Mediterranean diet and healthy ageing: a Sicilian perspective
Open accessAbstract
Traditional Mediterranean diet (MedDiet) is a common dietary pattern characterizing a lifestyle and culture proven to contribute to better health and quality of life in Mediterranean countries. By analyzing the diet of centenarians from the Sicani Mountains and eating habits of inhabitants of Palermo, it is reported that a close adherence to MedDiet is observed in the countryside, whereas in big towns this adherence is not so close. This has an effect on the rates of mortality at old age (and reciprocally longevity) that are lower in the countryside than in big towns. Concerning the health effects of the diet, the low content of animal protein and the low glycaemic index of the Sicilian MedDiet might directly modulate the insulin/IGF-1 and the mTOR pathways, known to be involved in ageing and longevity. In particular, the reduction of animal protein intake may significantly reduce serum IGF-1 concentrations and inhibit mTOR activity with a down-regulation of the signal that leads to the activation of FOXO3A and, consequently, to the transcription of homeostatic genes that favour longevity. The down-regulation of both IGF-1 and mTORC1 also induces an anti-inflammatory effect. In addition to the effects on sensing pathways, many single components of MedDiet are known to have positive effects on health, reducing inflammation, optimizing cholesterol and other important risk factors of age-related diseases. However, a key role is played by polyphenols represented in high amount in the Sicilian MedDiet (in particular in extra virgin olive oil) that can work as hormetins that provide an environmental chemical signature regulating stress resistance pathways such as nuclear factor erythroid 2-related factor 2.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
1 retracted
RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1200303 · Cited by 4,257 · see citing works
RetractedLópez-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details.
Pascual-Marqui, R. D. (2002) · PubMed · Cited by 3,340 · see citing works
Gleeson, M., Bishop, N. C., Stensel, D. J., Lindley, M. R., Mastana, S. S., & Nimmo, M. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3041 · Cited by 2,470 · see citing works
Mediterranean diet pyramid: a cultural model for healthy eating
Willett, W., Sacks, F., Trichopoulou, A., Drescher, G., Ferro-Luzzi, A., Helsing, E., & Trichopoulos, D. (1995) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.6.1402s · Cited by 2,461 · see citing works
Mediterranean diet pyramid today. Science and cultural updates
Bach-Faig, A., Berry, E. M., Lairon, D., Reguant-Aleix, J., Trichopoulou, A., Dernini, S., Medina, F. X., Battino, M. A., Belahsen, R., Miranda, G., et al. (2011) · Public Health Nutrition · doi:10.1017/s1368980011002515 · Cited by 1,813 · see citing works
THE DIET AND 15-YEAR DEATH RATE IN THE SEVEN COUNTRIES STUDY
KEYS, A., MIENOTTI, A., KARVONEN, M. J., ARAVANIS, C., BLACKBURN, H., BUZINA, R., DJORDJEVIC, B. S., DONTAS, A. S., FIDANZA, F., KEYS, M. H., et al. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114480 · Cited by 1,790 · see citing works
A standardized boundary element method volume conductor model
Fuchs, M., Kastner, J., Wagner, M., Hawes, S., & Ebersole, J. S. (2002) · Clinical Neurophysiology · doi:10.1016/s1388-2457(02)00030-5 · Cited by 990 · see citing works
Distinct DNA methylomes of newborns and centenarians
Heyn, H., Li, N., Ferreira, H. J., Moran, S., Pisano, D. G., Gomez, A., Diez, J., Sanchez-Mut, J. V., Setien, F., Carmona, F. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120658109 · Cited by 802 · see citing works
Guarente, L. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1100831 · Cited by 510 · see citing works
Inflammatory networks in ageing, age-related diseases and longevity
Vasto, S., Candore, G., Balistreri, C. R., Caruso, M., Colonna‐Romano, G., Grimaldi, M. P., Listı̀, F., Nuzzo, D., Lio, D., & Caruso, C. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.015 · Cited by 481 · see citing works
Self-citationVauzour, D. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/914273 · Cited by 431 · see citing works
