Antioxidant and Anti-Inflammatory Profiles of Spent Coffee Ground Extracts for the Treatment of Neurodegeneration

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Mosmann, T. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90303-4 · Cited by 56,104 · see citing works

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631 · see citing works

Mechanisms underlying inflammation in neurodegeneration

Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580 · see citing works

Nrf2–Keap1 defines a physiologically important stress response mechanism

Motohashi, H., & Yamamoto, M. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.09.003 · Cited by 1,725 · see citing works

The Shikimate Pathway and Aromatic Amino Acid Biosynthesis in Plants

Maeda, H. A., & Dudareva, N. (2012) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042811-105439 · Cited by 1,568 · see citing works

Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism

Block, M. L., & Hong, J.-S. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.004 · Cited by 1,557 · see citing works

THE SHIKIMATE PATHWAY

Herrmann, K. M., & Weaver, L. M. (1999) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.50.1.473 · Cited by 1,343 · see citing works

The Role of Polyphenols in Human Health and Food Systems: A Mini-Review

Cory, H., Passarelli, S., Szeto, J., Tamez, M., & Mattei, J. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00087 · Cited by 1,297 · see citing works

Sustainable management of coffee industry by-products and value addition—a review

Murthy, P. S., & Madhava Naidu, M. (2012) · Resources, Conservation and Recycling · doi:10.1016/j.resconrec.2012.06.005 · Cited by 1,055 · see citing works

Production, Composition, and Application of Coffee and Its Industrial Residues

Mussatto, S. I., Machado, E. M. S., Martins, S., & Teixeira, J. A. (2011) · Food and Bioprocess Technology · doi:10.1007/s11947-011-0565-z · Cited by 1,048 · see citing works

Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications

Liu, Z., Zhou, T., Ziegler, A. C., Dimitrion, P., & Zuo, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2525967 · Cited by 810 · see citing works

Does neuroinflammation fan the flame in neurodegenerative diseases?

Frank-Cannon, T. C., Alto, L. T., McAlpine, F. E., & Tansey, M. G. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-47 · Cited by 751 · see citing works

Spent coffee grounds: A review on current research and future prospects

Campos-Vega, R., Loarca-Piña, G., Vergara-Castañeda, H. A., & Oomah, B. D. (2015) · Trends in Food Science &amp; Technology · doi:10.1016/j.tifs.2015.04.012 · Cited by 679 · see citing works

Direct and indirect antioxidant properties of inducers of cytoprotective proteins

Dinkova‐Kostova, A. T., & Talalay, P. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700195 · Cited by 535 · see citing works

Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches

Morales, I., Guzmán-Martínez, L., Cerda-Troncoso, C., Farías, G. A., & Maccioni, R. B. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00112 · Cited by 490 · see citing works

Extraction of antioxidant phenolic compounds from spent coffee grounds

Mussatto, S. I., Ballesteros, L. F., Martins, S., & Teixeira, J. A. (2011) · Separation and Purification Technology · doi:10.1016/j.seppur.2011.09.036 · Cited by 441 · see citing works

Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases

Bartels, T., De Schepper, S., & Hong, S. (2020) · Science · doi:10.1126/science.abb8587 · Cited by 412 · see citing works

Development and validation of ultrasound-assisted solid-liquid extraction of phenolic compounds from waste spent coffee grounds

Al-Dhabi, N. A., Karuppiah, P., & Jeganathan, P. M. (2016) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2016.05.005 · Cited by 356 · see citing works

Mitochondrial biogenesis in neurodegeneration

Li, P. A., Hou, X., & Hao, S. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24042 · Cited by 353 · see citing works

Immune Signaling in Neurodegeneration

Hammond, T. R., Marsh, S. E., & Stevens, B. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.016 · Cited by 336 · see citing works

Spent coffee grounds: A review on current utilization

McNutt, J., & He, Q. S. (2018) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2018.11.054 · Cited by 318 · see citing works

