Cited by 111Immune Cell Function and InteractionInfluenza Virus Research Studiesinterferon and immune responses

The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.

Characterization of age-related changes in natural killer cells during primary influenza infection in mice

Nogusa, Shoko, Ritz, Barry W., Kassim, Sadik H., Jennings, Stephen R., Gardner, Elizabeth M.·2008·Mechanisms of Ageing and Development

DOI 10.1016/j.mad.2008.01.003

Open this paper in CoChat — free account

Abstract

The current investigation examined the importance of natural killer (NK) cells during the innate immune response to primary influenza infection in young and aged mice. Young (6-8 weeks) and aged (22 months) C57BL/6 mice were infected intranasally with influenza A virus, and NK cell-mediated cytotoxicity was determined in lung and spleen during the first 4 days of infection. Aged mice demonstrated both a decrease in influenza-inducible NK activity and a reduction in the percentage and number of NK1.1+ cells in response to primary influenza infection, relative to young mice. In order to further establish a role for NK cells in controlling influenza infection, young mice were depleted of NK cells in vivo by injecting rabbit anit-NK1.1 antibody 2 days and 1 day prior to influenza infection. Young mice depleted of NK cells exhibited increased weight loss and lung virus titers during the course of infection, compared to young mice infected with influenza virus. These data indicate that NK cell function is impaired in response to primary influenza infection in aged mice. More importantly, these results underscore the essential role of NK cells in controlling virus titers in lung during the early course of influenza infection, regardless of age.

Integrity signals

Registry

Crossref · 10.1016/j.mad.2008.01.003

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States
Thompson, W. W., Shay, D. K., Weintraub, E., Brammer, L., Cox, N., Anderson, L. J., & Fukuda, K. (2003) · JAMA · doi:10.1001/jama.289.2.179 · Cited by 3,673
The Efficacy of Influenza Vaccine in Elderly Persons: A Meta-Analysis and Review of the Literature
Gross, P. A., Hermogenes, A. W., Sacks, H. S., Lau, J., & Levandowski, R. A. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-123-7-199510010-00008 · Cited by 1,100
Principles of Geriatric Medicine and Gerontology.
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-817_6 · Cited by 1,056
Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo.
Bukowski, J. F., Woda, B. A., Habu, S., Okumura, K., & Welsh, R. M. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.131.3.1531 · Cited by 391
Design and performance testing of quantitative real time PCR assays for influenza A and B viral load measurement
Ward, C. (2003) · Journal of Clinical Virology · doi:10.1016/s1386-6532(03)00122-7 · Cited by 324
The role of immunity in susceptibility to respiratory infection in the aging lung
Meyer, K. C. (2001) · Respiration Physiology · doi:10.1016/s0034-5687(01)00261-4 · Cited by 143
Age-associated decrease in virus-specific CD8+ T lymphocytes during primary influenza infection
Po, J. L., Gardner, E. M., Anaraki, F., Katsikis, P. D., & Murasko, D. M. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00010-6 · Cited by 143
Self-citation
Caloric Restriction Decreases Survival of Aged Mice in Response to Primary Influenza Infection
Gardner, E. M. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.6.688 · Cited by 143
Self-citation
Natural killer cells in healthy aging
Solana, R., Alonso, M. C., & Peña, J. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00008-x · Cited by 116
Flow cytometric analysis reveals the presence of asialo GM1 on the surface membrane of alloimmune cytotoxic T lymphocytes.
Suttles, J., Schwarting, G. A., & Stout, R. D. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.5.1586 · Cited by 100

Show all 22 references

Research works printed but not linked: 1

MMWR, 2004. Update: influenza activity—United States, 2004–05 season, vol. 54. p. 328.

