How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis

Metals, Toxicity and Oxidative Stress

Valko, M., Morris, H., & Cronin, M. (2005) · Current Medicinal Chemistry · doi:10.2174/0929867053764635 · Cited by 5,018 · see citing works

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics · doi:10.1038/13810 · Cited by 4,990 · see citing works

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587 · see citing works

Low-Level Environmental Lead Exposure and Children’s Intellectual Function: An International Pooled Analysis

Lanphear, B. P., Hornung, R., Khoury, J., Yolton, K., Baghurst, P., Bellinger, D. C., Canfield, R. L., Dietrich, K. N., Bornschein, R., Greene, T., et al. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7688 · Cited by 2,205 · see citing works

Neuroglial activation and neuroinflammation in the brain of patients with autism

Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149 · see citing works

Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks

Bartos, M., Vida, I., & Jonas, P. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2044 · Cited by 2,070 · see citing works

Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders

Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y.-M., Szumlanski, C. L., & Weinshilboum, R. M. (1996) · Pharmacogenetics · doi:10.1097/00008571-199606000-00007 · Cited by 1,788 · see citing works

Methionine metabolism in mammals

Finkelstein, J. D. (1990) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(90)90070-2 · Cited by 1,495 · see citing works

Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking

Ebstein, R. P., Novick, O., Umansky, R., Priel, B., Osher, Y., Blaine, D., Bennett, E. R., Nemanov, L., Katz, M., & Belmaker, R. H. (1996) · Nature Genetics · doi:10.1038/ng0196-78 · Cited by 1,475 · see citing works

Biologic and pharmacologic regulation of mammalian glutathione synthesis

Griffith, O. W. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00176-8 · Cited by 1,195 · see citing works

Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking

Benjamin, J., Li, L., Patterson, C. A., Greenberg, B. D., Murphy, D. L., & Hamer, D. H. (1996) · Nature Genetics · doi:10.1038/ng0196-81 · Cited by 1,191 · see citing works

Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism

James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., & Neubrander, J. A. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1611 · Cited by 955 · see citing works

The Cognitive Neuroscience of Attention

Melara, R. D. (2004) · Sage eBooks · doi:10.4135/9781483328768.n11 · Cited by 797 · see citing works

X-Linked Mental Retardation and Autism Are Associated with a Mutation in the NLGN4 Gene, a Member of the Neuroligin Family

Laumonnier, F., Bonnet-Brilhault, F., Gomot, M., Blanc, R., David, A., Moizard, M.-P., Raynaud, M., Ronce, N., Lemonnier, E., Calvas, P., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/382137 · Cited by 768 · see citing works

Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder.

LaHoste, G. J., Swanson, J. M., Wigal, S. B., Glabe, C. G., Wigal, T. L., King, N., & Kennedy, J. L. (1996) · PubMed · Cited by 678 · see citing works

Oxidative stress in autism

Chauhan, A., & Chauhan, V. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.007 · Cited by 656 · see citing works

The Cognitive Neuroscience of Attention

(2020) · Routledge eBooks · doi:10.4324/9781003048916 · Cited by 653 · see citing works

Dendritic Spine Structural Anomalies in Fragile-X Mental Retardation Syndrome

Irwin, S. A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.1038 · Cited by 626 · see citing works

A Functional Polymorphism in the COMT Gene and Performance on a Test of Prefrontal Cognition

Malhotra, A. K., Kestler, L. J., Mazzanti, C. M., Bates, J. A., Goldberg, T. E., & Goldman, D. A. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.652 · Cited by 612 · see citing works

Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism

James, S. J., Melnyk, S., Jernigan, S., Cleves, M. A., Halsted, C. H., Wong, D. H., Cutler, P., Bock, K., Boris, M., Bradstreet, J., et al. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30366 · Cited by 605 · see citing works

Searching for ways out of the autism maze: genetic, epigenetic and environmental clues

Persico, A. M., & Bourgeron, T. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.05.010 · Cited by 575 · see citing works

Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children

Braun, J. M., Kahn, R. S., Froehlich, T., Auinger, P., & Lanphear, B. P. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9478 · Cited by 573 · see citing works

Localization of dopamine D4 receptors in GABAergic neurons of the primate brain

Mrzljak, L., Bergson, C., Pappy, M., Huff, R., Levenson, R., & Goldman-Rakic, P. S. (1996) · Nature · doi:10.1038/381245a0 · Cited by 494 · see citing works

The Effect of Oxygen on Biochemical Networks and the Evolution of Complex Life

Raymond, J., & Segrè, D. (2006) · Science · doi:10.1126/science.1118439 · Cited by 494 · see citing works

Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse

Aoyama, K., Suh, S. W., Hamby, A. M., Liu, J., Chan, W. Y., Chen, Y., & Swanson, R. A. (2006) · Nature Neuroscience · doi:10.1038/nn1609 · Cited by 484 · see citing works

Public Health and Economic Consequences of Methyl Mercury Toxicity to the Developing Brain

Trasande, L., Landrigan, P. J., & Schechter, C. B. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7743 · Cited by 466 · see citing works

The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus

Chang, F., Kídd, K. K., Livak, K. J., PAKSTIS, A. J., & Kídd, K. K. (1996) · Human Genetics · doi:10.1007/s004390050166 · Cited by 438 · see citing works

Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin—the antioxidant proteins

Chauhan, A., Chauhan, V., Brown, W. T., & Cohen, I. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.04.038 · Cited by 424 · see citing works

Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3

Samaco, R. C., Hogart, A., & LaSalle, J. M. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddi045 · Cited by 420 · see citing works

A genetic variant that disrupts <i>MET</i> transcription is associated with autism

Campbell, D. B., Sutcliffe, J. S., Ebert, P. J., Militerni, R., Bravaccio, C., Trillo, S., Elia, M., Schneider, C., Melmed, R., Sacco, R., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605296103 · Cited by 401 · see citing works

The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus

Wang, E., Ding, Y.-C., Flodman, P. L., Kidd, J. R., Kídd, K. K., Grady, D. L., Ryder, O. A., Spence, M. A., Swanson, J. M., & Moyzis, R. K. (2004) · The American Journal of Human Genetics · doi:10.1086/420854 · Cited by 401 · see citing works

Pervasive Developmental Disorders in Montreal, Quebec, Canada: Prevalence and Links With Immunizations

Fombonne, E., Zakarian, R., Bennett, A., Meng, L., & McLean-Heywood, D. (2006) · Pediatrics · doi:10.1542/peds.2005-2993 · Cited by 399 · see citing works

Induction of Cytoprotective Genes Through Nrf2 / Antioxidant Response Element Pathway: A New Therapeutic Approach for the Treatment of Inflammatory Diseases

Chen, X., & KUNSCH, C. A. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043452901 · Cited by 387 · see citing works

Neuropsychological correlates of hair arsenic, manganese, and cadmium levels in school-age children residing near a hazardous waste site

Wright, R. O., Amarasiriwardena, C. J., Woolf, A. D., Jim, R., & Bellinger, D. C. (2005) · NeuroToxicology · doi:10.1016/j.neuro.2005.10.001 · Cited by 387 · see citing works

Pharmacological and biochemical aspects of S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase.

