High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism
Abstract
Autism is a behaviorally defined disorder of unknown etiology that is thought to be influenced by genetic and environmental factors. High levels of homocysteine and oxidative stress are generally associated with neuropsychiatric disorders. The purpose of this study was to compare the level of homocysteine and other biomarkers in children with autism to corresponding values in age-matched healthy children. We measured total homocysteine (tHcy), vitamin B(12), paraoxonase and arylesterase activities of human paraoxonase 1 (PON1) in plasma and glutathione peroxidase (GPx) activity in erythrocytes from 21 children: 12 with autism (age: 8.29 +/- 2.76 years) and 9 controls (age: 8.33 +/- 1.82 years). We found statistically significant differences in tHcy levels and in arylesterase activity of PON1 in children with autism compared to the control group: 9.83 +/- 2.75 vs. 7.51 +/- 0.93 micromol/L (P < or =0.01) and 72.57 +/- 11.73 vs. 81.83 +/- 7.39 kU/L (P < or =0.005). In the autistic group there was a strong negative correlation between tHcy and GPx activity and the vitamin B(12) level was low or suboptimal. In conclusion, our study shows that in children with autism there are higher levels of tHcy, which is negatively correlated with GPx activity, low PON1 arylesterase activity and suboptimal levels of vitamin B(12).
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Both Reelin protein levels and PON1 enzymatic activity are significantly reduced in AD individuals compared to controls.
“Both Reelin protein levels and PON1 enzymatic activity (measured as “arylesterase” in these studies) are significantly reduced in AD individuals compared to controls [89, 236–238].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [237]
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- Authors
- Paşca, S. P., Nemeş, B., Vlase, L., Gagyi, C. E., Dronca, E., Miu, A. C., & Dronca, M.
- Affiliations
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- Babeș-Bolyai University (RO)
- Corresponding author
- Dronca, Maria
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 78
- Issue
- 19
- Pages
- 2244-2248
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2080260164
- Cited by
- 151
- References
- 39
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 7 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 11 · 2016: 7 · 2015: 8 · 2014: 10 · 2013: 7 · 2012: 17
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Keywords
- autism spectrum disorder, homocysteine, paraoxonase 1, arylesterase activity, glutathione peroxidase, vitamin B12, oxidative stress, biomarkers, children, erythrocytes, plasma
- MeSH terms
- Autistic Disorder, Carboxylic Ester Hydrolases, Child, Erythrocytes, Female, Glutathione Peroxidase, Homocysteine, Humans, Male, Vitamin B 12, Aryldialkylphosphatase
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