Innate immune responses in the ageing lung.

Boe, D M; Boule, L A; Kovacs, E J

doi:10.1111/cei.12881

Cited by 157Immune Response and InflammationImmune responses and vaccinationsPneumonia and Respiratory Infections

Innate immune responses in the ageing lung.

Open access

Boe, D M, Boule, L A, Kovacs, E J·2016·Clinical and Experimental Immunology

DOI 10.1111/cei.12881PMC PMC5167032

Open this paper in CoChat — free account Open PDF

Abstract

The world is undergoing an unprecedented shift in demographics, with the number of individuals over the age of 60 years projected to reach 2 billion or more by 2050, representing 22% of the global population. Elderly people are at a higher risk for chronic disease and more susceptible to infection, due in part to age-related dysfunction of the immune system resulting from low-grade chronic inflammation known as 'inflamm-ageing'. The innate immune system of older individuals exhibits a diminished ability to respond to microbial threats and clear infections, resulting in a greater occurrence of many infectious diseases in elderly people. In particular, the incidence of and mortality from lung infections increase sharply with age, with such infections often leading to worse outcomes, prolonged hospital stays and life-threatening complications, such as sepsis or acute respiratory distress syndrome. In this review, we highlight research on bacterial pneumonias and pulmonary viral infections and discuss age-related changes in innate immunity that contribute to the higher rate of these infections in older populations. By understanding more clearly the innate immune defects in elderly individuals, we can design age-specific therapies to address lung infections in such a vulnerable population.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/cei.12881

Cites

133 of 133 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In the elderly, apart from increased risk of severe disease, recovery could also be slower and poor, increasing the possibility of recrudescence or aggravation as time passes.
“Apart from the increased risk of severe disease, recovery could also be slower and poor, thus increasing the possibility of recrudescence or aggravation as time passes (Boe et al., 2017).”
From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Boe et al., 2017