Sorted by citations

Age-dependent dysregulation of innate immunity
Shaw, A. C., Goldstein, D. R., & Montgomery, R. R. (2013) · Nature Reviews Immunology · doi:10.1038/nri3547 · Cited by 1,061
Unmasking senescence: context-dependent effects of SASP in cancer
Faget, D. V., Ren, Q., & Stewart, S. A. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0156-2 · Cited by 863
Aging and Lung Disease
Cho, S. J., & Stout-Delgado, H. W. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034610 · Cited by 458
Control of Human Viral Infections by Natural Killer Cells
Jost, S., & Altfeld, M. A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100001 · Cited by 467
Innate Lymphoid Cells in Mucosal Immunity
Panda, S. K., & Colonna, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00861 · Cited by 288
Natural killer cells
Mandal, A., & Viswanathan, C. (2014) · Hematology/Oncology and Stem Cell Therapy · doi:10.1016/j.hemonc.2014.11.006 · Cited by 289
Impaired immune responses in the lungs of aged mice following influenza infection
Toapanta, F. R., & Ross, T. M. (2009) · Respiratory Research · doi:10.1186/1465-9921-10-112 · Cited by 259
Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice
Wong, C. K., Smith, C. A., Sakamoto, K., Kaminski, N., Koff, J. L., & Goldstein, D. R. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700397 · Cited by 246
Influenza Infection Induces Neuroinflammation, Alters Hippocampal Neuron Morphology, and Impairs Cognition in Adult Mice
Jurgens, H. A., Amancherla, K., & Johnson, R. W. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6389-11.2012 · Cited by 243
Natural killer cells in infection and inflammation of the lung
Culley, F. J. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03167.x · Cited by 253
Modeling Within-Host Dynamics of Influenza Virus Infection Including Immune Responses
Pawelek, K. A., Huynh, G. T., Quinlivan, M., Cullinane, A., Rong, L., & Perelson, A. S. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002588 · Cited by 240
I mmunosenescence and Inflammaging: Risk Factors of Severe COVID-19 in Older People
Pietrobon, A. J., Teixeira, F. M. E., & Sato, M. N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.579220 · Cited by 187
Innate immune responses in the ageing lung.
Boe, D. M., Boule, L. A., & Kovacs, E. J. (2016) · Clinical and Experimental Immunology · doi:10.1111/cei.12881 · Cited by 156
Adaptive immune responses mediated by natural killer cells
Paust, S., Senman, B. C., & von Andrian, U. H. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2010.00906.x · Cited by 154
Influenza Virus Directly Infects Human Natural Killer Cells and Induces Cell Apoptosis
Mao, H., Tu, W., Qin, G., Law, H., Sia, S. F., Chan, P., Liu, Y., Lam, K.-T., Zheng, J. H., Peiris, M. J. S., et al. (2009) · Journal of Virology · doi:10.1128/jvi.00805-09 · Cited by 150
Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection
Mehta, R. S., & Rezvani, K. (2016) · Virulence · doi:10.1080/21505594.2016.1208866 · Cited by 153
MARS: discovering novel cell types across heterogeneous single-cell experiments
Brbić, M., Žitnik, M., Wang, S., Pisco, A. O., Altman, R. B., Darmanis, S., & Leskovec, J. (2020) · Nature Methods · doi:10.1038/s41592-020-00979-3 · Cited by 144
The mucosal immune system of the respiratory tract
Sato, S., & Kiyono, H. (2012) · Current Opinion in Virology · doi:10.1016/j.coviro.2012.03.009 · Cited by 135
NK cells exacerbate the pathology of influenza virus infection in mice
Zhou, G., Juang, S. W. W., & Kane, K. P. (2013) · European Journal of Immunology · doi:10.1002/eji.201242620 · Cited by 128
Natural Killer Cells in the Lungs
Cong, J., & Wei, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01416 · Cited by 128
Critical Role of Natural Killer Cells in Lung Immunopathology During Influenza Infection in Mice
Abdul-Careem, M. F., Mian, M. F., Yue, G., Gillgrass, A. E., Chenoweth, M. J., Barra, N. G., Chew, M. V., Chan, T., Al-Garawi, A. A., Jordana, M., et al. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis340 · Cited by 127
Immunomodulatory and prophylactic effects of Bifidobacterium bifidum probiotic strain on influenza infection in mice
Mahooti, M., Abdolalipour, E., Salehzadeh, A., Mohebbi, S. R., Gorji, A., & Ghaemi, A. (2019) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-019-2667-0 · Cited by 94
Inhibition of Human Natural Killer Cell Activity by Influenza Virions and Hemagglutinin
Mao, H., Tu, W., Liu, Y., Qin, G., Zheng, J. H., Chan, P., Lam, K.-T., Peiris, M. J. S., & Lau, Y. (2010) · Journal of Virology · doi:10.1128/jvi.02340-09 · Cited by 97
