Cited by 74Effects and risks of endocrine disrupting chemicalsAutism Spectrum Disorder ResearchHeavy Metal Exposure and Toxicity

Plasma phthalate and bisphenol a levels and oxidant-antioxidant status in autistic children

Kondolot, Meda, Ozmert, Elif N., Ascı, Ali, Erkekoglu, Pınar, Oztop, Didem B., Gumus, Hakan, Kocer-Gumusel, Belma, Yurdakok, Kadriye·2016·Environmental Toxicology and Pharmacology

Abstract

Phthalates and bisphenol A (BPA) are endocrine disruting chemicals (EDCs) that are suggested to exert neurotoxic effects. This study aimed to determine plasma phthalates and BPA levels along with oxidant/antioxidant status in autistic children [n=51; including 12 children were diagnosed with "Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS)]. Plasma levels of BPA, di (2-ethylhexyl)-phthalate (DEHP) and its main metabolite mono (2-ethylhexyl)-phthalate (MEHP); thiobarbituric acid reactive substance (TBARS) and carbonyl groups; erythrocyte glutathione peroxidase (GPx1), thioredoxin reductase (TrxR), catalase (CAT), superoxide dismutase (SOD) and glutathione reductase (GR) activities and glutathione (GSH) and selenium levels were measured. Plasma BPA levels of children with PDD-NOS were significantly higher than both classic autistic children and controls (n=50). Carbonyl, selenium concentrations and GPx1, SOD and GR activities were higher (p<0.05); CAT activity was markedly lower in study group. BPA exposure might be associated with PDD-NOS. Intracellular imbalance between oxidant and antioxidant status might facilitate its neurotoxicity.

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Crossref · 10.1016/j.etap.2016.03.006

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  • The published literature on bisphenol A and autism is conflicting, reporting associations ranging from none to rather substantial links with clinical autism and autistic traits.

    “Concerning bisphenol A, the published literature, mostly characterized by smaller case–control studies is also conflicting, reporting associations ranging from none to rather substantial links with clinical autism and autistic traits [203–206].”

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Authors
Kondolot, M., Ozmert, E. N., Ascı, A., Erkekoglu, P., Oztop, D. B., Gumus, H., Kocer-Gumusel, B., & Yurdakok, K.
Affiliations
Erciyes University (TR)
Corresponding author
Kondolot, Meda
Venue
Environmental Toxicology and Pharmacology
Publisher
Elsevier BV
Published
2016-04
Volume
43
Pages
149-158
ISSN
1382-6689 (ISSN-L)
OpenAlex
W2293857789
Cited by
74
References
64
Citations by year
2026: 6 · 2025: 5 · 2024: 2 · 2023: 9 · 2022: 5 · 2021: 10 · 2020: 10 · 2019: 8 · 2018: 12 · 2017: 6 · 2016: 1
FWCI
5.68
Type
journal article
Language
en
Open access
closed
Locations
  • Environmental Toxicology and Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Erciyes University Scientific Research Unit
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords
phthalates, bisphenol A, autism spectrum disorder, pervasive developmental disorder not otherwise specified, endocrine disruptors, oxidative stress, antioxidant status, DEHP, mono(2-ethylhexyl) phthalate, lipid peroxidation, carbonyl compounds, selenium, glutathione, glutathione peroxidase 1, superoxide dismutase, catalase, thioredoxin reductase, glutathione reductase, neurotoxicity, children
MeSH terms
Bisphenol A Compounds, Autistic Disorder, Benzhydryl Compounds, Catalase, Child, Environmental Exposure, Environmental Pollutants, Humans, Phenols, Phthalic Acids, Selenium, Superoxide Dismutase, Thioredoxin-Disulfide Reductase

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