Amyloid-β Deposits Lead to Retinal Degeneration in a Mouse Model of Alzheimer Disease
Open accessAbstract
PURPOSE: To compare the temporal and spatial expression patterns of amyloid precursor protein (APP), amyloid-beta deposits, inflammatory chemokines, and apoptosis in the retina of a mouse model of Alzheimer disease (AD). METHODS: Retinas of transgenic mice harboring a mutant presenilin (PS1) and a mutant APP gene were processed for TUNEL and immunohistochemistry with antibodies against APP, amyloid-beta, monocyte chemotactic protein (MCP)-1, and F4/80. Comparisons were made between age groups and between transgenic and wild-type congeners. RESULTS: The neuroretina demonstrated age-dependent increases in APP in the ganglion cells (RGCs) and in neurons of the inner nuclear layer (INL). Amyloid-beta demonstrated significant age-dependent deposition in the nerve fiber layer (NFL). TUNEL-positive RGC increased in an age-dependent fashion and in transgenic compared with wild-type congeners. Concomitant overexpression of MCP-1 and intense immunoreactivity for F4/80 suggested that RGCs upregulate MCP-1 in response to amyloid-beta. Activated microglia proliferated in response to MCP-1. In the outer retina, retinal pigment epithelium (RPE) demonstrated moderate age-dependent APP immunoreactivity, but nearby drusenlike deposits were not present. Amyloid-beta was observed in the choriocapillaris of the older animals. CONCLUSIONS: Amyloid-beta deposits accumulate with age in the retina of a transgenic mouse model of AD. The amyloid-beta loads are accompanied by increased immunoreactivity for MCP-1, F4/80, and TUNEL-positive profiles in the RGC layer. The results suggest that amyloid-beta causes neurodegeneration in the retina of the doubly mutant transgenic mouse model of AD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Aβ played a major role in inflammation and neurodegeneration in AD.
“Thus, the authors suggested that Aβ played a major role in the inflammation and neurodegeneration in AD.”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Ning et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Complement factor H polymorphism in age-related macular degeneration
Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J.-Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., et al. (2005) · Science · doi:10.1126/science.1109557 · Cited by 4,492 · see citing works
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516 · see citing works
Complement factor H polymorphism and age-related macular degeneration
Edwards, A. O., Ritter, R., Abel, K. J., Manning, A., Panhuysen, C., & Farrer, L. A. (2005) · Science · doi:10.1126/science.1110189 · Cited by 2,449 · see citing works
Complement factor H variant increases the risk of age-related macular degeneration
Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424 · see citing works
Hageman, G. S., Anderson, D. H., Johnson, L. V., Hancox, L. S., Taiber, A. J., Hardisty, L. I., Hageman, J. L., Stockman, H. A., Borchardt, J. D., Gehrs, K. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501536102 · Cited by 1,961 · see citing works
Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C.-M., Pérez‐Tur, J., Hutton, M., Buée, L., Harigaya, Y., Yager, D., et al. (1996) · Nature · doi:10.1038/383710a0 · Cited by 1,453 · see citing works
Holcomb, L., Gordon, M. N., McGowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., et al. (1998) · Nature Medicine · doi:10.1038/nm0198-097 · Cited by 1,386 · see citing works
Wyss-Coray (2006) · doi:10.1038/nm1484 · Cited by 1,284 · see citing works
Hageman, G. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(01)00010-6 · Cited by 1,265 · see citing works
Drusen proteome analysis: an approach to the etiology of age-related macular degeneration
Crabb, J. W., Miyagi, M., Gu, X., Shadrach, K., West, K. A., Sakaguchi, H., Kamei, M., Hasan, A., Yan, L., Rayborn, M. E., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222551899 · Cited by 1,208 · see citing works
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies
Jankowsky, J. L., Slunt, H. H., Ratovitski, T., Jenkins, N. A., Copeland, N. G., & Borchelt, D. (2001) · Biomolecular Engineering · doi:10.1016/s1389-0344(01)00067-3 · Cited by 819 · see citing works
Complement activation by beta-amyloid in Alzheimer disease.