Age-related susceptibility to coronavirus infections: role of impaired and dysregulated host immunity
Channappanavar, R., & Perlman, S. M. (2020) · Journal of Clinical Investigation · doi:10.1172/jci144115 · Cited by 94
The role of dysregulated immune responses in COVID-19 pathogenesis
Tahaghoghi-Hajghorbani, S., Zafari, P., Masoumi, E., Rajabinejad, M., Jafari-Shakib, R., Hasani, B., & Rafiei, A. (2020) · Virus Research · doi:10.1016/j.virusres.2020.198197 · Cited by 88
NK cells in immunotolerant organs
Sun, H., Sun, C., Tian, Z., & Xiao, W. (2013) · Cellular and Molecular Immunology · doi:10.1038/cmi.2013.9 · Cited by 83
Comparison of immune reconstitution between anti-T-lymphocyte globulin and posttransplant cyclophosphamide as acute graft-versus-host disease prophylaxis in allogeneic myeloablative peripheral blood stem cell transplantation
Massoud, R., Gagelmann, N., Fritsche-Friedland, U., Zeck, G., Heidenreich, S., Wolschke, C., Ayuk, F. A., Christopeit, M., & Kröger, N. M. (2021) · Haematologica · doi:10.3324/haematol.2020.271445 · Cited by 80
Human CD49a+ Lung Natural Killer Cell Cytotoxicity in Response to Influenza A Virus
Cooper, G. E., Ostridge, K., Khakoo, S. I., Wilkinson, T. M. A., & Staples, K. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01671 · Cited by 84
Protection from H1N1 Influenza Virus Infections in Mice by Supplementation with Selenium: A Comparison with Selenium-Deficient Mice
Yu, L., Sun, L., Nan, Y., & Li-ying, Z. (2010) · Biological Trace Element Research · doi:10.1007/s12011-010-8726-x · Cited by 77
Natural killer cell function is altered during the primary response of aged mice to influenza infection
Beli, E., Clinthorne, J. F., Duriancik, D. M., Hwang, I., Kim, S., & Gardner, E. M. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.08.005 · Cited by 76
Self-citation
The aged nonhematopoietic environment impairs natural killer cell maturation and function
Shehata, H. M., Hoebe, K., & Chougnet, C. A. (2015) · Aging Cell · doi:10.1111/acel.12303 · Cited by 69
Die Another Way: Interplay between Influenza A Virus, Inflammation and Cell Death
Laghlali, G., Lawlor, K. E., & Tate, M. D. (2020) · Viruses · doi:10.3390/v12040401 · Cited by 71
Changes in Cytokine Levels and NK Cell Activation Associated with Influenza
Jost, S., Quillay, H., Reardon, J., Peterson, E., Simmons, R. P., Parry, B. A., Bryant, N. N. P., Binder, W. D., & Altfeld, M. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025060 · Cited by 65
Role of NK Cells in Influenza Infection
Schultz‐Cherry, S. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_403 · Cited by 59
Immunesenescence: A Predisposing Risk Factor for the Development of COVID-19?
Hazeldine, J., & Lord, J. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.573662 · Cited by 55
Innate lymphoid cells in lung infection and immunity
Stehle, C., Hernández, D. C., & Romagnani, C. (2018) · Immunological Reviews · doi:10.1111/imr.12712 · Cited by 55
Current progress in NK cell biology and NK cell-based cancer immunotherapy
Tarazona, R., López-Sejas, N., Guerrero, B., Hassouneh, F., Valhondo, I., Pera, A., Sánchez-Correa, B., Pastor, N., Durán, E., Alonso, C., et al. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02532-9 · Cited by 53
Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection
Zhou, K., Wang, J., Li, A., Zhao, W., Wang, D., Zhang, W., Yan, J., Gao, G. F., Liu, W., & Fang, M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501486 · Cited by 52
Single-cell profiling of immune system alterations in lymphoid, barrier and solid tissues in aged mice
Krishnarajah, S., Ingelfinger, F., Friebel, E., Cansever, D., Amorim, A., Andreadou, M., Bamert, D., Litscher, G., Lutz, M., Mayoux, M., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00148-x · Cited by 57
SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime
Domingues, R., Lippi, A., Setz, C., Outeiro, T. F., & Kriško, A. (2020) · Aging · doi:10.18632/aging.103989 · Cited by 52
Natural killer cell development and maturation in aged mice
Beli, E., Duriancik, D. M., Clinthorne, J. F., Lee, T., Kim, S., & Gardner, E. M. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.11.007 · Cited by 51
Self-citation
Protective Effect of Panax notoginseng Root Water Extract against Influenza A Virus Infection by Enhancing Antiviral Interferon-Mediated Immune Responses and Natural Killer Cell Activity
Choi, J., Jin, Y.-H., Lee, H.-E., Oh, T. W., Yim, N., Cho, W., & Yeul, J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01542 · Cited by 51
Host Protective Immune Responses against Influenza A Virus Infection
