Neuroinflammation: Modulation by flavonoids and mechanisms of action

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Items 101–200 of 315

1. A Novel Quinolyl‐Substituted Analogue of Resveratrol Inhibits LPS‐Induced Inflammatory Responses in Microglial Cells by Blocking the NF‐κB/MAPK Signaling Pathways
   Yue Hou, Yuchen Zhang, Yan Mi, Jian Wang, Haotian Zhang, Jikai Xu, Yanqiu Yang, Jingyu Liu, Lingling Ding, Jingyu Yang et al. · 2019 · Molecular Nutrition & Food Research
2. Inhibition of microglial activation by elderberry extracts and its phenolic components
   Ágnes Simonyi, Zihong Chen, Jinghua Jiang, Yijia Zong, Dennis Y. Chuang, Zezong Gu, Chi‐Hua Lu, Kevin L. Fritsche, C. Michael Greenlief, George Edwin Rottinghaus et al. · 2015 · Life Sciences
3. Dietary flavonoid intake at midlife and healthy aging in women
   Cécilia Samieri, Qi Sun, Mary K. Townsend, Eric B. Rimm, Francine Grodstein · 2014 · American Journal of Clinical Nutrition
4. Neuroprotective Effects of Baicalein on Acrolein-induced Neurotoxicity in the Nigrostriatal Dopaminergic System of Rat Brain
   Wei-Zhong Zhao, Hsiang‐Tsui Wang, Hui-Ju Huang, Yu‐Li Lo, Anya Maan-Yuh Lin · 2017 · Molecular Neurobiology
5. Phytochemicals for Improving Aspects of Cognitive Function and Psychological State Potentially Relevant to Sports Performance
   David O. Kennedy · 2019 · Sports Medicine
6. Common plant flavonoids prevent the assembly of amyloid curli fibres and can interfere with bacterial biofilm formation
   Mihaela Pruteanu, José Ignacio Hernández Lobato, Thomas Stach, Regine Hengge · 2020 · Environmental Microbiology
7. Dietary Polyphenols and Their Effects on Cell Biochemistry and Pathophysiology 2013
   Tullia Maraldi, David Vauzour, Cristina Angeloni · 2014 · Oxidative Medicine and Cellular Longevity
8. Does Parkinson’s Disease and Type-2 Diabetes Mellitus Present Common Pathophysiological Mechanisms and Treatments?
   Marcelo M. S. Lima, Adriano Targa, Ana Carolina D. Noseda, Laís Soares Rodrigues, Ana Márcia Delattre, Fabiola Vila dos Santos, Mariana Fortes, Maira J. Maturana, Anete Curte Ferraz · 2014 · CNS & Neurological Disorders - Drug Targets
9. Mechanisms of anti-inflammatory property of Anacardium occidentale stem bark: Inhibition of NF-κB and MAPK signalling in the microglia
   Olumayokun A. Olajide, Mutalib Adeniran Aderogba, Bernd L. Fiebich · 2012 · Journal of Ethnopharmacology
10. Modulation of BV-2 microglia functions by novel quercetin pivaloyl ester
    Nataša Mrvová, Martin Škandík, Marcela Kuniaková, Lucia Račková · 2015 · Neurochemistry International
11. Peiminine Protects Dopaminergic Neurons from Inflammation-Induced Cell Death by Inhibiting the ERK1/2 and NF-κB Signalling Pathways
    Guangxin Chen, Juxiong Liu, Liqiang Jiang, Xin Ran, Dewei He, Yuhang Li, Bingxu Huang, Wei Wang, Dianfeng Liu, Shoupeng Fu · 2018 · International Journal of Molecular Sciences
12. Effect of Luteolin and Apigenin on the Production of Il-31 and Il-33 in Lipopolysaccharides-Activated Microglia Cells and Their Mechanism of Action
    Denis Nchang Che, Byoung Ok Cho, Jisu Kim, Jae Young Shin, Hyun Ju Kang, Seon Il Jang · 2020 · Nutrients
