez, M. S., Thompson, J., Hay, R. T., & Dargemont, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.9108 · Cited by 224 · see citing works
Jobin, C., Panja, A. B., Hellerbrand, C., Iimuro, Y., DiDonato, J. A., Brenner, D. A., & Sartor, R. B. (1998) · PubMed · Cited by 224 · see citing works
Negative regulation of NF‐κB action by Set9‐mediated lysine methylation of the RelA subunit
Yang, X., Huang, B., Li, M., Lamb, A., Kelleher, N. L., & Chen, L. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.55 · Cited by 217 · see citing works
TPL-2 kinase regulates the proteolysis of the NF-κB-inhibitory protein NF-κB1 p105
Belich, M. P., Salmerón, A., Johnston, L. H., & Ley, S. C. (1999) · Nature · doi:10.1038/16946 · Cited by 213 · see citing works
Role of Rel/NF-κB transcription factors during the outgrowth of the vertebrate limb
Kanegae, Y., Tavares, A. T., Belmonte, J. C. I., & Verma, I. M. (1998) · Nature · doi:10.1038/33429 · Cited by 203 · see citing works
Torgerson, T. R., Colosia, A. D., Donahue, J. P., Lin, Y. Z., & Hawiger, J. (1998) · PubMed · Cited by 180 · see citing works
WIP1 phosphatase is a negative regulator of NF-κB signalling
Chew, J., Biswas, S. K., Shreeram, S., Humaidi, M., Wong, E. T., Dhillon, M. K., Teo, H., Hazra, A., Fang, C. C., López‐Collazo, E., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1873 · Cited by 172 · see citing works
Powell, P. P., Dixon, L. K., & Parkhouse, R. M. E. (1996) · Journal of Virology · doi:10.1128/jvi.70.12.8527-8533.1996 · Cited by 171 · see citing works
Jiang, X., Takahashi, N., Matsui, N., Tetsuka, T., & Okamoto, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208696200 · Cited by 171 · see citing works
Jobin, C., Panja, A. B., Hellerbrand, C., Iimuro, Y., DiDonato, J. A., Brenner, D. A., & Sartor, R. B. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.1.410 · Cited by 171 · see citing works
Takada, Y., & Aggarwal, B. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m304546200 · Cited by 169 · see citing works
Self-citationChoi, K., Lee, Y., Jung, M. G., Kwon, S. H., Kim, M., Jun, W. J., Lee, J., Lee, J. M., & Yoon, H. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0239 · Cited by 167 · see citing works
Torgerson, T. R., Colosia, A. D., Donahue, J. P., Lin, Y.-Z., & Hawiger, J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.11.6084 · Cited by 167 · see citing works
Fujita, F., Taniguchi, Y., Kato, T., Narita, Y., Furuya, A., Ogawa, T., Sakurai, H., Joh, T., Itoh, M., Delhase, M., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7780-7793.2003 · Cited by 164 · see citing works
Williams, S. A., Pettaway, C. A., Song, R., Papandreou, C. N., Logothetis, C. J., & McConkey, D. J. (2003) · PubMed · Cited by 164 · see citing works
Glycogen Synthase Kinase-3β Regulates NF-κB1/p105 Stability
Demarchi, F., Bertoli, C., Sandy, P., & Schneider, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305676200 · Cited by 162 · see citing works
Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF‐κB activation
Meyer, S. M., Kohler, N. G., & Joly, A. H. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00930-7 · Cited by 161 · see citing works
Bushdid, P. B., Brantley, D. M., Yull, F. E., Blaeuer, G. L., Hoffman, L. H., Niswander, L. A., & Kerr, L. D. (1998) · Nature · doi:10.1038/33435 · Cited by 158 · see citing works
Thoetkiattikul, H., Beck, M. H., & Strand, M. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505240102 · Cited by 151 · see citing works
Battistutta, R., Sarno, S., Moliner, E. D., Papinutto, E., Zanotti, G., & Pinna, L. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004257200 · Cited by 148 · see citing works
NF-κB in cancer—a friend turned foe
Ravi, R. K. (2004) · Drug Resistance Updates · doi:10.1016/j.drup.2004.01.003 · Cited by 147 · see citing works
Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-κB pathways
Dey, A., Tergaonkar, V., & Lane, D. P. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2759 · Cited by 146 · see citing works
García‐Piñeres, A., Lindenmeyer, M. T., & Merfort, I. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.01.024 · Cited by 146 · see citing works
Broide, D. H., Lawrence, T., Doherty, T. A., Cho, J. Y., Miller, M., McElwain, K., McElwain, S., & Karin, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509235102 · Cited by 144 · see citing works
Manna, S. K., Kuo, M. T., & Aggarwal, B. B. (1999) · Oncogene · doi:10.1038/sj.onc.1202811 · Cited by 144 · see citing works
Self-citationFunctional Interplay between Acetylation and Methylation of the RelA Subunit of NF-κB
Yang, X., Tajkhorshid, E., & Chen, L. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01343-09 · Cited by 143 · see citing works
The death domain kinase RIP has an essential role in DNA damage-induced NF-κB activationPreprint
Hur, G. M., Lewis, J., Yang, Q., Lin, Y., Nakano, H., Nedospasov, S. A., & Liu, Z.-G. (2003) · Genes & Development · doi:10.1101/gad.1062403 · Cited by 140 · see citing works