Rogers, J., Cooper, N. R., Webster, S., Schultz, J., McGeer, P. L., Styren, S. D., Civin, W. H., Brachova, L., Bradt, B., & Ward, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10016 · Cited by 817 · see citing works
Inflammatory processes in Alzheimer's disease
Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.017 · Cited by 782 · see citing works
The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease
Westerman, M. A., Cooper-Blacketer, D., Mariash, A., Kotilinek, L., Kawarabayashi, T., Younkin, L. H., Carlson, G. A., Younkin, S. G., & Ashe, K. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01858.2002 · Cited by 714 · see citing works
Optic-Nerve Degeneration in Alzheimer's Disease
Hinton, D. R., Sadun, A. A., Blanks, J. C., & Miller, C. A. (1986) · New England Journal of Medicine · doi:10.1056/nejm198608213150804 · Cited by 700 · see citing works
An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice
Ambati, J., Anand, A., Fernandez, S., Sakurai, E., Lynn, B. C., Kuziel, W. A., Rollins, B. J., & Ambati, B. K. (2003) · Nature Medicine · doi:10.1038/nm950 · Cited by 631 · see citing works
Retinal Abnormalities in Early Alzheimer’s Disease
Berisha, F., Feke, G. T., Trempe, C. L., McMeel, J. W., & Schepens, C. L. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-1029 · Cited by 505 · see citing works
Johnson, L. V., Leitner, W. P., Rivest, A. J., Staples, M. K., Radeke, M. J., & Anderson, D. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192203399 · Cited by 447 · see citing works
İşeri, P., Altıntaş, Ö., Tokay, T., & Yüksel, N. (2006) · Journal of Neuro-Ophthalmology · doi:10.1097/01.wno.0000204645.56873.26 · Cited by 400 · see citing works
Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer's disease
Paquet, C., Boissonnot, M., Roger, F., Dighiero, P. L., Gil, R., & Hugon, J. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.02.090 · Cited by 353 · see citing works
Retinal pathology in Alzheimer's disease. I. Ganglion cell loss in foveal/parafoveal retina.
Blanks, J., Torigoe, Y., Hinton, D., & Blanks, R. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00010-3 · Cited by 351 · see citing works
Morphological and functional retinal impairment in Alzheimer's disease patients
Parisi, V., Restuccia, R., Fattapposta, F., Mina, C., Bucci, M. G., & Pierelli, F. (2001) · Clinical Neurophysiology · doi:10.1016/s1388-2457(01)00620-4 · Cited by 344 · see citing works
Targeting amyloid-β in glaucoma treatment
Guo, L., Salt, T. E., Luong, V., Wood, N. W., Cheung, W., Maaß, A., Ferrari, G., Russo‐Marie, F., Sillito, A. M., Cheetham, M. E., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703707104 · Cited by 342 · see citing works
Bressler, S. B. (1990) · Archives of Ophthalmology · doi:10.1001/archopht.1990.01070120090035 · Cited by 325 · see citing works
Retinal ganglion cells in Alzheimer's disease and aging
Curcio, C., & Drucker, D. (1993) · Annals of Neurology · doi:10.1002/ana.410330305 · Cited by 323 · see citing works
Anderson, D. H., Talaga, K. C., Rivest, A. J., Barron, E., Hageman, G. S., & Johnson, L. V. (2004) · Experimental Eye Research · doi:10.1016/j.exer.2003.10.011 · Cited by 319 · see citing works
Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension.
McKinnon, S. J., Lehman, D. M., Kerrigan, L. A., Merges, C. A., Pease, M. E., Kerrigan, D., Ransom, N. L., Tahzib, N. G., Reitsamer, H. A., Levkovitch-Verbin, H., et al. (2002) · PubMed · Cited by 296 · see citing works
Retinal pathology in Alzheimer's disease. II. Regional neuron loss and glial changes in GCL
Blanks, J. C., Schmidt, S. Y., Torigoe, Y., Porrello, K. V., Hinton, D. R., & Blanks, R. H. I. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00009-7 · Cited by 287 · see citing works
Dentchev, T., Milam, A. H., Lee, V. M. ‐., Trojanowski, J. Q., & Dunaief, J. L. (2003) · PubMed · Cited by 252 · see citing works
Aβ1–40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation
Niwa, K., Younkin, L. H., Ebeling, C., Turner, S. K., Westaway, D. A., Younkin, S. G., Ashe, K. H., Carlson, G. A., & Iadecola, C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.17.9735 · Cited by 244 · see citing works
Glaucoma ocular Alzheimer s disease
McKinnon, S. J. (2003) · Frontiers in bioscience · doi:10.2741/1172 · Cited by 229 · see citing works
Assessment of Visual Impairment in Patients With Alzheimer's Disease
Sadun, A. A., Borchert, M., DeVita, E., Hinton, D. R., & Bassi, C. J. (1987) · American Journal of Ophthalmology · doi:10.1016/0002-9394(87)90001-8 · Cited by 224 · see citing works
Johnson, P. T., Betts, K. E., Radeke, M. J., Hageman, G. S., Anderson, D. H., & Johnson, L. V. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606234103 · Cited by 223 · see citing works
Luibl, V. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25843 · Cited by 203 · see citing works
Katz, B., Rimmer, S., Iragui, V. J., & Katzman, R. (1989) · Annals of Neurology · doi:10.1002/ana.410260207 · Cited by 198 · see citing works