13. Antioxidant and Anti-Inflammatory Profiles of Spent Coffee Ground Extracts for the Treatment of Neurodegeneration
    Angeloni, Simone, Freschi, Michela, Marrazzo, Pasquale, Hrelia, Silvana, Beghelli, Daniela, Juan-García, Ana, Juan, Cristina, Caprioli, Giovanni, Sagratini, Gianni, Angeloni, Cristina · 2021 · Oxidative Medicine and Cellular Longevity
14. Impact of Cocoa Consumption on Inflammation Processes—A Critical Review of Randomized Controlled Trials
    Sabine Ellinger, Peter Stehle · 2016 · Nutrients
15. Spatial Memory and Microglia Activation in a Mouse Model of Chronic Neuroinflammation and the Anti-inflammatory Effects of Apigenin
    Rose Chesworth, Rashmi Vasundhara Gamage, Faheem Ullah, Sandra Sonego, Christopher Millington, Amanda M. Fernandez, Huazheng Liang, Tim Karl, Gerald W Münch, Garry Niedermayer et al. · 2021 · Frontiers in Neuroscience
16. The Neuroprotective Effects and Therapeutic Potential of the Chalcone Cardamonin for Alzheimer’s Disease
    Kimberly Barber, Patricia Mendonca, Karam F. A. Soliman · 2023 · Brain Sciences
17. Cortical-blood vessel assembloids exhibit Alzheimer’s disease phenotypes by activating glia after SARS-CoV-2 infection
    Dasom Kong, Ki Hoon Park, Da‐Hyun Kim, Nam Gyo Kim, Seung‐Eun Lee, Nari Shin, Myung Geun Kook, Young Bong Kim, Kyung‐Sun Kang · 2023 · Cell Death Discovery
18. Antioxidant and Antineuroinflammatory Mechanisms of Kaempferol-3- O -β- d -Glucuronate on Lipopolysaccharide-Stimulated BV2 Microglial Cells through the Nrf2/HO-1 Signaling Cascade and MAPK/NF-κB Pathway
    Hyun Jung Lim, Ritu Prajapati, Su Hui Seong, Hyun Ah Jung, Jae Sue Choi · 2023 · ACS Omega
19. Anti-inflammatory properties of Honokiol in activated primary microglia and astrocytes
    Uta Rickert, François Cossais, Marvin Heimke, Philipp Arnold, Andrea Preuße-Prange, Henrik Wilms, Ralph Lucius · 2018 · Journal of Neuroimmunology
20. Food, pain, and drugs: Does it matter what pain patients eat?
    Rae Frances Bell, Jasenka Borzan, Eija Anneli Kalso, Guy Simonnet · 2012 · Pain
21. Anthocyanin effects on microglia M1/M2 phenotype: Consequence on neuronal fractalkine expression
    Manuela Meireles, Cláudia Marques, Sónia Norberto, Paulo F. Santos, Iva Fernandes, Nuno Filipe da Cruz Batista Mateus, Ana Faria, Conceição Calhau · 2016 · Behavioural Brain Research
22. Beneficial effects of white wine polyphenols-enriched diet on Alzheimer’s disease-like pathology
    Daniela Mendes, Maria Manuel Oliveira, Paula Isabel Moreira, J. Coutinho, Fernando M. Nunes, David M. Pereira, Patrı́cia Valentão, Paula B. Andrade, Romeu António Videira · 2018 · The Journal of Nutritional Biochemistry
23. Amelioration of intracellular stress and reduction of neural tube defects in embryos of diabetic mice by phytochemical quercetin
    Lixue Cao, Chengyu Tan, Fantong Meng, Peiyan Liu, E. Albert Reece, Zhiyong Zhao · 2016 · Scientific Reports
24. Enhancing the Cognitive Effects of Flavonoids With Physical Activity: Is There a Case for the Gut Microbiome?
    Carol L. Cheatham, David Christopher Nieman, Andrew Peter Neilson, Mary Ann Lila · 2022 · Frontiers in Neuroscience
25. Feeding the beast: Can microglia in the senescent brain be regulated by diet?
    Rodney W. Johnson · 2014 · Brain Behavior and Immunity
26. Amburana cearensis: Pharmacological and Neuroprotective Effects of Its Compounds
    Juliana Helena Castro e Silva, Rafael Short Ferreira, Érica Patrícia Lima Pereira, Suzana Braga‐de‐Souza, Monique Marylin Alves de Almeida, Cleonice Creusa dos Santos, Arthur Morgan Butt, Elisabetta Caiazzo, Raffaele Capasso, Víctor Diógenes Amaral da Silva et al. · 2020 · Molecules
27. The impact of chronic blackberry intake on the neuroinflammatory status of rats fed a standard or high-fat diet
    Manuela Meireles, Cláudia Marques, Sónia Norberto, Iva Fernandes, Nuno Filipe da Cruz Batista Mateus, Catarina Rendeiro, Jeremy P.E. Spencer, Ana Faria, Conceição Calhau · 2015 · The Journal of Nutritional Biochemistry
28. Protective effect of naringin on 3-nitropropionic acid-induced neurodegeneration through the modulation of matrix metalloproteinases and glial fibrillary acidic protein
    Kulasekaran Gopinath, Ganapasam Sudhandiran · 2015 · Canadian Journal of Physiology and Pharmacology
29. Quercetin attenuates AZT-induced neuroinflammation in the CNS
    Yi Yang, Xiaokang Liu, Ting Wu, Wenping Zhang, Jianhong Shu, Yulong He, Shao‐Jun Tang · 2018 · Scientific Reports
30. A Dietary Mixture of Oxysterols Induces In Vitro Intestinal Inflammation through TLR2/4 Activation: The Protective Effect of Cocoa Bean Shells
    Daniela Rossin, Letricia Barbosa‐Pereira, Noemi Iaia, Gabriella Testa, Barbara Sottero, Giuseppe Poli, Giuseppe Zeppa, Fiorella Biasi · 2019 · Antioxidants
31. The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis
    Achraf Ammar, Khaled Trabelsi, Patrick Müller, Bassem Bouaziz, Omar F. Boukhris, Jordan M. Glenn, Nick Bott, Tarak Driss, Hamdi Chtourou, Notger G. Müller et al. · 2020 · Journal of Clinical Medicine
32. Genetic Imaging of Neuroinflammation in Parkinson’s Disease: Recent Advancements
    Longping Yao, Jiayu Wu, Sümeyye Koç, Guohui Lu · 2021 · Frontiers in Cell and Developmental Biology
33. Structural evidence of quercetin multi-target bioactivity: A reverse virtual screening strategy
    Diego B. Carvalho, Margot Paulino, Fabio Polticelli, Florencia Arredondo, Robert J. Williams, Juan Andrés Abin‐Carriquiry · 2017 · European Journal of Pharmaceutical Sciences
34. Astilbin decreases proliferation and improves differentiation in HaCaT keratinocytes
    Chunhong Zhang, Qingqing Xu, Xi Tan, Liya Meng, Wei Guo, Ying Liu, Chunmin Zhang · 2017 · Biomedicine & Pharmacotherapy
35. Protective effects of chronic treatment with a standardized extract of Ginkgo biloba L. in the prefrontal cortex and dorsal hippocampus of middle-aged rats
    Marcelo Lima Ribeiro, Luciana M. Moreira, Demétrius Paiva Arçari, Letícia França dos Santos, Antônio Cezar Marques, José Pedrazzoli, Suzete Maria Cerutti · 2016 · Behavioural Brain Research
36. A Comprehensive Review on Anti-Inflammatory Response of Flavonoids in Experimentally-Induced Epileptic Seizures
    Shyam Sunder Rabidas, Chandra Prakāsh, Jyoti Tyagi, Jyoti Suryavanshi, Pavan Kumar, Jaydeep Bhattacharya, Deepak Sharma · 2023 · Brain Sciences
37. Neuroprotective Effects of Selected Microbial-Derived Phenolic Metabolites and Aroma Compounds from Wine in Human SH-SY5Y Neuroblastoma Cells and Their Putative Mechanisms of Action
    Adelaida Esteban‐Fernández, Catarina Rendeiro, Jeremy P. E. Spencer, D. Gigorro del Coso, Dolores González de Llano, Begoña Bartolomé, María Victoria Moreno-Arribas · 2017 · Frontiers in Nutrition
38. Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint
    Md. Fahim Faysal, Jishan Khan, Mehrukh Zehravi, Nikhil Nath, Laliteshwar Pratap Singh, Saloni Kakkar, Rajashekar Perusomula, Pathan Amanulla Khan, Firzan Nainu, Mohammed Asiri et al. · 2023 · Chinese Medicine
39. Improving the Efficacy of Plant Polyphenols
    Lucia Biasutto, Andrea Mattarei, Nicola Sassi A, Michele Azzolini, Matteo Romio, Cristina Paradisi, Mario Zoratti · 2014 · Anti-Cancer Agents in Medicinal Chemistry