Jung, H. E., & Lee, H. K. (2020) · Viruses · doi:10.3390/v12050504 · Cited by 55
Viruses comprise an extensive pool of mobile genetic elements in eukaryote cell cultures and human clinical samples
Thannesberger, J., Hellinger, H.-J., Klymiuk, I., Kastner, M.-T., Rieder, F. J. J., Schneider, M., Fister, S., Lion, T., Kosulin, K., Laengle, J., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201601168r · Cited by 47
Tissue-resident immunity in the lung: a first-line defense at the environmental interface
Zazara, D. E., Belios, I., Lücke, J., Zhang, T., & Giannou, A. D. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00964-2 · Cited by 48
The aging lung: microenvironment, mechanisms, and diseases
Wang, Y., Huang, X., Luo, G., Xu, Y., Deng, X., Lin, Y., Wang, Z., Zhou, S., Wang, S., Chen, H., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1383503 · Cited by 50
Bovine colostrum enhances natural killer cell activity and immune response in a mouse model of influenza infection and mediates intestinal immunity through toll-like receptors 2 and 4
Wong, E. B., Mallet, J., Duarte, J., Matar, C., & Ritz, B. W. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.02.007 · Cited by 44
Self-citation
Age-related changes in the natural killer cell response to seasonal influenza vaccination are not influenced by a synbiotic: A randomised controlled trial
Przemska-Kosicka, A., Childs, C. E., Maidens, C., Dong, H., Todd, S., Gosney, M. A., Tuohy, K. M., & Yaqoob, P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00591 · Cited by 43
Energy Intake and Response to Infection with Influenza
Gardner, E. M., Beli, E., Clinthorne, J. F., & Duriancik, D. M. (2011) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-081810-160812 · Cited by 43
Self-citation
Phenotype and functions of conventional and non-conventional NK cells
Erick, T. K., & Brossay, L. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.11.007 · Cited by 42
The Host Environment Is Responsible for Aging-Related Functional NK Cell Deficiency
Chiu, B., Martin, B. E., Stolberg, V. R., & Chensue, S. W. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301625 · Cited by 42
Differential lung NK cell responses in avian influenza virus infected chickens correlate with pathogenicity
Jansen, C. A., de Geus, E. D., van Haarlem, D. A., van de Haar, P. M., Löndt, B. Z., Graham, S. P., Göbel, T., van Eden, W., Brookes, S. M., & Vervelde, L. (2013) · Scientific Reports · doi:10.1038/srep02478 · Cited by 44
Low-dose supplementation with active hexose correlated compound improves the immune response to acute influenza infection in C57BL/6 mice
Nogusa, S., Gerbino, J., & Ritz, B. W. (2009) · Nutrition Research · doi:10.1016/j.nutres.2009.01.005 · Cited by 40
Self-citation
Evasion of natural killer cells by influenza virus
Guo, H., Kumar, P., & Malarkannan, S. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0610319 · Cited by 39
The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL ‐15/ IL ‐15Rα treatment
Nair, S., Fang, M., & Sigal, L. J. (2014) · Aging Cell · doi:10.1111/acel.12291 · Cited by 38
Short-Term Re-Feeding of Previously Energy-Restricted C57BL/6 Male Mice Restores Body Weight and Body Fat and Attenuates the Decline in Natural Killer Cell Function after Primary Influenza Infection , ,
Clinthorne, J. F., Adams, D. J., Fenton, J. I., Ritz, B. W., & Gardner, E. M. (2010) · Journal of Nutrition · doi:10.3945/jn.110.122408 · Cited by 38
Self-citation
Expansion of 2B4+ natural killer (NK) cells and decrease in NKp46+ NK cells in response to influenza
Jost, S., Reardon, J., Peterson, E., Poole, D. N., Bosch, R. J., Alter, G., & Altfeld, M. A. (2011) · Immunology · doi:10.1111/j.1365-2567.2010.03394.x · Cited by 36
Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection
Liu, Y., Zheng, J. H., Liu, Y., Wen, L., Huang, L., Xiang, Z., Lam, K.-T., Lv, A., Mao, H., Lau, Y., et al. (2017) · Cellular and Molecular Immunology · doi:10.1038/cmi.2017.10 · Cited by 36
Contribution of innate immune cells to pathogenesis of severe influenza virus infection
Cole, S., & Ho, L. (2017) · Clinical Science · doi:10.1042/cs20160484 · Cited by 38
Calorie Restriction Attenuates Terminal Differentiation of Immune Cells
White, M. J., Beaver, C., Goodier, M. R., Bottomley, C., Nielsen, C. M., Wolf, A., Boldrin, L., Whitmore, C. L., Morgan, J. E., Pearce, D. J., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00667 · Cited by 34
NK Cell Hyporesponsiveness: More Is Not Always Better
Frutoso, M., & Mortier, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184514 · Cited by 34