Ueland, P. M. (1982) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00053-5 · Cited by 375 · see citing works

Children and adolescents with autism exhibit reduced MEG steady-state gamma responses

Wilson, T. W., Rojas, D. C., Reite, M. L., Teale, P. D., & Rogers, S. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.002 · Cited by 350 · see citing works

Autism and Genetics

Smalley, S. L. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800340081013 · Cited by 349 · see citing works

The relationship of biliary glutathione disulfide efflux and intracellular glutathione disulfide content in perfused rat liver.

Akerboom, T. P. M., Bilzer, M., & Sies, H. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34713-6 · Cited by 342 · see citing works

Thermolabile variant of 5, 10-methylenetetrahydrofolate reductaseassociated with low red-cell folates: implications for folate intake recommendations

Molloy, A. M., Daly, S., Mills, J. L., Kirke, P. N., Whitehead, A. S., Ramsbottom, D., Conley, M. R., Weir, D. G., & Scott, J. M. (1997) · The Lancet · doi:10.1016/s0140-6736(96)12049-3 · Cited by 341 · see citing works

Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder

Persico, A. M., D'Agruma, L., Maiorano, N., Totaro, A., Militerni, R., Bravaccio, C., Wassink, T. H., Schneider, C., Melmed, R., Trillo, S., et al. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000850 · Cited by 337 · see citing works

STRUCTURE-BASED PERSPECTIVES ON B12-DEPENDENT ENZYMES

Ludwig, M. L., & Matthews, R. G. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.269 · Cited by 328 · see citing works

Stress-Induced Protein S-Glutathionylation in Arabidopsis

Dixon, D. P., Skipsey, M., Grundy, N. M., & Edwards, R. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.058917 · Cited by 313 · see citing works

Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals.

Thomas, D. J., Li, J., Waters, S. B., Xing, W., Adair, B. M., Drobná, Z., Devesa, V., & Stýblo, M. (2007) · PubMed · Cited by 306 · see citing works

A Polymorphism (80G->A) in the Reduced Folate Carrier Gene and Its Associations with Folate Status and Homocysteinemia

Chango, A., Fillon-Emery, N., de Courcy, G. P., Lambert, D., Pfister, M., Rosenblatt, D. S., & Nicolas, J. (2000) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2000.3034 · Cited by 295 · see citing works

On the epigenetic regulation of the human reelin promoter

Chen, Y. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf401 · Cited by 274 · see citing works

Evidence of Toxicity, Oxidative Stress, and Neuronal Insult in Autism

Kern, J. K., & Jones, A. M. (2006) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400600882079 · Cited by 265 · see citing works

A Common Mutation A1298C in Human Methylenetetrahydrofolate Reductase Gene: Association with Plasma Total Homocysteine and Folate Concentrations

Friedman, G., Goldschmidt, N., Friedlander, Y., Ben‐Yehuda, A., Selhub, J., Babaey, S., Mendel, M., Kidron, M., & Bar-On, H. (1999) · Journal of Nutrition · doi:10.1093/jn/129.9.1656 · Cited by 263 · see citing works

Oxidative activation of antioxidant defence

Winyard, P. G., Moody, C. J., & Jacob, C. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.06.001 · Cited by 254 · see citing works

Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methylmercury or Vaccines Containing Thimerosal

Burbacher, T. M., Shen, D. D., Liberato, N., Grant, K. S., Cernichiari, E., & Clarkson, T. W. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7712 · Cited by 246 · see citing works

A Functional Transsulfuration Pathway in the Brain Links to Glutathione Homeostasis

Vitvitsky, V., THOMAS, M. P., Ghorpade, A., Gendelman, H. E., & Banerjee, R. V. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602799200 · Cited by 242 · see citing works

Reelin glycoprotein: structure, biology and roles in health and disease

Fatemi, S. H. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001613 · Cited by 241 · see citing works

Increased excretion of a lipid peroxidation biomarker in autism

Ming, X., Stein, T. P., Brimacombe, M., Johnson, W. G., Lambert, G. H., & Wagner, G. C. (2005) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.06.002 · Cited by 236 · see citing works

Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism

Zoroğlu, S. S., Armutçu, F., Özen, Ş., Gürel, A., Sivaslı, E., Yetkin, O., & Meram, İ. (2004) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-004-0456-7 · Cited by 235 · see citing works

A Subpopulation of Neurons in the Medial Prefrontal Cortex Encodes Emotional Learning with Burst and Frequency Codes through a Dopamine D4Receptor-Dependent Basolateral Amygdala Input

Laviolette, S. R., Lipski, W. J., & Grace, A. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1168-05.2005 · Cited by 235 · see citing works

Dysregulation of Reelin and Bcl-2 Proteins in Autistic Cerebellum

Fatemi, S. H., Stary, J. M., Halt, A. R., & Realmuto, G. R. (2001) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1013234708757 · Cited by 212 · see citing works

Redox regulation of ubiquitin‐conjugating enzymes: mechanistic insights using the thiol‐specific oxidant diamide

Obin, M. S., Shang, F., Gong, X., Handelman, G. J., Blumberg, J. B., & Taylor, A. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.7.561 · Cited by 205 · see citing works

Neurotoxicity of organomercurial compounds

Sanfeliu, C., Sebastià, J., Cristòfol, R. M., & Rodrı́guez-Farré, E. (2003) · Neurotoxicity Research · doi:10.1007/bf03033386 · Cited by 201 · see citing works

What's Going on? The Question of Time Trends in Autism

Blaxill, M. F. (2004) · Public Health Reports · doi:10.1016/j.phr.2004.09.003 · Cited by 196 · see citing works

GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high‐risk population

Hung, R. J., Boffetta, P., Brennan, P., MALAVEILLE, C., Hautefeuille, A. H., Donato, F., Gelatti, U., Spaliviero, M., Placidi, D., Carta, A., et al. (2004) · International Journal of Cancer · doi:10.1002/ijc.20157 · Cited by 193 · see citing works

l-CYSTATHIONINE IN HUMAN BRAIN

Tallan, H. H., Moore, S., & Stein, W. H. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70493-6 · Cited by 180 · see citing works

Gene expression profiling reveals a signaling role of glutathione in redox regulation

Fratelli, M., Goodwin, L. O., Ørom, U. A., Lombardi, S., Tonelli, R., Mengozzi, M., & Ghezzi, P. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504398102 · Cited by 180 · see citing works

Evidence that methylation of the FMR-I locus is responsible for variable phenotypic expression of the fragile X syndrome.

McConkie‐Rosell, A., Lachiewicz, A. M., Spiridigliozzi, G. A., Tarleton, J. C., Schoenwald, S., Phelan, M. C., Goonewardena, P., Ding, X., & Brown, W. T. (1993) · PubMed · Cited by 168 · see citing works

Oxidative Stress Inactivates Cobalamin-Independent Methionine Synthase (MetE) in Escherichia coli

Hondorp, E. R., & Matthews, R. G. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020336 · Cited by 166 · see citing works

Autism and environmental genomics

Herbert, M. R., Russo, J. P., Yang, S., Roohi, J., Blaxill, M. F., Kahler, S. G., Cremer, L., & Hatchwell, E. (2006) · NeuroToxicology · doi:10.1016/j.neuro.2006.03.017 · Cited by 166 · see citing works

Candidate gene studies of attention-deficit/hyperactivity disorder.