Local neuroinflammation and the progression of Alzheimer’s disease
McGeer, P., & Mcgeer, E. (2011) · Journal of Neurovirology · doi:10.1080/13550280290100969 · Cited by 181 · see citing works
Brain Parenchymal and Microvascular Amyloid in Alzheimer's Disease
Vinters, H. V., Wang, Z. Z., & Secor, D. L. (1996) · Brain Pathology · doi:10.1111/j.1750-3639.1996.tb00799.x · Cited by 169 · see citing works
Yoshida, S., Yoshida, A., Ishibashi, T., Elner, S. G., & Elner, V. M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0302117 · Cited by 166 · see citing works
Reduction of optic nerve fibers in patients with Alzheimer disease identified by laser imaging
Danesh-Meyer, H. V., Birch, H., Ku, J. Y.-F., Carroll, S., & Gamble, G. (2006) · Neurology · doi:10.1212/01.wnl.0000244490.07925.8b · Cited by 164 · see citing works
Optic nerve head and nerve fiber layer in Alzheimer's disease
Tsai, C. S. (1991) · Archives of Ophthalmology · doi:10.1001/archopht.1991.01080020045040 · Cited by 163 · see citing works
Fryer, J. D., Taylor, J. W., DeMattos, R. B., Bales, K. R., Paul, S. M., Parsadanian, M., & Holtzman, D. M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07889.2003 · Cited by 160 · see citing works
Abnormal pattern electroretinograms in patients with senile dementia of the alzheimer type
Trick, G. L., Barris, M. C., & Bickler‐Bluth, M. (1989) · Annals of Neurology · doi:10.1002/ana.410260208 · Cited by 156 · see citing works
Retinal tau pathology in human glaucomas
Gupta, N., Fong, J., Ang, L. C., & Yücel, Y. H. (2008) · Canadian Journal of Ophthalmology · doi:10.3129/i07-185 · Cited by 134 · see citing works
Davies, M. H., Eubanks, J. P., & Powers, M. R. (2006) · PubMed · Cited by 125 · see citing works
Soluble Alzheimers β-amyloid constricts the cerebral vasculature in vivo
Suo, Z., Humphrey, J., Kundtz, A., Sethi, F. N., Placzek, A. N., Crawford, F., & Mullan, M. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00814-3 · Cited by 113 · see citing works
Synaptic Pathology, Altered Gene Expression, and Degeneration in Photoreceptors Impacted by Drusen
Johnson, P. T., Brown, M. N., Pulliam, B. C., Anderson, D. H., & Johnson, L. V. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0767 · Cited by 111 · see citing works
Ding, J., Lin, J. C., Mace, B. E., Herrmann, R., Sullivan, P. M., & Rickman, C. B. (2007) · Vision Research · doi:10.1016/j.visres.2007.07.025 · Cited by 97 · see citing works
Retinal nerve fiber layer abnormalities in Alzheimer's disease
Hedges, T. R., Galves, R. P., Speigelman, D., Barbas, N. R., Peli, E., & Yardley, C. J. (1996) · Acta Ophthalmologica Scandinavica · doi:10.1111/j.1600-0420.1996.tb00090.x · Cited by 92 · see citing works
Goldblum, D., Kipfer-Kauer, A., Sarra, G., Wolf, S., & Frueh, B. E. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-1249 · Cited by 71 · see citing works
Complement-Associated Deposits in the Human Retina
Seth, A., Cui, J. Z., To, E. C., Kwee, M., & Matsubara, J. A. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1072 · Cited by 68 · see citing works
Retinal Degeneration in the Macula of Patients with Alzheimer's Diseasea
Blanks, J. C., Torigoe, Y., Hinton, D. R., & Blanks, R. H. I. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb00188.x · Cited by 48 · see citing works
Murisier, F., Guichard, S., & Beermann, F. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.11.038 · Cited by 37 · see citing works
Optometric management of patients with Alzheimer's disease.
Baker, D. R., Mendez, M. F., Townsend, J. C., Ilsen, P. F., & Bright, D. C. (1997) · PubMed · Cited by 26 · see citing works
Syrian hamster prion protein (PrPC) is expressed in photoreceptor cells of the adult retina
Chishti, M. A., Strome, R., Carlson, G. A., & Westaway, D. A. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00669-1 · Cited by 22 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [36]Green RG, Harlan JB. Histopathologic features. In: Berger JW, Fine SL, Maguire MG, editors. Age-Related Macular Degeneration. St. Louis, MO: Mosby; 1999. pp. 81–154. [Google Scholar]
Cited by
Sorted by citations
The retina as a window to the brain—from eye research to CNS disorders
London, A., Benhar, I., & Schwartz, M. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.227 · Cited by 1,417 · see citing works
Kur, J., Newman, E. A., & Chan‐Ling, T. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.04.004 · Cited by 685 · see citing works
Koronyo-Hamaoui, M., Koronyo, Y., Ljubimov, A. V., Miller, C. A., Ko, M. K., Black, K. L., Schwartz, M., & Farkas, D. L. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.06.020 · Cited by 672 · see citing works
Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer’s disease
Koronyo, Y., Biggs, D., Barrón, E., Boyer, D. S., Pearlman, J. A., Au, W. J., Kile, S. J., Blanco, A., Fuchs, D.-T. S., Ashfaq, A., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.93621 · Cited by 504 · see citing works
The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma.