Inhibition of Nuclear Factor κB Activation by a Virus-encoded IκB-like Protein
Revilla, Y., Callejo, M., Rodríguez, J. M., Culebras, E., Nogal, M. L., Salas, M. L., Viñuela, E., & Fresno, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.5405 · Cited by 139 · see citing works
NF-κB: arresting a major culprit in cancer
Haefner, B. (2002) · Drug Discovery Today · doi:10.1016/s1359-6446(02)02309-7 · Cited by 138 · see citing works
Protein phosphatase 2A interacts with and directly dephosphorylates RelA
Yang, J., Fan, G.-H., Wadzinski, B. E., Sakurai, H., & Richmond, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106103200 · Cited by 130 · see citing works
Recruitment of IκBα to the hes1 promoter is associated with transcriptional repression
Aguilera, C. N., Hoya-Arias, R., Haegeman, G., Espinosa, L., & Bigas, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404429101 · Cited by 126 · see citing works
Aspirin Induces Apoptosis through the Inhibition of Proteasome Function
Dikshit, P., Chatterjee, M., Goswami, A., Mishra, A., & Jana, N. R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602629200 · Cited by 126 · see citing works
Zhu, H., Zhang, L., Dong, F., Guo, W., Wu, S., Teraishi, F., Davis, J. J., Chiao, P. J., & Fang, B. (2005) · Oncogene · doi:10.1038/sj.onc.1208683 · Cited by 125 · see citing works
Pande, V., & Ramos, M. J. (2005) · Current Medicinal Chemistry · doi:10.2174/0929867053363180 · Cited by 125 · see citing works
Singh, S., & Aggarwal, B. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10631 · Cited by 124 · see citing works
Self-citationDemidenko, Z. N., & Blagosklonny, M. V. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0204 · Cited by 123 · see citing works
Shishodia, S., & Aggarwal, B. B. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/1-4020-7847-1_8 · Cited by 123 · see citing works
Self-citationAhn, K. S., Sethi, G., Chao, T., Neuteboom, S., Chaturvedi, M. M., Palladino, M. A., Younes, A., & Aggarwal, B. B. (2007) · Blood · doi:10.1182/blood-2007-04-084996 · Cited by 122 · see citing works
Self-citationModulation of TNF-alpha-induced apoptosis in corneal fibroblasts by transcription factor NF-kappaB.
Mohan, R. R., Mohan, R. R., Kim, W. J., & Wilson, S. E. (2000) · PubMed · Cited by 119 · see citing works
Activation of p53 by roscovitine-mediated suppression of MDM2 expression
Lu, W., Chen, L., Peng, Y., & Chen, J. (2001) · Oncogene · doi:10.1038/sj.onc.1204412 · Cited by 117 · see citing works
Kawamura, I., Morishita, R., Tomita, N., Lacey, E., Aketa, M., Tsujimoto, S., Manda, T., Tomoi, M., Kida, I., Higaki, J., et al. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300819 · Cited by 117 · see citing works
Inhibition of NF-κB Activation by Panepoxydone
Erkel, G., Anke, T., & Sterner, O. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1335 · Cited by 113 · see citing works
Gene Expression Profiling of Lymphoid Malignancies
Staudt, L. M. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.103941 · Cited by 112 · see citing works
Proteolytic Cleavage of the p65-RelA Subunit of NF-κB during Poliovirus Infection
Neznanov, N., Chumakov, K. M., Neznanova, L., Almasan, A., Banerjee, A. K., & Gudkov, A. V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502303200 · Cited by 109 · see citing works
Sethi, G., Ahn, K. S., Chaturvedi, M., & Aggarwal, B. B. (2007) · Oncogene · doi:10.1038/sj.onc.1210544 · Cited by 105 · see citing works
Self-citationRegulation of NF‐κB Action by Reversible Acetylation
Greene, W. C., & Chen, L. (2004) · Novartis Foundation symposium · doi:10.1002/0470862637.ch15 · Cited by 102 · see citing works
Kolenko, V. M., Bloom, T., Rayman, P. A., Bukowski, R. M., Hsi, E. D., & Finke, J. H. (1999) · PubMed · Cited by 102 · see citing works
Shimada, H., & Rajagopalan, L. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.099630 · Cited by 98 · see citing works
Nuclear factor‐KappaB modulation as a therapeutic approach in hematologic malignancies
Panwalkar, A. W., Verstovšek, S., & Giles, F. J. (2004) · Cancer · doi:10.1002/cncr.20182 · Cited by 97 · see citing works
Gedey, R., Jin, X.-L., Hinthong, O., & Shisler, J. L. (2006) · Journal of Virology · doi:10.1128/jvi.00935-06 · Cited by 97 · see citing works
Koulich, E., Nguyen, T. N., Johnson, K., Giardina, C. A., & D’Mello, S. R. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00134.x · Cited by 97 · see citing works
McCarty, M. F., & Block, K. I. (2006) · Integrative Cancer Therapies · doi:10.1177/1534735406291499 · Cited by 95 · see citing works
D’Acquisto, F., Sautebin, L., Iuvone, T., Rosa, M. D., & Carnuccio, R. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01407-0 · Cited by 94 · see citing works
Inhibition of tumor growth by NF‐κB inhibitors
Umezawa, K. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00285.x · Cited by 91 · see citing works
Combined antitumor effect of radiation and ibuprofen in human prostate carcinoma cells.