NK-cells are involved in thymic atrophy induced by influenza A virus infection
Duan, X., Lu, J., Zhou, K., Wang, J., Wu, J., Gao, G. F., & Fang, M. (2015) · Journal of General Virology · doi:10.1099/jgv.0.000276 · Cited by 25
CD8 T Cells in Old Mice Contribute to the Innate Immune Response toMycobacterium tuberculosisvia Interleukin-12p70-Dependent and Antigen-Independent Production of Gamma Interferon
Vesosky, B., Rottinghaus, E. K., Davis, C. C., & Turner, J. (2009) · Infection and Immunity · doi:10.1128/iai.00295-09 · Cited by 25
Depletion but Activation of CD56dimCD16+ NK Cells in Acute Infection with Severe Fever with Thrombocytopenia Syndrome Virus
Li, M., Xiong, Y., Li, M., Zhang, W., Liu, J., Zhang, Y., Xiong, S., Zou, C., Liang, B., Lu, M., et al. (2020) · Virologica Sinica · doi:10.1007/s12250-020-00224-3 · Cited by 23
Bioactive Constituents of Verbena officinalis Alleviate Inflammation and Enhance Killing Efficiency of Natural Killer Cells
Dai, X., Zhou, X., Shao, R., Zhao, R., Yanamandra, A. K., Xing, Z., Ding, M., Wang, J., Liu, T., Zheng, Q., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087144 · Cited by 22
Innate lymphoid cells: the role in respiratory infections and lung tissue damage
Głobińska, A., & Kowalski, M. L. (2017) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2017.1366314 · Cited by 18
Antiviral Responses of Tissue-resident CD49a+ Lung Natural Killer Cells Are Dysregulated in Chronic Obstructive Pulmonary Disease
Cooper, G. E., Mayall, J., Donovan, C., Haw, T. J., Budden, K. F., Hansbro, N. G., Blomme, E. E., Maes, T., Kong, C. W., Horvat, J. C., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202205-0848oc · Cited by 17
Too young to die? How aging affects cellular innate immune responses to influenza virus and disease severity
Harpur, C. M., Page, M. A. L., & Tate, M. D. (2021) · Virulence · doi:10.1080/21505594.2021.1939608 · Cited by 16
Deficiency of eIF4B Increases Mouse Mortality and Impairs Antiviral Immunity
Chen, B., Chen, Y., Rai, K. R., Wang, X., Liu, S., Li, Y., Xiao, M., Ma, Y., Wang, G., Guo, G., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.723885 · Cited by 16
Immunosenescence and Inflammaging in COVID-19
Asghari, F., Asghary, A., Zolbanin, N. M., Faraji, F., & Jafari, R. (2023) · Viral Immunology · doi:10.1089/vim.2023.0045 · Cited by 17
Risk factors for prolonged viral clearance in adult patients with COVID-19 in Beijing, China: A prospective observational study
Xue, J., Zheng, J., Shang, X., Qin, E., Zhao, P., He, Y., Liu, M., Zhang, J., Liu, H., & Bai, C. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107031 · Cited by 14
Natural Killer Cells Dampen the Pathogenic Features of Recall Responses to Influenza Infection
Mooney, J. P., Qendro, T., Keith, M., Philbey, A., Groves, H., Tregoning, J. S., Goodier, M. R., & Riley, E. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00135 · Cited by 12
Immune Response to Chikungunya Virus: Sex as a Biological Variable and Implications for Natural Delivery via the Mosquito
Taylor, M., & Rayner, J. O. (2023) · Viruses · doi:10.3390/v15091869 · Cited by 11
Natural Killer cells in Innate Defense against Infective Pathogens
Yongchao, D. W. (2013) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.s13-006 · Cited by 11
Immune mechanisms of cardiac aging
Goldstein, D. R., & Abdel‐Latif, A. (2023) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2023.02 · Cited by 10
Differential Effects of Stimulatory Factors on Natural Killer Cell Activities of Young and Aged Mice
Nogusa, S., Murasko, D. M., & Gardner, E. M. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls079 · Cited by 10
Self-citation
Identification and Analysis of Natural Killer Cells in Murine Nasal Passages
Okada, K., Sato, S., Sato, A., Mandelboim, O., Yamasoba, T., & Kiyono, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142920 · Cited by 10
The Immune Response to Respiratory Viruses: From Start to Memory
Reijnders, T. D. Y., Schuurman, A. R., & van der Poll, T. (2021) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0041-1736459 · Cited by 11
Homeostatic migration and distribution of innate immune cells in primary and secondary lymphoid organs with ageing
Nikolich‐Žugich, J., & Davies, J. S. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12920 · Cited by 9
Bidirectional factors impact the migration of NK cells to draining lymph node in aged mice during influenza virus infection
Duan, X., Lu, J., Wang, H., Liu, X., Wang, J., Zhou, K., Jiang, W., Wang, Y., & Fang, M. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.06.021 · Cited by 10
Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2