Scapagnini, G., Vasto, S., Nader, A. G., Caruso, C., Zella, D., & Galvano, F. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8181-5 · Cited by 403 · see citing works
Self-citationReview of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds
Nassiri‐Asl, M., & Hosseinzadeh, H. (2009) · Phytotherapy Research · doi:10.1002/ptr.2761 · Cited by 299 · see citing works
Hayflick, L. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030220 · Cited by 260 · see citing works
Martín‐Peláez, S., Covas, M. I., Fitó, M., Kušar, A., & Pravst, I. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200421 · Cited by 259 · see citing works
Sonkoly, E., & Pivarcsi, A. (2009) · International Reviews of Immunology · doi:10.3109/08830180903208303 · Cited by 212 · see citing works
Correlation of Quantitative EEG in Acute Ischemic Stroke With 30-Day NIHSS Score
Finnigan, S., Rose, S., Walsh, M., Griffin, M., Janke, A. L., McMahon, K. L., Gillies, R., Strudwick, M. W., Pettigrew, C., Semple, J. M., et al. (2004) · Stroke · doi:10.1161/01.str.0000122622.73916.d2 · Cited by 200 · see citing works
Understanding ageing from an evolutionary perspective
Kirkwood, T. B. L. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01901.x · Cited by 183 · see citing works
Mann, G. E., Rowlands, D. J., Li, F., deWinter, P., & Siow, R. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.04.004 · Cited by 181 · see citing works
Importance of functional foods in the Mediterranean diet
Anta, R. M. O. (2006) · Public Health Nutrition · doi:10.1017/s1368980007668530 · Cited by 177 · see citing works
Buscemi, S., Rosafio, G., Arcoleo, G., Mattina, A., Canino, B., Montana, M., Verga, S., & Rini, G. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.031088 · Cited by 151 · see citing works
Self-citationXenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil
Menéndez, J. A., Joven, J., Aragonès, G., Barrajón‐Catalán, E., Beltrán‐Debón, R., Borrás‐Linares, I., Camps, J., Corominas-Faja, B., Cufí, S., Fernández‐Arroyo, S., et al. (2013) · Cell Cycle · doi:10.4161/cc.23756 · Cited by 150 · see citing works
Defining the Extent of Irreversible Brain Ischemia Using Perfusion Computed Tomography
Bivard, A., McElduff, P., Spratt, N. J., Levi, C. R., & Parsons, M. W. (2010) · Cerebrovascular Diseases · doi:10.1159/000321897 · Cited by 133 · see citing works
Fontana, L., Adelaiye-Ogala, R. M., Rastelli, A. L., Miles, K. M., Ciamporcero, E. S., Longo, V. D., Nguyen, H. M., Vessella, R. L., & Пили, Р. (2013) · Oncotarget · doi:10.18632/oncotarget.1586 · Cited by 132 · see citing works
NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies
Balistreri, C. R., Candore, G., Accardi, G., Colonna‐Romano, G., & Lio, D. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-24 · Cited by 108 · see citing works
Self-citationThe Emerging Role of MicroRNAs in the Regulation of Gene Expression by Nutrients
García-Segura, L., Pérez-Andrade, M. E., & Miranda‐Ríos, J. (2013) · Lifestyle Genomics · doi:10.1159/000345826 · Cited by 101 · see citing works
Tesoriere, L., Butera, D., Gentile, C., & Livrea, M. A. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0714113 · Cited by 94 · see citing works
Allegra, M., Ianaro, A., Tersigni, M., Panza, E., Tesoriere, L., & Livrea, M. A. (2013) · Journal of Nutrition · doi:10.3945/jn.113.183657 · Cited by 92 · see citing works
Pathophysiology of ageing, longevity and age related diseases
Bürkle, A., Caselli, G., Franceschi, C., Mariani, E., Sansoni, P., Santoni, A., Vecchio, G., Witkowski, J. M., & Caruso, C. (2007) · Immunity & Ageing · doi:10.1186/1742-4933-4-4 · Cited by 86 · see citing works
Self-citationGentile, C., Allegra, M., Angileri, F., Pintaudi, A. M., Livrea, M. A., & Tesoriere, L. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0220-5 · Cited by 69 · see citing works
Buscemi, S., Nicolucci, A., Mattina, A., Rosafio, G., Massenti, F. M., Lucisano, G., Galvano, F., Amodio, E., Pellegrini, F., Barile, A. M., et al. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.172 · Cited by 69 · see citing works
Self-citationBona, D. D., Accardi, G., Virruso, C., Candore, G., & Caruso, C. (2013) · Current Vascular Pharmacology · doi:10.2174/1570161111666131218152807 · Cited by 66 · see citing works
Self-citationMediterranean Diet And Longevity: An Example Of Nutraceuticals?
