B cells in the aged: CD27, CD5, and CD40 expression
Abstract
Ageing is characterized by numerous changes in lymphocyte subpopulations. In the present paper we have focused on B cells carrying the surface markers CD27, CD5 and CD40. CD27 is considered a marker of primed (memory) cells and its engagement promotes the differentiation of memory B cells into plasma cells. CD5 is expressed on B1 cells, which are considered to be responsible for T cell-independent antibody production other than autoantibodies. The CD40 molecule binds CD40L (CD154) and is necessary for T-dependent antibody responses. Here we show that the absolute number of CD5+ and CD40+ B cells is decreased in the elderly, while CD27+ B lymphocytes only marginally decrease in centenarians. However, there is a decrease of the percentage of CD5+ B cells, an increase of CD27+ B cells, while CD40 does not change significantly. These data, together with the increased number of NK cells during aging, suggest different regulation of antibody production in the elderly which might be another example of immune remodeling with aging, based on interactions between human B and NK cells.
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This defect might be linked to a reduced interaction with CD40L+ T helper cells, because, in older adults, the memory/effector T cells show a reduced expression of CD40L, necessary for B cells cooperation.
“This defect might be linked to a reduced interaction with CD40L+ T helper cells, because, in older adults, the memory/effector T cells show a reduced expression of CD40L, necessary for B cells cooperation (74).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [74]
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The aging of the immune system
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Shi, Y., Yamazaki, T., Okubo, Y., Uehara, Y., Sugane, K., & Agematsu, K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.5.3262 · Cited by 229 · see citing works
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Frasca, D., & Blomberg, B. B. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9501-7 · Cited by 172 · see citing works
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Haaland, D. A., Sabljic, T. F., Baribeau, D. A., Mukovozov, I., & Hart, L. E. (2008) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0b013e3181865eec · Cited by 71 · see citing works
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Abedin, S. M., Michel, J. J., Lemster, B. H., & Vallejo, A. N. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.04.012 · Cited by 70 · see citing works
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“However, data are controversial since not all studies have shown, in elderly, a significant decrease of naïve CD27- B cells and an increase of CD27+ memory B cells (30-35).”
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Immunosenescence and organ transplantation
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Variation Rhythms of Lymphocyte Subsets during Healthy Aging
Faria, A. M. C., de Moraes, S. M., de Freitas, L. H. F., Speziali, E., Soares, T. F., Neves, S. P. F., Vitelli-Avelar, D. M., Martins, M. Â., Barbosa, K. V. B. D., Soares, E. B., et al. (2008) · NeuroImmunoModulation · doi:10.1159/000156478 · Cited by 59 · see citing works
“Previous data hypothesized that the increased number of NK cells, accompanied by a decreased number of B cells is an another example of remodeling, because the antibodies produced do not seem to be markedly reduced, as might be expected from the decreased frequencies of B and T lymphocytes [”
Abraham, R. S., Ballman, K. V., Dispenzieri, A. A., Grill, D. E., Manske, M. K., Price-Troska, T. L., Gonzalez-Paz, N. C., Gertz, M. A., & Fonseca, R. (2004) · Blood · doi:10.1182/blood-2004-04-1424 · Cited by 60 · see citing works
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B cell function and influenza vaccine responses in healthy aging and disease
Frasca, D., & Blomberg, B. B. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.05.008 · Cited by 59 · see citing works
“The effects of influenza vaccination are different in individuals of different ages [16,17,18,19,20] and this depends on age-related differences in the innate and adaptive immune systems.”
BackgroundB Cell Immunosenescence in the Elderly and in Centenarians
Colonna‐Romano, G., Bulati, M., Aquino, A., Vitello, S., Lio, D., Candore, G., & Caruso, C. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0664 · Cited by 59 · see citing works
“…of B1 cells has been reported, 12 although we have shown a reduction of CD5 (cid:2) B cells (B1 cells) and a decreased expression of CD40 on B cells obtained from old and the old-est subjects, 19 which points out the problem of the source of the antibodies found in the serum of old subjects.”