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358 · see citing works
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works
Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States
Thompson, W. W., Shay, D. K., Weintraub, E., Brammer, L., Cox, N., Anderson, L. J., & Fukuda, K. (2003) · JAMA · doi:10.1001/jama.289.2.179 · Cited by 3,673 · see citing works
Respiratory Syncytial Virus Infection in Elderly and High-Risk Adults
Falsey, A. R., Hennessey, P., Formica, M. A., Cox, C., & Walsh, E. E. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043951 · Cited by 2,239 · see citing works
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates
Pichlmair, A., Schulz, O., Tan, C. P., Näslund, T. I., Liljeström, P., Weber, F., & Reis e Sousa, C. (2006) · Science · doi:10.1126/science.1132998 · Cited by 2,210 · see citing works
Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087 · see citing works
Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation
Buckley, C. D., Gilroy, D. W., & Serhan, C. N. (2014) · Immunity · doi:10.1016/j.immuni.2014.02.009 · Cited by 811 · see citing works
Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function
Hearps, A. C., Martin, G. E., Angelovich, T. A., Cheng, W., Maisa, A., Landay, A. L., Jaworowski, A., & Crowe, S. M. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00851.x · Cited by 547 · see citing works
Toll-like receptors: Activation, signalling and transcriptional modulation
Nardo, D. D. (2015) · Cytokine · doi:10.1016/j.cyto.2015.02.025 · Cited by 459 · see citing works
Effect of age on human neutrophil function
Wenisch, C., Patruta, S., Daxböck, F., Krause, R., & Hörl, W. H. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.1.40 · Cited by 452 · see citing works
Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study
Puzianowska-Kuźnicka, M., Owczarz, M., Wieczorowska-Tobis, K., Nadrowski, P., Chudek, J., Slusarczyk, P., Skalska, A., Jonas, M., Franek, E., & Mossakowska, M. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0076-x · Cited by 445 · see citing works
Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans
Butcher, S. K., Chahal, H., Nayak, L., Sinclair, A., Henriquez, N. V., Sapey, E., O'Mahony, D., & Lord, J. M. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.6.881 · Cited by 436 · see citing works
Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway
Agrawal, A., Agrawal, S., Cao, J.-N., Su, H., Osann, K., & Gupta, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6912 · Cited by 435 · see citing works
Trends in Hospitalizations for Pneumonia Among Persons Aged 65 Years or Older in the United States, 1988-2002
Fry, A. M. (2005) · JAMA · doi:10.1001/jama.294.21.2712 · Cited by 425 · see citing works
Acute viral infections of upper respiratory tract in elderly people living in the community: comparative, prospective, population based study of disease burden
Nicholson, K. G., Kent, J., Hammersley, V., & Cancio, E. (1997) · BMJ · doi:10.1136/bmj.315.7115.1060 · Cited by 381 · see citing works
Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence
Sapey, E., Greenwood, H., Walton, G., Mann, E., Love, A., Aaronson, N., Insall, R. H., Stockley, R. A., & Lord, J. M. (2014) · Blood · doi:10.1182/blood-2013-08-519520 · Cited by 358 · see citing works
Inflammaging decreases adaptive and innate immune responses in mice and humans
Frasca, D., & Blomberg, B. B. (2016) · Biogerontology · doi:10.1007/s10522-015-9578-8 · Cited by 357 · see citing works
Age-Associated Defect in Human TLR-1/2 Function
van Duin, D., Mohanty, S., Thomas, V., Ginter, S., Montgomery, R. R., Fikrig, E., Allore, H. G., Medzhitov, R., & Shaw, A. C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.2.970 · Cited by 352 · see citing works
Aging and innate immune cells
Plackett, T. P., Boehmer, E. D., Faunce, D. E., & Kovacs, E. J. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.1103592 · Cited by 351 · see citing works
Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians
Arai, Y., Martin-Ruiz, C. M., Takayama, M., Abe, Y., Takebayashi, T., Koyasu, S., Suematsu, M., Hirose, N., & von Zglinicki, T. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.07.029 · Cited by 333 · see citing works
The Effect of Aging on Nasal Mucociliary Clearance, Beat Frequency, and Ultrastructure of Respiratory Cilia
HO, J. C., CHAN, K. N., HU, W. H., LAM, W. K., ZHENG, L., TIPOE, G. L., SUN, J., LEUNG, R., & TSANG, K. W. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.4.9909121 · Cited by 324 · see citing works
Clinical Characteristics and Treatment Patterns Among Patients With Ventilator-Associated Pneumonia
Kollef, M. H., Morrow, L. E., Niederman, M. S., Leeper, K. V., Anzueto, A., Scott, L. B., & Rodino, F. J. (2006) · CHEST Journal · doi:10.1378/chest.129.5.1210 · Cited by 322 · see citing works
When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system
Silva, M. T. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0809549 · Cited by 321 · see citing works
Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals
Hazeldine, J., Harris, P., Chapple, I., Grant, M. M., Greenwood, H. L., Livesey, A., Sapey, E., & Lord, J. M. (2014) · Aging Cell · doi:10.1111/acel.12222 · Cited by 297 · see citing works
The aging lung
Kovacs, E. J., Lowery, E. M., Kuhlmann, E. A., & Brubaker, A. L. (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s51152 · Cited by 280 · see citing works
Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression
Boehmer, E. D., Góral, J., Faunce, D. E., & Kovacs, E. J. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0803389 · Cited by 266 · see citing works
Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice
Zhao, J., Zhao, J., Legge, K., & Perlman, S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci59777 · Cited by 265 · see citing works
Impaired immune responses in the lungs of aged mice following influenza infection
Toapanta, F. R., & Ross, T. M. (2009) · Respiratory Research · doi:10.1186/1465-9921-10-112 · Cited by 259 · see citing works
Immunity to Respiratory Viruses
Kohlmeier, J. E., & Woodland, D. L. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132625 · Cited by 254 · see citing works
Interleukin‐6, C‐Reactive Protein, and Tumor Necrosis Factor‐Alpha as Predictors of Mortality in Frail, Community‐Living Elderly Individuals
Giovannini, S., Onder, G., Liperoti, R., Russo, A., Carter, C., Capoluongo, E., Pahor, M., Bernabei, R., & Landi, F. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03570.x · Cited by 249 · see citing works
Impact of aging on dendritic cell functions in humans
Agrawal, A., & Gupta, S. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.06.004 · Cited by 246 · see citing works
Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease
Pillai, P. S., Molony, R. D., Martinod, K., Dong, H., Pang, I. K., Tal, M. C., Solis, A. G., Bielecki, P., Mohanty, S., Trentalange, M. J., et al. (2016) · Science · doi:10.1126/science.aaf3926 · Cited by 241 · see citing works
Risk Factors for Severe Respiratory Syncytial Virus Infection in Elderly Persons
Walsh, E. E., Peterson, D. R., & Falsey, A. R. (2004) · The Journal of Infectious Diseases · doi:10.1086/380907 · Cited by 237 · see citing works
Dysbiosis of upper respiratory tract microbiota in elderly pneumonia patients
de Steenhuijsen Piters, W. A. A., Huijskens, E. G. W., Wyllie, A. L., Biesbroek, G., van den Bergh, M. R., Veenhoven, R. H., Wang, X., Trzciński, K., Bonten, M. J., Rossen, J. W. A., et al. (2016) · The ISME Journal · doi:10.1038/ismej.2015.99 · Cited by 235 · see citing works
Culture and molecular-based profiles show shifts in bacterial communities of the upper respiratory tract that occur with age
Stearns, J. C., Davidson, C. J., McKeon, S., Whelan, F. J., Fontes, M. E., Schryvers, A. B., Bowdish, D. M. E., Kellner, J. D., & Surette, M. G. (2015) · The ISME Journal · doi:10.1038/ismej.2014.250 · Cited by 234 · see citing works
Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells
Pothlichet, J., Meunier, I., Davis, B. K., Ting, J. P.-Y., Skamene, E., von Messling, V., & Vidal, S. M. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003256 · Cited by 225 · see citing works
Respiratory Syncytial Virus Infection in Elderly Adults
Falsey, A. R., & Walsh, E. E. (2005) · Drugs & Aging · doi:10.2165/00002512-200522070-00004 · Cited by 222 · see citing works
Serum cytokine profiles in healthy young and elderly population assessed using multiplexed bead-based immunoassays
Kim, H. O., Kim, H.-S., Youn, J., Shin, E., & Park, S. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-113 · Cited by 220 · see citing works
Dysregulation of human Toll-like receptor function in aging
Shaw, A. C., Panda, A., Joshi, S. R., Qian, F., Allore, H. G., & Montgomery, R. R. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.10.007 · Cited by 215 · see citing works
Respiratory Syncytial Virus Infection in Older Adults: An Under-Recognized Problem
Branche, A. R., & Falsey, A. R. (2015) · Drugs & Aging · doi:10.1007/s40266-015-0258-9 · Cited by 212 · see citing works
Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia
Gauguet, S., D'Ortona, S., Ahnger-Pier, K., Duan, B., Surana, N. K., Lu, R., Cywes-Bentley, C., Gadjeva, M., Shan, Q., Priebe, G. P., et al. (2015) · Infection and Immunity · doi:10.1128/iai.00037-15 · Cited by 208 · see citing works
Global analyses revealed age‐related alterations in innate immune responses after stimulation of pathogen recognition receptors
Metcalf, T. U., Cubas, R. A., Ghneim, K., Cartwright, M. J., Grevenynghe, J. V., Richner, J. M., Olagnier, D. P., Wilkinson, P. A., Cameron, M. J., Park, B. S., et al. (2015) · Aging Cell · doi:10.1111/acel.12320 · Cited by 189 · see citing works
Loss of Phagocytic and Antigen Cross-Presenting Capacity in Aging Dendritic Cells Is Associated with Mitochondrial Dysfunction
Chougnet, C. A., Thacker, R. I., Shehata, H. M., Hennies, C. M., Lehn, M. A., Lages, C. S., & Janssen, E. M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501006 · Cited by 187 · see citing works
Microbiology of Ventilator–Associated Pneumonia Compared With That of Hospital-Acquired Pneumonia
Weber, D. J., Rutala, W. A., Sickbert-Bennett, E. E., Samsa, G. P., Brown, V., & Niederman, M. S. (2007) · Infection Control and Hospital Epidemiology · doi:10.1086/518460 · Cited by 185 · see citing works
Reduced Neutrophil Chemotaxis and Infiltration Contributes to Delayed Resolution of Cutaneous Wound Infection with Advanced Age
Brubaker, A. L., Rendon, J. L., Ramirez, L., Choudhry, M. A., & Kovacs, E. J. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201213 · Cited by 181 · see citing works
Aging Delays Resolution of Acute Inflammation in Mice: Reprogramming the Host Response with Novel Nano-Proresolving Medicines
Arnardottir, H. H., Dalli, J., Colas, R. A., Shinohara, M., & Serhan, C. N. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401313 · Cited by 170 · see citing works
Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway
Boehmer, E. D., Meehan, M. J., Cutro, B. T., & Kovacs, E. J. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.07.009 · Cited by 170 · see citing works
Aging impairs peritoneal but not bone marrow‐derived macrophage phagocytosis
Linehan, E., Dombrowski, Y., Snoddy, R., Fallon, P. G., Kissenpfennig, A., & Fitzgerald, D. C. (2014) · Aging Cell · doi:10.1111/acel.12223 · Cited by 169 · see citing works
Ageing is associated with diminished apoptotic cell clearancein vivo
Aprahamian, T. R., Takemura, Y., Goukassian, D. A., & Walsh, K. (2008) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03658.x · Cited by 168 · see citing works
Elderly Humans Show Prolonged In Vivo Inflammatory Activity during Pneumococcal Infections
Bruunsgaard, H., Skinhøj, P., Qvist, J., & Pedersen, B. K. (1999) · The Journal of Infectious Diseases · doi:10.1086/314873 · Cited by 167 · see citing works
IFN-γ–dependent transcription of MHC class II IA is impaired in macrophages from aged mice
Herrero, C., Marqués, L., Lloberas, J., & Celada, A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11696 · Cited by 162 · see citing works
Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis.
Simell, B., Vuorela, A., Ekström, N., Palmu, A., Reunanen, A., Meri, S., Käyhty, H., & Väkeväinen, M. (2011) · Vaccine · doi:10.1016/j.vaccine.2010.12.121 · Cited by 155 · see citing works
Sex and Gender Impact Immune Responses to Vaccines Among the Elderly
Fink, A. L., & Klein, S. L. (2015) · Physiology · doi:10.1152/physiol.00035.2015 · Cited by 154 · see citing works
Neutrophils and Macrophages: the Main Partners of Phagocyte Cell Systems
Silva, M. T., & Correia‐Neves, M. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00174 · Cited by 153 · see citing works
Community-Acquired Pneumonia in Elderly Patients
Stupka, J. E., Mortensen, E. M., Anzueto, A., & Restrepo, M. I. (2009) · Aging Health · doi:10.2217/ahe.09.74 · Cited by 145 · see citing works
Long-term clearance from small airways decreases with age
Svartengren, M., Falk, R., & Philipson, K. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00002105 · Cited by 144 · see citing works
Age‐Associated Inflammation and Toll‐Like Receptor Dysfunction Prime the Lungs for Pneumococcal Pneumonia
Hinojosa, E., Boyd, A. R., & Orihuela, C. J. (2009) · The Journal of Infectious Diseases · doi:10.1086/600870 · Cited by 143 · see citing works
Changes in the macrophage function with aging
la Fuente, M. D. (1985) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(85)90933-8 · Cited by 141 · see citing works
Age decreases macrophage IL-10 expression: Implications for functional recovery and tissue repair in spinal cord injury
Zhang, B., Bailey, W. M., Braun, K. J., & Gensel, J. C. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.08.001 · Cited by 126 · see citing works
Older Adults Have a Low Capacity To Opsonize Pneumococci Due to Low IgM Antibody Response to Pneumococcal Vaccinations
Park, S., & Nahm, M. H. (2010) · Infection and Immunity · doi:10.1128/iai.00768-10 · Cited by 125 · see citing works
Nosocomial infections in the elderly
Saviteer, S. M., Samsa, G., & Rutala, W. A. (1988) · The American Journal of Medicine · doi:10.1016/0002-9343(88)90101-5 · Cited by 119 · see citing works
Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia
Shivshankar, P., Boyd, A. R., Le Saux, C. J., Yeh, I., & Orihuela, C. J. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00720.x · Cited by 117 · see citing works
Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia
Boyd, A. R., Shivshankar, P., Jiang, S., Berton, M. T., & Orihuela, C. J. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.04.004 · Cited by 117 · see citing works
Intrinsic versus environmental influences on T‐cell responses in aging
Linton, P., Li, S. P., Zhang, Y., Bautista, B., Huynh, Q. L., & Trinh, T. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00266.x · Cited by 115 · see citing works
RIG-I-mediated Activation of p38 MAPK Is Essential for Viral Induction of Interferon and Activation of Dendritic Cells
Mikkelsen, S. S., Jensen, S. B., Chiliveru, S., Melchjorsen, J., Julkunen, I., Gaestel, M., Arthur, J. S. C., Flavell, R. A., Ghosh, S., & Paludan, S. R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807272200 · Cited by 115 · see citing works
Molecular composition of the alveolar lining fluid in the aging lung
Moliva, J. I., Rajaram, M. V. S., Sidiki, S., Sasindran, S. J., Guirado, E., Pan, X. J., Wang, S.-H., Ross, P., Lafuse, W. P., Schlesinger, L. S., et al. (2014) · AGE · doi:10.1007/s11357-014-9633-4 · Cited by 114 · see citing works
Innate Immune Dysfunctions in Aged Mice Facilitate the Systemic Dissemination of Methicillin-Resistant S. aureus
Tseng, C. W., Kyme, P. A., Arruda, A., Ramanujan, V. K., Tawackoli, W., & Liu, G. Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041454 · Cited by 112 · see citing works
Characterization of age-related changes in natural killer cells during primary influenza infection in mice
Nogusa, S., Ritz, B. W., Kassim, S. H., Jennings, S. R., & Gardner, E. M. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.01.003 · Cited by 111 · see citing works
Incidence and Cost of Pneumonia in Medicare Beneficiaries
Parks, C. L., Ryan, M., Chapman, J. D., Stason, W. B., Tompkins, C. P., Suaya, J. A., Polsky, D. E., Mannino, D. M., & Shepard, D. S. (2012) · CHEST Journal · doi:10.1378/chest.11-1160 · Cited by 109 · see citing works
Advanced Age Alters Monocyte and Macrophage Responses
Albright, J. M., Dunn, R. C., Shults, J. A., Boe, D. M., Afshar, M., & Kovacs, E. J. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6691 · Cited by 104 · see citing works
Granulocyte and natural killer activity in the elderly
Lorenzo, G. D., Balistreri, C. R., Candore, G., Cigna, D., Colombo, A., Romano, G. C., Colucci, A. T., Gervasi, F., Listı̀, F., Potestio, M., et al. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00156-0 · Cited by 103 · see citing works
Non-specific immunity in aging: Deficiency of monocyte and polymorphonuclear cell-mediated functions
Antonaci, S., Jirillo, E., Ventura, M. T., Garofalo, A. R., & Bonomo, L. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90121-0 · Cited by 103 · see citing works
Interleukin-1 Receptor Antagonist, Interleukin-6, and C-Reactive Protein as Predictors of Mortality in Nonagenarians: The Vitality 90+ Study
Jylhä, M. K., Paavilainen, P., Lehtimäki, T. J., Goebeler, S., Karhunen, P. J., Hervonen, A., & Hurme, M. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.9.1016 · Cited by 102 · see citing works
Age-dependent alterations of Fc gamma receptor-mediated effector functions of human polymorphonuclear leucocytes.
Fülöp, T., Fóris, G., Wórum, I., & Leovey, A. (1985) · PubMed Central · Cited by 99 · see citing works
Impaired antigen-induced CD8+ T cell clonal expansion in aging is due to defects in antigen presenting cell function
Plowden, J., Renshaw-Hoelscher, M., Gangappa, S., Engleman, C., Katz, J. M., & Sambhara, S. (2004) · Cellular Immunology · doi:10.1016/j.cellimm.2004.07.001 · Cited by 98 · see citing works
Effect of Aging on Cytokine Production in Response to Respiratory Syncytial Virus Infection
Looney, R. J., Falsey, A. R., Walsh, E. E., & Campbell, D. (2002) · The Journal of Infectious Diseases · doi:10.1086/339008 · Cited by 90 · see citing works
Immunosenescence and vaccine failure in the elderly: strategies for improving response
Boraschi, D., & Italiani, P. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.06.006 · Cited by 86 · see citing works
The amazing innate immune response to influenza A virus infection
Tripathi, S., White, M. R., & Hartshorn, K. L. (2013) · Innate Immunity · doi:10.1177/1753425913508992 · Cited by 85 · see citing works
Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock
Vanzant, E. L., Hilton, R., López, C. M., Zhang, J., Ungaro, R. F., Gentile, L. F., Szpila, B. E., Maier, R. V., Cuschieri, J., Bihorac, A., et al. (2015) · Critical Care · doi:10.1186/s13054-015-0788-x · Cited by 82 · see citing works
Impaired secretion of interferons by dendritic cells from aged subjects to influenza
Prakash, S., Agrawal, S., Cao, J., Gupta, S., & Agrawal, A. (2012) · AGE · doi:10.1007/s11357-012-9477-8 · Cited by 80 · see citing works
An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibition
Nomellini, V., Faunce, D. E., Gómez, C. R., & Kovacs, E. J. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1007672 · Cited by 78 · see citing works
The effect of ageing on macrophage Toll-like receptor-mediated responses in the fight against pathogens
Dunston, C. R., & Griffiths, H. R. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04213.x · Cited by 76 · see citing works
Natural killer cell function is altered during the primary response of aged mice to influenza infection
Beli, E., Clinthorne, J. F., Duriancik, D. M., Hwang, I., Kim, S., & Gardner, E. M. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.08.005 · Cited by 76 · see citing works
Reduction in superoxide anion secretion and bactericidal activity of neutrophils from aged rats: reversal by the combination of gamma interferon and growth hormone
Fu, Y. K., Arkins, S., Li, Y. M., Dantzer, R., & Kelley, K. W. (1994) · Infection and Immunity · doi:10.1128/iai.62.1.1-8.1994 · Cited by 71 · see citing works
Mammalian NLR proteins; discriminating foe from friend
Kaparakis‐Liaskos, M., Philpott, D. J., & Ferrero, R. L. (2007) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100105 · Cited by 70 · see citing works
The aged nonhematopoietic environment impairs natural killer cell maturation and function
Shehata, H. M., Hoebe, K., & Chougnet, C. A. (2015) · Aging Cell · doi:10.1111/acel.12303 · Cited by 69 · see citing works
Age-related differences in the neutrophil response to pulmonary pseudomonas infection
Chen, M. M., Palmer, J. L., Plackett, T. P., Deburghgraeve, C. R., & Kovacs, E. J. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2013.12.010 · Cited by 68 · see citing works
Age‐Related Differences in Pulmonary Cytokine Response to Respiratory Syncytial Virus Infection: Modulation by Anti‐inflammatory and Antiviral Treatment
Boukhvalova, M. S., Yim, K. C., Kuhn, K. H., Hemming, P., Prince, G. A., Porter, D. D., & Blanco, J. C. G. (2007) · The Journal of Infectious Diseases · doi:10.1086/510628 · Cited by 67 · see citing works
Dysregulated inflammation as a risk factor for pneumonia in the elderly.
Boyd, A. R., & Orihuela, C. J. (2011) · Europe PMC (PubMed Central) · Cited by 66 · see citing works
Increased Viral Loads and Exacerbated Innate Host Responses in Aged Macaques Infected with the 2009 Pandemic H1N1 Influenza A Virus