Vasto, S., Barera, A., Rizzo, C., Carlo, M. D., Caruso, C., & Panotopoulos, G. (2013) · Current Vascular Pharmacology · doi:10.2174/1570161111666131219111818 · Cited by 62 · see citing works
Self-citationFundamentals of Nutrigenetics and Nutrigenomics
Bouchard, C., & Ordovás, J. M. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-398397-8.00001-0 · Cited by 56 · see citing works
“Positive biology”: the centenarian lesson
Caruso, C., Passarino, G., Puca, A. A., & Scapagnini, G. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-5 · Cited by 54 · see citing works
Self-citationDiversity v. globalization: traditional foods at the epicentre
Trichopoulou, A. (2012) · Public Health Nutrition · doi:10.1017/s1368980012000304 · Cited by 48 · see citing works
Mediterranean Diet and Longevity in Sicily: Survey in a Sicani Mountains Population
Vasto, S., Scapagnini, G., Rizzo, C., Monastero, R., Marchese, A., & Caruso, C. (2012) · Rejuvenation Research · doi:10.1089/rej.2011.1280 · Cited by 48 · see citing works
Self-citationNon-Alcoholic Steatohepatitis and Hepatocellular Carcinoma: Implications for Lycopene Intervention
Ip, B. C., & Wang, X. (2013) · Nutrients · doi:10.3390/nu6010124 · Cited by 47 · see citing works
Nutraceutical Properties of Extra-Virgin Olive Oil: A Natural Remedy for Age-Related Disease?
Virruso, C., Accardi, G., Colonna‐Romano, G., Candore, G., Vasto, S., & Caruso, C. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1532 · Cited by 45 · see citing works
Self-citationCentenarians and diet: what they eat in the Western part of Sicily
Vasto, S., Rizzo, C., & Caruso, C. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-10 · Cited by 44 · see citing works
Self-citationCharacterization of street food consumption in palermo: possible effects on health
Buscemi, S., Barile, A. M., Maniaci, V., Batsis, J. A., Mattina, A., & Verga, S. (2011) · Nutrition Journal · doi:10.1186/1475-2891-10-119 · Cited by 41 · see citing works
Self-citationPro-Inflammatory Genetic Markers of Atherosclerosis
Incalcaterra, E., Accardi, G., Balistreri, C. R., Caimi, G., Candore, G., Caruso, M., & Caruso, C. (2013) · Current Atherosclerosis Reports · doi:10.1007/s11883-013-0329-5 · Cited by 38 · see citing works
Self-citationRoadmap of miR-122-related clinical application from bench to bedside
Qiu, Z., & Dai, Y. (2013) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2014.867327 · Cited by 20 · see citing works
Nutrition and the healthy heart with an exercise boost
Whayne, T. F., & Maulik, N. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y2012-074 · Cited by 20 · see citing works
Muccini, F. M. (2012) · Modern Italy · doi:10.1080/13532944.2012.669630 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes
Kolb, H., & Martin, S. (2017) · BMC Medicine · doi:10.1186/s12916-017-0901-x · Cited by 735 · see citing works
Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693 · see citing works
Self-citationRigacci, S., & Stefani, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060843 · Cited by 293 · see citing works
Ferulic Acid: A Hope for Alzheimer’s Disease Therapy from Plants
Sgarbossa, A., Giacomazza, D., & Carlo, M. D. (2015) · Nutrients · doi:10.3390/nu7075246 · Cited by 285 · see citing works
Benefits of the Mediterranean diet: Epidemiological and molecular aspects
Serra‐Majem, L., Román‐Viñas, B., Sánchez‐Villegas, A., Guasch‐Ferré, M., Corella, D., & Vecchia, C. L. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.06.001 · Cited by 240 · see citing works
Anti-senescence compounds: A potential nutraceutical approach to healthy aging
Gurău, F., Baldoni, S., Prattichizzo, F., Espinosa, E., Amenta, F., Procopio, A. D., Albertini, M. C., Bonafè, M., & Olivieri, F. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.05.001 · Cited by 179 · see citing works
Mediterranean diet and the hallmarks of ageing
