Investigating degeneration of the retina in young and aged tau P301L mice
Abstract
Aims Tau is a microtubule-binding protein facilitating the stability of the cytoskeleton. It is important for neurons as several neurodegenerative diseases involve hyperphosphorylation and aggregation of tau. It is known that mutated tau P301L results in aggregation of tau proteins, leading to neuronal loss in the brain. The aim of this study was to investigate the effect of tau mutation on the retina using a transgenic tau P301L mouse model. Main methods Morphometric analysis was utilized to quantify the neurodegenerative changes, including the thickness of the inner nuclear layer (INL), and the density and size of retinal ganglion cells (RGCs). Sections of retina tissue stained by hematoxylin and eosin (H&E) and immunohistochemistry were analyzed. Comparisons were made between the tau P301L mice and control mice, as well as between different age groups. Key findings A significant decrease in the thickness of the INL in tau P301L mice was found when compared with that of control mice. The effect was more pronounced in the peripheral area, and the effect increased with age. Regarding density of RGCs, tau P301L mice showed a similar age-related decline as in control mice. Furthermore, the RGCs from tau P301L mice increased in size with age, and the RGCs from control mice decreased in size with age. Significance Tau may be an age-independent factor of accelerated neurodegeneration, with effects differing by types of neurons and regions of the retina.
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Reductions in FA and increases in RAD correlate with axon loss in abnormal WM in both MCI and AD patients.
“Similar to our findings, reductions in FA and increases in RAD were found to correlate with axon loss in abnormal WM in both MCI and AD patients 25,51–54”
From Amyloid-beta induced retrograde axonal degeneration in a mouse tauopathy model (2019) · cites this paper as [25]
Mouse retinal ganglion cells project axons through the optic nerve and optic tract, terminating in the lateral geniculate nucleus.
“Mouse RGCs, whose cell bodies are in the retina, project axons into the brain through the optic nerve (ON) and optic tract (OT), before terminating in the lateral geniculate nucleus (LGN) 25.”
From Amyloid-beta induced retrograde axonal degeneration in a mouse tauopathy model (2019) · cites this paper as [25]
The relationship between DTI-detected WM changes and histologically detected axonal loss has been observed in several animal and human studies.
“The relationship between DTI-detected WM changes and histologically detected axonal loss has been observed in several animal and human studies 25, 51–54”
From Amyloid-beta induced retrograde axonal degeneration in a mouse tauopathy model (2019) · cites this paper as [25]
In mouse models, reductions in AxD are seen during acute axonal degeneration.
“In mouse models, Reductions in AxD are also seen during acute axonal degeneration 25, 57.”
From Amyloid-beta induced retrograde axonal degeneration in a mouse tauopathy model (2019) · cites this paper as [25]
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Amyloid-beta induced retrograde axonal degeneration in a mouse tauopathy model
Nishioka, C., Liang, H.-F., Barsamian, B., & Sun, S.-W. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.01.007 · Cited by 30 · see citing works
- Authors
- Ho, W. L., Leung, Y., Cheng, S. S. Y., Lok, C. K. M., Ho, Y.-S., Baum, L., Yang, X., Chiu, K., & Chang, R. C.-C.
- Affiliations
- University of Hong Kong (HK)
- Chinese University of Hong Kong (HK)
- Shenzhen Center for Disease Control and Prevention (CN)
- Corresponding author
- Chiu, Kin
- Chang, Raymond Chuen-Chung
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 124
- Pages
- 16-23
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W1995025780
- Cited by
- 15
- References
- 5
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 2
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- PolyU Institutional Research Archive (Hong Kong Polytechnic University) (submittedVersion)
- Funders
- HKU Alzheimer's Disease Research Network under Strategic Research Theme of Ageing
- Ms. Kit-Wan Chow
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Keywords
- P301L tau, tauopathy, retinal degeneration, retinal ganglion cells, inner nuclear layer thickness, age-related neurodegeneration, transgenic mouse model, neuronal loss, retinal aging
- MeSH terms
- Age Factors, Animals, Disease Models, Animal, Female, Humans, Immunohistochemistry, Male, Mice, Transgenic, Mutation, Neurons, Retina, Retinal Ganglion Cells, tau Proteins, Neurodegenerative Diseases, Mice
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