Reduction of optic nerve fibers in patients with Alzheimer disease identified by laser imaging
Open accessAbstract
In this case-control study, we compared the optic nerves (ONs) by clinical examination and scanning laser ophthalmoscopy (SLO) of 40 patients with Alzheimer disease (AD) and 50 controls. There was a reduction in the number of ON fibers in patients with AD, with a threefold greater odds ratio for a larger optic cup-to-disc ratio in patients with AD.
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Patients with AD often develop visual anomalies correlated with abnormalities in the eye.
“However, in the last few decades it has been demonstrated that patients with AD often develop visual anomalies, which are correlated with abnormalities in the eye.”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Danesh-Meyer et al., 2006
AD is associated with reduction in number of optic nerve head axons and decrease in thickness of peripapillary and macular RNFL.
“Among them, there is a reduction in the number of optic nerve head axons and a decrease in the thickness of the peripapillary and macular retinal nerve fiber layer (RNFL) (Tsai et al., 1991; Hedges et al., 1996; Danesh-Meyer et al., 2006; Iseri et al., 2006; Paquet et al., 2007; Garcia-Martin et al., 2014; Salobrar-Garcia et al., 2015; Salobrar-García et al., 2016c) (Table 1).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Danesh-Meyer et al., 2006
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- Authors
- Danesh-Meyer, H. V., Birch, H., Ku, J. Y.-F., Carroll, S., & Gamble, G.
- Affiliations
- University of Auckland (NZ)
- Venue
- Neurology
- Published
- 2006-11-28
- Volume
- 67
- Issue
- 10
- Pages
- 1852-1854
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2047691268
- Cited by
- 164
- References
- 9
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 1 · 2023: 6 · 2022: 8 · 2021: 11 · 2020: 13 · 2019: 8 · 2018: 6 · 2017: 9 · 2016: 19 · 2015: 10 · 2014: 9 · 2013: 10 · 2012: 12
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- ResearchSpace (University of Auckland) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- Alzheimer's disease, optic nerve fibers, optic nerve head, scanning laser ophthalmoscopy, cup-to-disc ratio, neurodegeneration, retinal imaging biomarkers
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cell Count, Female, Humans, Male, Optic Nerve, Optic Nerve Diseases, Predictive Value of Tests, Retinal Ganglion Cells, Wallerian Degeneration, Case-Control Studies, Microscopy, Confocal, Ophthalmoscopes
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