Shannon, O. M., Ashor, A. W., Scialò, F., Saretzki, G. C., Martin-Ruiz, C. M., Lara, J., Matu, J., Griffiths, A., Robinson, N., Lionetti, L., et al. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-020-00841-x · Cited by 131 · see citing works
Validation of a food frequency questionnaire for use in Italian adults living in Sicily
Buscemi, S., Rosafio, G., Vasto, S., Massenti, F. M., Grosso, G., Galvano, F., Rini, N., Barile, A. M., Maniaci, V., Cosentino, L., et al. (2015) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2015.1025718 · Cited by 126 · see citing works
Self-citationImpact of Polyphenolic-Food on Longevity: An Elixir of Life. An Overview
Meccariello, R., & D’Angelo, S. (2021) · Antioxidants · doi:10.3390/antiox10040507 · Cited by 110 · see citing works
Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview
Martemucci, G., Portincasa, P., Ciaula, A. D., Mariano, M., Centonze, V., & D‘Alessandro, A. G. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111707 · Cited by 110 · see citing works
Interventions on Gut Microbiota for Healthy Aging
Zeppa, S. D., Agostini, D., Ferrini, F., Gervasi, M., Barbieri, E., Bartolacci, A., Piccoli, G., Saltarelli, R., Sestili, P., & Stocchi, V. (2022) · Cells · doi:10.3390/cells12010034 · Cited by 91 · see citing works
Nutrition and longevity—From mechanisms to uncertainties
Ekmekcioglu, C. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1676698 · Cited by 87 · see citing works
Influence of the Mediterranean Diet on Healthy Aging
Andreo-López, M. C., Contreras-Bolívar, V., Muñoz‐Torres, M., García-Fontana, B., & García‐Fontana, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054491 · Cited by 86 · see citing works
Aboul-Enein, B. H., Bernstein, J., & Neary, A. (2016) · Eastern Mediterranean Health Journal · doi:10.26719/2016.22.10.763 · Cited by 77 · see citing works
Anticancer Effects of Nutraceuticals in the Mediterranean Diet: An Epigenetic Diet Model
Divella, R., Daniele, A., Savino, E., & Paradiso, A. (2020) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20193 · Cited by 75 · see citing works
Nutrigerontology: a key for achieving successful ageing and longevity
Aiello, A., Accardi, G., Candore, G., Carruba, G., Davinelli, S., Passarino, G., Scapagnini, G., Vasto, S., & Caruso, C. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0071-2 · Cited by 69 · see citing works
Self-citationGil‐Solsona, R., Raro, M., Sales, C., Lacalle-Bergeron, L., Díaz, R., Ibáñez, M., Beltrán, J., Sancho, J. V., & Hernández, F. J. (2016) · Food Control · doi:10.1016/j.foodcont.2016.06.008 · Cited by 67 · see citing works
Nutrients and Pathways that Regulate Health Span and Life Span
Pignatti, C., D’Adamo, S., Stefanelli, C., Flamigni, F., & Cetrullo, S. (2020) · Geriatrics · doi:10.3390/geriatrics5040095 · Cited by 64 · see citing works
The Mediterranean Lifestyle as a Non-Pharmacological and Natural Antioxidant for Healthy Aging
Chatzianagnostou, K., Turco, S. D., Pingitore, A., Sabatino, L., & Vassalle, C. (2015) · Antioxidants · doi:10.3390/antiox4040719 · Cited by 65 · see citing works
Veneziani, G., Esposto, S., Taticchi, A., Urbani, S., Selvaggini, R., Sordini, B., & Servili, M. (2017) · LWT · doi:10.1016/j.lwt.2017.09.034 · Cited by 64 · see citing works
Vinceti, M., Filippini, T., Violi, F., Rothman, K. J., Costanzini, S., Malagoli, C., Wise, L. A., Odone, A., Signorelli, C., Iacuzio, L., et al. (2017) · Environmental Health · doi:10.1186/s12940-017-0297-2 · Cited by 60 · see citing works
Centenarians as a model to discover genetic and epigenetic signatures of healthy ageing
Puca, A. A., Spinelli, C., Accardi, G., Villa, F., & Caruso, C. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.10.004 · Cited by 58 · see citing works
Self-citationSánchez-Muniz, F. J., Macho‐González, A., Garcimartín, A., Santos-López, J. A., Benedı́, J., Bastida, S., & González‐Muñoz, M. J. (2019) · Nutrients · doi:10.3390/nu11071558 · Cited by 56 · see citing works