Faraone, S. V., & Khan, S. (2006) · PubMed · Cited by 165 · see citing works

Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal

Waly, M. I., Olteanu, H., Banerjee, R. V., Choi, S.-W., Mason, J. B., Parker, B. S., Sukumar, S. V., Shim, S., Sharma, A. K., Benzecry, J., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001476 · Cited by 164 · see citing works

Excretion of GSSG and Glutathione Conjugates Mediated by MRP1 and CM0AT/MRP2

Suzuki, H., & Sugiyama, Y. (1998) · Seminars in Liver Disease · doi:10.1055/s-2007-1007170 · Cited by 163 · see citing works

Environmental Distribution, Analysis, and Toxicity of Organometal(loid) Compounds

Dopp, E., Hartmann, L. M., Florea, A., Rettenmeier, A. W., & Hirner, A. V. (2004) · Critical Reviews in Toxicology · doi:10.1080/10408440490270160 · Cited by 160 · see citing works

Duplication of the 15q11‐13 Region in a Patient with Autism, Epilepsy and Ataxia

Bundey, S., Hardy, C., Vickers, S., Kilpatrick, M. W., & Corbett, J. A. (1994) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1994.tb11916.x · Cited by 151 · see citing works

High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism

Paşca, S. P., Nemeş, B., Vlase, L., Gagyi, C. E., Dronca, E., Miu, A. C., & Dronca, M. (2006) · Life Sciences · doi:10.1016/j.lfs.2005.09.040 · Cited by 151 · see citing works

Structures of the N-terminal modules imply large domain motions during catalysis by methionine synthase

Evans, J. C., Huddler, D. P., Hilgers, M. T., Romanchuk, G. L., Matthews, R. G., & Ludwig, M. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308082100 · Cited by 146 · see citing works

Mean total arsenic concentrations in chicken 1989-2000 and estimated exposures for consumers of chicken.

Lasky, T., Sun, W., Kadry, A. M., & Hoffman, M. K. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6407 · Cited by 139 · see citing works

Rapid Trafficking of the Neuronal Glutamate Transporter, EAAC1

Fournier, K. M., González, M. I., & Robinson, M. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404032200 · Cited by 137 · see citing works

Oxidative stress in autism.

McGinnis, W. R. (2005) · PubMed · Cited by 134 · see citing works

Altered Vascular Phenotype in Autism

Yao, Y., Walsh, W. J., McGinnis, W. R., & Praticò, D. (2006) · Archives of Neurology · doi:10.1001/archneur.63.8.1161 · Cited by 131 · see citing works

Dopamine D4 and D2L Receptor Stimulation of the Mitogen-Activated Protein Kinase Pathway Is Dependent on trans- Activation of the Platelet-Derived Growth Factor Receptor

Oak, J. N., Lavine, N. E., & Tol, H. H. M. V. (2001) · Molecular Pharmacology · doi:10.1124/mol.60.1.92 · Cited by 130 · see citing works

Reaction mechanism and regulation of cystathionine β-synthase

Banerjee, R. V., Evande, R., Kabil, Ö., Ojha, S., & Taoka, S. (2003) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/s1570-9639(03)00044-x · Cited by 125 · see citing works

Paraoxonase gene variants are associated with autism in North America, but not in Italy: possible regional specificity in gene–environment interactions

D'Amelio, M., Ricci, I., Sacco, R., Liu, X., D'Agruma, L., Muscarella, L. A., Guarnieri, V, Militerni, R., Bravaccio, C., Elia, M., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001714 · Cited by 125 · see citing works

The role of mercury in the pathogenesis of autism

Bernard, S., Enayati, A., Roger, H., Binstock, T., & Redwood, L. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001177 · Cited by 124 · see citing works

A mutation in adenylosuccinate lyase associated with mental retardation and autistic features

Stone, R. L., Aimi, J., Barshop, B. A., Jaeken, J., Berghe, G., Zalkin, H., & Dixon, J. E. (1992) · Nature Genetics · doi:10.1038/ng0492-59 · Cited by 123 · see citing works

Functional Dissection of Reelin Signaling by Site-Directed Disruption of Disabled-1 Adaptor Binding to Apolipoprotein E Receptor 2: Distinct Roles in Development and Synaptic Plasticity

Beffert, U., Durudas, A., Weeber, E. J., Stolt, P. C., Giehl, K. M., Sweatt, J. D., Hammer, R. E., & Herz, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4566-05.2006 · Cited by 121 · see citing works

Transcobalamin II 775G>C polymorphism and indices of vitamin B12 status in healthy older adults

Miller, J. W., Ramos, M. I., Garrod, M. G., Flynn, M. A., & Green, R. (2002) · Blood · doi:10.1182/blood-2002-01-0209 · Cited by 120 · see citing works

Association of paraoxonase 1 gene polymorphisms with risk of Parkinson’s disease: a meta-analysis

Zintzaras, E., & Hadjigeorgiou, G. M. (2004) · Journal of Human Genetics · doi:10.1007/s10038-004-0176-x · Cited by 114 · see citing works

A Clinical and Laboratory Evaluation of Methionine Cycle-Transsulfuration and Androgen Pathway Markers in Children with Autistic Disorders

Geier, D. A., & Geier, M. R. (2006) · Hormone Research in Paediatrics · doi:10.1159/000094467 · Cited by 107 · see citing works

Role of neuronal glutamate transporter in the cysteine uptake and intracellular glutathione levels in cultured cortical neurons

Himi, T., Ikeda, M., Yasuhara, T., Nishida, M., & Morita, I. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-003-0049-z · Cited by 107 · see citing works

Increases in the Number of Reactive Glia in the Visual Cortex of Macaca fascicularis Following Subclinical Long-Term Methyl Mercury Exposure

Charleston, J. S., Bolender, R. P., Mottet, N. K., Body, R. L., Vahter, M. E., & Burbacher, T. M. (1994) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1994.1244 · Cited by 107 · see citing works

Immunohistochemical localization of the neuron-specific glutamate transporter EAAC1 (EAAT3) in rat brain and spinal cord revealed by a novel monoclonal antibody

Shashidharan, P., Huntley, G. W., Murray, J., Buku, A., Moran, T. M., Walsh, M. J., Morrison, J. H., & Plaitakis, A. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00921-9 · Cited by 107 · see citing works

Homocysteine thiolactone inhibits insulin signaling, and glutathione has a protective effect

Najib, S., & Sánchez‐Margalet, V. (2001) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0270085 · Cited by 106 · see citing works

Brief report: Duplication of chromosome 15q11-13 in two individuals with autistic disorder

Baker, P., Piven, J., Schwartz, S., & Patil, S. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172133 · Cited by 106 · see citing works

DRD4 and DAT1 polymorphisms modulate human gamma band responses

Demiralp, T., Herrmann, C. S., Erdal, M. E., Ergenoglu, T., Keskin, Y. H., Ergen, M., & Beydagi, H. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl011 · Cited by 105 · see citing works

Domain alternation switches B12-dependent methionine synthase to the activation conformation

Barian, V., Pattridge, K. A., Lennon, B. W., Huddler, D. P., Matthews, R. G., & Ludwig, M. L. (2001) · Nature Structural Biology · doi:10.1038/nsb738 · Cited by 104 · see citing works