Ramirez, A. I., de Hoz, R., Salobrar-Garcia, E., Salazar, J. J., Rojas, B., Ajoy, D., López-Cuenca, I., Rojas, P., Triviño, A., & Ramírez, J. M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00214 · Cited by 466 · see citing works
Melanopsin retinal ganglion cell loss in A lzheimer disease
Morgia, C. L., Ross‐Cisneros, F. N., Koronyo, Y., Hannibal, J., Gallassi, R., Cantalupo, G., Sambati, L., Pan, B. X., Tozer, K. R., Barboni, P., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24548 · Cited by 389 · see citing works
Spectral-Domain OCT Measurements in Alzheimer’s Disease
Chan, V. T. T., Sun, Z., Tang, S., Chen, L. J., Wong, A., Tham, C. C. Y., Wong, T. Y., Chen, C., Ikram, M. K., Whitson, H. E., et al. (2018) · Ophthalmology · doi:10.1016/j.ophtha.2018.08.009 · Cited by 362 · see citing works
Hadoux, X., Hui, F., Lim, J. K. H., Masters, C. L., Pébay, A., Chevalier, S., Ha, J. J., Loi, S. M., Fowler, C. J., Rowe, C. C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12242-1 · Cited by 306 · see citing works
Jeremic, D., Jiménez-Díaz, L., & Navarro-López, J. D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101496 · Cited by 306 · see citing works
Parallel findings in age-related macular degeneration and Alzheimer’s disease
Ohno-Matsui, K. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.02.004 · Cited by 280 · see citing works
Induction of cerebral β-amyloidosis: Intracerebral versus systemic Aβ inoculation
Eisele, Y. S., Bolmont, T., Heikenwalder, M., Langer, F., Jacobson, L. H., Yan, Z.-X., Roth, K., Aguzzi, A., Staufenbiel, M., Walker, L. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903200106 · Cited by 279 · see citing works
Ocular indicators of Alzheimer’s: exploring disease in the retina
Hart, N. J., Koronyo, Y., Black, K. L., & Koronyo‐Hamaoui, M. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1613-6 · Cited by 260 · see citing works
Association of Retinal Neurodegeneration on Optical Coherence Tomography With Dementia
Mutlu, Ü., Colijn, J. M., Ikram, M. A., Bonnemaijer, P. W. M., Licher, S., Wolters, F. J., Tiemeier, H. W., Koudstaal, P. J., Klaver, C. C. W., & Ikram, M. K. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.1563 · Cited by 240 · see citing works
The Aging Eye: Common Degenerative Mechanisms Between the Alzheimer's Brain and Retinal Disease
Sivak, J. M. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10827 · Cited by 217 · see citing works
Optical Coherence Tomography in Alzheimer’s Disease: A Meta-Analysis
Coppola, G., Renzo, A. D., Ziccardi, L., Martelli, F., Fadda, A., Manni, G., Barboni, P., Pierelli, F., Sadun, A. A., & Parisi, V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134750 · Cited by 205 · see citing works
Koronyo, Y., Salumbides, B. C., Black, K. L., & Koronyo‐Hamaoui, M. (2012) · Neurodegenerative Diseases · doi:10.1159/000335154 · Cited by 199 · see citing works
Long-Term In Vivo Imaging of Fibrillar Tau in the Retina of P301S Transgenic Mice
Schön, C., Hoffmann, N. A., Ochs, S. M., Burgold, S., Filser, S., Steinbach, S., Seeliger, M. W., Arzberger, T., Goedert, M., Kretzschmar, H. A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0053547 · Cited by 192 · see citing works
Liu, B., Rasool, S., Yang, Z., Glabe, C. G., Schreiber, S. S., Ge, J., & Tan, Z. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.090159 · Cited by 182 · see citing works
Javaid, F. Z., Brenton, J., Guo, L., & Cordeiro, M. F. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00055 · Cited by 179 · see citing works
Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology
Hampel, H. J., (APMI), F. T. A. P. M. I., Toschi, N., Babiloni, C., Baldacci, F., Black, K. L., Bokde, A. L. W., Bun, R. S., Cacciola, F., Cavedo, E., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179932 · Cited by 181 · see citing works
Optical Coherence Tomography in Alzheimer’s Disease and Other Neurodegenerative Diseases
Doustar, J., Torbati, T., Black, K. L., Koronyo, Y., & Koronyo‐Hamaoui, M. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00701 · Cited by 176 · see citing works
Gharbiya, M., Trebbastoni, A., Parisi, F., Manganiello, S., Cruciani, F., D’Antonio, F., Vico, U. D., Imbriano, L., Campanelli, A., & de Lena, C. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132039 · Cited by 174 · see citing works
Grimaldi, A., Brighi, C., Peruzzi, G., Ragozzino, D., Bonanni, V., Limatola, C., Ruocco, G., & Angelantonio, S. D. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0740-5 · Cited by 166 · see citing works
Alzheimers Disease and Retinal Neurodegeneration