Harris, R., Yang, J., Pagan, K., Cho, S. J., & Stout-Delgado, H. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212097 · Cited by 9
Natural killer cells immunosenescence and the impact of lifestyle management
Wang, L., Mao, L., Xiao, W., & Chen, P. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149216 · Cited by 8
Human placental hematopoietic stem cell derived natural killer cells (CYNK-001) mediate protection against influenza a viral infection
Gleason, J., Zhao, Y., Raitman, I., Kang, L., He, S., & HARIRI, R. J. (2022) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2022.2055945 · Cited by 8
A Case-Control Study on the Changes in Natural Killer Cell Activity following Administration of Polyvalent Mechanical Bacterial Lysate in Korean Adults with Recurrent Respiratory Tract Infection
Lee, Y. K., Haam, J.-H., Suh, E., Cho, S. H., & Kim, Y. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11113014 · Cited by 7
Respiratory viral infections in the elderly: From the perspective of the aging immune system
Zhang, X., Xu, J., Wang, Y., Li, H., Yu, J., Shang, L., Shang, L., Hou, B., Zhang, X., & Cao, B. (2023) · The Innovation Medicine · doi:10.59717/j.xinn-med.2023.100022 · Cited by 5
Impact of aging on gut-lung-adipose tissue interactions and lipid metabolism during influenza infection in mice
Bogard, G., Makki, K., Rodrigues, P. B., Tan, J., Molendi‐Coste, O., Barthelemy, J., Descat, A., Bouilloux, F., Lecœur, C., Grangette, C., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-21363-1 · Cited by 5
High baseline frequencies of natural killer cells are associated with asymptomatic SARS-CoV-2 infection
Graydon, E. K., Malloy, A. M. W., Machmach, K., Sun, P., Paquin‐Proulx, D., Lizewski, S. E., Lizewski, R. A., Weir, D. L., Goforth, C. W., Anderson, S. K., et al. (2023) · Current Research in Immunology · doi:10.1016/j.crimmu.2023.100064 · Cited by 4
Reduced MCMV Δm157 viral clearance in the absence of TSAd
Moussa, P., Abrahamsen, G., Fodil, N., Gopalakrishnan, R. P., Mancini, M., Dissen, E., Saether, P. C., Wiltshire, S. A., Boivin, G. A., Caignard, G., et al. (2015) · Scientific Reports · doi:10.1038/srep09219 · Cited by 4
Targeting immunosenescence in lung diseases: mechanistic insights and clinical interventions
Zhang, Y., Yu, X., Li, P., Ouyang, Y., Zhu, L., & Luo, F. (2026) · BMC Medicine · doi:10.1186/s12916-026-04833-9 · Cited by 2
Aging and respiratory infections in laboratory animals
Манских, В. Н. (2015) · Advances in Gerontology · doi:10.1134/s2079057015010075 · Cited by 2
Natural Killer Cells Are Dispensable for Virus Control in Rag2 −/− Mice During Primary RSV Infection
Nakawesi, J., Min, T. S. T., & Johansson, C. (2025) · European Journal of Immunology · doi:10.1002/eji.70045 · Cited by 1
Perspectives on the Development of Immune Memory Associated with Vaccination
He, P., Zhou, Y., Yu, F., Zhou, T., Li, F., Mi, Y., Zhang, W., & Zhu, B. (2026) · Vaccines · doi:10.3390/vaccines14050420 · Cited by 1
Sex and the Aging Immune System
Gibson, D. C., & Bupp, M. G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00059-2 · Cited by 1
Changes in Natural Killer Cells in Aged Mice
Nair, S., & Sigal, L. J. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_97-1 · Cited by 1
Effect of Lighting Regimes and the Melatonin Receptor Antagonist Luzindole on the Composition of Peripheral Blood Leukocytes of Wistar Rats in Postnatal Ontogenesis
Uzenbaeva, L. B., Кижина, А. Г., Калинина, С. Н., Хижкин, Е. А., Ilyukha, V. A., Печорина, Э. Ф., & Fokina, V. O. (2021) · Advances in Gerontology · doi:10.1134/s2079057021020156 · Cited by 1
Changes in Natural Killer Cells in Aged Mice
Nair, S., & Sigal, L. J. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_97 · Cited by 1
Mechanisms of Disease
Mitchell, M. G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814610-1.00005-5 · Cited by 1
Natural Killer Cells: Deciphering Their Role, Diversity and Functions
Toledo, V. P. C. P., Sathler-Avelar, R., Vitelli-Avelar, D. M., Peruhype-Magalhães, V., Silveira-Lemos, D., Campi‐Azevedo, A. C., Andrade, M. C., Teixeira‐Carvalho, A., & Martins‐Filho, O. A. (2009) · Springer eBooks · doi:10.1007/978-3-642-02309-5_1 · Cited by 1
The innate and adaptive immune response to avian influenza virus
Vervelde, L., & Kapczynski, D. R. (2016) · Wiley eBooks · doi:10.1002/9781118924341.ch6 · Cited by 1
The effect of regulatory T cells on an age-altered specific CD8 T cell response following influenza infection
Williams-Bey, Y., & Murasko, D. (2010) · iDEA - Drexel University Institutional Repository · doi:10.17918/etd-3346 · Cited by 1