Palayoor, S. T., Bump, E. A., Calderwood, S. K., Bartol, S., & Coleman, C. N. (1998) · PubMed · Cited by 91 · see citing works
FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells.
Venkataraman, L., Burakoff, S. J., & Sen, R. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.3.1091 · Cited by 90 · see citing works
Antwerp, D. J. V., & Verma, I. M. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6037 · Cited by 90 · see citing works
Noels, H., Loo, G., Hagens, S., Broeckx, V., Beyaert, R., Marynen, P., & Baens, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611038200 · Cited by 88 · see citing works
Bentires‐Alj, M., Hellin, A., Ameyar‐Zazoua, M., Chouaı̈b, S., Merville, M. P., & Bours, V. (1999) · PubMed · Cited by 88 · see citing works
Koul, D., Yao, Y., Abbruzzese, J. L., Yung, W. K. A., & Reddy, S. A. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007806200 · Cited by 87 · see citing works
Kolenko, V. M., Bloom, T., Rayman, P. A., Bukowski, R. M., Hsi, E. D., & Finke, J. H. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.2.590 · Cited by 87 · see citing works
TAT Fusion Proteins Containing Tyrosine 42-deleted IκBα Arrest Osteoclastogenesis
Abu‐Amer, Y., Dowdy, S. F., Ross, F. P., Clohisy, J. C. F., & Teitelbaum, S. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104725200 · Cited by 85 · see citing works
Liang, M., Bardhan, S., Pace, E. A., Rosman, D. S., Beutler, J. A., Porco, J. A. J., & Gilmore, T. D. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.11.013 · Cited by 83 · see citing works
McDade, T. P., Perugini, R. A., Vittimberga, F. J., Carrigan, R. C., & Callery, M. P. (1999) · Journal of Surgical Research · doi:10.1006/jsre.1998.5560 · Cited by 82 · see citing works
Camus-Bouclainville, C., Fiette, L., Bouchiha, S., Pignolet, B., Counor, D., Filipe, C., Gelfi, J., & Messud-Petit, F. (2004) · Journal of Virology · doi:10.1128/jvi.78.5.2510-2516.2004 · Cited by 82 · see citing works
Swinney, D. C., Xu, Y.-Z., Scarafia, L. E., Lee, I., Mak, A. Y., Gan, Q.-F., Ramesha, C. S., Mulkins, M. A., Dunn, J., So, O., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200842200 · Cited by 82 · see citing works
Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKβ
Nagashima, K., Sasseville, V. G., Wen, D., Bielecki, A., Yang, H., Simpson, C., Grant, E. P., Hepperle, M. E., Harriman, G., Jaffee, B., et al. (2006) · Blood · doi:10.1182/blood-2005-09-3852 · Cited by 78 · see citing works
Koulich, E., Nguyen, T. N., Johnson, K., Giardina, C. A., & D’Mello, S. R. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00303.x · Cited by 77 · see citing works
Activation of the Heat Shock Factor 1 by Serine Protease Inhibitors
Rossi, A., Elia, G., & Santoro, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.26.16446 · Cited by 77 · see citing works
Cisplatin Mimics ARF Tumor Suppressor Regulation of RelA (p65) Nuclear Factor-κB Transactivation
Campbell, K. J., Witty, J., Rocha, S., & Perkins, N. D. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2234 · Cited by 77 · see citing works
Tepper, M. A., Nadler, S. G., Esselstyn, J. M., & STERBENZ, K. G. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.5.2427 · Cited by 74 · see citing works
Dey, A., Wong, E. T., Cheok, C. F., Tergaonkar, V., & Lane, D. P. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402257 · Cited by 73 · see citing works
Nuclear transport as a target for cell growth
Kau, T. R., & Silver, P. A. (2003) · Drug Discovery Today · doi:10.1016/s1359-6446(02)02562-x · Cited by 71 · see citing works
Nutlin-3 inhibits the NFκB Pathway in a p53 Dependent Manner: Implications in Lung Cancer Therapy
Dey, A., Wong, E. T., Bist, P., Tergaonkar, V., & Lane, D. (2007) · Cell Cycle · doi:10.4161/cc.6.17.4643 · Cited by 70 · see citing works
Bernard, D., Monté, D., Vandenbunder, B., & Abbadie, C. (2002) · Oncogene · doi:10.1038/sj.onc.1205536 · Cited by 70 · see citing works
Allen, C. T., Saigal, K., Nottingham, L. K., Arun, P., Chen, Z., & Waes, C. V. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4470 · Cited by 70 · see citing works
Potent Inhibitors of Proteasome
Iqbal, M. A., Chatterjee, S., Kauer, J. C., Das, M. K., Messina, P. A., Freed, B., Biazzo, W., & Siman, R. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00013a002 · Cited by 68 · see citing works
Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway.