Guo, L., Duggan, J., & Cordeiro, M. F. (2010) · Current Alzheimer Research · doi:10.2174/156720510790274491 · Cited by 161 · see citing works
Chiasseu, M., Alarcón-Martínez, L., Belforte, N., Quintero, H., Dotigny, F., Destroismaisons, L., Velde, C. V., Panayi, F., Louis, C., & Polo, A. D. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0199-3 · Cited by 158 · see citing works
Gao, L., Liu, Y., Li, X., Bai, Q., & Liu, P. (2014) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2014.10.011 · Cited by 155 · see citing works
Alber, J., Goldfarb, D., Thompson, L. I., Arthur, E., Hernandez, K., Cheng, D., DeBuc, D. C., Cordeiro, F., Provetti‐Cunha, L., den Haan, J., et al. (2020) · Alzheimer's & Dementia · doi:10.1002/alz.12006 · Cited by 154 · see citing works
Ocular changes in TgF344-AD rat model of Alzheimer's disease
Tsai, Y., Lu, B., Ljubimov, A. V., Girman, S., Ross-Cisneros, F. N., Sadun, A. A., Svendsen, C. N., Cohen, R. M., & Wang, S. (2014) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.13-12888 · Cited by 153 · see citing works
Soluble and Mature Amyloid Fibrils in Drusen Deposits
Isas, J. M., Luibl, V., Johnson, L. V., Kayed, R., Wetzel, R. B., Glabe, C. G., Langen, R., & Chen, J. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4207 · Cited by 153 · see citing works
The ins and outs of cholesterol in the vertebrate retina
Fliesler, S. J., & Brétillon, L. (2010) · Journal of Lipid Research · doi:10.1194/jlr.r010538 · Cited by 153 · see citing works
Retinal microvascular network attenuation in Alzheimer's disease
Williams, M. A., McGowan, A., Cardwell, C. R., Cheung, C. Y.-L., Craig, D., Passmore, P., Silvestri, G., Maxwell, A. P., & McKay, G. J. (2015) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2015.04.001 · Cited by 153 · see citing works
Liu, R. T., Gao, J., Cao, S., Sandhu, N., Cui, J. Z., Chou, C. L., Fang, E., & Matsubara, J. A. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10849 · Cited by 152 · see citing works
Biomarkers for Alzheimer’s Disease Early Diagnosis
Ausó, E., Gómez‐Vicente, V., & Esquiva, G. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10030114 · Cited by 149 · see citing works
Gupta, V., You, Y., Li, J., Gupta, V. B., Golzan, M., Klistorner, A. I., van den Buuse, M., & Graham, S. L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.026 · Cited by 149 · see citing works
Gupta, V. B., Chitranshi, N., den Haan, J., Mirzaei, M., You, Y., Lim, J. K. H., Basavarajappa, D. K., Godinez, A., Angelantonio, S. D., Sachdev, P. S., et al. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100899 · Cited by 143 · see citing works
Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer’s disease
Dutescu, R. M., Li, Q., Crowston, J. G., Masters, C. L., Baird, P. N., & Culvenor, J. G. (2009) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-009-1060-3 · Cited by 139 · see citing works
Little, K., Llorián‐Salvador, M., Scullion, S., Hernández, C., Simó‐Servat, O., del Marco, À., Bosma, E. K., Vargas-Soria, M., Carranza-Naval, M. J., Bergen, T. V., et al. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.10.008 · Cited by 136 · see citing works
Gasparini, L., Anthony Crowther, R., Martin, K. R., Berg, N., Coleman, M., Goedert, M., & Spillantini, M. G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.03.002 · Cited by 133 · see citing works
Hoh Kam, J., Lenassi, E., & Jeffery, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013127 · Cited by 131 · see citing works
Bayhan, H. A., Bayhan, S. A., Çelikbilek, A., Tanık, N., & Gürdal, C. (2014) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.12386 · Cited by 131 · see citing works
Ferrari, L. D., Huang, S., Magnani, G., Ambrosi, A., Comı, G., & Leocani, L. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160886 · Cited by 130 · see citing works
Alzheimer’s Retinopathy: Seeing Disease in the Eyes
Mirzaei, N., Shi, H., Oviatt, M., Doustar, J., Rentsendorj, A., Fuchs, D.-T. S., Sheyn, J., Black, K. L., Koronyo, Y., & Koronyo‐Hamaoui, M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00921 · Cited by 130 · see citing works
Mitolo, M., Tonon, C., Morgia, C. L., Testa, C. M., Carelli, V., & Lodi, R. (2018) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000494921 · Cited by 120 · see citing works
Amyloid-beta and tau protein beyond Alzheimer’s disease
Abyadeh, M., Gupta, V., Paulo, J. A., Mahmoudabad, A. G., Shadfar, S., Mirshahvaladi, S., Gupta, V. B., Nguyen, C. T. O., Finkelstein, D. I., You, Y., et al. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.386406 · Cited by 121 · see citing works