Prediction of Heterogeneity in Intelligence and Adult Prognosis by Genetic Polymorphisms in the Dopamine System Among Children With Attention-Deficit/Hyperactivity Disorder

Mill, J. S., Caspi, A., Williams, B. S., Craig, I., Taylor, A., Polo-Tomás, M., Berridge, C. W., Poulton, R., & Moffitt, T. E. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.4.462 · Cited by 102 · see citing works

The Human Aminophospholipid-Transporting ATPase Gene ATP10C Maps Adjacent to UBE3A and Exhibits Similar Imprinted Expression

Herzing, L. B. K., Kim, S., Cook, E. H., & Ledbetter, D. H. (2001) · The American Journal of Human Genetics · doi:10.1086/320616 · Cited by 101 · see citing works

SH3 Binding Domains in the Dopamine D4 Receptor

Oldenhof, J., Vickery, R. G., Anafi, M., Oak, J. N., Ray, A. P., Schoots, O., Pawson, T. J., von Zastrow, M., & Tol, H. H. M. V. (1998) · Biochemistry · doi:10.1021/bi981634+ · Cited by 100 · see citing works

Glutathionylcobalamin as an intermediate in the formation of cobalamin coenzymes

Pezacka, E. H., Green, R., & Jacobsen, D. W. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)90351-m · Cited by 97 · see citing works

Spectroscopic and Computational Studies of Co1+Cobalamin: Spectral and Electronic Properties of the “Superreduced” B12 Cofactor

Liptak, M. D., & Brunold, T. C. (2006) · Journal of the American Chemical Society · doi:10.1021/ja061433q · Cited by 94 · see citing works

Aluminum and other metals in Alzheimer's disease: A review of potential therapy with chelating agents

Domingo, J. L. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-102-315 · Cited by 91 · see citing works

Suppression of transient 40-Hz auditory response by haloperidol suggests modulation of human selective attention by dopamine D2 receptors

Ahveninen, J., Kähkönen, S., Tiitinen, H., Pekkonen, E., Huttunen, J., Kaakkola, S., Ilmoniemi, R. J., & Jääskeläinen, I. P. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01429-4 · Cited by 87 · see citing works

Autometallographic Determination of Inorganic Mercury Distribution in the Cortex of the Calcarine Sulcus of the Monkey Macaca fascicularis Following Long-Term Subclinical Exposure to Methylmercury and Mercuric Chloride

Charleston, J. S., Body, R. L., Mottet, N. K., Vahter, M. E., & Burbacher, T. M. (1995) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1995.1114 · Cited by 86 · see citing works

Interactive Effects of a DRD4 Polymorphism, Lead, and Sex on Executive Functions in Children

Froehlich, T. E., Lanphear, B. P., Dietrich, K. N., Cory‐Slechta, D. A., Wang, N., & Kahn, R. S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.039 · Cited by 82 · see citing works

Homologous pairing of 15q11–13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples

Thatcher, K. N., Peddada, S., Yasui, D. H., & LaSalle, J. M. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi073 · Cited by 82 · see citing works

Analysis of case-parent trios at a locus with a deletion allele: association of GSTM1 with autism

Buyske, S. G., Williams, T. A., Mars, A. E., Stenroos, E. S., Ming, S. X., Wang, R., Sreenath, M., Factura, M. F., Reddy, C., Lambert, G. H., et al. (2006) · BMC Genetics · doi:10.1186/1471-2156-7-8 · Cited by 75 · see citing works

Redox control of the transsulfuration and glutathione biosynthesis pathways.

Deplancke, B., & Gaskins, H. (2002) · Current opinion in clinical nutrition and metabolic care · doi:10.1097/00075197-200201000-00015 · Cited by 74 · see citing works

Chromosome 15q11-13 abnormalities and other medical conditions in individuals with autism spectrum disorders

Bolton, P., Veltman, M. W. M., Weisblatt, E. J. L., Holmes, J. R., Thomas, N. S., Youings, S. A., Thompson, R. J., Roberts, S. E., Dennis, N. R., Browne, C. E., et al. (2004) · Psychiatric Genetics · doi:10.1097/00041444-200409000-00002 · Cited by 71 · see citing works

D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia

Sharma, A. K., Kramer, M. L., Wick, P. F., Liu, D., Chari, S., Shim, S., Tan, W., Ouellette, D., Nagata, M., DuRand, C. J., et al. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000522 · Cited by 60 · see citing works

The Fragile X Syndrome

Hagerman, R. J., McBogg, P., & Hagerman, P. J. (1983) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-198306000-00009 · Cited by 56 · see citing works

The ubiquitin-proteasome system is responsible for cysteine-responsive regulation of cysteine dioxygenase concentration in liver

Stipanuk, M. H., Hirschberger, L. L., Londono, M. P., Cresenzi, C. L., & Yu, A. F. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00336.2003 · Cited by 54 · see citing works

Thimerosal induces TH2 responses via influencing cytokine secretion by human dendritic cells

Agrawal, A., Kaushal, P., Agrawal, S., Gollapudi, S. V. S., & Gupta, S. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0706467 · Cited by 53 · see citing works

Adenosine Deaminase Activity Decreased in Autism

STUBBS, G., Litt, M. J., Lis, E. W., Jackson, R. H., Voth, W., LINDBERG, A., & Litt, R. M. (1982) · Journal of the American Academy of Child Psychiatry · doi:10.1097/00004583-198201000-00012 · Cited by 53 · see citing works

Testosterone Regulation of Homocysteine Metabolism Modulates Redox Status in Human Prostate Cancer Cells

Prudova, A., Albin, M. M., Bauman, Z. M., Lin, A., Vitvitsky, V., & Banerjee, R. V. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1712 · Cited by 50 · see citing works

The presence of a transsulfuration pathway in the lens: a new oxidative stress defense system

Persa, C., Pierce, A., Ma, Z., Kabil, Ö., & Lou, M. F. (2004) · Experimental Eye Research · doi:10.1016/j.exer.2004.06.029 · Cited by 48 · see citing works

D(4) dopamine receptor differentially regulates Akt/nuclear factor-kappa b and extracellular signal-regulated kinase pathways in D(4)MN9D cells.

Zhen, X., Zhang, J., Johnson, G., & Friedman, E. (2001) · PubMed · Cited by 43 · see citing works

Sequence variants of the DRD4 gene in autism: Further evidence that rare DRD4 7R haplotypes are ADHD specific

Grady, D., Harxhi, A., Smith, M., Flodman, P., Spence, M., Swanson, J., & Moyzis, R. (2005) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30182 · Cited by 41 · see citing works

A model for modulation of neuronal synchronization by D4 dopamine receptor-mediated phospholipid methylation

Kuznetsova, A. Y., & Deth, R. C. (2007) · Journal of Computational Neuroscience · doi:10.1007/s10827-007-0057-3 · Cited by 41 · see citing works

Immunotoxic Effects of Mercuric Compounds on Human Lymphocytes and Monocytes. IV. Alterations in Cellular Glutathione Content

Shenker, B. J., Rooney, C., And, L. V., Mayro, J. S., & Shapiro, I. M. (1993) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923979309025999 · Cited by 41 · see citing works

A study of the glutathione metaboloma peptides by energy‐resolved mass spectrometry as a tool to investigate into the interference of toxic heavy metals with their metabolic processes