Wechsler, A. S., Gordon, M., Dendorfer, U., & LeClair, K. P. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.6.2515 · Cited by 67 · see citing works
Kupatt, C., Wichels, R., Deiss, M., Molnar, A., Lebherz, C., Raake, P. W. J., von Degenfeld, G., Hahnel, D., & Boekstegers, P. (2002) · Gene Therapy · doi:10.1038/sj.gt.3301673 · Cited by 67 · see citing works
NF-kB inhibitor blocks B cell development at two checkpoints
Feng, B., Cheng, S., Pear, W. S., & Liou, H. (2004) · Medical Immunology · doi:10.1186/1476-9433-3-1 · Cited by 66 · see citing works
Sánchez‐Duffhues, G., Calzado, M. A., de Vinuesa, A. G., Appendino, G., Fiebich, B. L., Loock, U., Lefarth‐Risse, A., Krohn, K., & Muñóz, E. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.01.004 · Cited by 65 · see citing works
Caspase‐8 and caspase‐10 activate NF‐κB through RIP, NIK and IKKα kinases
Shikama, Y., Yamada, M., & Miyashita, T. (2003) · European Journal of Immunology · doi:10.1002/eji.200324013 · Cited by 62 · see citing works
Expression and induction of nuclear factor-kappa B-related proteins in thymocytes.
Sen, J. M., Venkataraman, L., Shinkai, Y., Pierce, J. W., Alt, F. W., Burakoff, S. J., & Sen, R. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.7.3213 · Cited by 61 · see citing works
Adachi, M., Zhang, Y., Zhao, X., Minami, T., Kawamura, R., Hinoda, Y., & Imai, K. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0806 · Cited by 59 · see citing works
Higuchi, M., Singh, S., Chan, H., & Aggarwal, B. B. (1995) · Blood · doi:10.1182/blood.v86.6.2248.bloodjournal8662248 · Cited by 58 · see citing works
Self-citationInhibition of NF-κB Acetylation and its Transcriptional Activity by Daxx
Park, J., Lee, J. H., La, M., Jang, M. J., Chae, G. W., Kim, S. B., Tak, H., Jung, Y., Byun, B., Ahn, J. K., et al. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.02.047 · Cited by 57 · see citing works
Barišić, S., Strozyk, E. A., Peters, N., Walczak, H., & Kulms, D. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.98 · Cited by 57 · see citing works
Naturally occurring and synthetic inhibitors of NF-kappaB functions.
Umezawa, K., Ariga, A., & Matsumoto, N. (2000) · PubMed · Cited by 56 · see citing works
Chang, N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106607200 · Cited by 54 · see citing works
Mechanism of cytosine arabinoside-mediated apoptosis: role of Rel A (p65) dephosphorylation
Sreenivasan, Y., Sarkar, A., & Manna, S. K. (2003) · Oncogene · doi:10.1038/sj.onc.1206486 · Cited by 53 · see citing works
Li, H.-L. (2002) · World Journal of Gastroenterology · doi:10.3748/wjg.v8.i3.431 · Cited by 52 · see citing works
Wagner, S., Hofmann, A., Siedle, B., Terfloth, L., Merfort, I., & Gasteiger, J. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm051125n · Cited by 52 · see citing works
Tang, W., Li, Y., Yu, D., Thomas‐Tikhonenko, A., Spiegelman, V. S., & Fuchs, S. Y. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2597 · Cited by 52 · see citing works
Flagged first, then by citations
1 of the 232 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
NF‐κB and the link between inflammation and cancer
DiDonato, J. A., Mercurio, F., & Karin, M. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01099.x · Cited by 1,490 · see citing works
NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review
Shih, R., Wang, C.-Y., & Yang, C. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00077 · Cited by 912 · see citing works
Gupta, S. C., Kim, J. H., Prasad, S., & Aggarwal, B. B. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9235-2 · Cited by 806 · see citing works
Self-citationCorticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease
Barnes, P. J. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.1564 · Cited by 698 · see citing works
Mechanisms of NF-κB p65 and strategies for therapeutic manipulation
Giridharan, S., & Srinivasan, M. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s140188 · Cited by 686 · see citing works
Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches
Park, M., & Hong, J. T. (2016) · Cells · doi:10.3390/cells5020015 · Cited by 631 · see citing works
Exploiting Synthetic Lethality for the Therapy of ABC Diffuse Large B Cell Lymphoma
Yang, Y., Shaffer, A. L., Emre, N. C. T., Ceribelli, M., Zhang, M., Wright, G. W., Xiao, W., Powell, J. I., Platig, J., Kohlhammer, H., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.024 · Cited by 524 · see citing works
Rahimifard, M., Maqbool, F., Moeini-Nodeh, S., Niaz, K., Abdollahi, M., Braidy, N., Nabavi, S. M., & Nabavi, S. F. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.02.004 · Cited by 481 · see citing works
Role of the NFκB-signaling pathway in cancer
Xia, L., Tan, S., Zhou, Y., Lin, J., Wang, H., Oyang, L., Tian, Y., Liu, L., Su, M., Wang, H., et al. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s161109 · Cited by 461 · see citing works
Epigenetic changes induced by curcumin and other natural compounds