Gupta, V., Chitranshi, N., Gupta, V. B., Golzan, M., Dheer, Y., Wall, R. V., Georgevsky, D., King, A. E., Vickers, J. C., Chung, R. S., et al. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.04.059 · Cited by 114 · see citing works
Imaging multiple phases of neurodegeneration: a novel approach to assessing cell death in vivo
Cordeiro, M. F., Guo, L., Coxon, K. M., Duggan, J., Nizari, S., Normando, E. M., Sensi, S. L., Sillito, A. M., Fitzke, F. W., Salt, T. E., et al. (2010) · Cell Death and Disease · doi:10.1038/cddis.2009.3 · Cited by 113 · see citing works
Retinal ganglion cell dendritic degeneration in a mouse model of Alzheimer's disease
Williams, P. A., Thirgood, R. A., Oliphant, H., Frizzati, A., Littlewood, E., Votruba, M., Good, M. A., Williams, J. H., & Morgan, J. E. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.01.006 · Cited by 104 · see citing works
Alzheimer's disease pathophysiology in the Retina
Gaire, B. P., Koronyo, Y., Fuchs, D.-T. S., Shi, H., Rentsendorj, A., Danziger, R., Vit, J., Mirzaei, N., Doustar, J., Sheyn, J., et al. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101273 · Cited by 102 · see citing works
Chiu, K., Chan, T. F., Wu, A., Leung, I. Y.-P., So, K., & Chang, R. C. (2011) · AGE · doi:10.1007/s11357-011-9260-2 · Cited by 98 · see citing works
p53 in neurodegenerative diseases and brain cancers
Checler, F., & da Costa, C. A. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.11.009 · Cited by 97 · see citing works
Jentsch, S., Schweitzer, D., Schmidtke, K., Peters, S., Dawczynski, J., Bär, K., & Hammer, M. (2014) · Acta Ophthalmologica · doi:10.1111/aos.12609 · Cited by 96 · see citing works
Choi, S. H., Park, S. J., & Kim, N. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162202 · Cited by 95 · see citing works
Cao, K., Farahi, M., Dakanali, M., Chang, W. M., Sigurdson, C. J., Theodorakis, E. A., & Yang, J. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3063698 · Cited by 93 · see citing works
Kurji, K. H., Cui, J. Z., Lin, T. R., Harriman, D. I., Prasad, S. S., Kojic, L., & Matsubara, J. A. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3622 · Cited by 87 · see citing works
Normal‑tension glaucoma: Pathogenesis and genetics (Review)
Trivli, A., Koliarakis, I., Terzidou, C., Goulielmos, G. N., Siganos, C. S., Spandidos, D. A., Dalianis, G., & Detorakis, Ε. T. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.7011 · Cited by 86 · see citing works
Liu, R. T., Wang, A., To, E. C., Gao, J., Cao, S., Cui, J. Z., & Matsubara, J. A. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.07.003 · Cited by 84 · see citing works
Colligris, P., de Lara, M. J. P., Colligris, B., & Pintor, J. J. (2018) · Journal of Ophthalmology · doi:10.1155/2018/8538573 · Cited by 84 · see citing works
Chiquita, S., Rodrigues‐Neves, A. C., Baptista, F. I., Carecho, R., Moreira, P. I., Castelo-Branco, M. S., & Ambrósio, A. F. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1461-6 · Cited by 82 · see citing works
Madeira, M. H., Boia, R., Ambrósio, A. F., & Santiago, A. R. (2017) · Mediators of Inflammation · doi:10.1155/2017/4761081 · Cited by 84 · see citing works
Amyloid Beta Immunoreactivity in the Retinal Ganglion Cell Layer of the Alzheimer’s Eye
Lee, S., Jiang, K., McIlmoyle, B. J., To, E. C., Xu, Q., Hirsch‐Reinshagen, V., Mackenzie, I. R., Hsiung, G. R., Eadie, B. D., Šarunic, M. V., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00758 · Cited by 77 · see citing works
Intracellular amyloid beta alters the tight junction of retinal pigment epithelium in 5XFAD mice
Park, S. W., Kim, J. H., Mook‐Jung, I., Kim, K.-W., Park, W. J., Park, K. H., & Kim, J. H. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.008 · Cited by 76 · see citing works
Aging-associated sensory decline and Alzheimer’s disease
Hong, S., Baek, S.-H., Lai, M. K. P., Arumugam, T. V., & Jo, D.-G. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00776-y · Cited by 76 · see citing works
Criscuolo, C., Cerri, E., Fabiani, C., Capsoni, S., Cattaneo, A., & Domenici, L. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.03.017 · Cited by 74 · see citing works
Absence of Alzheimer Disease Neuropathologic Changes in Eyes of Subjects With Alzheimer Disease
Williams, E. A., McGuone, D., Frosch, M. P., Hyman, B. T., Laver, N., & Stemmer-Rachamimov, A. O. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx020 · Cited by 71 · see citing works
Shi, H., Koronyo, Y., Fuchs, D.-T. S., Sheyn, J., Wawrowsky, K., Lahiri, S., Black, K. L., & Koronyo‐Hamaoui, M. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01076-4 · Cited by 70 · see citing works