Neuroinflammation: Modulation by flavonoids and mechanisms of action

Spencer, J. P. E., Vafeiadou, K., Williams, R. J., & Vauzour, D. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.016 · Cited by 315 · see citing works

Sulforaphane as a Potential Protective Phytochemical against Neurodegenerative Diseases

Tarozzi, A., Angeloni, C., Malaguti, M., Morroni, F., Hrelia, S., & Hrelia, P. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/415078 · Cited by 286 · see citing works

The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials

Pohl, F., & Lin, P. K. T. (2018) · Molecules · doi:10.3390/molecules23123283 · Cited by 281 · see citing works

Valorization of spent coffee grounds: A review

Kovalcik, A., Obruca, S., & Marova, I. (2018) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2018.05.002 · Cited by 277 · see citing works

Spent coffee grounds as a valuable source of phenolic compounds and bioenergy

Zuorro, A., & Lavecchia, R. (2012) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2011.12.003 · Cited by 261 · see citing works

Oxidative Stress and Proinflammatory Cytokines Contribute to Demyelination and Axonal Damage in a Cerebellar Culture Model of Neuroinflammation

di Penta, A., Moreno, B., Reix, S., Fernández-Díez, B., Villanueva, M., Errea, O., Escala, N., Vandenbroeck, K., Comella, J. X., & Villoslada, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054722 · Cited by 258 · see citing works

Supercritical fluid extraction from spent coffee grounds and coffee husks: Antioxidant activity and effect of operational variables on extract composition

Andrade, K. S., Gonçalvez, R. T., Maraschin, M., Ribeiro‐do‐Valle, R. M., Martínez, J., & Ferreira, S. R. S. (2011) · Talanta · doi:10.1016/j.talanta.2011.11.031 · Cited by 249 · see citing works

Melatonin Stimulates the SIRT 1/Nrf2 Signaling Pathway Counteracting Lipopolysaccharide ( LPS )‐Induced Oxidative Stress to Rescue Postnatal Rat Brain

Shah, S. A., Khan, M., Jo, M. H., Jo, M. G., Amin, F. U., & Kim, M. O. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12588 · Cited by 242 · see citing works

Monoamine oxidase inhibitors: Promising therapeutic agents for Alzheimer’s disease (Review)

Cai, Z. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2040 · Cited by 216 · see citing works

NF-κB-Mediated Neuroinflammation in Parkinson’s Disease and Potential Therapeutic Effect of Polyphenols

Singh, S. S., Nand, S., Birla, H., Zahra, W., Singh, S. P., & Singh, S. P. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-00147-2 · Cited by 215 · see citing works

Gastrodin Inhibits Expression of Inducible NO Synthase, Cyclooxygenase-2 and Proinflammatory Cytokines in Cultured LPS-Stimulated Microglia via MAPK Pathways

Dai, J.-N., Zong, Y., Zhong, L., Li, Y., Zhang, W., Bian, L., Ai, Q., Liu, Y., Sun, J., & Lü, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021891 · Cited by 213 · see citing works

Espresso Coffee Residues: A Valuable Source of Unextracted Compounds

Cruz, R., Cardoso, M. M., Fernandes, L., Oliveira, M., Mendes, E., Baptista, P. C., Morais, S., & Casal, S. I. P. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf3018854 · Cited by 206 · see citing works

Characterization of polysaccharides extracted from spent coffee grounds by alkali pretreatment

Ballesteros, L. F., Cerqueira, M. Â., Teixeira, J. A., & Mussatto, S. I. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.03.047 · Cited by 199 · see citing works

Sequential co-production of biodiesel and bioethanol with spent coffee grounds

Kwon, E. E., Yi, H., & Jeon, Y. J. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.03.052 · Cited by 199 · see citing works

Neu1 desialylation of sialyl α-2,3-linked β-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling

Amith, S. R., Jayanth, P., Franchuk, S. L., Finlay, T. M., Seyrantepe, V., Beyaert, R., Pshezhetsky, A. V., & Szewczuk, M. R. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.09.038 · Cited by 194 · see citing works

Coffee silverskin extracts: Quantification of 30 bioactive compounds by a new HPLC-MS/MS method and evaluation of their antioxidant and antibacterial activities

Nzekoue, F. K., Angeloni, S., Navarini, L., Angeloni, C., Freschi, M., Hrelia, S., Vitali, L. A., Sagratini, G., Vittori, S., & Caprioli, G. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109128 · Cited by 165 · see citing works

Influence of extraction process on antioxidant capacity of spent coffee

Bravo, J., Monente, C., Juániz, I., Peña, M.-P. D., & Cid, C. (2011) · Food Research International · doi:10.1016/j.foodres.2011.04.026 · Cited by 164 · see citing works

Nuclear factor‐kappa β as a therapeutic target for Alzheimer's disease

Jha, N. K., Jha, S. K., Kar, R., Nand, P., Swati, K., & Goswami, V. K. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14687 · Cited by 160 · see citing works

Neuroinflammation as a Factor of Neurodegenerative Disease: Thalidomide Analogs as Treatments

Jung, Y. J., Tweedie, D., Scerba, M. T., & Greig, N. H. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00313 · Cited by 154 · see citing works

Signal transduction and epigenetic mechanisms in the control of microglia activation during neuroinflammation

Kaminska, B., Mota, M., & Pizzi, M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.10.026 · Cited by 153 · see citing works

Evaluation of Spent Coffee Obtained from the Most Common Coffeemakers as a Source of Hydrophilic Bioactive Compounds

Bravo, J., Juániz, I., Monente, C., Cämmerer, B., Kroh, L. W., Peña, M.-P. D., & Cid, C. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf3040594 · Cited by 149 · see citing works

Neuroinflammatory responses in Alzheimer’s disease

Dansokho, C., & Heneka, M. T. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1831-7 · Cited by 143 · see citing works

Antioxidant capacities and total phenolic contents of 30 flowers

Chen, G., Chen, S.-G., Xiao, Y., & Fu, N. (2017) · Industrial Crops and Products · doi:10.1016/j.indcrop.2017.10.051 · Cited by 142 · see citing works

Nutraceutical polyphenols: New analytical challenges and opportunities

Piccolella, S., Crescente, G., Candela, L., & Pacifico, S. (2019) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2019.07.022 · Cited by 142 · see citing works

Chemical Composition, Antioxidant and Enzyme Inhibitory Properties of Different Extracts Obtained from Spent Coffee Ground and Coffee Silverskin

Zengin, G., Sinan, K. I., Mahomoodally, M. F., Angeloni, S., Mustafa, A. M., Vittori, S., Maggi, F., & Caprioli, G. (2020) · Foods · doi:10.3390/foods9060713 · Cited by 122 · see citing works

Coffee By-Products and Their Suitability for Developing Active Food Packaging Materials

Oliveira, G., Passos, C. P., Ferreira, P., Coimbra, M. A., & Gonçalves, I. (2021) · Foods · doi:10.3390/foods10030683 · Cited by 120 · see citing works

Seasonal Variation in Total Phenolic and Flavonoid Contents and DPPH Scavenging Activity of Bellis perennis L. Flowers

Siatka, T., & Kašparová, M. (2010) · Molecules · doi:10.3390/molecules15129450 · Cited by 113 · see citing works

Monoamine oxidase inhibitors, and iron chelators in depressive illness and neurodegenerative diseases

Youdim, M. B. H. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1942-9 · Cited by 113 · see citing works

Intermittent increases in cytosolic Ca2+ stimulate mitochondrial biogenesis in muscle cells.