Genetics of longevity. Data from the studies on Sicilian centenarians
Balistreri, C. R., Candore, G., Accardi, G., Bova, M., Buffa, S., Bulati, M., Forte, G. I., Listı̀, F., Martorana, A., Palmeri, M., et al. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-8 · Cited by 56 · see citing works
“During ageing, B cell compartment also shows significant modifications in numbers and functions [9-12].”
BackgroundImmunosenescence and Anti-Immunosenescence Therapies: The Case of Probiotics
Candore, G., Balistreri, C. R., Colonna‐Romano, G., Grimaldi, M. P., Lio, D., Listı̀, F., Scola, L., Vasto, S., & Caruso, C. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0662 · Cited by 55 · see citing works
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B Cell Production of Both OPG and RANKL is Significantly Increased in Aged Mice
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“It is generally agreed that B cell precursors are diminished with age as are memory B cells in the periphery [27, 39].”
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“CD27? B cells (primed/memory) are maintained in elderly [70].”
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“Furthermore, there is evidence that the proportion of CD5expressing B cells declines with age (27), and that the density of CD5 molecules on B cells is reduced by IL-4 which is important for their differentiation (28), but increased by PMA stimulation (29).”
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“In addition to a reduced output of naive B cells and intrinsic repertoire differences of old HSCs, some truncation of the repertoire might reflect expanded clones of memory B cells [100].”
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“[27] Colonna-Romano G, Bulati M, Aquino A, et al.”
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“In concordance with our findings, Colonna-Romano et al and others reported no change in the IgMCD27 B-cell percentage with increased age [32, 33].”
ResultCYTOKINE SERUM PROFILE IN A GROUP OF SICILIAN NONAGENARIANS
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“[ 19 , 20 ] In this view our data might be related to different the role played by IL-4 and IL-13 in Th2 switch and B cell response maintenance in aging.”
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“The memory/ effector T cells show reduced expression of CD40L and reduced B cell synthesis [49].”
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“Naïve and memory B cells have similar levels in young and elderly individuals There are several conflicting reports concerning the effects of aging on the composition of CD19+ B cells (Colonna-Romano et al. 2003, 2009; Chong et al. 2005; Shi et al. 2005).”
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“Since the B cell compartment is heavily remodelled during aging (Colonna-Romano et al., 2003) it may be hypothesized that a B-cell subtype prevailing in people of far advanced age is more resistant to apoptosis.”
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“On the contrary, a reduction of CD27naïve B-cells, with no reciprocal increase of CD27+ memory B-cells, had previously been reported in older individuals and centenarians.(30) A possible explanation for these conflicting data has later been suggested to be the substantial age difference between the cohorts analyzed.”
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“The ratio between naïve and memory B cells varies in human subjects and is influenced by age [9,10].”
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“For instance, CD27 was the marker of the priming memory B cells, and the CD27 memory B cells decreased slightly (Colonna-Romano et al., 2003) or significantly (Shi et al.”
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- Authors
- Colonna-Romano, G., Bulati, M., Aquino, A., Scialabba, G., Candore, G., Lio, D., Motta, M., Malaguarnera, M., & Caruso, C.
- Affiliations
- University of Palermo (IT)
- University of Catania (IT)
- ORCID
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 124
- Issue
- 4
- Pages
- 389-393
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2033140693
- Cited by
- 137
- References
- 26
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 6 · 2014: 9 · 2013: 10 · 2012: 11
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- B cells, aging, CD27, CD5, CD40, memory B cells, B-1 cells, centenarians, immunosenescence, natural killer cells, antibody production, T cell-independent antibody response, T cell-dependent antibody response, B cell differentiation
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, B-Lymphocytes, Humans, Middle Aged, Biomarkers, Tumor Necrosis Factor Receptor Superfamily, Member 7, Lymphocyte Count, CD5 Antigens, CD40 Antigens
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