Neuropharmacological Effects of Quercetin: A Literature-Based Review
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animal experiments and human trials. QUR protects the organism against neurotoxic chemicals and also can prevent the evolution and development of neuronal injury and neurodegeneration. The present work aimed to summarize the literature about the neuroprotective effect of QUR using known database sources. Besides, this review focuses on the assessment of the potential utilization of QUR as a complementary or alternative medicine for preventing and treating neurodegenerative diseases. An up-to-date search was conducted in PubMed, Science Direct and Google Scholar for published work dealing with the neuroprotective effects of QUR against neurotoxic chemicals or in neuronal injury, and in the treatment of neurodegenerative diseases. Findings suggest that QUR possess neuropharmacological protective effects in neurodegenerative brain disorders such as Alzheimer's disease, Amyloid β peptide, Parkinson's disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis. In summary, this review emphasizes the neuroprotective effects of QUR and its advantages in being used in complementary medicine for the prevention and treatment o of different neurodegenerative diseases.
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Nanoparticles allow adequate targeted transport of phytochemicals to the central nervous system with controlled release time.
“After several decades of research in nanotechnology to transport drugs to the CNS, it is possible to have nanoparticles that allow an adequate transport of phytochemicals in a targeted way and with a control in the release time [213,214].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [214]
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Self-citationADORA2A rs5760423 and CYP1A2 rs762551 Polymorphisms as Risk Factors for Parkinson’s Disease
Siokas, V., Aloizou, A.-M., Tsouris, Z., Liampas, I., Liakos, P., Calina, D., Docea, A. O., Tsatsakis, A., Bogdanos, D. P., Hadjigeorgiou, G. M., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030381 · Cited by 29 · see citing works
Self-citationAshrafpour, M., Parsaei, S., & Sepehri, H. (2015) · National Journal of Physiology Pharmacy and Pharmacology · doi:10.5455/njppp.2015.5.2308201563 · Cited by 28 · see citing works
Frontiers Production Office (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00011 · Cited by 27 · see citing works
Quercetin-biapigenin nanoparticles are effective to penetrate the blood–brain barrier
Oliveira, A. I., Pinho, C., Sarmento, B. F. C. C., & Dias, A. C. P. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-00917-6 · Cited by 26 · see citing works
When Neuroscience Meets Pharmacology: A Neuropharmacology Literature Analysis
Yeung, A. W. K., Tzvetkov, N. T., & Atanasov, A. G. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00852 · Cited by 25 · see citing works
Omi, N., Shiba, H., Nishimura, E., Tsukamoto, S., Maruki‐Uchida, H., Oda, M., & Morita, M. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0303-x · Cited by 25 · see citing works
EVALUATION OF POLYPHENOLIC PROFILE AND ANTIOXIDANT ACTIVITY FOR SOME SALVIA SPECIES
Hanganu, D. (2019) · FARMACIA · doi:10.31925/farmacia.2019.5.8 · Cited by 24 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Pany S. Pal A. Sahu P. K. (2014). Neuroprotective Effect of Quercetin in Neurotoxicity Induced Rats: Role of Neuroinflammation in Neurodegeneration. Asian J. Pharm. Clin. Res. 7 (4), 152– 156.
Cited by
Sorted by citations
Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works
Self-citationWróbel-Biedrawa, D., Grabowska, K., Galanty, A., Sobolewska, D., & Podolak, I. (2022) · Life · doi:10.3390/life12040591 · Cited by 95 · see citing works
Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective
Quispe, C., Herrera-Bravo, J., Javed, Z., Khan, K., Raza, S., Gulsunoglu-Konuskan, Z., Daştan, S. D., Sytar, O., Martorell, M., Sharifi-Rad, J., et al. (2022) · BioMed Research International · doi:10.1155/2022/1375892 · Cited by 92 · see citing works
Self-citationAmin, R., Quispe, C., Docea, A. O., Ydyrys, A., Kulbayeva, M., Durna Daştan, S., Calina, D., & Sharifi-Rad, J. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105376 · Cited by 74 · see citing works
Self-citationReversal of brain aging by targeting telomerase: A nutraceutical approach
Tsoukalas, D., Buga, A., Docea, A., Sarandi, E., Mitrut, R., Renieri, E., Spandidos, D., Rogoveanu, I., Cercelaru, L., Niculescu, M., et al. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.5032 · Cited by 40 · see citing works
Self-citationAbd El-Aziz, N. M. A., Shehata, M. G., Alsulami, T., Badr, A. N., Elbakatoshy, M. R., Ali, H. S., & El-Sohaimy, S. A. (2022) · Pharmaceuticals · doi:10.3390/ph16010012 · Cited by 31 · see citing works
- Authors
- Islam, M. S., Quispe, C., Hossain, R., Islam, M. T., Al-Harrasi, A., Al-Rawahi, A., Martorell, M., Mamurova, A., Seilkhan, A., Altybaeva, N., Abdullayeva, B., Docea, A. O., Calina, D., & Sharifi-Rad, J.
- Affiliations
- Gopalganj Science and Technology University (BD)
- Arturo Prat University (CL)
- University of Nizwa (OM)
- University of Concepción (CL)
- Al-Farabi Kazakh National University (KZ)
- University of Medicine and Pharmacy of Craiova (RO)
- Corresponding author
- Islam, Muhammad Torequl
- ORCID
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2021-06-17
- Volume
- 12
- Pages
- 665031-665031
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC8248808
- OpenAlex
- W3175593057
- Cited by
- 165
- References
- 207
- Citations by year
- 2026: 25 · 2025: 25 · 2024: 30 · 2023: 42 · 2022: 36 · 2021: 7
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Pharmacology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- quercetin, neuroprotection, neurodegenerative diseases, neurotoxicity, Alzheimer's disease, amyloid-beta, Parkinson's disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis, complementary and alternative medicine, flavonoids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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