Rubino, F. M., Pitton, M., Brambilla, G., & Colombi, A. (2006) · Journal of Mass Spectrometry · doi:10.1002/jms.1143 · Cited by 34 · see citing works

A New Role for Glutathione: Protection of Vitamin B12 from Depletion by Xenobiotics

Watson, W. P., Munter, T., & Golding, B. T. (2004) · Chemical Research in Toxicology · doi:10.1021/tx0497898 · Cited by 31 · see citing works

Preventive mechanism of cellular glutathione in monomethylarsonic acid-induced cytolethality

Sakurai, T., Ochiai, M., Kojima, C., Ohta, T., Sakurai, M. H., Takada, N. O., Qu, W., Waalkes, M. P., Himeno, S., & Fujiwara, K. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.11.008 · Cited by 31 · see citing works

CYP450, genetics and Parkinson’s disease: gene × environment interactions hold the key

Mellick, G. D. (2006) · Springer eBooks · doi:10.1007/978-3-211-45295-0_25 · Cited by 30 · see citing works

Relationship between dopamine‐stimulated phospholipid methylation and the single‐carbon folate pathway

Zhao, R., Chen, Y., Tan, W., Waly, M. I., Sharma, A. K., Stover, P. J., Rosowsky, A., Malewicz, B., & Deth, R. C. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00471.x · Cited by 24 · see citing works

D4 Dopamine Receptor Differentially Regulates Akt/Nuclear Factor-κB and Extracellular Signal-Regulated Kinase Pathways in D4MN9D Cells

Zhen, X., Zhang, J., Johnson, G. P., & Friedman, E. (2001) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12314-0 · Cited by 24 · see citing works

Endotoxin Induces Glutathione Reductase Activity in Lungs of Mice

Hamburg, D. C., Tonoki, H., Welty, S. E., Geske, R. S., Montgomery, C. A., & Hansen, T. N. (1994) · Pediatric Research · doi:10.1203/00006450-199403000-00006 · Cited by 14 · see citing works

Corrections

(2005) · Annals of Neurology · doi:10.1002/ana.20397 · Cited by 14 · see citing works

Two‐loci ADA haplotypes in autistic disorder

Lucarelli, P., Saccucci, P., Bottini, N., Luca, D. D., Fiumara, A., Elia, M., Bottini, N., Porfirio, M. C., & Curatolo, P. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10272 · Cited by 12 · see citing works

HOMOLOGOUS PAIRING AND

Kowalczykowski, C., & Eggleston, A. K. (1994) · Cited by 9 · see citing works

Major metabolic homocysteine-derivative, homocysteine thiolactone, exerts changes in pancreatic β-cell glucose-sensing, cellular signal transduction and integrity

Patterson, S., Flatt, P. R., & McClenaghan, N. H. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.02.011 · Cited by 7 · see citing works

Untitled work

Jonnal (2000) · doi:10.1002/1096-8628(20001204)96:6

Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses

Modabbernia, A., Velthorst, E., & Reichenberg, A. (2017) · Molecular Autism · doi:10.1186/s13229-017-0121-4 · Cited by 809 · see citing works

Consensus Paper: Pathological Role of the Cerebellum in Autism

Fatemi, S. H., Aldinger, K. A., Ashwood, P., Bauman, M. L., Blaha, C. D., Blatt, G. J., Chauhan, A., Chauhan, V., Dager, S. R., Dickson, P. E., et al. (2012) · The Cerebellum · doi:10.1007/s12311-012-0355-9 · Cited by 723 · see citing works

Environmental toxicants and autism spectrum disorders: a systematic review

Rossignol, D. A., Genuis, S. J., & Frye, R. E. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.4 · Cited by 458 · see citing works

Redox dysregulation, neurodevelopment, and schizophrenia

Do, K. Q., Cabungcal, J. H., Frank, A., Steullet, P., & Cuenod, M. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.05.001 · Cited by 384 · see citing works

Oxidative stress-related biomarkers in autism: Systematic review and meta-analyses

Frustaci, A., Neri, M., Cesario, A., Adams, J. B., Domenici, E., Bernardina, B. D., & Bonassi, S. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.03.011 · Cited by 370 · see citing works

Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders

Herbert, M. R. (2010) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328336a01f · Cited by 356 · see citing works

Oxidative Stress in Autism Spectrum Disorder

Bjørklund, G., Meguid, N. A., El-Bana, M. A., Tinkov, A. A., Saad, K., Dadar, M., Hemimi, M., Skalny, A. V., Hosnedlová, B., Kizek, R., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-019-01742-2 · Cited by 323 · see citing works

Role of Dopamine Receptors in ADHD: A Systematic Meta-analysis

Wu, J., Xiao, H., Sun, H., Zou, L., & Zhu, L.-Q. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8278-5 · Cited by 274 · see citing works

A mechanistic view of polybrominated diphenyl ether (PBDE) developmental neurotoxicity

Costa, L. G., de Laat, R., Tagliaferri, S., & Pellacani, C. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.11.011 · Cited by 256 · see citing works

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

Smaga, I., Niedzielska, E., Gawlik, M., Moniczewski, A., Krzek, J., Przegaliński, E., Pera, J., & Filip, M. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2014.12.015 · Cited by 252 · see citing works

Environmental factors influencing the risk of autism

Karimi, P., Kamali, E., Mousavi, S. M., & Karahmadi, M. (2017) · Journal of Research in Medical Sciences · doi:10.4103/1735-1995.200272 · Cited by 261 · see citing works

Microbiome disturbances and autism spectrum disorders

Rosenfeld, C. S. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.063826 · Cited by 229 · see citing works

Toxicity of inhaled particulate matter on the central nervous system: neuroinflammation, neuropsychological effects and neurodegenerative disease

Wang, Y., Xiong, L., & Tang, M. X. (2017) · Journal of Applied Toxicology · doi:10.1002/jat.3451 · Cited by 210 · see citing works

Complementary and Alternative Medicine Treatments for Children with Autism Spectrum Disorders

Levy, S. E., & Hyman, S. L. (2008) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2008.06.004 · Cited by 209 · see citing works

Neurotoxicants Are in the Air: Convergence of Human, Animal, andIn VitroStudies on the Effects of Air Pollution on the Brain

Costa, L. G., Cole, T. B., Coburn, J. L., Chang, Y.-C., Dao, K., & Roqué, P. J. (2014) · BioMed Research International · doi:10.1155/2014/736385 · Cited by 205 · see citing works

Biomarkers in Autism

Goldani, A. A. S., Downs, S. R., Widjaja, F., Lawton, B., & Hendren, R. L. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00100 · Cited by 204 · see citing works

Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6

Tsilioni, I., Taliou, A., Francis, K., & Theoharides, T. C. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.142 · Cited by 199 · see citing works

Brain Region-Specific Glutathione Redox Imbalance in Autism

Chauhan, A., AUDHYA, T. K., & Chauhan, V. P. S. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0775-4 · Cited by 196 · see citing works

The Glutathione System: A New Drug Target in Neuroimmune Disorders

Morris, G., Anderson, G., Dean, O. M., Berk, M., Gałecki, P., Martín-Subero, M., & Maes, M. H. J. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8705-x · Cited by 187 · see citing works