Ojuka, E., Jones, T. E., Han, D.-H., Chen, M. M., Wamhoff, B., Sturek, M., & Holloszy, J. (2002) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00242.2002 · Cited by 112 · see citing works

Quinine conjugates and quinine analogues as potential antimalarial agents

Jones, R. A., Panda, S. S., & Hall, C. D. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.02.002 · Cited by 101 · see citing works

Evaluation of ultrasound assisted potassium permanganate pre-treatment of spent coffee waste

Ravindran, R., Jaiswal, S., Abu‐Ghannam, N., & Jaiswal, A. K. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.11.034 · Cited by 100 · see citing works

A convenient guide to help select replacement solvents for dichloromethane in chromatography

Taygerly, J. P., Miller, L. M., Yee, A., & Peterson, E. A. (2012) · Green Chemistry · doi:10.1039/c2gc36064k · Cited by 94 · see citing works

Assessment of Total (Free and Bound) Phenolic Compounds in Spent Coffee Extracts

Monente, C., Ludwig, I. A., Irigoyen, A., De Peña, M.-P., & Cid, C. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b01619 · Cited by 93 · see citing works

Neuroprotective Effect of Sulforaphane against Methylglyoxal Cytotoxicity

Angeloni, C., Malaguti, M., Rizzo, B., Barbalace, M. C., Fabbri, D., & Hrelia, S. (2015) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.5b00067 · Cited by 92 · see citing works

Development of an advanced integrative process to create valuable biosugars including manno-oligosaccharides and mannose from spent coffee grounds

Nguyễn, Q. A., Cho, E. J., Lee, D.-S., & Bae, H. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.10.018 · Cited by 88 · see citing works

In vitro health promoting properties of antioxidant dietary fiber extracted from spent coffee ( Coffee arabica L.) grounds

Vázquez-Sánchez, K., Martínez-Sáez, N., Rebollo‐Hernanz, M., del Castillo, M. D., Gaytán‐Martínez, M., & Campos-Vega, R. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.04.064 · Cited by 86 · see citing works

Environmental impacts of biodiesel production from waste spent coffee grounds and its implementation in a compression ignition engine

Kamil, M., Ramadan, K. M., Awad, O. I., Ibrahim, T. K., Inayat, A., & Ma, X. (2019) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.04.156 · Cited by 84 · see citing works

New trends in coffee diterpenes research from technological to health aspects

Moeenfard, M., & Alves, A. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109207 · Cited by 82 · see citing works

Central role of nitric oxide synthase in AICAR and caffeine-induced mitochondrial biogenesis in L6 myocytes

McConell, G. K., Ng, G. P. Y., Phillips, M., Ruan, Z., Macaulay, S. L., & Wadley, G. D. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00377.2009 · Cited by 80 · see citing works

Circular reutilization of coffee waste for sound absorbing panels: A perspective on material recycling

Yun, B. Y., Cho, H., Kim, Y. U., Lee, S. C., Berardi, U., & Kim, S. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109281 · Cited by 72 · see citing works

Wet in situ transesterification of spent coffee grounds with supercritical methanol for the production of biodiesel

Son, J., Kim, B., Park, J., Yang, J., & Lee, J. W. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.03.067 · Cited by 70 · see citing works

Extraction of lipids from spent coffee grounds with non-polar renewable solvents as alternative

Loyao, A. S., Villasica, S. L. G., Peña, P. L. L. D., & Go, A. W. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2018.04.017 · Cited by 68 · see citing works

Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells

Yang, B., Li, R., Greenlief, C. M., Fritsche, K. L., Gu, Z., Cui, J., Lee, J. C., Beversdorf, D. Q., & Sun, G. Y. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1232-3 · Cited by 67 · see citing works

Improving the recovery of phenolic compounds from spent coffee grounds by using hydrothermal delignification coupled with ultrasound assisted extraction

Arauzo, P. J., Lucian, M., Du, L., Olszewski, M. P., Fiori, L., & Kruse, A. (2020) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2020.105616 · Cited by 66 · see citing works

Comparative HPLC/ESI-MS and HPLC/DAD study of different populations of cultivated, wild and commercial Gentiana lutea L.

Mustafa, A. M., Caprioli, G., Ricciutelli, M., Maggi, F., Marín, R., Vittori, S., & Sagratini, G. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.11.089 · Cited by 63 · see citing works

An analytical method for the simultaneous quantification of 30 bioactive compounds in spent coffee ground by HPLC‐MS/MS

Angeloni, S., Nzekoue, F. K., Navarini, L., Sagratini, G., Torregiani, E., Vittori, S., & Caprioli, G. (2020) · Journal of Mass Spectrometry · doi:10.1002/jms.4519 · Cited by 62 · see citing works

Antioxidant and genoprotective effects of spent coffee extracts in human cells

Bravo, J., Arbillaga, L., Peña, M.-P. D., & Cid, C. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.08.002 · Cited by 58 · see citing works

Eriodictyol alleviates lipopolysaccharide‐triggered oxidative stress and synaptic dysfunctions in BV‐2 microglial cells and mouse brain

He, P., Yan, S., Wen, X., Zhang, S., Liu, Z., Liu, X., & Xiao, C. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28736 · Cited by 55 · see citing works

Extraction, Characterization and Bioactivity of Coffee Anthocyanins

Pushpa, S. M., Manjunatha, M. R., Sulochanamma, G., & Naidu, M. M. (2012) · CFTRI Institutional Repository · Cited by 54 · see citing works

A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress

Giusti, L., Angeloni, C., Barbalace, M. C., Lacerenza, S., Ciregia, F., Ronci, M., Urbani, A., Manera, C., Digiacomo, M., Macchia, M., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082329 · Cited by 53 · see citing works

Characterization of Odor-Active Compounds, Polyphenols, and Fatty Acids in Coffee Silverskin

Angeloni, S., Scortichini, S., Fiorini, D., Sagratini, G., Vittori, S., Neiens, S. D., Steinhaus, M., Zheljazkov, V. D., Maggi, F., & Caprioli, G. (2020) · Molecules · doi:10.3390/molecules25132993 · Cited by 50 · see citing works

Isogentisin—A novel compound for the prevention of smoking-caused endothelial injury

Schmieder, A., Schwaiger, S., Csordás, A., Backović, A., Meßner, B., Wick, G., Stuppner, H., & Bernhard, D. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.10.019 · Cited by 43 · see citing works

Role of quercetin in modulating rat cardiomyocyte gene expression profile

Angeloni, C., Leoncini, E., Malaguti, M., Angelini, S., Hrelia, P., & Hrelia, S. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01091.2007 · Cited by 41 · see citing works

Combined Treatment with Three Natural Antioxidants Enhances Neuroprotection in a SH-SY5Y 3D Culture Model

Marrazzo, P., Angeloni, C., & Hrelia, S. (2019) · Antioxidants · doi:10.3390/antiox8100420 · Cited by 41 · see citing works

Evaluation of the Use of a Coffee Industry By-Product in a Cereal-Based Extruded Food Product

Beltrán-Medina, E. A., Guatemala-Morales, G. M., Padilla‐Camberos, E., Corona‐González, R. I., Mondragón-Cortez, P. M., & Arriola-Guevara, E. (2020) · Foods · doi:10.3390/foods9081008 · Cited by 40 · see citing works

Polar Constituents, Essential Oil and Antioxidant Activity of Marsh Woundwort (Stachys palustris L.)

