Cited by 165Medicinal Plants and NeuroprotectionFlavonoids in Medical ResearchNeurological Disorders and Treatments

Neuropharmacological Effects of Quercetin: A Literature-Based Review

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Islam, Md. Shahazul, Quispe, Cristina, Hossain, Rajib, Islam, Muhammad Torequl, Al-Harrasi, Ahmed, Al-Rawahi, Ahmed, Martorell, Miquel, Mamurova, Assem +6 more·2021·Frontiers in Pharmacology

Abstract

animal experiments and human trials. QUR protects the organism against neurotoxic chemicals and also can prevent the evolution and development of neuronal injury and neurodegeneration. The present work aimed to summarize the literature about the neuroprotective effect of QUR using known database sources. Besides, this review focuses on the assessment of the potential utilization of QUR as a complementary or alternative medicine for preventing and treating neurodegenerative diseases. An up-to-date search was conducted in PubMed, Science Direct and Google Scholar for published work dealing with the neuroprotective effects of QUR against neurotoxic chemicals or in neuronal injury, and in the treatment of neurodegenerative diseases. Findings suggest that QUR possess neuropharmacological protective effects in neurodegenerative brain disorders such as Alzheimer's disease, Amyloid β peptide, Parkinson's disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis. In summary, this review emphasizes the neuroprotective effects of QUR and its advantages in being used in complementary medicine for the prevention and treatment o of different neurodegenerative diseases.

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Crossref · 10.3389/fphar.2021.665031

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  1. Pany S. Pal A. Sahu P. K. (2014). Neuroprotective Effect of Quercetin in Neurotoxicity Induced Rats: Role of Neuroinflammation in Neurodegeneration. Asian J. Pharm. Clin. Res. 7 (4), 152– 156.

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Authors
Islam, M. S., Quispe, C., Hossain, R., Islam, M. T., Al-Harrasi, A., Al-Rawahi, A., Martorell, M., Mamurova, A., Seilkhan, A., Altybaeva, N., Abdullayeva, B., Docea, A. O., Calina, D., & Sharifi-Rad, J.
Affiliations
  • Gopalganj Science and Technology University (BD)
  • Arturo Prat University (CL)
  • University of Nizwa (OM)
  • University of Concepción (CL)
  • Al-Farabi Kazakh National University (KZ)
  • University of Medicine and Pharmacy of Craiova (RO)
Corresponding author
Islam, Muhammad Torequl
Venue
Frontiers in Pharmacology
Published
2021-06-17
Volume
12
Pages
665031-665031
ISSN
1663-9812 (ISSN-L)
OpenAlex
W3175593057
Cited by
165
References
207
Citations by year
2026: 25 · 2025: 25 · 2024: 30 · 2023: 42 · 2022: 36 · 2021: 7
FWCI
6.60
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Pharmacology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Greater South Information System
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
  • Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
Keywords
quercetin, neuroprotection, neurodegenerative diseases, neurotoxicity, Alzheimer's disease, amyloid-beta, Parkinson's disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis, complementary and alternative medicine, flavonoids

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