Understanding and Determining the Etiology of Autism

Currenti, S. A. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9453-8 · Cited by 185 · see citing works

Focal brain inflammation and autism

Theoharides, T. C., Asadi, S., & Patel, A. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-46 · Cited by 178 · see citing works

Tipping the balance of autism risk: potential mechanisms linking pesticides and autism

Shelton, J. F., Hertz-Picciotto, I., & Pessah, I. N. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104553 · Cited by 164 · see citing works

Does Inorganic Mercury Play a Role in Alzheimer's Disease? A Systematic Review and an Integrated Molecular Mechanism

Mutter, J., Curth, A., Naumann, J., Deth, R. C., & Walach, H. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100705 · Cited by 163 · see citing works

The biological significance of methionine sulfoxide stereochemistry

Lee, B. C., & Gladyshev, V. N. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.11.008 · Cited by 162 · see citing works

Decreased Brain Levels of Vitamin B12 in Aging, Autism and Schizophrenia

Zhang, Y., Hodgson, N., Trivedi, M. S., Abdolmaleky, H. M., Fournier, M., Cuénod, M., Kim, Q., & Deth, R. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146797 · Cited by 164 · see citing works

Perinatal stress, brain inflammation and risk of autism-Review and proposal

Angelidou, A., Asadi, S., Alysandratos, K., Karagkouni, A., Kourembanas, S., & Theoharides, T. C. (2012) · BMC Pediatrics · doi:10.1186/1471-2431-12-89 · Cited by 153 · see citing works

ALL OUR SONS: THE DEVELOPMENTAL NEUROBIOLOGY AND NEUROENDOCRINOLOGY OF BOYS AT RISK

Schore, A. N. (2017) · Infant Mental Health Journal · doi:10.1002/imhj.21616 · Cited by 144 · see citing works

Redox metabolism abnormalities in autistic children associated with mitochondrial disease

Frye, R. E., DeLaTorre, R., Taylor, H., Slattery, J. M., Melnyk, S., Chowdhury, N., & James, S. J. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.51 · Cited by 143 · see citing works

Hypothesis: a Unifying Mechanism for Nutrition and Chemicals as Lifelong Modulators of DNA Hypomethylation

Lee, D., Jacobs, D. R., & Porta, M. S. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0900741 · Cited by 140 · see citing works

Family history of autoimmune diseases is associated with an increased risk of autism in children: A systematic review and meta-analysis

Wu, S., Ding, Y., Wu, F., Li, R., Xie, G., Hou, J., & Mao, P. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.004 · Cited by 139 · see citing works

Mast cells, brain inflammation and autism

Theoharides, T. C., Stewart, J. M., Panagiotidou, S., & Melamed, I. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.086 · Cited by 138 · see citing works

Autism: Metabolism, Mitochondria, and the Microbiome

Macfabe, D. (2013) · Global Advances in Health and Medicine · doi:10.7453/gahmj.2013.089 · Cited by 131 · see citing works

The dopamine D4 receptor: biochemical and signalling properties

Rondou, P., Haegeman, G., & Craenenbroeck, K. V. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0293-y · Cited by 132 · see citing works

One carbon metabolism disturbances and the C677T MTHFR gene polymorphism in children with autism spectrum disorders

Pașca, S. P., Dronca, E., Kaucsár, T., Crăciun, E. C., Endreffy, E., Ferencz, B., Iftene, F., Benga, I., Cornean, R., Banerjee, R. V., et al. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00463.x · Cited by 128 · see citing works

Potential role of organochlorine pesticides in the pathogenesis of neurodevelopmental, neurodegenerative, and neurobehavioral disorders: A review

Saravi, S. S. S., & Dehpour, A. R. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.11.006 · Cited by 125 · see citing works

The association between gestational diabetes and ASD and ADHD: a systematic review and meta-analysis

Rowland, J., & Wilson, C. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-84573-3 · Cited by 120 · see citing works

Classification and adaptive behavior prediction of children with autism spectrum disorder based upon multivariate data analysis of markers of oxidative stress and DNA methylation

Howsmon, D. P., Krüger, U., Melnyk, S., James, S. J., & Hahn, J. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005385 · Cited by 122 · see citing works

The Role of Heavy Metal Pollution in Neurobehavioral Disorders: a Focus on Autism

Gorini, F., Muratori, F., & Morales, M. A. (2014) · Review Journal of Autism and Developmental Disorders · doi:10.1007/s40489-014-0028-3 · Cited by 120 · see citing works

Red blood cells as an organ? How deep omics characterization of the most abundant cell in the human body highlights other systemic metabolic functions beyond oxygen transport

Nemkov, T. G., Reisz, J. A., Xia, Y., Zimring, J. C., & D’Alessandro, A. (2018) · Expert Review of Proteomics · doi:10.1080/14789450.2018.1531710 · Cited by 113 · see citing works

Short-term sleep deprivation leads to decreased systemic redox metabolites and altered epigenetic status

Trivedi, M. S., Holger, D. J., Bui, A., Craddock, T. J. A., & Tartar, J. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181978 · Cited by 115 · see citing works

A comparison of temporal trends in United States autism prevalence to trends in suspected environmental factors

Nevison, C. D. (2014) · Environmental Health · doi:10.1186/1476-069x-13-73 · Cited by 111 · see citing works

Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study

Jyonouchi, H., Geng, L., Cushing‐Ruby, A., & Quraishi, H. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-52 · Cited by 112 · see citing works

Neurometabolic disorders and dysfunction in autism spectrum disorders

Zecavati, N., & Spence, S. J. (2009) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-009-0021-x · Cited by 110 · see citing works

Are ASD and ADHD a Continuum? A Comparison of Pathophysiological Similarities Between the Disorders

Kern, J. K., Geier, D. A., Sykes, L. K., Geier, M. R., & Deth, R. C. (2012) · Journal of Attention Disorders · doi:10.1177/1087054712459886 · Cited by 106 · see citing works

Microglia and astrocytes underlie neuroinflammation and synaptic susceptibility in autism spectrum disorder

Xiong, Y., Chen, J., & Li, Y. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1125428 · Cited by 109 · see citing works

Effects of Mycotoxins on Neuropsychiatric Symptoms and Immune Processes

Ratnaseelan, A. M., Tsilioni, I., & Theoharides, T. C. (2018) · Clinical Therapeutics · doi:10.1016/j.clinthera.2018.05.004 · Cited by 105 · see citing works

Oxidative stress in egyptian children with autism: Relation to autoimmunity

Mostafa, G. A., El-Hadidi, E. S., Hewedi, D. H., & Abdou, M. M. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.12.003 · Cited by 101 · see citing works

Evidence of parallels between mercury intoxication and the brain pathology in autism

Kern, J. K., Geier, D. A., AUDHYA, T. K., King, P. G., Sykes, L. K., & Geier, M. R. (2012) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2012-1887 · Cited by 100 · see citing works

Excitotoxicity in the Pathogenesis of Autism

Essa, M. M., Braidy, N., Vijayan, K. R., Subash, S., & Guillemin, G. J. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9354-3 · Cited by 97 · see citing works

Bisphenol A induces oxidative stress and mitochondrial dysfunction in lymphoblasts from children with autism and unaffected siblings

Kaur, K., Chauhan, V. P. S., Gu, F., & Chauhan, A. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.07.030 · Cited by 96 · see citing works