Jones-Odeh, E., & Hammond, C. J. (2015) · Eye · doi:10.1038/eye.2015.158 · Cited by 70 · see citing works
Potential Utility of Retinal Imaging for Alzheimer’s Disease: A Review
Liao, H., Zhu, Z., & Peng, Y. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00188 · Cited by 68 · see citing works
Gupta, V., Gupta, V. B., Chitranshi, N., Gangoda, S. V. S., Wall, R. V., Abbasi, M., Golzan, M., Dheer, Y., Shah, T. M., Avolio, A. P., et al. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2295-x · Cited by 69 · see citing works
Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer’s Type Dementia
Bulut, M., Yaman, A., Erol, M. K., Kurtuluş, F., Toslak, D., Doğan, B., Çoban, D. T., & Başar, E. K. (2016) · Journal of Ophthalmology · doi:10.1155/2016/7291257 · Cited by 66 · see citing works
Differential Accumulation of Secreted AβPP Metabolites in Ocular Fluids1
Prakasam, A., Muthuswamy, A., Ablonczy, Z., Greig, N. H., Fauq, A. H., Rao, K. S. J., Pappolla, M. A., & Sambamurti, K. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100210 · Cited by 65 · see citing works
Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer’s Disease
Lim, J. K. H., Li, Q.-X., He, Z., Vingrys, A. J., Chinnery, H. R., Mullen, J., Bui, B. V., & Nguyen, C. T. O. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00862 · Cited by 65 · see citing works
Sharafi, S. M., Sylvestre, J., Chevrefils, C., Soucy, J., Beaulieu, S., Pascoal, T. A., Arbour, J. D., Rhéaume, M., Robillard, A., Chayer, C., et al. (2019) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2019.09.006 · Cited by 65 · see citing works
Review: tauopathy in the retina and optic nerve: does it shadow pathological changes in the brain?
Ho, W.-L., Leung, Y., Tsang, A. W.-T., So, K., Chiu, K., & Chang, R. C. (2012) · Europe PMC (PubMed Central) · Cited by 62 · see citing works
Retinal macroglia changes in a triple transgenic mouse model of Alzheimer's disease
Edwards, M. M., Rodriguez, J. J., Gutiérrez-Lanza, R., Yates, J., Verkhratsky, A., & Lutty, G. A. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.08.006 · Cited by 62 · see citing works
Uchida, A., Pillai, J. A., Bermel, R. A., Bonner‐Jackson, A., Rae-Grant, A. D., Fernandez, H. H., Bena, J., Jones, S. E., Leverenz, J. B., Srivastava, S. K., et al. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-23240 · Cited by 62 · see citing works
Alber, J., Bouwman, F. H., den Haan, J., Rissman, R. A., Groef, L. D., Koronyo‐Hamaoui, M., Lengyel, I., & Thal, D. R. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13529 · Cited by 61 · see citing works
Shah, T. M., Gupta, S. M., Chatterjee, P., Campbell, M., & Martins, R. N. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.251 · Cited by 62 · see citing works
Sleep and circadian rhythm disruption and stress intersect in Alzheimer's disease
Phan, T., & Malkani, R. G. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.10.001 · Cited by 64 · see citing works
Mirzaei, M., Pushpitha, K., Deng, L., Chitranshi, N., Gupta, V. B., Rajput, R., Mangani, A. S., Dheer, Y., Godinez, A., McKay, M. J., et al. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1479-4 · Cited by 61 · see citing works
Zhu, Z., Duan, P., Song, H., Zhou, R., & Chen, T. (2021) · Bioengineered · doi:10.1080/21655979.2021.2010369 · Cited by 59 · see citing works
The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research
Vandenabeele, M., Veys, L., Lemmens, S., Hadoux, X., Gelders, G., Masin, L., Serneels, L., Theunis, J., Saito, T., Saido, T. C., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01102-5 · Cited by 58 · see citing works
The current research status of normal tension glaucoma
Mi, X.-S., Yuan, T., & So, K. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s67263 · Cited by 57 · see citing works
Ocular manifestations of Alzheimer's disease in animal models
Parnell, M., Guo, L., Abdi, M., & Cordeiro, M. F. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/786494 · Cited by 56 · see citing works
Alzheimer’s Disease Seen through the Eye: Ocular Alterations and Neurodegeneration
Romaus‐Sanjurjo, D., Regueiro, U., López‐López, M., Vázquez‐Vázquez, L., Ouro, A., Lema, I., & Sobrino, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052486 · Cited by 56 · see citing works
The role of optical coherence tomography in Alzheimer’s disease
Cunha, L. P., Almeida, A. L. M., Costa-Cunha, L. V. F., Costa, C. F., & Monteiro, M. L. R. (2016) · International Journal of Retina and Vitreous · doi:10.1186/s40942-016-0049-4 · Cited by 57 · see citing works