Reuter, S., Gupta, S. C., Park, B., Goel, A., & Aggarwal, B. B. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0222-1 · Cited by 363 · see citing works
Self-citationCurcumin as an Alternative Epigenetic Modulator: Mechanism of Action and Potential Effects
Hassan, F., Rehman, M. S.-U., Khan, M. S., Ali, M. A., Javed, A., Nawaz, A. S., & Yang, C. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00514 · Cited by 369 · see citing works
Curcumin mediates anticancer effects by modulating multiple cell signaling pathways
Kunnumakkara, A. B., Bordoloi, D., Harsha, C., Banik, K., Gupta, S. C., & Aggarwal, B. B. (2017) · Clinical Science · doi:10.1042/cs20160935 · Cited by 334 · see citing works
Self-citationSkin aging and oxidative stress: Equol’s anti-aging effects via biochemical and molecular mechanisms
Lephart, E. D. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.001 · Cited by 325 · see citing works
The Role of Curcumin in Cancer Treatment
Zoi, V., Galani, V., Lianos, G. D., Voulgaris, S., Kyritsis, A. P., & Alexiou, G. Α. (2021) · Biomedicines · doi:10.3390/biomedicines9091086 · Cited by 335 · see citing works
Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols
Gupta, S. C., Tyagi, A. K., Deshmukh-Taskar, P., Hinojosa, M., Prasad, S., & Aggarwal, B. B. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.06.006 · Cited by 317 · see citing works
Self-citationChemosensitization of tumors by resveratrol
Gupta, S. C., Kannappan, R., Reuter, S., Kim, J. H., & Aggarwal, B. B. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05852.x · Cited by 308 · see citing works
Self-citationNF-kappaB Is Involved in the Regulation of EMT Genes in Breast Cancer Cells
Pires, B. R. B., Mencalha, A. L., Ferreira, G. M., de Souza, W. F., Morgado-Díaz, J. A., Maia, A. M., Corrêa, S., & Abdelhay, E. S. F. W. (2017) · PLOS ONE · doi:10.1371/journal.pone.0169622 · Cited by 296 · see citing works
Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin
Rosales‐Corral, S., Acuña-Castroviejo, D., Coto‐Montes, A. M., Boga, J. A., Manchester, L. C., Fuentes‐Broto, L., Korkmaz, A., Ma, S., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00937.x · Cited by 293 · see citing works
Macrophages, Inflammation, and Lung Cancer
Conway, E. M., Pikor, L. A., Kung, S. H. Y., Hamilton, M. J., Lam, S. C., Lam, W. L., & Bennewith, K. L. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201508-1545ci · Cited by 285 · see citing works
Anticancer activity of complexes of the third row transition metals, rhenium, osmium, and iridium
Konkankit, C. C., Marker, S. C., Knopf, K. M., & Wilson, J. J. (2018) · Dalton Transactions · doi:10.1039/c8dt01858h · Cited by 285 · see citing works
PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)
He, M., Cao, C., Ni, Z., Liu, Y., Song, P., Hao, S., He, Y., Sun, X., & Rao, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00999-9 · Cited by 283 · see citing works
Soundararajan, P., & Kim, J. S. (2018) · Molecules · doi:10.3390/molecules23112983 · Cited by 268 · see citing works
Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA
Zou, Z., Huang, B., Wu, X., Zhang, H., Qi, J., Bradner, J. E., Nair, S. K., & Chen, L.-F. (2013) · Oncogene · doi:10.1038/onc.2013.179 · Cited by 260 · see citing works
Antiviral potential of curcumin
Mathew, D. C., & Hsu, W. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.12.017 · Cited by 260 · see citing works
Emerging roles of lncRNAs in the post-transcriptional regulation in cancer
He, R., Luo, D., & Mo, Y. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.01.003 · Cited by 258 · see citing works
The Science behind Microgreens as an Exciting New Food for the 21st Century
Choe, U., Yu, L. L., & Wang, T. T. Y. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03096 · Cited by 277 · see citing works
TF-PROTACs Enable Targeted Degradation of Transcription Factors
Liu, J., Chen, H., Kaniskan, H. Ü., Xie, L., Chen, X., Jin, J., & Wei, W. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c03852 · Cited by 247 · see citing works
Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases
Gupta, S. C., Kunnumakkara, A. B., Aggarwal, S., & Aggarwal, B. B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02160 · Cited by 246 · see citing works
Self-citationNF-kappaB: Two Sides of the Same Coin
Pires, B. R. B., Silva, R. C. M. C., Ferreira, G. M., & Abdelhay, E. S. F. W. (2018) · Genes · doi:10.3390/genes9010024 · Cited by 235 · see citing works
NFkappaB is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases
Fiordelisi, A., Iaccarino, G., Morisco, C., Coscioni, E., & Sorriento, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071599 · Cited by 217 · see citing works
Singh, S. S., Nand, S., Birla, H., Zahra, W., Singh, S. P., & Singh, S. P. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-00147-2 · Cited by 215 · see citing works
Tocmo, R., Peña-Fronteras, J. T., Calumba, K. F., Mendoza, M., & Johnson, J. J. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12561 · Cited by 221 · see citing works
