Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease
Open accessAbstract
The purpose of our article is to assess the current understanding of Indian spice, curcumin, against amyloid-β (Aβ)-induced toxicity in Alzheimer's disease (AD) pathogenesis. Natural products, such as ginger, curcumin, and gingko biloba have been used as diets and dietary supplements to treat human diseases, including cancer, cardiovascular, respiratory, infectious, diabetes, obesity, metabolic syndromes, and neurological disorders. Products derived from plants are known to have protective effects, including anti-inflammatory, antioxidant, anti-arthritis, pro-healing, and boosting memory cognitive functions. In the last decade, several groups have designed and synthesized curcumin and its derivatives and extensively tested using cell and mouse models of AD. Recent research on Aβ and curcumin has revealed that curcumin prevents Aβ aggregation and crosses the blood-brain barrier, reach brain cells, and protect neurons from various toxic insults of aging and Aβ in humans. Recent research has also reported that curcumin ameliorates cognitive decline and improves synaptic functions in mouse models of AD. Further, recent groups have initiated studies on elderly individuals and patients with AD and the outcome of these studies is currently being assessed. This article highlights the beneficial effects of curcumin on AD. This article also critically assesses the current limitations of curcumin's bioavailability and urgent need for new formulations to increase its brain levels to treat patients with AD.
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Curcumin may offer therapeutic efficacy in the pathogenesis of Alzheimer's disease.
“According to recent findings, curcumin may offer therapeutic efficacy in the pathogenesis of AD, and in vitro studies suggested that curcumin inhibits Aβ aggregation and Aβ-induced neuroinflammation [81].”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [81]
Curcumin inhibits amyloid beta aggregation and amyloid beta-induced neuroinflammation in vitro.
“According to recent findings, curcumin may offer therapeutic efficacy in the pathogenesis of AD, and in vitro studies suggested that curcumin inhibits Aβ aggregation and Aβ-induced neuroinflammation [81].”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [81]
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- Authors
- Reddy, P. H., Manczak, M., Yin, X., Grady, M. C., Mitchell, A., Tonk, S., Kuruva, C. S., Bhatti, J. S., Kandimalla, R., Vijayan, M., Kumar, S., Wang, R., Pradeepkiran, J. A., Ogunmokun, G., Thamarai, K., Quesada, K., Boles, A., & Reddy, A. P.
- Affiliations
- Texas Tech University (US)
- Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA
- Texas Tech University Health Sciences Center (US)
- Sri Guru Gobind Singh College (IN)
- Corresponding author
- Reddy, P. Hemachandra
- ORCID
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2018-01-09
- Volume
- 61
- Issue
- 3
- Pages
- 843-866
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC5796761
- OpenAlex
- W2784122958
- Cited by
- 354
- References
- 120
- Citations by year
- 2026: 17 · 2025: 49 · 2024: 47 · 2023: 63 · 2022: 47 · 2021: 44 · 2020: 49 · 2019: 29 · 2018: 8
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG042178, R01AG047812)
- National Institute of Neurological Disorders and Stroke (R01NS105473)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- curcumin, Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Animals, Blood-Brain Barrier, Curcumin, Disease Models, Animal, Humans, Randomized Controlled Trials as Topic, Amyloid beta-Peptides, Spices, Neuroprotective Agents, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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