Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer's Disease
Open accessAbstract
Alzheimer's disease (AD) is a type of incurable neurodegenerative disease that is characterized by the accumulation of amyloid-β (Aβ; plaques) and tau hyperphosphorylation as neurofibrillary tangles (NFTs) in the brain followed by neuronal death, cognitive decline, and memory loss. The high prevalence of AD in the developed world has become a major public health challenge associated with social and economic burdens on individuals and society. Due to there being limited options for early diagnosis and determining the exact pathophysiology of AD, finding effective therapeutic strategies has become a great challenge. Several possible risk factors associated with AD pathology have been identified; however, their roles are still inconclusive. Recent clinical trials of the drugs targeting Aβ and tau have failed to find a cure for the AD pathology. Therefore, effective preventive strategies should be followed to reduce the exponential increase in the prevalence of cognitive decline and dementia, especially AD. Although the search for new therapeutic targets is a great challenge for the scientific community, the roles of lifestyle interventions and nutraceuticals in the prevention of many metabolic and neurodegenerative diseases are highly appreciated in the literature. In this article, we summarize the molecular mechanisms involved in AD pathology and the possible ameliorative action of lifestyle and nutritional interventions including diet, exercise, Calorie restriction (CR), and various bioactive compounds on cognitive decline and dementia. This article will provide insights into the role of non-pharmacologic interventions in the modulation of AD pathology, which may offer the benefit of improving quality of life by reducing cognitive decline and incident AD.
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Lifestyle interventions including physical exercise, caloric restriction, and antioxidant nutritional supplements are effective in reducing modifiable AD risk factors.
“life-style interventions including physical exercise, caloric restriction and nutritional supplements with antioxidant compounds are effective in reducing the modifiable AD risk factors”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Bhatti et al., 2019
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Bhatti, J. S., Kumar, S., Vijayan, M., Bhatti, G. K., & Reddy, P. H. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.012 · Cited by 60 · see citing works
Self-citationSerum Magnesium Level and Clinical Deterioration in Alzheimer’s Disease
Çilliler, A. E., Öztürk, Ş., & Özbakır, Ş. (2007) · Gerontology · doi:10.1159/000110873 · Cited by 58 · see citing works
de la Torre, J. C. (2013) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317513494457 · Cited by 54 · see citing works
Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring
Izquierdo, V., Palomera‐Ávalos, V., López-Ruiz, S., Canudas, A.-M., Pallàs, M., & Griñán‐Ferré, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051134 · Cited by 54 · see citing works
Vascular effects of flavonoids
Rezende, B. A., Pereira, A., Côrtes, S. F., & Lemos, V. S. (2015) · Current Medicinal Chemistry · doi:10.2174/0929867323666151111143616 · Cited by 48 · see citing works
Molecular and cellular bases of diabetes: Focus on type 2 diabetes mouse model-TallyHo
Tamarai, K., Bhatti, J. S., & Reddy, P. H. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.05.004 · Cited by 47 · see citing works
Self-citationMagnesium depletion and pathogenesis of Alzheimer's disease.
Durlach, J. (1990) · PubMed · Cited by 43 · see citing works
Magnesium deficiency impairs fear conditioning in mice
Bardgett, M. E., Schultheis, P. J., McGill, D. L., Richmond, R. E., & Wagge, J. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.020 · Cited by 42 · see citing works
'Mediterranean' dietary pattern for the primary prevention of cardiovascular disease
Rees, K., Hartley, L., Clarke, A., Thorogood, M., & Stranges, S. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009825 · Cited by 41 · see citing works
Neuroepigenetics of Aging and Age-Related Neurodegenerative Disorders
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Vitamin D Combined with Resveratrol Prevents Cognitive Decline in SAMP8 Mice
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The Mediterranean Diet and Cardiovascular Disease
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Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease
Reddy, P. H., & Oliver, D. M. (2019) · Cells · doi:10.3390/cells8050488 · Cited by 496 · see citing works
Self-citationRole of diet and exercise in aging, Alzheimer’s disease, and other chronic diseases
Khemka, S., Reddy, A., Garcia, R. I., Jacobs, M., Reddy, R. P., Roghani, A. K., Pattoor, V., Basu, T., Sehar, U., & Reddy, P. H. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102091 · Cited by 88 · see citing works
Self-citationPiccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73 · see citing works
Bhatti, J. S., Tamarai, K., Kandimalla, R., Manczak, M., Yin, X., Ramasubramanian, B., Sawant, N., Pradeepkiran, J. A., Vijayan, M., Kumar, S., et al. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.02.007 · Cited by 30 · see citing works
Self-citation
- Authors
- Bhatti, G. K., Reddy, A. P., Reddy, P. H., & Bhatti, J. S.
- Affiliations
- Chandigarh University (IN)
- Texas Tech University Health Sciences Center (US)
- Texas Tech University (US)
- Sri Guru Gobind Singh College (IN)
- Corresponding author
- Bhatti, Jasvinder Singh
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2020-01-10
- Volume
- 11
- Pages
- 369-369
- ISSN
- 1663-4365 (ISSN-L)
- PMC
- PMC6966236
- OpenAlex
- W3000512444
- Cited by
- 145
- References
- 210
- Citations by year
- 2026: 11 · 2025: 23 · 2024: 22 · 2023: 31 · 2022: 22 · 2021: 25 · 2020: 9 · 2019: 2
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Aging Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Alzheimer's Association (AG042178, AG047812)
- CH Foundation
- Texas Tech University
- Garrison Family Foundation
- National Institutes of Health (– AG042178)
- National Institute on Aging (R01AG042178, R01AG047812)
- National Institute of Neurological Disorders and Stroke (R01NS105473)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Alzheimer's disease, cognitive decline, dementia, lifestyle intervention, dietary intervention, nutraceuticals, caloric restriction, physical activity, diet, amyloid-beta, tau hyperphosphorylation, neurofibrillary tangles, bioactive compounds
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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