Small Molecule NF-κB Pathway Inhibitors in Clinic
Ramadass, V., Vaiyapuri, T., & Tergaonkar, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145164 · Cited by 214 · see citing works
Moro, C., Palacios, I., Lozano, M., D’Arrigo, M., Guillamón, E., Villares, A., Martínez, J. A., & Garcia-Lafuente, A. M. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.07.049 · Cited by 208 · see citing works
Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB
D’Ignazio, L., Batie, M., & Rocha, S. (2017) · Biomedicines · doi:10.3390/biomedicines5020021 · Cited by 206 · see citing works
Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortality
Choi, H., Kim, Y., Mirzaaghasi, A., Heo, J., Kim, Y. N., Shin, J. H., Kim, S., Kim, N. H., Cho, E. S., Yook, J. I., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaz6980 · Cited by 203 · see citing works
Fan, W., Huang, Y., Zheng, H., Li, S., Li, Z., Li, Y., Cheng, X., He, C., & Sun, J. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110915 · Cited by 205 · see citing works
Puar, Y., Shanmugam, M. K., Fan, L., Arfuso, F., Sethi, G., & Tergaonkar, V. (2018) · Biomedicines · doi:10.3390/biomedicines6030082 · Cited by 199 · see citing works
Lu, C., Yuan, Z., Zhang, X., Yan, R., Zhao, Y., Liao, M., & Chen, J. (2012) · International Immunopharmacology · doi:10.1016/j.intimp.2012.06.010 · Cited by 194 · see citing works
Maccari, R., & Ottanà, R. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm500907a · Cited by 194 · see citing works
Zhang, Y., Yang, X., Bian, F., Wu, P., Xing, S., Xu, G., Li, W., Chi, J., Ouyang, C., Zheng, T., et al. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.02.012 · Cited by 193 · see citing works
Yasui, Y., Hosokawa, M., Mikami, N., Miyashita, K., & Tanaka, T. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2011.05.006 · Cited by 191 · see citing works
Role of inflammatory signaling in atrial fibrillation
Scott, L., Li, N., & Dobrev, D. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.10.020 · Cited by 188 · see citing works
Interplay between DNA repair and inflammation, and the link to cancer
Kidane, D., Chae, W. J., Czochor, J. R., Eckert, K. A., Glazer, P. M., Bothwell, A. L. M., & Sweasy, J. B. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.875514 · Cited by 186 · see citing works
METTL3 Attenuates LPS-Induced Inflammatory Response in Macrophages via NF-κB Signaling Pathway
Wang, J., Yan, S., Lu, H., Wang, S., & Xu, D. (2019) · Mediators of Inflammation · doi:10.1155/2019/3120391 · Cited by 186 · see citing works
Xu, S., Wang, J. Q., Jiang, J., Song, J., Zhu, W. P., Zhang, F., Shao, M., Xu, H., Ma, X., & Lyu, F. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02824-z · Cited by 171 · see citing works
NF-κB in Cancer: A Matter of Life and Death
Aggarwal, B. B., & Sung, B. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0260 · Cited by 168 · see citing works
Self-citationSrinivasan, M., & Lahiri, D. K. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.989834 · Cited by 164 · see citing works
Tu, S. P., Jin, H., Shi, J. D., Zhu, L. M., Suo, Y., Lü, G., Liu, A., Wang, T. C., & Yang, C. S. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0247 · Cited by 167 · see citing works
Therapeutic approaches to asthma–chronic obstructive pulmonary disease overlap syndromes
Barnes, P. J. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.05.052 · Cited by 161 · see citing works
Dragoni, S., Laforenza, U., Bonetti, E., Lodola, F., Bottino, C., Berra‐Romani, R., Bongio, G. C., Cinelli, M. P., Guerra, G., Pedrazzoli, P., et al. (2011) · Stem Cells · doi:10.1002/stem.734 · Cited by 158 · see citing works
Custodero, C., Mankowski, R. T., Lee, S. A., Chen, Z., Wu, S. S., Manini, T. M., Hincapie-Echeverri, J., Sabbà, C., Beavers, D. P., Cauley, J. A., et al. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.05.004 · Cited by 158 · see citing works
Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic
Shah, F., Logsdon, D. P., Messmann, R. A., Fehrenbacher, J. C., Fishel, M. L., & Kelley, M. R. (2017) · npj Precision Oncology · doi:10.1038/s41698-017-0023-0 · Cited by 153 · see citing works
Strategies for Targeting the NLRP3 Inflammasome in the Clinical and Preclinical Space
Schwaid, A. G., & Spencer, K. B. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01307 · Cited by 152 · see citing works
NF-κB: master regulator of cellular responses in health and disease
Hoffmann, A., Cheng, G., & Baltimore, D. (2025) · Immunity & Inflammation · doi:10.1007/s44466-025-00014-0 · Cited by 169 · see citing works
Huang, B., Liu, J., Meng, T., Li, Y., He, D., Ran, X., Chen, G., Guo, W., Kan, X., Fu, S., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02527 · Cited by 147 · see citing works
Sarısözen, C., Abouzeid, A. H., & Torchilin, V. P. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.07.001 · Cited by 145 · see citing works