Josset, L., Engelmann, F., Haberthur, K., Kelly, S. M., Park, B. S., Kawoaka, Y., García‐Sastre, A., Katze, M. G., & Messaoudi, I. (2012) · Journal of Virology · doi:10.1128/jvi.01571-12 · Cited by 66 · see citing works
Impaired Innate Mucosal Immunity in Aged Mice Permits Prolonged Streptococcus pneumoniae Colonization
Krone, C. L., Trzciński, K., Zborowski, T., Sanders, E. A. M., & Bogaert, D. (2013) · Infection and Immunity · doi:10.1128/iai.00618-13 · Cited by 63 · see citing works
Enhanced inflammation in aged mice following infection withStreptococcus pneumoniaeis associated with decreased IL-10 and augmented chemokine production
Williams, A. E., José, R. J. P., Brown, J., & Chambers, R. C. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00141.2014 · Cited by 62 · see citing works
Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence
Hinojosa, C. A., Mgbemena, V. E., Roekel, S. V., Austad, S. N., Miller, R. A., Bose, S., & Orihuela, C. J. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.08.013 · Cited by 61 · see citing works
Age-related differences in granulocyte Chemotaxis and degranulation
McLaughlin, B., O'MALLEY, K., & Cotter, T. G. (1986) · Clinical Science · doi:10.1042/cs0700059 · Cited by 61 · see citing works
Role of NK Cells in Influenza Infection
Schultz‐Cherry, S. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_403 · Cited by 59 · see citing works
The Endogenous Bacteria Alter Gut Epithelial Apoptosis and Decrease Mortality Following Pseudomonas aeruginosa Pneumonia
Fox, A. C., McConnell, K. W., Yoseph, B. P., Breed, E. R., Liang, Z., Clark, A. T., O’Donnell, D., Zee-Cheng, B. R., Jung, E., Dominguez, J. A., et al. (2012) · Shock · doi:10.1097/shk.0b013e31826e47e8 · Cited by 59 · see citing works
Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation.
Nomellini, V., Brubaker, A. L., Mahbub, S., Palmer, J. L., Gómez, C. R., & Kovacs, E. J. (2012) · Europe PMC (PubMed Central) · Cited by 57 · see citing works
Effect of age on susceptibility to post-traumatic infection in the elderly
Butcher, S. K., Killampalli, V. V., Chahal, H., Alpar, E. K., & Lord, J. M. (2003) · Biochemical Society Transactions · doi:10.1042/bst0310449 · Cited by 57 · see citing works
Respiratory syncytial virus infection in elderly and high-risk adults.
Falsey, A. R. (2005) · PubMed · Cited by 56 · see citing works
Innate immune recognition of respiratory syncytial virus infection
Kim, T. H., & Lee, H. K. (2014) · BMB Reports · doi:10.5483/bmbrep.2014.47.4.050 · Cited by 55 · see citing works
An Aged Mouse Model for RSV Infection and Diminished CD8 + CTL Responses
Zhang, Y., Wang, Y., Gilmore, X., Xu, K., Wyde, P. R., & Mbawuike, I. N. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222700208 · Cited by 52 · see citing works
Effects of Aging on Endotoxin Tolerance Induced by Lipopolysaccharides Derived from Porphyromonas gingivalis and Escherichia coli
Sun, Y., Li, H., Yang, M., Shu, W., Sun, M., & Xu, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039224 · Cited by 50 · see citing works
CD4 T cell defects in the aged: Causes, consequences and strategies to circumvent
Zhang, W., Brahmakshatriya, V., & Swain, S. L. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.002 · Cited by 49 · see citing works
Elevated A20 contributes to age-dependent macrophage dysfunction in the lungs
Hinojosa, C. A., Babu, R. A. S., Rahman, M. M., Fernandes, G., Boyd, A. R., & Orihuela, C. J. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.007 · Cited by 49 · see citing works
Age-associated changes of neutrophil responsiveness in a human healthy elderly population.
Polignano, A., Tortorella, C., Venezia, A., Jirillo, E., & Antonaci, S. (1994) · PubMed · Cited by 45 · see citing works
Aging and CD8+ T cell immunity to respiratory virus infections
ELY, K., ROBERTS, A., Kohlmeier, J. E., Blackman, M. A., & Woodland, D. L. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2006.11.017 · Cited by 44 · see citing works
Streptococcus pneumoniae Colonization Disrupts the Microbial Community within the Upper Respiratory Tract of Aging Mice
Thevaranjan, N., Whelan, F., Puchta, A., Ashu, E. E., Rossi, L., Surette, M. G., & Bowdish, D. M. E. (2016) · Infection and Immunity · doi:10.1128/iai.01275-15 · Cited by 44 · see citing works
Direct Medical Costs and Utilization of Health Care Services to Treat Pneumonia in the United States: An Analysis of the 2007–2011 Medical Expenditure Panel Survey
Park, H., Adeyemi, A., & Rascati, K. L. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.04.013 · Cited by 40 · see citing works
Interleukin-6 predicts short-term global functional decline in the oldest old: results from the BELFRAIL study
Adriaensen, W. J., Matheï, C., Vaes, B., Pottelbergh, G. V., Wallemacq, P. E., & Degryse, J. (2014) · AGE · doi:10.1007/s11357-014-9723-3 · Cited by 40 · see citing works
Relationship between respiratory burst and adhesiveness capacity in elderly polymorphonuclear cells
Tortorella, C., Ottolenghi, A., Pugliese, P., Jirillo, E., & Antonaci, S. (1993) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(93)90071-x · Cited by 40 · see citing works
Relationship of Patient Age to Clinical Features and Outcome for In-Hospital Treatment of Pneumonia
Fedullo, A. J., & Swinburne, A. J. (1985) · Journal of Gerontology · doi:10.1093/geronj/40.1.29 · Cited by 39 · see citing works
Animal models of respiratory syncytial virus infection and disease
Sacco, R. E., Durbin, R. K., & Durbin, J. E. (2015) · Current Opinion in Virology · doi:10.1016/j.coviro.2015.06.003 · Cited by 37 · see citing works
Host response to respiratory syncytial virus infection
Arruvito, L., Raiden, S., & Geffner, J. R. (2015) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000159 · Cited by 35 · see citing works
Local immune response to respiratory syncytial virus infection is diminished in senescence-accelerated mice
Liu, B., & Kimura, Y. (2007) · Journal of General Virology · doi:10.1099/vir.0.83089-0 · Cited by 35 · see citing works
LIPOPOLYSACCARIDE-INDUCED NEUTROPHILIC INFLAMMATION IN THE LUNGS DIFFERS WITH AGE
Ito, Y., Betsuyaku, T., Nasuhara, Y., & Nishimura, M. (2007) · Experimental Lung Research · doi:10.1080/01902140701634843 · Cited by 34 · see citing works
Aging Enhances Susceptibility to Cigarette Smoke–Induced Inflammation through Bronchiolar Chemokines
Moriyama, C., Betsuyaku, T., Ito, Y., Hamamura, I., Hata, J., Takahashi, H., Nasuhara, Y., & Nishimura, M. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0025oc · Cited by 33 · see citing works
Significance of serum immune markers in identification of global functional impairment in the oldest old: cross-sectional results from the BELFRAIL study
Adriaensen, W. J., Matheï, C., Pottelbergh, G. V., Vaes, B., Legrand, D., Wallemacq, P. E., & Degryse, J. (2013) · AGE · doi:10.1007/s11357-013-9558-3 · Cited by 33 · see citing works
Age-Dependent Replication of Respiratory Syncytial Virus in the Cotton Rat
Curtis, S. J., Ottolini, M. G., Porter, D. D., & Prince, G. A. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222700912 · Cited by 33 · see citing works
Vaccines for the Elderly
Giudice, G. D., Weinberger, B., & Grubeck‐Loebenstein, B. (2014) · Gerontology · doi:10.1159/000366162 · Cited by 32 · see citing works
Respiratory Infections by HMPV and RSV Are Clinically Indistinguishable but Induce Different Host Response in Aged Individuals
Ditt, V., Lüsebrink, J., Tillmann, R. L., Schildgen, V., & Schildgen, O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016314 · Cited by 31 · see citing works
Vaccine strategies to enhance immune responses in the aged
Lefebvre, J. S., & Haynes, L. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.05.014 · Cited by 31 · see citing works
Activation profile of CXCL8-stimulated neutrophils and aging
Dalboni, T. M., Abe, A. E., de Oliveira, C. E., Lara, V. S., Campanelli, A. P., Gasparoto, C. T., & Gasparoto, T. H. (2013) · Cytokine · doi:10.1016/j.cyto.2013.01.016 · Cited by 30 · see citing works
Respiratory Microbiota Dynamics following Streptococcus pneumoniae Acquisition in Young and Elderly Mice
Krone, C. L., Biesbroek, G., Trzciński, K., Sanders, E. A. M., & Bogaert, D. (2014) · Infection and Immunity · doi:10.1128/iai.01290-13 · Cited by 30 · see citing works
Respiratory Syncytial Virus (RSV) Infection in Elderly Mice Results in Altered Antiviral Gene Expression and Enhanced Pathology
Wong, T. M., Boyapalle, S., Sampayo-Escobar, V., Nguyen, H. D., Bedi, R., Kamath, S. G., Moore, M. L., Mohapatra, S., & Mohapatra, S. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088764 · Cited by 30 · see citing works
The role of dendritic cells in innate and adaptive immunity to respiratory syncytial virus, and implications for vaccine development
Garg, R., Shrivastava, P., & den Hurk, S. V. D. L. (2012) · Expert Review of Vaccines · doi:10.1586/erv.12.117 · Cited by 30 · see citing works
Characterization of the Inflammatory Infiltrate in Streptococcus pneumoniae Pneumonia in Young and Elderly Patients
Menter, T., Giefing-Kroell, C., Grubeck‐Loebenstein, B., & Tzankov, A. (2014) · Pathobiology · doi:10.1159/000360165 · Cited by 29 · see citing works
Attenuated Response of Aged Mice to Respiratory Francisella novicida Is Characterized by Reduced Cell Death and Absence of Subsequent Hypercytokinemia
Mares, C. A., Sharma, J., Ojeda, S. S., Li, Q., Campos, J. A., Morris, E. G., Coalson, J. J., & Teale, J. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014088 · Cited by 26 · see citing works
The Role of Toll-like Receptors in Age-Associated Lung Diseases
Volkova, M., Zhang, Y., Shaw, A. C., & Lee, C. G. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr226 · Cited by 25 · see citing works
Healthy Elderly People Lack Neutrophil‐Mediated Functional Activity to Type V Group B Streptococcus
Amaya, R., Baker, C. J., Keitel, W. A., & Edwards, M. S. (2003) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52009.x · Cited by 20 · see citing works
Impaired Immune Response to Vaccination against Infection with Human Respiratory Syncytial Virus at Advanced Age
Guichelaar, T., Hoeboer, J., Widjojoatmodjo, M. N., Reemers, S. S. N., van Els, C. A. C. M., Otten, R., van Remmerden, Y., Boes, J., & Luytjes, W. (2014) · Journal of Virology · doi:10.1128/jvi.01101-14 · Cited by 18 · see citing works
Natural killer cell cytotoxicity in elderly humans after influenza immunization
Kutza, J., Gross, P., Kaye, D., & Murasko, D. M. (1996) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.3.1.105-108.1996 · Cited by 18 · see citing works
Perspectives on vaccine development for the elderly
Oviedo‐Orta, E., Li, C. K.-F., & Rappuoli, R. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.07.008 · Cited by 15 · see citing works
G-CSF Enhances Resolution of Staphylococcus aureus Wound Infection in an Age-Dependent Manner
Brubaker, A. L., & Kovacs, E. J. (2013) · Shock · doi:10.1097/shk.0b013e3182a43651 · Cited by 11 · see citing works

