Cited by 354Curcumin's Biomedical ApplicationsAlzheimer's disease research and treatmentsMedicinal Plants and Neuroprotection

Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

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Reddy, P. Hemachandra, Manczak, Maria, Yin, Xiangling, Grady, Mary Catherine, Mitchell, Andrew, Tonk, Sahil, Kuruva, Chandra Sekhar, Bhatti, Jasvinder Singh +10 more·2018·Journal of Alzheimer s Disease

Abstract

The purpose of our article is to assess the current understanding of Indian spice, curcumin, against amyloid-β (Aβ)-induced toxicity in Alzheimer's disease (AD) pathogenesis. Natural products, such as ginger, curcumin, and gingko biloba have been used as diets and dietary supplements to treat human diseases, including cancer, cardiovascular, respiratory, infectious, diabetes, obesity, metabolic syndromes, and neurological disorders. Products derived from plants are known to have protective effects, including anti-inflammatory, antioxidant, anti-arthritis, pro-healing, and boosting memory cognitive functions. In the last decade, several groups have designed and synthesized curcumin and its derivatives and extensively tested using cell and mouse models of AD. Recent research on Aβ and curcumin has revealed that curcumin prevents Aβ aggregation and crosses the blood-brain barrier, reach brain cells, and protect neurons from various toxic insults of aging and Aβ in humans. Recent research has also reported that curcumin ameliorates cognitive decline and improves synaptic functions in mouse models of AD. Further, recent groups have initiated studies on elderly individuals and patients with AD and the outcome of these studies is currently being assessed. This article highlights the beneficial effects of curcumin on AD. This article also critically assesses the current limitations of curcumin's bioavailability and urgent need for new formulations to increase its brain levels to treat patients with AD.

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Authors
Reddy, P. H., Manczak, M., Yin, X., Grady, M. C., Mitchell, A., Tonk, S., Kuruva, C. S., Bhatti, J. S., Kandimalla, R., Vijayan, M., Kumar, S., Wang, R., Pradeepkiran, J. A., Ogunmokun, G., Thamarai, K., Quesada, K., Boles, A., & Reddy, A. P.
Affiliations
  • Texas Tech University (US)
  • Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA
  • Texas Tech University Health Sciences Center (US)
  • Sri Guru Gobind Singh College (IN)
Corresponding author
Reddy, P. Hemachandra
Venue
Journal of Alzheimer s Disease
Published
2018-01-09
Volume
61
Issue
3
Pages
843-866
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W2784122958
Cited by
354
References
120
Citations by year
2026: 17 · 2025: 49 · 2024: 47 · 2023: 63 · 2022: 47 · 2021: 44 · 2020: 49 · 2019: 29 · 2018: 8
FWCI
2.71
Type
journal article
Language
en
Open access
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (R01AG042178, R01AG047812)
  • National Institute of Neurological Disorders and Stroke (R01NS105473)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
curcumin, Alzheimer's disease
MeSH terms
Alzheimer Disease, Animals, Blood-Brain Barrier, Curcumin, Disease Models, Animal, Humans, Randomized Controlled Trials as Topic, Amyloid beta-Peptides, Spices, Neuroprotective Agents, Mice

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