The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
A double-negative (IgD−CD27−) B cell population is increased in the peripheral blood of elderly people
Open accessAbstract
The T cell branch of the immune system has been extensively studied in the elderly and it is known that the elderly have impaired immune function, mainly due to the chronic antigenic load that ultimately causes shrinkage of the T cell repertoire and filling of the immunologic space with memory T cells. In the present paper, we describe the IgD(-)CD27(-) double-negative B cell population which (as we have recently described) is higher in the elderly. Most of these cells were IgG(+). Evaluation of the telomere length and expression of the ABCB1 transporter and anti-apoptotic molecule, Bcl2, shows that they have the markers of memory B cells. We also show that these cells do not act as antigen presenting cells, as indicated by the low levels of CD80 and DR, nor do they express significant levels of the CD40 molecule necessary to interact with T lymphocytes through the ligand, CD154. Hence, we hypothesize that these expanded cells are late memory or exhausted cells that have down-modulated the expression of CD27 and filled the immunologic space in the elderly. These cells might be the age-related manifestation of time-enduring stimulation or dysregulation of the immune system.
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In the citing paper
“Late/exhausted memory B cells also have shorter telomeres [117, 118].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [118]
In the citing paper
“Conversely, the percentage of late/exhausted memory B cells, the antigen-experienced and pro-inflammatory B-cell subset, increases with age [117, 118].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [118]
In the citing paper
“CMV may down-regulate B-cell responses either directly through TNF-α [118] or indirectly through the induction of terminally differentiated T cells and senescent T cells [126], and reduced generation of memory T cells [127].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [118]
In the citing paper
“The reduced serum levels of IgM and IgD suggest a shift in the balance from the naïve (CD27) toward the memory compartment (CD27+), although this is not observed in all studies (71, 75–77).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [77]
In the citing paper
“This is accompanied by an impaired ability to produce high affinity protective antibodies against infectious agents and the shrinkage of the repertoire diversity.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [77]
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Citations
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Evolution of Autoantibody Responses via Somatic Hypermutation Outside of Germinal Centers
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Inflammation and aging: signaling pathways and intervention therapies
Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443
Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693
Self-citationA B-cell subset uniquely responsive to innate stimuli accumulates in aged mice
Hao, Y., O'Neill, P., Naradikian, M. S., Scholz, J. L., & Cancro, M. P. (2011) · Blood · doi:10.1182/blood-2011-01-330530 · Cited by 622
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
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Immunosenescence and human vaccine immune responses
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Metadata
- Authors
- Colonna-Romano, G., Bulati, M., Aquino, A., Pellicanò, M., Vitello, S., Lio, D., Candore, G., & Caruso, C.
- Affiliations
- University of Palermo (IT)
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 130
- Issue
- 10
- Pages
- 681-690
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2073872022
- Cited by
- 270
- References
- 55
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 22 · 2023: 33 · 2022: 14 · 2021: 28 · 2020: 18 · 2019: 20 · 2018: 13 · 2017: 16 · 2016: 16 · 2015: 8 · 2014: 12 · 2013: 8 · 2012: 12
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Keywords
- double negative B cells, older adults, immunosenescence, memory B cells, B cell exhaustion, telomere length, Bcl-2, antigen presentation, CD80, CD40, CD154, peripheral blood
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Aging, Cells, Cultured, Flow Cytometry, HLA-DR Antigens, Humans, Immunoglobulin D, Immunologic Memory, Middle Aged, B-Lymphocyte Subsets, Telomere, B7-1 Antigen, Tumor Necrosis Factor Receptor Superfamily, Member 7, ATP Binding Cassette Transporter, Subfamily B, Antigens, CD19, CD40 Antigens, Proto-Oncogene Proteins c-bcl-2, Ki-67 Antigen, ATP Binding Cassette Transporter, Subfamily B, Member 1, Young Adult
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