Flagged first, then by citations

1 of the 134 references couldn’t be matched to a known paper.

Sorted by citations

The aging lung: Physiology, disease, and immunity
Schneider, J. L., Rowe, J. H., Garcia-de-Alba, C., Kim, C. F., Sharpe, A. H., & Haigis, M. C. (2021) · Cell · doi:10.1016/j.cell.2021.03.005 · Cited by 500 · see citing works
Clinical and Laboratory Predictors of In-Hospital Mortality in 305 Patients with COVID-19: A Cohort Study in Wuhan, China
Wang, K., Zuo, P., Liu, Y., Zhang, M., Zhao, X., Xie, S., Zhang, H., Chen, X., & Liu, C. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa538 · Cited by 308 · see citing works
Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?
Brandsma, C.-A., de Vries, M., Costa, R., Woldhuis, R. R., Königshoff, M., & Timens, W. (2017) · European Respiratory Review · doi:10.1183/16000617.0073-2017 · Cited by 221 · see citing works
Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection
Bao, L., Zhang, C., Dong, J., Zhao, L., Li, Y., & Sun, J. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01840 · Cited by 207 · see citing works
Influencia de la infección SARS-CoV-2 sobre enfermedades neurodegenerativas y neuropsiquiátricas: ¿una pandemia demorada?
Serrano-Castro, P. J., Estivill‐Torrús, G., Cabezudo‐García, P., Bueno, J. A. R., Ciano-Petersen, N. L., Aguilar-Castillo, M. J., Suárez-Pérez, J., Jiménez-Hernández, M. D., Moya-Molina, M. Á., Oliver‐Martos, B., et al. (2020) · Neurología · doi:10.1016/j.nrl.2020.04.002 · Cited by 172 · see citing works
Bacterial Pneumonia in Older Adults
Henig, O., & Kaye, K. S. (2017) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2017.07.015 · Cited by 157 · see citing works
SARS-CoV-2 and COVID-19: A genetic, epidemiological, and evolutionary perspective
Sironi, M., Hasnain, S. E., Rosenthal, B. M., Phan, T. G., Luciani, F., Shaw, M., Sallum, M. A. M., Mirhashemi, M. E., Morand, S., & Gónzález‐Candelas, F. (2020) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2020.104384 · Cited by 143 · see citing works
Evolutionary Parasitology
Schmid‐Hempel, P. (2021) · doi:10.1093/oso/9780198832140.001.0001 · Cited by 130 · see citing works
Bacterial-Host Interactions: Physiology and Pathophysiology of Respiratory Infection
Håkansson, A., Orihuela, C. J., & Bogaert, D. (2018) · Physiological Reviews · doi:10.1152/physrev.00040.2016 · Cited by 126 · see citing works
BTS clinical statement on aspiration pneumonia
Simpson, A. J., Allen, J.-L., Chatwin, M., Crawford, H., Elverson, J., Ewan, V. C., Forton, J. T., McMullan, R., Plevris, J. N., Renton, K., et al. (2023) · Thorax · doi:10.1136/thorax-2022-219699 · Cited by 104 · see citing works
Inhaled particulate accumulation with age impairs immune function and architecture in human lung lymph nodes
Ural, B. B., Caron, D. P., Dogra, P., Wells, S. B., Szabo, P. A., Granot, T., Senda, T., Poon, M. M. L., Lam, N., Thapa, P., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-02073-x · Cited by 96 · see citing works
Prevention and treatment of COVID‐19 disease by controlled modulation of innate immunity
Schijns, V. E. C. J., & Lavelle, E. C. (2020) · European Journal of Immunology · doi:10.1002/eji.202048693 · Cited by 84 · see citing works
Age is the work of art? Impact of neutrophil and organism age on neutrophil extracellular trap formation
Ortmann, W., & Kolaczkowska, E. (2018) · Cell and Tissue Research · doi:10.1007/s00441-017-2751-4 · Cited by 80 · see citing works
Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: A delayed pandemic?
Serrano-Castro, P. J., Estivill‐Torrús, G., Cabezudo‐García, P., Bueno, J. A. R., Ciano-Petersen, N. L., Aguilar-Castillo, M. J., Suárez-Pérez, J., Jiménez-Hernández, M. D., Moya-Molina, M. Á., Oliver‐Martos, B., et al. (2020) · Neurología (English Edition) · doi:10.1016/j.nrleng.2020.04.002 · Cited by 82 · see citing works
Pathophysiology of aged lymphatic vessels
Shang, T., Liang, J., Kapron, C. M., & Liu, J. (2019) · Aging · doi:10.18632/aging.102213 · Cited by 78 · see citing works
Tuberculosis in the elderly: Why inflammation matters
Piergallini, T. J., & Turner, J. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.12.021 · Cited by 76 · see citing works
The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma
Bullone, M., & Lavoie, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122612 · Cited by 72 · see citing works
The Impacts of Cellular Senescence in Elderly Pneumonia and in Age-Related Lung Diseases That Increase the Risk of Respiratory Infections
Yanagi, S., Tsubouchi, H., Miura, A., Matsuo, A., Matsumoto, N., & Nakazato, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030503 · Cited by 69 · see citing works
Why COVID-19 Transmission Is More Efficient and Aggressive Than Viral Transmission in Previous Coronavirus Epidemics?
Elrashdy, F., Redwan, E. M. M. M., & Uversky, V. N. (2020) · Biomolecules · doi:10.3390/biom10091312 · Cited by 64 · see citing works
Risk factors, management and prevention of transfusion-related acute lung injury: a comprehensive update
Kuldanek, S. A., Kelher, M. R., & Silliman, C. C. (2019) · Expert Review of Hematology · doi:10.1080/17474086.2019.1640599 · Cited by 64 · see citing works
Severe acute respiratory syndrome coronavirus 2 infection reaches the human nervous system: How?
Uversky, V. N., Elrashdy, F., Aljaddawi, A. A., Ali, S. M., Khan, R. H., & Redwan, E. M. M. M. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24752 · Cited by 57 · see citing works
Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters
Delval, L., Hantute-Ghesquier, A., Sencio, V., Flaman, J., Robil, C., Angulo, F. S., Lipskaia, L., Çobanoglu, Ö., Lacoste, A., Machelart, A., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00442-w · Cited by 55 · see citing works
Older but Not Wiser: the Age-Driven Changes in Neutrophil Responses during Pulmonary Infections
Simmons, S. R., Bhalla, M., Herring, S. E., Tchalla, E. Y. I., & Ghanem, E. N. B. (2021) · Infection and Immunity · doi:10.1128/iai.00653-20 · Cited by 54 · see citing works
One size does not fit all – Patterns of vulnerability and resilience in the COVID-19 pandemic and why heterogeneity of disease matters
Sominsky, L., Walker, D. W., & Spencer, S. (2020) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2020.03.016 · Cited by 40 · see citing works
Economic burden of respiratory syncytial virus infection in adults: a systematic literature review
Grace, M., Colosia, A. D., Wolowacz, S. E., Panozzo, C. A., & Ghaswalla, P. K. (2023) · Journal of Medical Economics · doi:10.1080/13696998.2023.2213125 · Cited by 52 · see citing works
The severe COVID-19: A sepsis induced by viral infection? And its immunomodulatory therapy
Lin, H. (2020) · Chinese Journal of Traumatology · doi:10.1016/j.cjtee.2020.06.002 · Cited by 59 · see citing works
Pulmonary effects of aging
Tran, D., Rajwani, K., & Berlin, D. (2017) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000546 · Cited by 45 · see citing works
The diversity of myeloid immune cells shaping wound repair and fibrosis in the lung
Florez‐Sampedro, L., Song, S., & Melgert, B. N. (2018) · Regeneration · doi:10.1002/reg2.97 · Cited by 44 · see citing works
Serum copper-to-zinc-ratio and risk of incident infection in men: the Kuopio Ischaemic Heart Disease Risk Factor Study
Laine, J. T., Tuomainen, T., Salonen, J. T., & Virtanen, J. K. (2020) · European Journal of Epidemiology · doi:10.1007/s10654-020-00644-1 · Cited by 44 · see citing works
Neutrophil dynamics and inflammaging in acute ischemic stroke: A transcriptomic review
Bui, T. A., Jickling, G. C., & Winship, I. R. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1041333 · Cited by 44 · see citing works
Type I Interferon signaling controls the accumulation and transcriptomes of monocytes in the aged lung
D’Souza, S. S., Zhang, Y., Bailey, J. T., Fung, I. T. H., Kuentzel, M. L., Chittur, S. V., & Yang, Q. (2021) · Aging Cell · doi:10.1111/acel.13470 · Cited by 35 · see citing works
Age-Related Changes in Immunological and Physiological Responses Following Pulmonary Challenge
Miller, E. J., & Linge, H. M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061294 · Cited by 35 · see citing works
Extracellular adenosine signaling reverses the age‐driven decline in the ability of neutrophils to kill Streptococcus pneumoniae
Bhalla, M., Simmons, S. R., Abamonte, A., Herring, S. E., Roggensack, S. E., & Ghanem, E. N. B. (2020) · Aging Cell · doi:10.1111/acel.13218 · Cited by 31 · see citing works
COVID-19 and Neurodegenerative Diseases: Prion-Like Spread and Long-Term Consequences
Baazaoui, N., & Iqbal, K. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220105 · Cited by 32 · see citing works
Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies
Schiffers, C., Reynaert, N. L., Wouters, E. F. �., & van der Vliet, A. (2021) · Antioxidants · doi:10.3390/antiox10111799 · Cited by 31 · see citing works
Impact of Trypanosoma cruzi infection on nitric oxide synthase and arginase expression and activity in young and elderly mice
Felizardo, A. A., Caldas, I. S., Mendonça, A. A. S., Gonçalves, R. V., Tana, F. L., de Almeida, L. A., & Novaes, R. D. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.031 · Cited by 28 · see citing works