Gupta, S. C., Kim, J. H., Kannappan, R., Reuter, S., Dougherty, P. M., & Aggarwal, B. B. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.011028 · Cited by 144 · see citing works
Self-citationRationale and Means to Target Pro-Inflammatory Interleukin-8 (CXCL8) Signaling in Cancer
Campbell, L. M., Maxwell, P. J., & Waugh, D. J. J. (2013) · Pharmaceuticals · doi:10.3390/ph6080929 · Cited by 142 · see citing works
CDK8/19 Mediator kinases potentiate induction of transcription by NFκB
Chen, M., Liang, J., Ji, H., Yang, Z., Altilia, S., Hu, B., Schronce, A., McDermott, M. S. J., Schools, G. P., Lim, C., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710467114 · Cited by 141 · see citing works
Prescott, J. A., & Cook, S. J. (2018) · Cells · doi:10.3390/cells7090115 · Cited by 139 · see citing works
Haydar, D., Cory, T. J., Birket, S. E., Murphy, B. S., Pennypacker, K. R., Sinai, A. P., & Feola, D. J. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801228 · Cited by 136 · see citing works
Yeo, I. J., Lee, C., Han, S., Yun, J., & Hong, J. T. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107394 · Cited by 135 · see citing works
Tocotrienols fight cancer by targeting multiple cell signaling pathways
Kannappan, R., Gupta, S. C., Kim, J. H., & Aggarwal, B. B. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0220-3 · Cited by 132 · see citing works
Self-citationInhibitory kappa B kinases as targets for pharmacological regulation
Gamble, C., McIntosh, K., Scott, R., Ho, K. H., Plevin, R. J., & Paul, A. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01608.x · Cited by 132 · see citing works
In vitro anti-inflammatory activity of phenolic rich extracts from white and red common beans
Garcia-Lafuente, A. M., Moro, C., MANCHÓN, N., Gonzalo‐Ruiz, A., Villares, A., Guillamón, E., Rostagno, M. A., & Mateo‐Vivaracho, L. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.04.004 · Cited by 131 · see citing works
Zhang, J., Späth, S. S., Marjani, S. L., Zhang, W., & Pan, X. (2018) · Precision Clinical Medicine · doi:10.1093/pcmedi/pby007 · Cited by 128 · see citing works
Wagner, A. E., Terschluesen, A. M., & Rimbach, G. H. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/964539 · Cited by 127 · see citing works
Μaione, F., Piccolo, M., Vita, S. D., Chini, M. G., Cristiano, C., Caro, C. D., Lippiello, P., Miniaci, M. C., Santamaria, R., Irace, C., et al. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.11.018 · Cited by 126 · see citing works
Triterpenoids from Ganoderma lucidum and Their Potential Anti-inflammatory Effects
Wu, Y., Han, F., Luan, S., Ai, R., Zhang, P., Li, H., & Chen, L. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b01195 · Cited by 124 · see citing works
Advances in anti-cancer effects and underlying mechanisms of marine algae polysaccharides
Yao, W., Qiu, H., Cheong, K., & Zhong, S. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.09.055 · Cited by 123 · see citing works
Transcription Factor Inhibition: Lessons Learned and Emerging Targets
Chen, A. W., & Koehler, A. N. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.01.004 · Cited by 118 · see citing works
<scp>NF</scp>‐κB as the mediator of metformin's effect on ageing and ageing‐related diseases
Kanigur Sultuybek, G., Soydas, T., & Yenmis, G. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13073 · Cited by 119 · see citing works
Aging: Molecular Pathways and Implications on the Cardiovascular System
de Almeida, A. J. P. O., Ribeiro, T. P., & de Medeiros, I. A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7941563 · Cited by 117 · see citing works
Qin, S., Yang, C., Huang, W., Du, S., Mai, H., Xiao, J., & Lü, T. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.01.014 · Cited by 118 · see citing works
Zeligs, K., Neuman, M. K., & Annunziata, C. M. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1374 · Cited by 116 · see citing works
Wang, W. J., Liu, P., Hao, C., Wu, L., Wan, W., & Mao, X. (2017) · Scientific Reports · doi:10.1038/srep44252 · Cited by 115 · see citing works
Harrison, I. F., Smith, A. D., & Dexter, D. T. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.12.037 · Cited by 115 · see citing works
Yang, G., Shen, W., Zhang, Y., Liu, M., Zhang, L., Liu, Q., Lu, H. H., & Bo, J. (2017) · Oncotarget · doi:10.18632/oncotarget.16386 · Cited by 114 · see citing works
A multi-targeted approach to suppress tumor-promoting inflammation
Samadi, A. K., Bilsland, A. E., Georgakilas, A. G., Amedei, A., Amin, A., Bishayee, A., Azmi, A. S., Lokeshwar, B. L., Grue, B., Panis, C., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.03.006 · Cited by 113 · see citing works
Models for the study of skin wound healing. The role of Nrf2 and NF-κB
Ambrožová, N., Jitka Ulrichová, A., & Galandáková, A. (2017) · Biomedical Papers · doi:10.5507/bp.2016.063 · Cited by 112 · see citing works
Li, R., Zhou, Y., Zhang, S., Li, J., Zheng, Y., & Fan, X. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174660 · Cited by 112 · see citing works