Davinelli, S., & Scapagnini, G. (2016) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-016-0149-0 · Cited by 55 · see citing works
Lifestyle effects on aging and CVD: A spotlight on the nutrient-sensing network
Yang, K., Hou, R., Zhao, J., Wang, X., Wei, J., Pan, X., & Zhu, X. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102121 · Cited by 57 · see citing works
Genetic, Social, and Lifestyle Drivers of Healthy Aging and Longevity
Castruita, P. A., Piña‐Escudero, S. D., Rentería, M. E., & Yokoyama, J. S. (2022) · Current Genetic Medicine Reports · doi:10.1007/s40142-022-00205-w · Cited by 54 · see citing works
Nutrient sensing pathways as therapeutic targets for healthy ageing
Aiello, A., Accardi, G., Candore, G., Gambino, C. M., Mirisola, M. G., Taormina, G., Virruso, C., & Caruso, C. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1294684 · Cited by 52 · see citing works
Self-citationApplications of recovered bioactive compounds in food products
Veneziani, G., Novelli, E., Esposto, S., Taticchi, A., & Servili, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805314-0.00011-x · Cited by 51 · see citing works
Nuzzo, D., Galizzi, G., Amato, A., Terzo, S., Picone, P., Cristaldi, L., Mulè, F., & Carlo, M. D. (2020) · Antioxidants · doi:10.3390/antiox9040317 · Cited by 50 · see citing works
Nuzzo, D., Amato, A., Picone, P., Terzo, S., Galizzi, G., Bonina, F. P., Mulè, F., & Carlo, M. D. (2018) · Nutrients · doi:10.3390/nu10091130 · Cited by 47 · see citing works
Healthy ageing and Mediterranean diet: A focus on hormetic phytochemicals
Alì, S., Davinelli, S., Accardi, G., Aiello, A., Caruso, C., Duro, G., Ligotti, M. E., Pojero, F., Scapagnini, G., & Candore, G. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111592 · Cited by 45 · see citing works
Self-citationUngvari, Z. I., Fekete, M., Fekete, J. T., Grosso, G., Ungvari, A., & Győrffy, B. (2024) · GeroScience · doi:10.1007/s11357-024-01296-9 · Cited by 39 · see citing works
Aiello, A., Accardi, G., Aprile, S., Caldarella, R., Carru, C., Ciaccio, M., Vivo, I. D., Gambino, C. M., Ligotti, M. E., Vasto, S., et al. (2021) · Aging and Disease · doi:10.14336/ad.2021.0226 · Cited by 39 · see citing works
Self-citationDietary Patterns and All-Cause Mortality: A Systematic Review
Boushey, C. J., Ard, J. D., Bazzano, L., Heymsfield, S. B., Mayer‐Davis, E. J., Sabaté, J., Snetselaar, L. G., Horn, L. V., Schneeman, B. O., English, L., et al. (2020) · doi:10.52570/nesr.dgac2020.sr0108 · Cited by 41 · see citing works
Critselis, E., & Panagiotakos, D. B. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1631752 · Cited by 37 · see citing works
Nutraceutical effects of table green olives: a pilot study with Nocellara del Belice olives
Accardi, G., Aiello, A., Gargano, V., Gambino, C. M., Caracappa, S., Marineo, S., Vesco, G., Carru, C., Zinellu, A., Zarcone, M., et al. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0067-y · Cited by 37 · see citing works
Self-citationZappalà, G., Buscemi, S., Mulè, S., Verde, M., D’Urso, M., Corleo, D., & Marranzano, M. (2017) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-017-0454-1 · Cited by 37 · see citing works
Self-citationFasting, dietary restriction, and immunosenescence
Longo, V. D., & Cortellino, S. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.07.035 · Cited by 36 · see citing works
Aliberti, S. M., De Caro, F., Funk, R. H. W., Schiavo, L., Gonnella, J., Boccia, G., & Capunzo, M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031589 · Cited by 33 · see citing works
Villani, A. M., Sultana, J., Doecke, J., & Mantzioris, E. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1757-3 · Cited by 32 · see citing works
Multimorbidity Clusters in the Oldest Old: Results from the EpiChron Cohort
Ioakeim‐Skoufa, I., Clerencia-Sierra, M., Juste, A. M., Peña, C. E. D. M., Poblador‐Plou, B., Aza‐Pascual‐Salcedo, M., González‐Rubio, F., Prados‐Torres, A., & Miguel, A. G. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191610180 · Cited by 32 · see citing works
Mediterranean nutraceutical foods: Strategy to improve vascular ageing
Accardi, G., Aiello, A., Gambino, C. M., Virruso, C., Caruso, C., & Candore, G. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.02.007 · Cited by 32 · see citing works
Self-citationGirolamo, F. D., Masotti, A., Lante, I., Scapaticci, M., Calvano, C. D., Zambonin, C. G., Muraca, M., & Putignani, L. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160920896 · Cited by 31 · see citing works
Mediterranean Diet attenuates risk of frailty and sarcopenia: New insights and future directions
McClure, R., & Villani, A. M. (2017) · JCSM Clinical Reports · doi:10.17987/jcsm-cr.v2i2.45 · Cited by 29 · see citing works
Intrinsic and environmental basis of aging: A narrative review
Navarro, C., Salazar, J. J., Diaz, M. P., Chacín, M., Santeliz, R., Vera, I., D’Marco, L., Parra, H., Bernal, M. C., Castro, A. V., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18239 · Cited by 29 · see citing works
Nuzzo, D., Contardi, M., Kossyvaki, D., Picone, P., Cristaldi, L., Galizzi, G., Bosco, G., Scoglio, S., Athanassiou, A., & Carlo, M. D. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9481390 · Cited by 25 · see citing works
Aliberti, S. M., Donato, A., Funk, R. H. W., & Capunzo, M. (2024) · Nutrients · doi:10.3390/nu16050729 · Cited by 25 · see citing works
Age-associated changes in circulatory fatty acids: new insights on adults and long-lived individuals
Alì, S., Aiello, A., Zotti, T., Accardi, G., Cardinale, G., Vito, P., Calabrò, A., Ligotti, M. E., Intrieri, M., Corbi, G., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00696-z · Cited by 24 · see citing works
Self-citationWhat olive oil for healthy ageing?
Aiello, A., Guccione, G. D., Accardi, G., & Caruso, C. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.10.016 · Cited by 24 · see citing works
Self-citationMalcomson, F. C., & Mathers, J. C. (2018) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-2835-0_13 · Cited by 21 · see citing works
Accardi, G., Aprile, S., Candore, G., Caruso, C., Cusimano, R., Cristaldi, L., Bona, D. D., Duro, G., Galimberti, D., Gambino, C. M., et al. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190313115233 · Cited by 22 · see citing works
Self-citationMa, T.-C., Zhou, J. W., Wang, C., Fang, M., & Gao, F. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.853332 · Cited by 22 · see citing works
Jurado‐Fasoli, L., Amaro‐Gahete, F. J., De‐la‐O, A., Martínez‐Téllez, B., Ruiz, J. R., Gutiérrez, Á., & Castillo, M. J. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.01.019 · Cited by 21 · see citing works
Papanikolaοu, C., Melliou, E., & Magiatis, P. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.81394 · Cited by 19 · see citing works
The Phenotypic Characterization of the Cammalleri Sisters, an Example of Exceptional Longevity
Accardi, G., Aiello, A., Aprile, S., Caldarella, R., Cammarata, G., Carru, C., Caruso, C., Ciaccio, M., Colomba, P., Galimberti, D., et al. (2020) · Rejuvenation Research · doi:10.1089/rej.2019.2299 · Cited by 19 · see citing works
Self-citationMariolis, A. D., Foscolou, A., Tyrovolas, S., Piscopo, S., Valacchi, G., Tsakountakis, N., Zeimbekis, A., Bountziouka, V. P., Gotsis, E., Metallinos, G., et al. (2016) · Aging and Disease · doi:10.14336/ad.2015.1002 · Cited by 18 · see citing works
Proposal of a Bioregional Strategic Framework for a Sustainable Food System in Sicily
Guarnaccia, P., Zingale, S., Scuderi, A., Gori, E., Santiglia, V., & Timpanaro, G. (2020) · Agronomy · doi:10.3390/agronomy10101546 · Cited by 18 · see citing works
What are the determinants of adherence to the mediterranean diet?
Buscemi, S. (2021) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2021.1889995 · Cited by 18 · see citing works
Self-citationDecoding T cell senescence in cancer: Is revisiting required?
Magkouta, S., Markaki, E., Evangelou, K., Petty, R., Verginis, P., & Gorgoulis, V. G. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.11.003 · Cited by 17 · see citing works
Kocabaş, Ş., & Şanlıer, N. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1986803 · Cited by 16 · see citing works
Topalović, D., Živković, L., Pirković, A., Djelić, N., Bajić, V., Dekanski, D., & Spremo‐Potparević, B. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/762192 · Cited by 14 · see citing works
Bernardo, M. D., & Carlo, M. D. (2017) · InTech eBooks · doi:10.5772/intechopen.70301 · Cited by 13 · see citing works
Chance and Causality in Ageing and Longevity
Accardi, G., Aiello, A., Vasto, S., & Caruso, C. (2019) · Springer eBooks · doi:10.1007/978-3-030-20762-5_1 · Cited by 14 · see citing works
Self-citationβ-glucans: ex vivo inflammatory and oxidative stress results after pasta intake
Barera, A., Buscemi, S., Monastero, R., Caruso, C., Caldarella, R., Ciaccio, M., & Vasto, S. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0068-x · Cited by 13 · see citing works
Self-citationBaldassano, S., Accardi, G., Aiello, A., Buscemi, S., Miceli, G. D., Galimberti, D., Candore, G., Ruisi, P., Caruso, C., & Vasto, S. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.05.059 · Cited by 12 · see citing works
Self-citationAliberti, S. M., Capunzo, M., Galimberti, D., Accardi, G., Aiello, A., Calabrò, A., Caruso, C., & Candore, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104796 · Cited by 12 · see citing works
Self-citationUpdates in Pathobiology: Causality and Chance in Ageing,Age-Related Diseases and Longevity
Caruso, C., & Accardi, G. (2017) · Cited by 11 · see citing works
Self-citationAdherence to Mediterranean diet and nutritional status in a sample of nonagenarians
Bonaccorsi, G., Lorini, C., Santomauro, F., Sofi, F., Vannetti, F., Pasquini, G., & Macchi, C. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.12.016 · Cited by 9 · see citing works
Aiello, A., Caruso, C., & Accardi, G. (2019) · Encyclopedia of Gerontology and Population Aging · doi:10.1007/978-3-319-69892-2_134-1 · Cited by 8 · see citing works
Self-citationDietary Inflammatory Index in Ageing and Longevity
Falzone, L., Libra, M., & Polesel, J. (2019) · Springer eBooks · doi:10.1007/978-3-030-20762-5_5 · Cited by 7 · see citing works
Pathobiology of aging: An introduction to age-related diseases
Caruso, C., Accardi, G., Ligotti, M. E., Vasto, S., & Candore, G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822569-1.00010-x · Cited by 6 · see citing works
Self-citationZhao, L., Zhao, C., Wang, Z., Chen, Z., Zheng, H., Ai, S., Tao, J., Li, D., Sun, W., & Wang, Y. (2025) · Renal Failure · doi:10.1080/0886022x.2025.2508295 · Cited by 6 · see citing works
Second Primary Cancers following Colorectal Cancer in Sicily, Italy
Collatuzzo, G., Ferrante, M., Ippolito, A., Prima, A. A. D., Colarossi, C., Scarpulla, S., Boffetta, P., & Sciacca, S. (2022) · Cancers · doi:10.3390/cancers14215204 · Cited by 5 · see citing works
Changes in the Microbiota Composition and Function in Relation to Aging
Maukonen, J., & Ouwehand, A. C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00060-7 · Cited by 5 · see citing works
Effects of nutraceuticals of Mediterranean diet on aging and longevity
Aiello, A., Accardi, G., Caruso, C., & Candore, G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818649-7.00047-3 · Cited by 5 · see citing works
Self-citationMediterranean Diet to Promote Healthy Aging
Román‐Viñas, B., & Serra‐Majem, L. (2018) · Current Geriatrics Reports · doi:10.1007/s13670-018-0242-4 · Cited by 4 · see citing works
Bigman, G., & Ryan, A. S. (2023) · International perspectives on aging · doi:10.1007/978-3-031-30915-1_6 · Cited by 3 · see citing works
Hormetic Effects of Phytochemicals with Anti-Ageing Properties