Cellular Mechanisms of Inflammaging and Periodontal Disease
Clark, D. L., Radaic, A., & Kapila, Y. L. (2022) · Frontiers in Dental Medicine · doi:10.3389/fdmed.2022.844865 · Cited by 26 · see citing works
Respiratory Syncytial Virus Sequelae Among Adults in High-Income Countries: A Systematic Literature Review and Meta-analysis
Ubamadu, E., Betancur, E., Gessner, B. D., Menon, S., Vroling, H., Curcio, D., Rozenbaum, M. H., Kurosky, S. K., Torres, Z. A., & Begier, E. M. (2024) · Infectious Diseases and Therapy · doi:10.1007/s40121-024-00974-7 · Cited by 26 · see citing works
UGRP1-modulated MARCO+ alveolar macrophages contribute to age-related lung fibrosis
Chen, Y., Hao, X., Li, M., Tian, Z., & Cheng, M. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00338-8 · Cited by 25 · see citing works
A1 adenosine receptor signaling reduces Streptococcus pneumoniae adherence to pulmonary epithelial cells by targeting expression of platelet‐activating factor receptor
Bhalla, M., Yeoh, J. H., Lamneck, C., Herring, S. E., Tchalla, E. Y. I., Heinzinger, L. R., Leong, J. M., & Ghanem, E. N. B. (2019) · Cellular Microbiology · doi:10.1111/cmi.13141 · Cited by 26 · see citing works
Neutrophils Are Required During Immunization With the Pneumococcal Conjugate Vaccine for Protective Antibody Responses and Host Defense Against Infection
Tchalla, E. Y. I., Bhalla, M., Wohlfert, E. A., & Ghanem, E. N. B. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa242 · Cited by 25 · see citing works
COVID-19 and cytokine storm syndrome: can what we know about interleukin-6 in ovarian cancer be applied?
Macciò, A., Oppi, S., & Madeddu, C. (2021) · Journal of Ovarian Research · doi:10.1186/s13048-021-00772-6 · Cited by 24 · see citing works
Age‐related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity
Galletti, J. G., & de Paiva, C. S. (2021) · Immunology · doi:10.1111/imm.13338 · Cited by 23 · see citing works
Exploring the management approaches of cytokines including viral infection and neuroinflammation for neurological disorders
Rahman, M. M., Mim, S. A., Tumpa, M. A. A., Sarker, M. T., Ahmed, M., Alghamdi, B. S. A., Hafeez, A., Alexiou, A. T., Perveen, A., & Ashraf, G. M. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155962 · Cited by 23 · see citing works
Transcriptome Profiling Reveals CD73 and Age-Driven Changes in Neutrophil Responses against Streptococcus pneumoniae
Bhalla, M., Heinzinger, L. R., Morenikeji, O. B., Marzullo, B. J., Thomas, B. N., & Ghanem, E. N. B. (2021) · Infection and Immunity · doi:10.1128/iai.00258-21 · Cited by 21 · see citing works
Influence of aging on deterioration of patients with COVID-19
Pang, L., Liu, Y., Shen, M., Ye, J., Chen, R., Lan, Z., Wu, Z., Guo, Y., & Zhang, P. (2020) · Aging · doi:10.18632/aging.202136 · Cited by 20 · see citing works
Immunosenescence: the importance of considering age in health and disease
Weinberger, B. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12879 · Cited by 20 · see citing works
Advanced age is associated with changes in alveolar macrophages and their responses to the stress of traumatic injury
Boe, D. M., Hulsebus, H. J., Najarro, K. M., Mullen, J. E., Kim, H., Tan, A. C., McMahan, R. H., & Kovacs, E. J. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.3hi0620-399rr · Cited by 19 · see citing works
Ecological immunology
Schmid‐Hempel, P. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780198832140.003.0005 · Cited by 19 · see citing works
Epithelial damage and ageing: the perfect storm
Hewitt, R. J., Pearmain, L., Lyka, E., & Dickens, J. A. (2025) · Thorax · doi:10.1136/thorax-2024-222060 · Cited by 19 · see citing works
Micronutrients and many important factors that affect the physiological functions of toll-like receptors
El-Zayat, S. R., Sibaii, H., & Mannaa, F. A. E. (2019) · Bulletin of the National Research Centre/Bulletin of the National Research Center · doi:10.1186/s42269-019-0165-z · Cited by 18 · see citing works
Risk Factors for Transfusion-Related Acute Lung Injury
Hu, L., Wang, B., Jiang, Y., Zhu, B., Wang, C., Yu, Q., Hou, W., Xia, Z., Wu, G., & Sun, Y. (2021) · Respiratory Care · doi:10.4187/respcare.08829 · Cited by 17 · see citing works
Differences in the coronal proteome acquired by particles depositing in the lungs of asthmatic versus healthy humans
Kumar, A., Bicer, E. M., Pfeffer, P., Monopoli, M. P., Dawson, K. A., Eriksson, J., Edwards, K., Lynham, S., Arno, M. J., Behndig, A., et al. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.06.008 · Cited by 17 · see citing works
Aging and physiological barriers: mechanisms of barrier integrity changes and implications for age-related diseases
Solovev, I. A., Sergeeva, A. D., Geraskina, A., Shaposhnikov, M. V., Vedunova, M. V., Borysova, O., & Moskalev, A. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09833-7 · Cited by 16 · see citing works
Pharmacotherapy for community-acquired pneumonia in the elderly
Viasus, D., Núñez-Ramos, J. A., Viloria, S., & Carratalà, J. (2017) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2017.1340940 · Cited by 16 · see citing works
PGE2accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking
Penke, L. R. K., Speth, J. M., Draijer, C., Zasłona, Z., Chen, J., Mancuso, P., Freeman, C. M., Curtis, J. L., Goldstein, D. R., & Peters-Golden, M. L. (2020) · Life Science Alliance · doi:10.26508/lsa.202000800 · Cited by 15 · see citing works
Impact of aging on immune function in the pathogenesis of pulmonary diseases: potential for therapeutic targets
Shaikh, S. B., Goracci, C., Tjitropranoto, A., & Rahman, I. (2023) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2023.2205127 · Cited by 14 · see citing works
Intrinsically altered lung‐resident γδT cells control lung melanoma by producing interleukin‐17A in the elderly
Cheng, M., Chen, Y., Huang, D., Chen, W., Xu, W., Chen, Y., Shen, G., Xu, T., Shen, G., Tian, Z., et al. (2020) · Aging Cell · doi:10.1111/acel.13099 · Cited by 15 · see citing works
Risk factors for the development of hospital-acquired pneumonia in patients with carbapenem-resistant Acinetobacter baumannii respiratory colonization and the role of multisite colonization: a multicenter retrospective study
Russo, A., Serapide, F., Alessandri, F., Gullì, S. P., Bruni, A., Longhini, F., Quirino, A., Morena, R., Marascio, N., Matera, G., et al. (2025) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-025-05137-1 · Cited by 13 · see citing works
Aging-related changes in the gene expression profile of human lungs
Jeong, I., Lim, J., Park, J., & Oh, Y. (2020) · Aging · doi:10.18632/aging.103885 · Cited by 13 · see citing works
A risk signature of four aging-related genes has clinical prognostic value and is associated with a tumor immune microenvironment in glioma
Luo, H., Tao, C., Long, X., Huang, K., & Zhu, X. (2021) · Aging · doi:10.18632/aging.203146 · Cited by 13 · see citing works
Baseline characteristics of COVID-19 Italian patients admitted to Desio Hospital, Lombardy: a retrospective study
Sulejmani, A., Galimberti, E., Giacobone, C., Milano, A., Scopetta, E., Intra, J., Falbo, R., Sarto, C., Leoni, V., & Brambilla, P. (2021) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2020.1846211 · Cited by 12 · see citing works
Regulatory T cells in lung disease and transplantation
Lao, P., Chen, J., Tang, L., Zhang, J., Chen, Y., Fang, Y., & Fan, X. (2023) · Bioscience Reports · doi:10.1042/bsr20231331 · Cited by 12 · see citing works
The Association of Airway Comorbidities With the Clinical Phenotypes and Outcomes of Patients With Antineutrophil Cytoplasmic Autoantibody–associated Vasculitis
Ono, N., Inoue, Y., Miyamura, T., Ueda, N., Nagano, S., Inoue, H., Oryoji, K., Ota, S.-I., Sawabe, T., Yoshizawa, S., et al. (2019) · The Journal of Rheumatology · doi:10.3899/jrheum.190373 · Cited by 12 · see citing works
Impaired expression of CXCL5 and matrix metalloproteinases in the lungs of mice with high susceptibility to Streptococcus pneumoniae infection
Mancuso, R. I., Miyaji, E. N., da Silva, C. C. F., Portaro, F. C. V., Schanoski, A. S., Ribeiro, O. G., & Oliveira, M. L. S. (2017) · Immunity Inflammation and Disease · doi:10.1002/iid3.205 · Cited by 11 · see citing works
Rev-erb-α antagonism in alveolar macrophages protects against pneumococcal infection in elderly mice
Angulo, F. S., Joseph, C. V., Delval, L., Deruyter, L., Heumel, S., Bicharel, M., Rodrigues, P. B., Sencio, V., Bourguignon, T., Machado, M., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115273 · Cited by 10 · see citing works
A Murine Model for Enhancement of Streptococcus pneumoniae Pathogenicity upon Viral Infection and Advanced Age
Joma, B. H., Siwapornchai, N., Vanguri, V. K., Shrestha, A., Roggensack, S. E., Davidson, B. A., Tai, A., Håkansson, A., Meydani, S. N., Leong, J. M., et al. (2021) · Infection and Immunity · doi:10.1128/iai.00471-20 · Cited by 11 · see citing works
Aging and lung diseases: Unraveling mechanisms and therapeutic targets
Zhou, Y., Chen, G., Li, X., Li, X., Lin, Z., Liu, L., Pu, D., Chen, J., Chen, Y., Lin, Z., et al. (2025) · Chinese Medical Journal - Pulmonary and Critical Care Medicine · doi:10.1016/j.pccm.2025.11.005 · Cited by 9 · see citing works