40. Attenuation of Morphine Withdrawal Syndrome by Prosopis Farcta Extract and Its Bioactive Component Luteolin in Comparison with Clonidine in Rats
    Ardeshir Moayeri, Maryam Azimi, Elahe Karimi, Ali Aidy, Naser Abbasi · 2018 · Medical science monitor basic research/Medical science monitor. Basic research
41. Anti-Inflammatory and Anti-Nociceptive Effects of Cocoa: A Review on Future Perspectives in Treatment of Pain
    Martina De Feo, Antonella Paladini, Claudio Ferri, Augusto Carducci, Rita Del Pinto, Giustino Varrassi, Davide Grassi · 2020 · Pain and Therapy
42. Sutherlandia frutescens Ethanol Extracts Inhibit Oxidative Stress and Inflammatory Responses in Neurons and Microglial Cells
    Jinghua Jiang, Dennis Y. Chuang, Yijia Zong, Jayleenkumar Patel, Korey J. Brownstein, Wei Lei, Chi‐Hua Lu, Ágnes Simonyi, Zezong Gu, Jiankun Cui et al. · 2014 · PLoS ONE
43. Astilbin alleviates sepsis-induced acute lung injury by inhibiting the expression of macrophage inhibitory factor in rats
    Hongbo Zhang, Li-chao Sun, Li-Da Zhi, Qian-Kuan Wen, Zhiwei Qi, Shengtao Yan, Wen Li, Guoqiang Zhang · 2017 · Archives of Pharmacal Research
44. Eruca sativa seed extract: A novel natural product able to counteract neuroinflammation
    Agnese Gugliandolo, Sabrina Giacoppo, Marcello Ficicchia, Angelo Aliquï¿ ⁄, Placido Bramanti, Emanuela Mazzon · 2018 · Molecular Medicine Reports
45. Beta-naphthoflavone inhibits LPS-induced inflammation in BV-2 cells via AKT/Nrf-2/HO-1-NF-κB signaling axis
    Xiyu Gao, Dewei He, Dianfeng Liu, Guiqiu Hu, Yufei Zhang, Tianyu Meng, Yingchun Su, Ang Zhou, Bingxu Huang, Jian Du et al. · 2020 · Immunobiology
46. The Role of Natural Compounds and their Nanocarriers in the Treatment of CNS Inflammation
    Bikram Khadka, Jae‐Young Lee, Dong Ho Park, Ki-Taek Kim, Jong‐Sup Bae · 2020 · Biomolecules
47. Nonpharmacological Modulation of Chronic Inflammation in Parkinson’s Disease: Role of Diet Interventions
    Stefania Kalampokini, Anouck Becker, Klaus C Fassbender, Epameinondas Lyros, Marcus Michael Unger · 2019 · Parkinson s Disease
48. Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke
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49. Volatile anesthetics-induced neuroinflammatory and anti-inflammatory responses
    Franziska Elisabeth Blum, Zhiyi Zuo · 2013 · Medical Gas Research
50. Regulation of NF-Κb Activity in Astrocytes: Effects of Flavonoids at Dietary-Relevant Concentrations
    Spilsbury, Alison, Vauzour, David, Spencer, Jeremy P.E., Rattray, Marcus · 2012 · Biochemical and Biophysical Research Communications
51. Anti-Neuroinflammatory Agents for the Treatment of Alzheimer’s Disease
    Wei Zhou, Wenhui Hu · 2013 · Future Medicinal Chemistry
52. Antioxidative, anti-inflammatory potentials and phytochemical profile of Commiphora africana (A. Rich.) Engl. (Burseraceae) and Loeseneriella africana (Willd.) (Celastraceae) stem leaves extracts
    Moussa Compaoré, Roland Nâg-Tiéro Meda, Bakasso Sahabi, Laurian Vlase, Martin Kiendrébeogo · 2016 · Asian Pacific Journal of Tropical Biomedicine
53. Chrysin Is Immunomodulatory and Anti-Inflammatory against Complete Freund’s Adjuvant-Induced Arthritis in a Pre-Clinical Rodent Model
    Muhammad Asif Faheem, Tasleem Akhtar, Nadia Naseem, Usman Aftab, Muhammad Shoaib Zafar, Safdar Hussain, Muhammad Shahzad, Glenda Carolyn Gobe · 2023 · Pharmaceutics
54. Flavonol Intake and Cognitive Decline in Middle-Aged Adults
    Martin M. Root, Erin Ravine, Anne Harper · 2015 · Journal of Medicinal Food
55. Flavonoids in the Treatment of Neuropathic Pain
    Prashant N. Rao, Ojas Mainkar, Nitin Bansal, Neal Rakesh, Paul Ryan Haffey, Ivan Urits, Vwaire Orhurhu, Alan D. Kaye, Richard D. Urman, Amitabh Gulati et al. · 2021 · Current Pain and Headache Reports
56. Flavonoids and Alzheimer’s disease: reviewing the evidence for neuroprotective potential
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57. Astaxanthin and Canthaxanthin (Xanthophyll) as Supplements in Rainbow Trout Diet: In Vivo Assessment of Residual Levels and Contributions to Human Health
    Paola Brizio, Alessandro Benedetto, Marzia Righetti, Marino Prearo, Laura Gasco, Stefania Squadrone, Maria Cesarina Abete · 2013 · Journal of Agricultural and Food Chemistry
58. Cognitive Enhancers (Nootropics). Part 3: Drugs Interacting with Targets other than Receptors or Enzymes. Disease-modifying Drugs
    Wolfgang Froestl, Andrea Pfeifer, Andreas Muhs · 2013 · Journal of Alzheimer s Disease
59. Astragalosides from Radix Astragali benefits experimental autoimmune encephalomyelitis in C57BL /6 mice at multiple levels
    Yixin He, Min Du, Hailian Shi, Fei Huang, Hongshuai Liu, Hui Wu, Beibei Zhang, Wei Dou, Xiaojun Wu, Zhengtao Wang · 2014 · BMC Complementary and Alternative Medicine
60. Flavonoids isolated from Lespedeza cuneata G. Don and their inhibitory effects on nitric oxide production in lipopolysaccharide-stimulated BV - 2 microglia cells
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61. TDP-43 maintains chondrocyte homeostasis and alleviates cartilage degradation in osteoarthritis
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62. Absorption, metabolism, and excretion of fermented orange juice (poly)phenols in rats
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63. Possible neuromodulating role of different grape (Vitis vinifera L.) derived polyphenols against Alzheimer’s dementia: treatment and mechanisms
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64. Flavonoids as positive allosteric modulators of α7 nicotinic receptors
    Beatriz Elizabeth Nielsen, Isabel Bermúdez, Cecilia Bouzat · 2019 · Neuropharmacology
65. Flavonoids Isolated from Vitex grandifolia, an Underutilized Vegetable, Exert Monoamine A & B Inhibitory and Anti-inflammatory Effects and Their Structure-activity Relationship
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66. Evaluation of Anti-inflammatory Nutraceuticals in LPS-induced Mouse Neuroinflammation Model: An Update
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67. Targeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer’s Disease
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68. A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia
    Joseph A. Lutz, Mukul Kulshrestha, Dennis Trent Rogers, John Martin Littleton · 2014 · Fitoterapia
69. Apigenin from Croton betulaster Müll restores the immune profile of microglia against glioma cells
    Paulo Lucas Cerqueira Coelho, Jéssika Alves Oliveira Amparo, Alessandra B. da Silva, Karina C. da Silva, Suzana Braga‐de‐Souza, Pedro Rocha Barbosa, Giselle Pinto de Faria Lopes, Sílvia Lima Costa · 2019 · Phytotherapy Research
70. Oxidative Stress in DNA Damage and Neurodegenerative Diseases: Unveiling The Mechanisms and Therapeutic Opportunities
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71. Effects of Anthocyanin Supplementation on Serum Lipids, Glucose, Markers of Inflammation and Cognition in Adults With Increased Risk of Dementia – A Pilot Study
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72. Biological evaluation of synthetic chalcone and flavone derivatives as anti-inflammatory agents
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73. Amazon-derived nutraceuticals: Promises to mitigate chronic inflammatory states and neuroinflammation
    Charles Elias Assmann, Grazielle Castagna Cezimbra Weis, Jéssica Righi da Rosa, Beatriz da Silva Rosa Bonadiman, Audrei de Oliveira Alves, Maria Rosa Chitolina Schetinger, Euler Esteves Ribeiro, Vera Maria Morsch, Ivana Beatrice Mânica da Cruz · 2021 · Neurochemistry International
74. (Poly)phenols and brain health – beyond their antioxidant capacity
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75. Potential effect of herbal antidepressants on cognitive deficit: Pharmacological activity and possible molecular mechanism
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76. Ficus deltoidea: Potential inhibitor of pro-inflammatory mediators in lipopolysaccharide-induced activation of microglial cells
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77. Anthocyanin-rich fruits and mental health outcomes in an Italian cohort
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78. Biological and therapeutic role of LSD1 in Alzheimer’s diseases
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79. Inclusion of cocoa as a dietary supplement represses expression of inflammatory proteins in spinal trigeminal nucleus in response to chronic trigeminal nerve stimulation
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80. Pelargonidin Improves Passive Avoidance Task Performance in a Rat Amyloid Beta25-35 Model of Alzheimer's Disease Via Estrogen Receptor Independent Pathways.
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81. Spirulina platensis Suppressed iNOS and Proinflammatory Cytokines in Lipopolysaccharide-Induced BV2 Microglia
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82. Dietary flavonoids in health and diseases: A concise review of their role in homeostasis and therapeutics
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83. Flavonoids, the Family of Plant-Derived Antioxidants Making Inroads into Novel Therapeutic Design Against Ionizing Radiation-Induced Oxidative Stress in Parkinson’s Disease
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84. De Novo Generation and Identification of Novel Compounds with Drug Efficacy Based on Machine Learning
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85. Neuroprotective Efficacy of Apple Cider Vinegar on Zinc-High Fat Diet-Induced Mono Amine Oxidase Alteration in Murine Model of AD
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86. Effects of Catalpol on Alzheimer’s Disease and Its Mechanisms
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87. Determining the chemical profile of Caragana jubata (Pall.) Poir. by UPLC–QTOF–MS analysis and evaluating its anti-ischemic stroke effects
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88. Mild Inflammatory Profile without Gliosis in the c-Rel Deficient Mouse Modeling a Late-Onset Parkinsonism
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89. The Impact of Gastrointestinal Modifications, Blood-Brain Barrier Transport, and Intracellular Metabolism on Polyphenol Bioavailability
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90. Oro‐facial pain and nutrition: a forgotten relationship?
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91. The critical role of calcineurin/NFAT (C/N) pathways and effective antitumor prospect for colorectal cancers
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92. A Major Diplotaxis harra-Derived Bioflavonoid Glycoside as a Protective Agent against Chemically Induced Neurotoxicity and Parkinson’s Models; In Silico Target Prediction; and Biphasic HPTLC-Based Quantification
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93. Flavonoids as Promising Multitarget Agents in Alzheimer’s Disease Therapy
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94. Supercritical CO2-Based Extraction and Detection of Phenolic Compounds and Saponins from the Leaves of Three Medicago varia Mart. Varieties by Tandem Mass Spectrometry
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95. Behavioural effects of compounds co-consumed in dietary forms of caffeinated plants
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96. Attenuation of spatial memory in 5xFAD mice by targeting cholinesterases, oxidative stress and inflammatory signaling using 2-(hydroxyl-(2-nitrophenyl)methyl)cyclopentanone
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97. Flavonoids
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98. Bidirectional Responses of Eight Neuroinflammation-Related Transcriptional Factors to 64 Flavonoids in Astrocytes with Transposable Insulated Signaling Pathway Reporters
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99. Unlocking the Nutritional Power of Vegetables: A Guide to Vibrant Health
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100. Arabidopsis thaliana extracts optimized for polyphenols production as potential therapeutics for the APOE-modulated neuroinflammation characteristic of Alzheimer’s disease in vitro
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