Venditti, A., Frezza, C., Bianco, A., Serafini, M., Cianfaglione, K., Nagy, D. U., Iannarelli, R., Caprioli, G., & Maggi, F. (2016) · Chemistry & Biodiversity · doi:10.1002/cbdv.201600401 · Cited by 39 · see citing works

Optimization of the Extraction from Spent Coffee Grounds Using the Desirability Approach

Gigliobianco, M. R., Campisi, B., Peregrina, D. V., Censi, R., Khamitova, G., Angeloni, S., Caprioli, G., Zannotti, M., Ferraro, S., Giovannetti, R., et al. (2020) · Antioxidants · doi:10.3390/antiox9050370 · Cited by 39 · see citing works

Isoliquiritigenin Reduces LPS-Induced Inflammation by Preventing Mitochondrial Fission in BV-2 Microglial Cells

Lee, D. G., Nam, B. R., Huh, J., & Lee, D. (2020) · Inflammation · doi:10.1007/s10753-020-01370-2 · Cited by 36 · see citing works

Increasing the Sustainability of the Coffee Agro-Industry: Spent Coffee Grounds as a Source of New Beverages

Machado, E. M. S., Mussatto, S. I., Teixeira, J. A., Vilanova, M., & Oliveira, J. M. (2018) · Beverages · doi:10.3390/beverages4040105 · Cited by 35 · see citing works

Novel Targets of Sulforaphane in Primary Cardiomyocytes Identified by Proteomic Analysis

Angeloni, C., Turroni, S., Bianchi, L., Fabbri, D., Motori, E., Malaguti, M., Leoncini, E., Maraldi, T., Bini, L., Brigidi, P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083283 · Cited by 34 · see citing works

Dangguishaoyao-San attenuates LPS-induced neuroinflammation via the TLRs/NF-κB signaling pathway

Ding, R.-R., Chen, W., Guo, C.-Y., Liao, W.-T., Yang, X., Liao, F.-E., Lin, J.-M., Mei, H., & Zeng, Y. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.108 · Cited by 33 · see citing works

Inhibition of monoamine oxidase by isogentisin and its 3-0-glucoside

Osamu, S., Yoshinao, K., Masakazu, O., Chari, V. M., Klapfenberger, R., Wagner, H., & Hostettmann, K. (1978) · Biochemical Pharmacology · doi:10.1016/0006-2952(78)90072-2 · Cited by 31 · see citing works

Inhibition of Type A and Type B Monoamine Oxidase by Isogentisin and its 3-O-Glucoside

Suzuki, O., Katsumata, Y., Oya, M., Chari, V. M., Klapfenberger, R., Wagner, H., & Hostettmann, K. (1980) · Planta Medica · doi:10.1055/s-2008-1074899 · Cited by 26 · see citing works

Determination of gentisin, isogentisin, and amarogentin in Gentiana lutea L. by capillary electrophoresis

Citová, I., Ganzera, M., Stuppner, H., & Solich, P. (2007) · Journal of Separation Science · doi:10.1002/jssc.200700325 · Cited by 26 · see citing works

Metabolic effects of physiological levels of caffeine in myotubes

Schnuck, J., Gould, L. M., Parry, H. A., Johnson, M. A., Gannon, N. P., Sunderland, K., & Vaughan, R. (2017) · Journal of physiology and biochemistry · doi:10.1007/s13105-017-0601-1 · Cited by 25 · see citing works

Caffeine and Ca2+ stimulate mitochondrial oxidative phosphorylation in saponin-skinned human skeletal muscle fibers due to activation of actomyosin ATPase

Khuchua, Z. A., Belikova, Y., Kuznetsov, A. V., Gellerich, F. N., Schild, L., Neumann, H., & Kunz, W. S. (1994) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(94)90058-2 · Cited by 23 · see citing works

Physiological Implications of Microglia–Synapse Interactions

Wake, H., Horiuchi, H., Kato, D., Moorhouse, A. J., & Nabekura, J. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9658-2_6 · Cited by 15 · see citing works

Human Urinary Kallidinogenase Reduces Lipopolysaccharide-Induced Neuroinflammation and Oxidative Stress in BV-2 Cells

Zhao, Z., Xu, Z., Liu, T., Huang, S., Huang, H., & Huang, X. (2019) · Pain Research and Management · doi:10.1155/2019/6393150 · Cited by 9 · see citing works

Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation

Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works

Neuroprotective Effects of Agri-Food By-Products Rich in Phenolic Compounds

Rojas-García, A., Fernández‐Ochoa, Á., Cádiz‐Gurrea, M. D. L. L., Arraéz-Román, D., & Segura‐Carretero, A. (2023) · Nutrients · doi:10.3390/nu15020449 · Cited by 87 · see citing works

Coffee By-Products as Sustainable Novel Foods: Report of the 2nd International Electronic Conference on Foods—“Future Foods and Food Technologies for a Sustainable World”

Lachenmeier, D. W., Schwarz, S., Rieke-Zapp, J., Cantergiani, E., Rawel, H. M., Martin-Cabrejas, M. A., Martuscelli, M., Gottstein, V., & Angeloni, S. (2021) · Foods · doi:10.3390/foods11010003 · Cited by 50 · see citing works

Mechanisms Underlying Neurodegenerative Disorders and Potential Neuroprotective Activity of Agrifood By-Products

Angeloni, C., Malaguti, M., Prata, C., Freschi, M., Barbalace, M. C., & Hrelia, S. (2022) · Antioxidants · doi:10.3390/antiox12010094 · Cited by 52 · see citing works

Antifungal Activity of Spent Coffee Ground Extracts

Calheiros, D., Días, M. I., Calhelha, R. C., Barros, L., Ferreira, I. C. F. R., Fernandes, C., & Gonçalves, T. (2023) · Microorganisms · doi:10.3390/microorganisms11020242 · Cited by 48 · see citing works

A Comprehensive Analytical Review of Polyphenols: Evaluating Neuroprotection in Alzheimer’s Disease

Vicente-Zurdo, D., Gómez-Mejía, E., Rosales‐Conrado, N., & León‐González, M. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115906 · Cited by 32 · see citing works

Agri-Food Wastes as Natural Source of Bioactive Antioxidants

Hrelia, S., Angeloni, C., & Barbalace, M. C. (2023) · Antioxidants · doi:10.3390/antiox12020351 · Cited by 27 · see citing works

Antioxidant and anti-inflammatory effects of fractions from ripe fruits of Solanum lycocarpum St. Hil. (Solanaceae) and putative identification of bioactive compounds by GC–MS and LC-DAD-MS

Morais, M. G., Saldanha, A. A., Azevedo, L. S., Mendes, I. C., Rodrigues, J. P. C., Amado, P. A., Farias, K. D. S., Zanuncio, V. S. S., Cassemiro, N. S., Silva, D. B., et al. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111145 · Cited by 26 · see citing works

Identification of Anti-Neuroinflammatory Bioactive Compounds in Essential Oils and Aqueous Distillation Residues Obtained from Commercial Varieties of Cannabis sativa L.

Barbalace, M. C., Freschi, M., Rinaldi, I., Mazzara, E., Maraldi, T., Malaguti, M., Prata, C., Maggi, F., Petrelli, R., Hrelia, S., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316601 · Cited by 24 · see citing works

Review of potential and prospective strategies for the valorization of coffee grounds within the framework of a sustainable and circular bioeconomy

Arias, A., Ioannidou, S. M., Giannakis, N., Feijóo, G., Moreira, M. T., & Koutinas, A. (2023) · Industrial Crops and Products · doi:10.1016/j.indcrop.2023.117504 · Cited by 23 · see citing works

Stevia Polyphenols, Their Antimicrobial and Anti-Inflammatory Properties, and Inhibitory Effect on Digestive Enzymes

Myint, K. Z., Zhou, Z., Shi, Q., Chen, J., Dong, X., & Xia, Y. (2023) · Molecules · doi:10.3390/molecules28227572 · Cited by 21 · see citing works

Digital light processing-printed nanozyme-integrated hydrogels enable spatiotemporal immunomodulation and repair of infected wounds

Cheng, F., Zhang, X., Dai, J., Wang, L., Wu, Q., Ang, L. K., & Li, H. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.03.013 · Cited by 18 · see citing works