Caruso, C., Accardi, G., Aiello, A., & Candore, G. (2024) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-66768-8_10 · Cited by 3 · see citing works
Self-citationMediterranean diet and metabolic status in post-menopausal women living in a mediterranean area
Fiore, V., Capraro, M., Ragusa, R., Godos, J., Mistretta, A., & Marranzano, M. (2019) · Nutrition and Healthy Aging · doi:10.3233/nha-190062 · Cited by 3 · see citing works
Zappalá, G., Platania, A., Bellia, M. A., Ragusa, R., & Marranzano, M. (2019) · Mediterranean Journal of Nutrition and Metabolism · doi:10.3233/mnm-190306 · Cited by 3 · see citing works
(2021) · Frontiers research topics · doi:10.3389/978-2-88966-718-5 · Cited by 3 · see citing works
Dietary Supplements as Surrogate of Mediterranean Diet in Healthy Smoking Subjects
Vasto, S., Accardi, G., Aiello, A., Gaudio, F. D., Barera, A., Indelicato, S., Galimberti, D., Italiano, E., Monastero, R., Rizzo, C., et al. (2017) · Rejuvenation Research · doi:10.1089/rej.2017.1950 · Cited by 2 · see citing works
Self-citationAn Emerging Longevity Blue Zone in Sicily: The Case of Caltabellotta and the Sicani Mountains
Errigo, A., Pes, G. M., Caruso, C., Accardi, G., Aiello, A., Candore, G., & Vasto, S. (2025) · Journal of Ageing and Longevity · doi:10.3390/jal5030026 · Cited by 1 · see citing works
Self-citationMediterranean Diet for Active and Healthy Aging
Noreen, N., Shah, M. A., Khan, F., Niaz, K., Muhammad, F., Shah, I., & Abdollahi, M. R. (2020) · Springer eBooks · doi:10.1007/978-981-15-3552-9_11 · Cited by 1 · see citing works
The Impact of Olive Oil and Mediterranean Diet on the Prevention of Cardiovascular Diseases
Akram, M., Ansari, R., Akhter, N., Otekunrin, O. A., Zafar, S., Ishaque, M., Munir, N., Sciarra, L., My, G., Matarrese, E. C. G., et al. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.97146 · Cited by 1 · see citing works
(2021) · International Journal of Research in Environmental Science · doi:10.20431/2454-9444.0703001 · Cited by 1 · see citing works
Factors that affect human longevity
Bolin, T. (2017) · K-State Research Exchange (Kansas State University) · Cited by 1 · see citing works
Aiello, A., Caruso, C., & Accardi, G. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_134
Self-citationNutrition, ageing, and longevity
Cederholm, T., & Hellénius, M.-L. (2017) · doi:10.1093/med/9780198701590.003.0165
Knowledge Level of Street Fruit Vendors on Food Hygiene in the Tamale Metropolis
Kpekurah, P. (2025) · Universal Journal of Food Science and Technology · doi:10.31586/ujfst.2025.1226
Roberson, L. B., Heinrich, E., Naber, J., Dada, O. M., Malm, E. K., Obeng, R., Dodd, A., & Heemer, A. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5251476
Wang, X., Pang, J., Yu, X., Zhang, X., Wang, S., Pan, Q., Chen, A., Xu, L., Li, N., Li, X., et al. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3416-1
- Authors
- Vasto, S., Buscemi, S., Barera, A., Di Carlo, M., Accardi, G., & Caruso, C.
- Affiliations
- Istituto di Biomedicina e di Immunologia Molecolare Alberto Monroy (IT)
- University of Palermo (IT)
- Venue
- Gerontology
- Publisher
- S. Karger AG
- Published
- 2014
- Volume
- 60
- Issue
- 6
- Pages
- 508-518
- ISSN
- 0304-324X (ISSN-L)
- 1423-0003
- OpenAlex
- W2082998818
- Cited by
- 94
- References
- 46
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 13 · 2020: 9 · 2019: 14 · 2018: 7 · 2017: 14 · 2016: 9 · 2015: 5 · 2014: 1
- FWCI
- 9.57
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- Mediterranean diet, healthy aging, centenarians, Sicily, urban-rural differences, longevity, animal protein intake, glycemic index, insulin-like growth factor I, mTOR signaling, FOXO3, insulin signaling, inflammation, polyphenols, extra virgin olive oil, hormesis, Nrf2, age-related diseases
- MeSH terms
- Feeding Behavior, Health Status, Humans, Life Style, Longevity, Sicily, Diet, Mediterranean
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review