Şahin, K., Orhan, C., Akdemir, F., Tuzcu, M., Iben, C., & Şahin, N. (2011) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.2010.01123.x · Cited by 111 · see citing works
Sarısözen, C., Dhokai, S., Tsikudo, E. G., Luther, E., Rachman, I. M., & Torchilin, V. P. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.08.013 · Cited by 108 · see citing works
NF-κB Pathways in the Pathogenesis of Multiple Sclerosis and the Therapeutic Implications
Leibowitz, S., & Yan, J. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00084 · Cited by 98 · see citing works
Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells
Silva, V. R., Santos, L. D. S., Dias, R. B., Quadros, C. A., & Bezerra, D. P. (2021) · 癌症:英文版 · doi:10.1002/cac2.12235 · Cited by 106 · see citing works
Souissi, M., Azelmat, J., Chaieb, K., & Grenier, D. (2019) · Anaerobe · doi:10.1016/j.anaerobe.2019.102089 · Cited by 105 · see citing works
Gupta, S. C., Prasad, S., Rajalekshmi, D. S., Nair, M. S., Mo, Y.-Y., & Aggarwal, B. B. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0080 · Cited by 104 · see citing works
Self-citationHuang, Z., Shi, Y., Zhai, Y., Du, C.-C., Zhai, J., Yu, R.-J., Kou, L., Xiao, J., Zhao, Y., & Yao, Q. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.04.033 · Cited by 104 · see citing works
Sirtuin-1 (SIRT1) Is Required for Promoting Chondrogenic Differentiation of Mesenchymal Stem Cells
Buhrmann, C., Busch, F., Shayan, P., & Shakibaei, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.568790 · Cited by 103 · see citing works
Exosome-based delivery of super-repressor IκBα ameliorates kidney ischemia-reperfusion injury
Kim, S., Lee, S. A., Yoon, H., Kim, M. Y., Yoo, J.-K., Ahn, S.-H., Park, C. H., Park, J., Nam, B. Y., Park, J. T., et al. (2021) · Kidney International · doi:10.1016/j.kint.2021.04.039 · Cited by 100 · see citing works
Li, J., Wang, S., Bai, J., Yang, X., Zhang, Y., Che, Y., Li, H., & Yang, Y. (2018) · Hypertension · doi:10.1161/hypertensionaha.117.10390 · Cited by 100 · see citing works
Tafani, M., Pucci, B., Russo, A., Schito, L., Pellegrini, L., Perrone, G. A., Villanova, L., Salvatori, L., Ravenna, L., Petrangeli, E., et al. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00013 · Cited by 99 · see citing works
Qian, Z., Rhodes, C. A., McCroskey, L. C., Wen, J., Appiah‐Kubi, G., Wang, J., D, D. C. G., & Pei, D. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201610888 · Cited by 99 · see citing works
Busch, F., Mobasheri, A., Shayan, P., Lueders, C., Stahlmann, R., & Shakibaei, M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.377028 · Cited by 98 · see citing works
NF-κB Signaling and Inflammation—Drug Repurposing to Treat Inflammatory Disorders?
Roberti, A., Chaffey, L., & Greaves, D. R. (2022) · Biology · doi:10.3390/biology11030372 · Cited by 103 · see citing works
Jiang, M., Zhou, M., Han, Y., Xing, L., Zhao, H., Dong, L., Bai, G., & Luo, G. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.03.032 · Cited by 97 · see citing works
Robinson, G., Most, D., Ferguson, L. B., Mayfield, J., Harris, R. A., & Blednov, Y. A. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801284-0.00002-6 · Cited by 96 · see citing works
Blednov, Y. A., Benavidez, J. M., Black, M., Ferguson, L. B., Schoenhard, G. L., Goate, A., Edenberg, H. J., Wetherill, L. F., HESSELBROCK, V. M., Foroud, T., et al. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12610 · Cited by 96 · see citing works
Chemokine Receptor Signaling and the Hallmarks of Cancer
Lacalle, R. A., Blanco, R., Carmona‐Rodríguez, L., Martín‐Leal, A., Mira, E., & Mañes, S. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.09.011 · Cited by 96 · see citing works
- Authors
- Gupta, S. C., Sundaram, C., Reuter, S., & Aggarwal, B. B.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Aggarwal, Bharat B.
- Venue
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 1799
- Issue
- 10-12
- Pages
- 775-787
- ISSN
- 1874-9399 (ISSN-L)
- PMC
- PMC2955987
- OpenAlex
- W1973354681
- Cited by
- 762
- References
- 232
- Citations by year
- 2026: 38 · 2025: 32 · 2024: 39 · 2023: 36 · 2022: 42 · 2021: 59 · 2020: 63 · 2019: 66 · 2018: 70 · 2017: 63 · 2016: 45 · 2015: 45 · 2014: 41 · 2013: 50 · 2012: 35
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA-16672, P01CA091844, P01CA124787, CA-124787-01A2, P30CA016672)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- NF-κB signaling, NF-κB inhibitors, small molecules, canonical NF-κB pathway, non-canonical NF-κB signaling, protein kinases, proteasome inhibitors, protein phosphatase, inflammation, cancer, chronic disease
- MeSH terms
- Animals, Cell Survival, Cell Transformation, Neoplastic, Gene Expression Regulation, Humans, Inflammation, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Phosphorylation, Signal Transduction, NF-kappa B, Neovascularization, Physiologic, Cell Proliferation, I-kappa B Kinase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review