A new perspective for mitigation of SARS-CoV-2 infection: priming the innate immune system for viral attack
Kolodny, O., Berger, M., Feldman, M. W., & Ram, Y. (2020) · Open Biology · doi:10.1098/rsob.200138 · Cited by 9 · see citing works
Intranasal Vaccine Delivery Technology for Respiratory Tract Disease Application with a Special Emphasis on Pneumococcal Disease
Walkowski, W., Bassett, J., Bhalla, M., Pfeifer, B. A., & Ghanem, E. N. B. (2021) · Vaccines · doi:10.3390/vaccines9060589 · Cited by 10 · see citing works
Immune aging: biological mechanisms, clinical symptoms, and management in lung transplant recipients
Kapse, B., Budev, M. M., Singer, J. P., & Greenland, J. R. (2024) · Frontiers in Transplantation · doi:10.3389/frtra.2024.1356948 · Cited by 8 · see citing works
Integrative metagenomics and metabolomics reveal age-associated gut microbiota and metabolite alterations in a hamster model of COVID-19
Rodrigues, P. B., Rodovalho, V. D. R., Sencio, V., Benech, N., Creskey, M., Angulo, F. S., Delval, L., Robil, C., Gosset, P., Machelart, A., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2486511 · Cited by 10 · see citing works
The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology
Harding, S. D., Faccenda, E., Southan, C., Pawson, A. J., Maffia, P., Alexander, S. P. H., Davenport, A. P., Fabbro, D., Levi‐Schaffer, F., Spedding, M., et al. (2020) · Immunology · doi:10.1111/imm.13175 · Cited by 8 · see citing works
Liposomal Encapsulation of Polysaccharides (LEPS) as an Effective Vaccine Strategy to Protect Aged Hosts Against S. pneumoniae Infection
Bhalla, M., Nayerhoda, R., Tchalla, E. Y. I., Abamonte, A., Park, D., Simmons, S. R., Pfeifer, B. A., & Ghanem, E. N. B. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.798868 · Cited by 8 · see citing works
Age-dependent changes in phagocytic activity: in vivo response of mouse pulmonary antigen presenting cells to direct lung delivery of charged PEGDA nanoparticles
Sudduth, E. R., Ruiz, A. L., Trautmann-Rodriguez, M., & Fromen, C. A. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02743-7 · Cited by 7 · see citing works
Predictors and prognosis of elderly hip fracture patients with perioperative atrial fibrillation: a nested case–control study
Li, W., Min, A., Zhao, W., Li, W., Li, S., Ran, S., Fu, M., Yu, Q., Kou, J., Wang, Z., et al. (2025) · BMC Geriatrics · doi:10.1186/s12877-024-05647-1 · Cited by 7 · see citing works
Real‐World Assessment of Economic and Clinical Outcomes in Thai Patients With Respiratory Syncytial Virus Infection Across Age Groups: A Retrospective Cohort Analysis
Khaing, W., Tan, C. J., Patikorn, C., Techasaensiri, C., Pattanaprateep, O., Dhippayom, T., Bruminhent, J., & Chaiyakunapruk, N. (2024) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.70039 · Cited by 6 · see citing works
The Microbiome and Pulmonary Immune Function
Baker, J. M., & Dickson, R. P. (2024) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2024.10.006 · Cited by 6 · see citing works
NETosis in Alzheimer’s Disease: Understanding the Role of Neutrophil Extracellular Traps (NETs) in Neuroinflammation and Disease Pathogenesis
Rao, R., Verma, H., Gangwar, P., Yadav, A., Yadav, B., Patel, A., Kaur, S., Dhiman, M., & Mantha, A. K. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05435-x · Cited by 5 · see citing works
New MoDC-Targeting TNF Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice
Gogoi, H., Mansouri, S., Katikaneni, D. S., & Jin, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01674 · Cited by 5 · see citing works
Age-Specific Differences in the Severity of COVID-19 Between Children and Adults: Reality and Reasons
Tajbakhsh, A., Jaberi, K. R., Hayat, S. M. G., Sharifi, M., Johnston, T. P., Guest, P. C., Jafari, M., & Sahebkar, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-71697-4_5 · Cited by 5 · see citing works
COVID-19 Pandemic: Is Chronic Inflammation a Major Cause of Death?Preprint
Tskhay, A., Yezhova, A., & Alibek, K. (2020) · medRxiv · doi:10.1101/2020.05.12.20099572 · Cited by 5 · see citing works
Melatonin and Cytokines Modulate Daily Instrumental Activities of Elderly People with SARS-CoV-2 Infection
França, D. C. H., Fujimori, M., de Queiroz, A. A., Borges, M. D., Neto, A. M. M., de Camargos, P. J. D. V., Ribeiro, E. B., França, E. L., Honório‐França, A. C., & Fagundes-Triches, D. L. G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108647 · Cited by 4 · see citing works
Community vulnerability to epidemics in Nepal: A high-resolution spatial assessment amidst COVID-19 pandemic
Khanal, L., Paudel, B. K., & Acharya, B. K. (2020) · Nepalese Journal of Zoology · doi:10.3126/njz.v4i1.30670 · Cited by 4 · see citing works
Characteristics and complications of fracture in older adults with chronic kidney disease: a cross-sectional study
Meng, Y., Fu, M., Guo, J., Wang, Z., Zhang, Y., & Hou, Z. (2022) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-022-03253-8 · Cited by 4 · see citing works
Longitudinal prevalence and co-carriage of pathogens associated with nursing home acquired pneumonia in three long-term care facilities
Whealy, R. N., Roberts, A., Furstenau, T., Timm, S., Maltinsky, S., Wells, S. J., Drake, K., Ramirez, K., Bolduc, C., Ross, A., et al. (2025) · PLOS Global Public Health · doi:10.1371/journal.pgph.0004954 · Cited by 3 · see citing works
A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
Lenhard, A. P., Joma, B. H., Siwapornchai, N., Håkansson, A., Leong, J. M., & Ghanem, E. N. B. (2022) · Journal of Visualized Experiments · doi:10.3791/64419 · Cited by 4 · see citing works
Chronically hypertensive transgenic mice expressing human AT1R haplotype-I exhibit increased susceptibility to Francisella tularensis
Ketkar, H., Alqahtani, M., Tang, S., Parambath, S. P., Bakshi, C. S., & Jain, S. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1173577 · Cited by 3 · see citing works
Virulence evolution
Schmid‐Hempel, P. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780198832140.003.0013 · Cited by 3 · see citing works
Prediction of early postoperative desaturation in extreme older patients after spinal anesthesia for femur fracture surgery: a retrospective analysis
Jo, Y. Y., Park, C., Lee, J. Y., Kwon, S. K., & Kwak, H. J. (2019) · Korean Journal of Anesthesiology · doi:10.4097/kja.19220 · Cited by 3 · see citing works
Telomerase RNA component knockout exacerbates Staphylococcus aureus pneumonia by extensive inflammation and dysfunction of T cellsPreprint
Reisser, Y., Hornung, F., Häder, A., Lauf, T., Nietzsche, S., Löffler, B., & Deinhardt‐Emmer, S. (2024) · eLife · doi:10.7554/elife.100433 · Cited by 3 · see citing works
Natural senotherapeutics in respiratory health: Addressing cellular senescence, inflammaging, and immunosenescence in the aging lung
Juan, M. E., Verdaguer, E., Prohens, R., Ettcheto, M., Auladell, C., Camins, A., & Olloquequi, J. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178620 · Cited by 2 · see citing works
Host–parasite co-evolution
Schmid‐Hempel, P. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780198832140.003.0014 · Cited by 2 · see citing works
The diversity and natural history of parasites
Schmid‐Hempel, P. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780198832140.003.0003 · Cited by 2 · see citing works
Symptomatology and imaging findings in early post-Covid period: A comparative study in older vs younger patients
Bahat, G., Medetalibeyoğlu, A., Şenkal, N., Cebeci, T., Ören, M. M., Başaran, S., Arıcı, H., Çatma, Y., Köse, M., Karan, M. A., et al. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111907 · Cited by 2 · see citing works
Age-related modifications of macrophages influenced by “inflammageing” in graft vs. host disease
Hong, Y., Wan, B., & Li, X. (2020) · Biocell · doi:10.32604/biocell.2020.08887 · Cited by 2 · see citing works
Integrative metagenomics and metabolomics reveal age-associated gut microbiota and metabolite alterations in experimental COVID-19Preprint
Rodrigues, P. B., Rodovalho, V. D. R., Sencio, V., Benech, N., Creskey, M., Angulo, F. S., Delval, L., Robil, C., Gosset, P., Machelart, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.05.622058 · Cited by 2 · see citing works
Reporting of biochemical blood values in COVID-19 patients: A retrospective study
Eriten, B., & Eriten, S. (2023) · Medicine · doi:10.1097/md.0000000000035833 · Cited by 1 · see citing works
Evaluating preoperative risk factors for deep vein thrombosis in elderly patients with hip fractures and chronic kidney disease: a retrospective study
Jia, R., Men, X., Ran, F., Li, X., & Long, Y. (2025) · European journal of medical research · doi:10.1186/s40001-025-03409-2 · Cited by 1 · see citing works
Lifelong Exercise as a Modulator of CD4 + T Cell Immunometabolism
Silva, B. S. D. A., Sardeli, A. V., Agostinete, R. R., Batatinha, H., Peres, A., Neto, J. C. R., Teixeira, J., Coelho-e-Silva, M. J., Oliveira, P. J., & Lira, F. S. (2026) · European Journal of Clinical Investigation · doi:10.1111/eci.70204 · Cited by 1 · see citing works

Authors: Boe, D. M., Boule, L. A., & Kovacs, E. J.
Affiliations: University of Colorado Anschutz (US)
Division of GI, Endocrine and Tumor Surgery, Department of Surgery, Mucosal Inflammation Program, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA
Corresponding author: Kovacs, E J
ORCID: Boe, D M
Kovacs, E J
Venue: Clinical and Experimental Immunology
Publisher: Oxford University Press (OUP)
Published: 2016-11-02
Volume: 187
Issue: 1
Pages: 16-25
ISSN: 0009-9104 (ISSN-L)
1365-2249
DOI: 10.1111/cei.12881
PMC: PMC5167032
OpenAlex: W2548930368
Cited by: 156
References: 134
Citations by year: 2026: 11 · 2025: 14 · 2024: 11 · 2023: 18 · 2022: 13 · 2021: 38 · 2020: 28 · 2019: 7 · 2018: 3 · 2017: 12 · 2016: 1
FWCI: 0.74
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Clinical & Experimental Immunology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (NIH-R01)
National Institute on Aging (R01AG018859)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
Keywords: innate immunity, aging, pulmonary infection, bacterial pneumonia, age-related immune dysfunction, older adults, sepsis, acute respiratory distress syndrome
MeSH terms: Age Factors, Aged, Aging, Animals, Humans, Immunity, Innate, Lung, Lung Diseases, Respiratory Distress Syndrome, Incidence, Pneumonia, Bacterial

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Innate immune responses in the ageing lung.

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks