Plasma phthalate and bisphenol a levels and oxidant-antioxidant status in autistic children
Abstract
Phthalates and bisphenol A (BPA) are endocrine disruting chemicals (EDCs) that are suggested to exert neurotoxic effects. This study aimed to determine plasma phthalates and BPA levels along with oxidant/antioxidant status in autistic children [n=51; including 12 children were diagnosed with "Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS)]. Plasma levels of BPA, di (2-ethylhexyl)-phthalate (DEHP) and its main metabolite mono (2-ethylhexyl)-phthalate (MEHP); thiobarbituric acid reactive substance (TBARS) and carbonyl groups; erythrocyte glutathione peroxidase (GPx1), thioredoxin reductase (TrxR), catalase (CAT), superoxide dismutase (SOD) and glutathione reductase (GR) activities and glutathione (GSH) and selenium levels were measured. Plasma BPA levels of children with PDD-NOS were significantly higher than both classic autistic children and controls (n=50). Carbonyl, selenium concentrations and GPx1, SOD and GR activities were higher (p<0.05); CAT activity was markedly lower in study group. BPA exposure might be associated with PDD-NOS. Intracellular imbalance between oxidant and antioxidant status might facilitate its neurotoxicity.
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The published literature on bisphenol A and autism is conflicting, reporting associations ranging from none to rather substantial links with clinical autism and autistic traits.
“Concerning bisphenol A, the published literature, mostly characterized by smaller case–control studies is also conflicting, reporting associations ranging from none to rather substantial links with clinical autism and autistic traits [203–206].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [205]
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The contribution of environmental exposure to the etiology of autism spectrum disorder
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- Authors
- Kondolot, M., Ozmert, E. N., Ascı, A., Erkekoglu, P., Oztop, D. B., Gumus, H., Kocer-Gumusel, B., & Yurdakok, K.
- Affiliations
- Erciyes University (TR)
- Corresponding author
- Kondolot, Meda
- ORCID
- Kondolot, Meda
- Venue
- Environmental Toxicology and Pharmacology
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 43
- Pages
- 149-158
- ISSN
- 1382-6689 (ISSN-L)
- OpenAlex
- W2293857789
- Cited by
- 74
- References
- 64
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 2 · 2023: 9 · 2022: 5 · 2021: 10 · 2020: 10 · 2019: 8 · 2018: 12 · 2017: 6 · 2016: 1
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Environmental Toxicology and Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Erciyes University Scientific Research Unit
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- phthalates, bisphenol A, autism spectrum disorder, pervasive developmental disorder not otherwise specified, endocrine disruptors, oxidative stress, antioxidant status, DEHP, mono(2-ethylhexyl) phthalate, lipid peroxidation, carbonyl compounds, selenium, glutathione, glutathione peroxidase 1, superoxide dismutase, catalase, thioredoxin reductase, glutathione reductase, neurotoxicity, children
- MeSH terms
- Bisphenol A Compounds, Autistic Disorder, Benzhydryl Compounds, Catalase, Child, Environmental Exposure, Environmental Pollutants, Humans, Phenols, Phthalic Acids, Selenium, Superoxide Dismutase, Thioredoxin-Disulfide Reductase
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