The aging kidney: role of endothelial oxidative stress and inflammation
Abstract
The population in the Western world is aging. In 1996 those aged 60 years and over formed 21% of the EU population, by 2022 this proportion will have risen to 27%. Based on current trends a third of the EU population could be 60 years of age and over by the age 2050. Epidemiological studies suggest that even in the absence of other risk factors (e.g. diabetes, hypertension, hypercholesterolemia), advanced age itself significantly increases cardiovascular morbidity by promoting the development of atherosclerosis and by impairing normal cellular functions. One of the most prominent organs affected by aging is the kidney. There is evidence that age-associated phenotypic changes may be an important cause of renal failure. We propose that vascular oxidative stress and inflammation are generalized phenomena during senescence, which importantly contribute to the morphological and functional changes in the aging kidney. The present review focuses on some of the mechanisms by which advanced age may promote vascular oxidative and nitrosative stress and the possible downstream mechanisms by which reactive oxygen and nitrogen species may impair vascular and renal function in aging.
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Chronic low-grade inflammation is a key mechanism mediating age-related arterial dysfunction.
“and is a key mechanism mediating age-related arterial dysfunction (34, 45, 149, 162)”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [34]
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Ruiz, M. D. C. M., Cuenca‐Bermejo, L., Veronese, N., Fernández‐Villalba, E., Cuello, A. M. G., Kublickiene, K. R., Raparelli, V., Norris, C. M., Kautzky‐Willer, A., Pilote, L., et al. (2023) · Nutrients · doi:10.3390/nu15071710 · Cited by 24 · see citing works
“In particular, aging has a pivotal role in the structural and functional changes that occur in the kidney during our lives [36].”
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“And, the kidney is among the well-known critical organs that are most senescence-sensitive and vulnerable to chronic inflammatory insults, such as glomerulonephritis and glomerulosclerosis [40].”
BackgroundXiao, Q. (2022) · Renal Failure · doi:10.1080/0886022x.2022.2056485 · Cited by 21 · see citing works
“Besides, research by Csiszar pointed out that vascular oxidative stress and inflammation occur generally during senescence [51].”
RetractedNatural Anti-inflammatory and Anti-allergy Agents: Herbs and Botanical Ingredients
Saini, R., & Dhiman, N. K. (2021) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/1871523021666220411111743 · Cited by 20 · see citing works
Effects of Aging and Methionine Restriction on Rat Kidney Metabolome
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Impaired NRF2 Inhibits Recovery from Ischemic Reperfusion Injury in the Aging Kidney
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“Targeting oxidative stress and mitochondrial impairment has been used to prevent age-related kidney injury in several previous studies [50,51], and NRF2 may be the key factor by which to modulate the process in the aging kidney.”
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“We focused on ECs for the role of autophagy in renal aging, taking into account that vascular oxidative stress and chronic inflammation are common phenomena during senescence [44].”
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SUL-138 mitigates accelerated endothelial aging and protects the kidney
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- Authors
- Csiszar, A., Toth, J., Peti-Peterdi, J., & Ungvari, Z.
- Affiliations
- New York Medical College (US)
- Semmelweis University (HU)
- ORCID
- Ungvari, Z.
- Venue
- Acta Physiologica Hungarica
- Publisher
- Akademiai Kiado Zrt.
- Published
- 2007-03
- Volume
- 94
- Issue
- 1-2
- Pages
- 107-115
- ISSN
- 0231-424X (ISSN-L)
- 1588-2683
- OpenAlex
- W2071112830
- Cited by
- 43
- References
- 62
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Physiologica Hungarica (publishedVersion)
- PubMed (publishedVersion)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- Funders
- American Heart Association
- Philip Morris International
- National Heart, Lung, and Blood Institute (R01HL077256, HL077256)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK064324)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- kidney aging, endothelial oxidative stress, inflammation, senescence, nitrosative stress, reactive oxygen species, reactive nitrogen species, renal failure, vascular function, renal function, atherosclerosis, cardiovascular morbidity
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Animals, Endothelium, Vascular, Humans, Inflammation, Kidney, Middle Aged, Renal Circulation, Renin-Angiotensin System, Oxidative Stress
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