Mercury induces inflammatory mediator release from human mast cells

Kempuraj, D., Asadi, S., Zhang, B., Manola, A., Hogan, J. A., Peterson, E. L., & Theoharides, T. C. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-20 · Cited by 96 · see citing works

The Interplay between DNA Methylation, Folate and Neurocognitive Development

Irwin, R. E., Pentieva, K. D., Cassidy, T., Lees‐Murdock, D. J., McLaughlin, M., Prasad, G., McNulty, H., & Walsh, C. P. (2016) · Epigenomics · doi:10.2217/epi-2016-0003 · Cited by 94 · see citing works

Lack of Correlation Between Metallic Elements Analyzed in Hair by ICP-MS and Autism

Palma, G. D., Catalani, S., Franco, A., Brighenti, M., & Apostoli, P. (2011) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-011-1245-6 · Cited by 91 · see citing works

Effect of bisphenol A on Drosophila melanogaster behavior – A new model for the studies on neurodevelopmental disorders

Kaur, K., Simon, A. F., Chauhan, V. P. S., & Chauhan, A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.001 · Cited by 90 · see citing works

Iron and vitamin D levels among autism spectrum disorders children

Bener, A., Khattab, A., Bhugra, D., & Hoffmann, G. (2017) · Annals of African Medicine · doi:10.4103/aam.aam_17_17 · Cited by 88 · see citing works

Chelation for autism spectrum disorder (ASD)

James, S., Stevenson, S. W., Silove, N., & Williams, K. J. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010766.pub2 · Cited by 88 · see citing works

Impaired synthesis and antioxidant defense of glutathione in the cerebellum of autistic subjects: Alterations in the activities and protein expression of glutathione-related enzymes

Gu, F., Chauhan, V. P. S., & Chauhan, A. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.021 · Cited by 88 · see citing works

Epigenetic Findings in Autism: New Perspectives for Therapy

Siniscalco, D., Cirillo, A., Bradstreet, J. J., & Antonucci, N. (2013) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph10094261 · Cited by 87 · see citing works

Complementary and Alternative Medicine Treatments for Children with Autism Spectrum Disorders

Levy, S. E., & Hyman, S. L. (2014) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2014.09.004 · Cited by 85 · see citing works

Food allergy and autism spectrum disorders: Is there a link?

Jyonouchi, H. (2009) · Current Allergy and Asthma Reports · doi:10.1007/s11882-009-0029-y · Cited by 84 · see citing works

The dual hit hypothesis of schizophrenia: Evidence from animal models

Guerrin, C. G. J., Doorduin, J., Sommer, I. E., & de Vries, E. F. J. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.025 · Cited by 81 · see citing works

Genetics and Mitochondrial Abnormalities in Autism Spectrum Disorders:A Review

Dhillon, S., Hellings, J. A., & Butler, M. G. (2011) · Current Genomics · doi:10.2174/138920211796429745 · Cited by 81 · see citing works

Is high prevalence of vitamin D deficiency evidence for autism disorder? In a highly endogamous population

Bener, A., Khattab, A., & Al-Dabbagh, M. (2014) · Journal of Pediatric Neurosciences · doi:10.4103/1817-1745.147574 · Cited by 80 · see citing works

Autism: an emerging ‘neuroimmune disorder’ in search of therapy

Theoharides, T. C., Kempuraj, D., & Redwood, L. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560903107789 · Cited by 79 · see citing works

A review of recent reports on autism: 1000 studies published in 2007

Hughes, J. R. (2008) · Epilepsy &amp; Behavior · doi:10.1016/j.yebeh.2008.06.015 · Cited by 76 · see citing works

Single Turnover of Substrate-Bound Ferric Cysteine Dioxygenase with Superoxide Anion: Enzymatic Reactivation, Product Formation, and a Transient Intermediate

Crawford, J. A., Li, W., & Pierce, B. S. (2011) · Biochemistry · doi:10.1021/bi2011724 · Cited by 76 · see citing works

Oxytocin improves animal behaviors and ameliorates oxidative stress and inflammation in autistic mice

Wang, Y., Zhao, S., Liu, X., Zheng, Y., Li, L., & Su, M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.07.148 · Cited by 75 · see citing works

Exploring the Multifactorial Nature of Autism Through Computational Systems Biology: Calcium and the Rho GTPase RAC1 Under the Spotlight

Zeidán‐Chuliá, F., Rybarczyk-Filho, J. L., Salmina, A. B., de Oliveira, B. H. N., Noda, M., & Moreira, J. C. F. (2013) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8224-3 · Cited by 74 · see citing works

A comprehensive review of mercury provoked autism.

Geier, D. A., King, P. G., Sykes, L. K., & Geier, M. R. (2008) · PubMed · Cited by 74 · see citing works

Redox/methylation mediated abnormal DNA methylation as regulators of ambient fine particulate matter-induced neurodevelopment related impairment in human neuronal cells

Wei, H., Liang, F., Meng, G., Nie, Z., Zhou, R., Cheng, W., Wu, X., Feng, Y., & Wang, Y. (2016) · Scientific Reports · doi:10.1038/srep33402 · Cited by 72 · see citing works

Biomarker-guided interventions of clinically relevant conditions associated with autism spectrum disorders and attention deficit hyperactivity disorder.

Bradstreet, J. J., Smith, S. A., Baral, M., & Rossignol, D. A. (2010) · PubMed · Cited by 71 · see citing works

Role of mycotoxins in the pathobiology of autism: A first evidence

Santis, B. D., Brera, C., Mezzelani, A., Soricelli, S., Ciceri, F., Moretti, G., Debegnach, F., Bonaglia, M. C., Villa, L. M., Molteni, M., et al. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1357793 · Cited by 72 · see citing works

Interplay between pro-inflammatory cytokines and brain oxidative stress biomarkers: Evidence of parallels between butyl paraben intoxication and the valproic acid brain physiopathology in autism rat model

Hegazy, H. G., Ali, E. H. A., & Elgoly, A. H. M. (2014) · Cytokine · doi:10.1016/j.cyto.2014.10.027 · Cited by 69 · see citing works

Potential Role of Selenoenzymes and Antioxidant Metabolism in relation to Autism Etiology and Pathology

Raymond, L. J., Deth, R. C., & Ralston, N. V. C. (2014) · Autism Research and Treatment · doi:10.1155/2014/164938 · Cited by 67 · see citing works

Understanding intellectual disability and autism spectrum disorders from common mouse models: synapses to behaviour

Verma, V., Paul, A., Vishwanath, A. A., Vaidya, B., & Clement, J. P. (2019) · Open Biology · doi:10.1098/rsob.180265 · Cited by 65 · see citing works

Plasma antioxidant capacity is reduced in Asperger syndrome

Parellada, M., Moreno, C., MacDowell, K. S., Leza, J. C., Giráldez, M., Bailón, C., Castro, C., Miranda-Azpiazu, P., Fraguas, D., & Arango, C. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.10.004 · Cited by 67 · see citing works

Tetrahydrobiopterin as a Novel Therapeutic Intervention for Autism

Frye, R. E., Huffman, L. C., & Elliott, G. R. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.004 · Cited by 65 · see citing works

Relationship between chronic lead toxicity and plasma neurotransmitters in autistic patients from Saudi Arabia

El-Ansary, A. K., Bacha, A. B., & Ayahdi, L. Y. A. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2011.06.982 · Cited by 64 · see citing works

Comparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls

Yektaş, Ç., Alpay, M., & Tufan, A. E. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s212361 · Cited by 66 · see citing works

Gene-Environment Interactions and Epigenetic Pathways in Autism: The Importance of One-Carbon Metabolism

Schaevitz, L. R., & Berger-Sweeney, J. E. (2012) · ILAR Journal · doi:10.1093/ilar.53.3-4.322 · Cited by 64 · see citing works

Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin

Asadi, S., & Theoharides, T. C. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-85 · Cited by 64 · see citing works

Homocysteine, Vitamins B6 and Folic Acid in Experimental Models of Myocardial Infarction and Heart Failure—How Strong Is That Link?

Bajić, Z., Šobot, T., Škrbić, R., Stojiljković, M. P., Ponorac, N., Matavulj, A., & Djuric, D. M. (2022) · Biomolecules · doi:10.3390/biom12040536 · Cited by 65 · see citing works

Elevated serum neurotensin and CRH levels in children with autistic spectrum disorders and tail-chasing Bull Terriers with a phenotype similar to autism

Tsilioni, I., Dodman, N. H., Petra, A. I., Taliou, A., Francis, K., Moon-Fanelli, A. A., Shuster, L., & Theoharides, T. C. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.106 · Cited by 63 · see citing works

A macroepigenetic approach to identify factors responsible for the autism epidemic in the United States

Dufault, R., Lukiw, W. J., Crider, R. A., Schnoll, R., Wallinga, D. B., & Deth, R. C. (2012) · Clinical Epigenetics · doi:10.1186/1868-7083-4-6 · Cited by 61 · see citing works

Second-Sphere Interactions between the C93–Y157 Cross-Link and the Substrate-Bound Fe Site Influence the O2 Coupling Efficiency in Mouse Cysteine Dioxygenase

Li, W., Blaesi, E. J., Pecore, M. D., Crowell, J. K., & Pierce, B. S. (2013) · Biochemistry · doi:10.1021/bi4010232 · Cited by 60 · see citing works

Cerebral hypoperfusion in autism spectrum disorder

Bjørklund, G., Kern, J. K., Urbina, M. A., Saad, K., Elhoufey, A. A., Geier, D. A., Chirumbolo, S., Geier, M. R., Mehta, J. A., & Aaseth, J. (2018) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2018-005 · Cited by 60 · see citing works

Fetal DNA methylation of autism spectrum disorders candidate genes: association with spontaneous preterm birth

Behnia, F., Parets, S. E., Kechichian, T. B., Yin, H., Dutta, E. H., Saade, G. R., Smith, A. K., & Menon, R. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.02.011 · Cited by 59 · see citing works

Causation model of autism: Audiovisual brain specialization in infancy competes with social brain networks

Heffler, K. F., & Oestreicher, L. M. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2015.06.019 · Cited by 59 · see citing works

1D-spectral editing and 2D multispectral in vivo 1H-MRS and 1H-MRSI - Methods and applications

Bogner, W., Hangel, G. J., Esmaeili, M., & Andronesi, O. C. (2016) · Analytical Biochemistry · doi:10.1016/j.ab.2016.12.020 · Cited by 55 · see citing works

Cerebral Folate Deficiency Syndrome: Early Diagnosis, Intervention and Treatment Strategies

Ramaekers, V. T., & Quadros, E. V. (2022) · Nutrients · doi:10.3390/nu14153096 · Cited by 54 · see citing works

Autism, Gut-Blood-Brain Barrier, and Mast Cells

Theoharides, T. C., & Doyle, R. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181845f48 · Cited by 54 · see citing works

Mast Cells, Stress, Fear and Autism Spectrum Disorder

Theoharides, T. C., Kavalioti, M., & Tsilioni, I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153611 · Cited by 55 · see citing works

Chronic metals ingestion by prairie voles produces sex-specific deficits in social behavior: An animal model of autism

Curtis, J. T., Hood, A. N., Chen, Y., Cobb, G. P., & Wallace, D. R. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.04.028 · Cited by 52 · see citing works

Demethylation of Specific Wnt/β‐Catenin Pathway Genes and its Upregulation in Rat Brain Induced by Prenatal Valproate Exposure

Wang, Z., Xu, L., Zhu, X., Cui, W., Sun, Y., Nishijo, H., Peng, Y., & Li, R. (2010) · The Anatomical Record · doi:10.1002/ar.21232 · Cited by 51 · see citing works

Diagnostic and Severity-Tracking Biomarkers for Autism Spectrum Disorder

Bjørklund, G., Meguid, N. A., El-Ansary, A. K., El‐Bana, M. A., Dadar, M., Aaseth, J., Hemimi, M., Osredkar, J., & Chirumbolo, S. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1192-1 · Cited by 51 · see citing works

The plausibility of a role for mercury in the etiology of autism: a cellular perspective

Garrecht, M., & Austin, D. (2011) · Toxicological & Environmental Chemistry Reviews · doi:10.1080/02772248.2011.580588 · Cited by 49 · see citing works

The “missing link” in autoimmunity and autism: Extracellular mitochondrial components secreted from activated live mast cells

Theoharides, T. C., Asadi, S., Panagiotidou, S., & Weng, Z. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.06.018 · Cited by 48 · see citing works

Metal Profiles in Autism Spectrum Disorders: A Crosstalk between Toxic and Essential Metals

Błażewicz, A., & Grabrucker, A. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010308 · Cited by 51 · see citing works

One-carbon metabolism in neurodevelopmental disorders: Using broad-based nutraceutics to treat cognitive deficits in complex spectrum disorders

Schaevitz, L. R., Berger-Sweeney, J. E., & Ricceri, L. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.04.007 · Cited by 47 · see citing works

Modeling autism: a systems biology approach

Randolph-Gips, M. M., & Srinivasan, P. N. (2012) · Journal of Clinical Bioinformatics · doi:10.1186/2043-9113-2-17 · Cited by 48 · see citing works

Oxidative Stress in Autism and Its Implications for Dopamine-Stimulated Phospholipid Methylation

Deth, R. C., Muratore, C., & Waly, M. I. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1272-5_12

Autism: A Redox/Methylation Disorder

Deth, R. C. (2013) · Global Advances in Health and Medicine · doi:10.7453/gahmj.2013.087 · Cited by 12 · see citing works

Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism

Melnyk, S., Fuchs, G. J., Schulz, E., Lopez, M., Kahler, S. G., Fussell, J. J., Bellando, J., Pavliv, O., Rose, S., Seidel, L., et al. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-011-1260-7 · Cited by 250 · see citing works

Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism

James, S. J., Melnyk, S., Jernigan, S., Cleves, M. A., Halsted, C. H., Wong, D. H., Cutler, P., Bock, K., Boris, M., Bradstreet, J., et al. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30366 · Cited by 605 · see citing works

A Significant Factor in Autism: Methyl Mercury Induced Oxidative Stress in Genetically Susceptible Individuals

Leslie, K. E., & Koger, S. M. (2011) · Journal of Developmental and Physical Disabilities · doi:10.1007/s10882-011-9230-8 · Cited by 9 · see citing works