Authors: Nogusa, S., Ritz, B. W., Kassim, S. H., Jennings, S. R., & Gardner, E. M.
Affiliations: Drexel University (US)
Corresponding author: Gardner, Elizabeth M.
ORCID: Ritz, Barry W.
Kassim, Sadik H.
Jennings, Stephen R.
Gardner, Elizabeth M.
Venue: Mechanisms of Ageing and Development
Publisher: Elsevier BV
Published: 2008-04
Volume: 129
Issue: 4
Pages: 223-230
ISSN: 0047-6374 (ISSN-L)
DOI: 10.1016/j.mad.2008.01.003
OpenAlex: W2078343139
Cited by: 111
References: 22
Citations by year: 2026: 4 · 2025: 2 · 2024: 1 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 13 · 2019: 7 · 2018: 6 · 2017: 8 · 2016: 7 · 2015: 6 · 2014: 4 · 2013: 10 · 2012: 5
FWCI: 2.50
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Mechanisms of Ageing and Development (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords: natural killer cells, influenza A virus, aging, innate immunity, NK cell cytotoxicity, NK1.1, NK cell depletion, lung viral titers, age-related immune decline, C57BL/6 mice
MeSH terms: Aging, Animals, Cytotoxicity, Immunologic, Killer Cells, Natural, Kinetics, Male, Mice, Inbred C57BL, Orthomyxoviridae Infections, Pneumonia, RNA, Messenger, Viral Matrix Proteins, Weight Loss, Gene Expression Regulation, Viral, Lymphocyte Count, Mice, Influenza A Virus, H1N1 Subtype

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Characterization of age-related changes in natural killer cells during primary influenza infection in mice

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks