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Cited by 293

The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.

Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease

Zaplatic, Elizabeta, Bule, Muhammed, Shah, Syed Zahid Ali, Uddin, Md. Sahab, Niaz, Kamal·2019·Life Sciences
DOI 10.1016/j.lfs.2019.03.055
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Abstract

Quercetin belongs to the flavonoids family, which is present in most of the plants including fruits, vegetables, green tea and even in red wine having antioxidant activities. It is available as a food supplement in the market and has physiological health effects. Quercetin has anti-inflammatory, anticancer and anti-prostate activities along with its beneficial effects on high cholesterol, kidney transplantation, asthma, diabetes, viral infections, pulmonary, schizophrenia and cardiovascular diseases. Quercetin possesses scavenging potential of hydroxyl radical (OH-), hydrogen peroxide (H2O2), and superoxide anion (O2-). These reactive oxygen species (ROS) hampers lipid, protein, amino acids and deoxyribonucleic acid (DNA) processing leading to epigenetic alterations. Quercetin has the ability to combat these harmful effects. ROS plays a vital role in the progression of Alzheimer's disease (AD), and we propose that quercetin would be the best choice to overcome cellular and molecular signals in regulating normal physiological functions. However, data are not well documented regarding exact cellular mechanisms of quercetin. The neuroprotective effects of quercetin are mainly due to potential up- and/or down-regulation of cytokines via nuclear factor (erythroid-derived 2)-like 2 (Nrf2), Paraoxonase-2, c-Jun N-terminal kinase (JNK), Protein kinase C, Mitogen-activated protein kinase (MAPK) signalling cascades, and PI3K/Akt pathways. Therefore, the aim of the present review was to elaborate on the cellular and molecular mechanisms of the quercetin involved in the protection against AD.

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Metadata

Authors
Zaplatic, E., Bule, M., Shah, S. Z. A., Uddin, M. S., & Niaz, K.
Venue
Life Sciences
Publisher
Elsevier BV
Published
2019-05
Volume
224
Pages
109-119
ISSN
0024-3205 (ISSN-L)
DOI
10.1016/j.lfs.2019.03.055
OpenAlex
W2926646262
Cited by
293
References
120
FWCI
22.29
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease. https://app.cochat.ai/papers/10.1016/j.lfs.2019.03.055
The paper
Zaplatic, E., Bule, M., Shah, S. Z. A., Uddin, M. S., & Niaz, K. (2019). Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease. Life Sciences. https://doi.org/10.1016/j.lfs.2019.03.055

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.