Salobrar‐García, E., Mendez-Hernandez, C. D., de Hoz, R., Ramirez, A. I., López‐Cuenca, I., Fernández‐Albarral, J. A., Rojas, P., Wang, S., García-Feijoo, J., Gil, P., et al. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10040231 · Cited by 57 · see citing works
Fourgeux, C., Martine, L., Björkhem, I., Diczfalusy, U., Joffre, C., Acar, N., Creuzot-Garcher, C. P., Bron, A. M., & Brétillon, L. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3655 · Cited by 55 · see citing works
Shi, H., Koronyo, Y., Fuchs, D.-T. S., Sheyn, J., Jallow, O., Mandalia, K., Graham, S. L., Gupta, V., Mirzaei, M., Kramerov, A. A., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13086 · Cited by 51 · see citing works
Gao, L., Chen, X., Tang, Y., Zhao, J., Li, Q., Fan, X., Xu, H., & Yin, Z. Q. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.04.013 · Cited by 53 · see citing works
Dong, N., Li, X., Xiao, L., Yu, W., Wang, B., & Chu, L. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-9446 · Cited by 54 · see citing works
Trebbastoni, A., D’Antonio, F., Bruscolini, A., Marcelli, M., Cecere, M., Campanelli, A., Imbriano, L., de Lena, C., & Gharbiya, M. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.07.006 · Cited by 53 · see citing works
Emerging ocular biomarkers of Alzheimer disease
van Wijngaarden, P., Hadoux, X., Alwan, M., Keel, S., & Dirani, M. (2016) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.12872 · Cited by 52 · see citing works
Attenuation of Choroidal Thickness in Patients With Alzheimer Disease
Trebbastoni, A., Marcelli, M., Mallone, F., D’Antonio, F., Imbriano, L., Campanelli, A., de Lena, C., & Gharbiya, M. (2016) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000176 · Cited by 52 · see citing works
Chibhabha, F., Yang, Y., Ying, K., Jia, F., Zhang, Q., Ullah, S., Liang, Z., Xie, M., & Li, F. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01101k · Cited by 52 · see citing works
Xu, Q., Cao, S., Rajapakse, S., & Matsubara, J. A. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-017-0647-7 · Cited by 52 · see citing works
Fernando, M., Lee, S. D., Wark, J. R., Xiao, D., Lim, B. Y., O’Hara-Wright, M., Kim, H. J., Smith, G. C., Wong, T., Teber, E., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.04.003 · Cited by 49 · see citing works
Reflections on the Utility of the Retina as a Biomarker for Alzheimer’s Disease: A Literature Review
Ngolab, J., Honma, P. S., & Rissman, R. A. (2019) · Neurology and Therapy · doi:10.1007/s40120-019-00173-4 · Cited by 49 · see citing works
Doustar, J., Rentsendorj, A., Torbati, T., Regis, G. C., Fuchs, D.-T. S., Sheyn, J., Mirzaei, N., Graham, S. L., Shah, P. K., Mastali, M., et al. (2020) · Aging Cell · doi:10.1111/acel.13246 · Cited by 47 · see citing works
Palmer, D. D., Dumont, J. R., Dexter, T. D., Prado, M. A. M., Finger, E. C., Bussey, T. J., & Saksida, L. M. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107443 · Cited by 52 · see citing works
Alzheimer’s Disease-Related Protein Expression in the Retina of Octodon degus
Du, L. Y., Chang, L., Ardiles, Á. O., Tapia‐Rojas, C., Araya, J., Inestrosa, N. C., Palacios, A. G., & Acosta, M. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135499 · Cited by 47 · see citing works
- Authors
- Ning, A., Cui, J., To, E., Ashe, K. H., & Matsubara, J.
- Affiliations
- University of British Columbia (CA)
- University of Minnesota (US)
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2008-11-01
- Volume
- 49
- Issue
- 11
- Pages
- 5136
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- PMC
- PMC3947384
- OpenAlex
- W2007162302
- Cited by
- 303
- References
- 54
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 17 · 2023: 17 · 2022: 25 · 2021: 25 · 2020: 27 · 2019: 11 · 2018: 28 · 2017: 14 · 2016: 21 · 2015: 20 · 2014: 15 · 2013: 8 · 2012: 19
- FWCI
- 7.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Investigative Ophthalmology & Visual Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Canadian Institutes of Health Research (77736_2, 77736_1, 97806_1)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Keywords
- amyloid-beta deposition, retinal degeneration, Alzheimer's disease, amyloid precursor protein, retinal ganglion cells, microglial activation, MCP-1, apoptosis, retinal pigment epithelium, choriocapillaris, transgenic mouse model, neurodegeneration
- MeSH terms
- Alzheimer Disease, Animals, Antigens, Differentiation, Disease Models, Animal, Immunohistochemistry, Membrane Glycoproteins, Mice, Transgenic, Retina, Retinal Degeneration, Biomarkers, Amyloid beta-Peptides, Apoptosis, Chemokine CCL2, In Situ Nick-End Labeling, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review