Mediterranean nutraceutical foods: Strategy to improve vascular ageing
Abstract
Ageing is characterized by a decline in all systemic functions. A greater susceptibility to apoptosis and senescence may contribute to proliferative and functional impairment of endothelial progenitor cells. They play an important role in neo-angiogenesis and endothelial repair. Vascular ageing is associated with changes in the structure and functions of vessels' wall. There are many possible causes of this damage. For sure, inflammation and oxidative stress play a fundamental role in the pathogenesis of endothelial dysfunction, commonly attributed to a reduced availability of nitric oxide. Inflammageing, the chronic low-grade inflammation that characterizes elderly people, aggravates vascular pathology and provokes atherosclerosis, the major cardiovascular disease. Nutraceutical and molecular biology represent new insights in this field. In fact, the first could represent a possible treatment in the prevention or delay of vascular ageing; the second could offer new possible targets for potential therapeutic interventions. In this review, we pay attention on the causes of vascular ageing and on the effects of nutraceuticals on it.
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The Mediterranean diet down-regulates the levels of inflammatory mediators, such as soluble ICAM-1, VCAM-1, C reactive protein, and IL-6, as well as many other biomarkers of inflammation.
“In particular, the Mediterranean diet down-regulates the levels of inflammatory mediators, such as soluble intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM-1), C reactive protein, and IL-6, as well as many other biomarkers of inflammation (87–90).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [88]
Cites
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,562 · see citing works
The clinical implications of endothelial dysfunction
Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749 · see citing works
Solon-Biet, S. M., McMahon, A. C., Ballard, J. W. O., Ruohonen, K., Wu, L. E., Cogger, V. C., Warren, A., Huang, X., Pichaud, N., Melvin, R. G., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.009 · Cited by 904 · see citing works
Interventions to slow aging in humans: are we ready?
Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell · doi:10.1111/acel.12338 · Cited by 592 · see citing works
Self-citationMediterranean diet and healthy ageing: a Sicilian perspective
Vasto, S., Buscemi, S., Barera, A., Di Carlo, M., Accardi, G., & Caruso, C. (2014) · Gerontology · doi:10.1159/000363060 · Cited by 94 · see citing works
Self-citationMalavolta, M., Pierpaoli, E., Giacconi, R., Costarelli, L., Piacenza, F., Basso, A., Cardelli, M., & Provinciali, M. (2016) · Current Drug Targets · doi:10.2174/1389450116666150907105104 · Cited by 68 · see citing works
The aging kidney: role of endothelial oxidative stress and inflammation
Csiszar, A., Toth, J., Peti-Peterdi, J., & Ungvari, Z. (2007) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.94.2007.1-2.10 · Cited by 43 · see citing works
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Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693 · see citing works
Self-citationNutrigerontology: a key for achieving successful ageing and longevity
Aiello, A., Accardi, G., Candore, G., Carruba, G., Davinelli, S., Passarino, G., Scapagnini, G., Vasto, S., & Caruso, C. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0071-2 · Cited by 69 · see citing works
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- Authors
- Accardi, G., Aiello, A., Gambino, C. M., Virruso, C., Caruso, C., & Candore, G.
- Affiliations
- University of Palermo (IT)
- Corresponding author
- Candore, Giuseppina
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 159
- Pages
- 63-70
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2257002388
- Cited by
- 32
- References
- 7
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 4
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- vascular aging, nutraceuticals, Mediterranean diet, endothelial progenitor cells, endothelial dysfunction, inflammaging, oxidative stress, inflammation, atherosclerosis, nitric oxide, apoptosis, senescence, neoangiogenesis, cardiovascular disease prevention
- MeSH terms
- Aging, Endothelium, Vascular, Humans, Vascular Diseases, Diet, Mediterranean, Endothelial Progenitor Cells
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