In-Vitro and In-Silico Investigation for the Spent-Coffee Bioactive Phenolics as a Promising Aflatoxins Production Inhibitor

Farouk, A., Alsulami, T. S., Ali, H., & Badr, A. N. (2023) · Toxins · doi:10.3390/toxins15030225 · Cited by 16 · see citing works

Green valorization of coffee industry residues: Emerging innovations and their role in sustainable food and feed applications

Urugo, M. M., Getachew, P., Lambe, B. T., Yohannis, E., Afework, A., Meteke, N., Yasin, S., Milkias, M., Tola, Y. B., Teka, T. A., et al. (2025) · Applied Food Research · doi:10.1016/j.afres.2025.101181 · Cited by 19 · see citing works

Multi‐Targeting Phytochemicals for Alzheimer's Disease

Bhattacharya, R. S., Singh, R., Panghal, A., Thakur, A., Singh, L., Verma, R. K., Singh, C., Goyal, M., & Kumar, J. (2025) · Phytotherapy Research · doi:10.1002/ptr.8435 · Cited by 17 · see citing works

Advances in Alzheimer’s disease therapeutics: biochemistry, exploring bioactive compounds and novel approaches

Atoki, A. V., Aja, P. M., Ondari, E. N., & Shinkafi, T. S. (2023) · International Journal of Food Properties · doi:10.1080/10942912.2023.2243050 · Cited by 19 · see citing works

Unveiling the neuroprotective potential of Ipomoea carnea ethanol extract via the modulation of tau and β-secretase pathways in AlCl3-induced memory impairment in rats in relation to its phytochemical profiling

El‐Kashak, W. A., Essa, A. F., Abdelhameed, M. F., Ahmed, Y. H., Elkarim, A. S. A., Elghonemy, M. M., Ibrahim, B. M. M., Gaara, A. H., Mohamed, T. K., & Elshamy, A. I. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01687-0 · Cited by 12 · see citing works

Anti-adipogenic and antioxidant activities of spent coffee grounds extracts: impacts of chlorogenic acid and caffeic acid

Kim, G., Jeong, H. J., Kim, S., & Han, G. D. (2025) · Food Science and Biotechnology · doi:10.1007/s10068-025-01886-z · Cited by 11 · see citing works

A2A Adenosine Receptor Antagonists: Are Triazolotriazine and Purine Scaffolds Interchangeable?

Spinaci, A., Lambertucci, C., Buccioni, M., Ben, D. D., Graiff, C., Barbalace, M. C., Hrelia, S., Angeloni, C., Tayebati, S. K., Ubaldi, M., et al. (2022) · Molecules · doi:10.3390/molecules27082386 · Cited by 11 · see citing works

By-Product Extracts from Castanea sativa Counteract Hallmarks of Neuroinflammation in a Microglial Model

Marrazzo, P., Mandrone, M., Chiocchio, I., Zambonin, L., Barbalace, M. C., Zalambani, C., Angeloni, C., Malaguti, M., Prata, C., Poli, F., et al. (2023) · Antioxidants · doi:10.3390/antiox12040808 · Cited by 10 · see citing works

Recovering bioactive compounds and antioxidant capacity of medium roasted spent coffee grounds through varied hydrothermal brewing cycles

Maiyah, N., Kerdpiboon, S., Supapvanich, S., KERR, W. L., Sriprom, P., Chotigavin, N., Klaypradit, W., & Puttongsiri, T. (2025) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2025.101789 · Cited by 13 · see citing works

Sequential extraction of industrial spent coffee grounds using pressurized fluids as solvents

Kanaan, A. F., dos Santos, K. C., Menezes, M. A. H., Hamerski, F., Voll, F. A. P., & Corazza, M. L. (2024) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2024.106503 · Cited by 9 · see citing works

Chemical characterization of spent coffee grounds: Integrating chemometric analysis with insights into antibacterial mechanisms of action

Ayadi, D. Z., Akermi, S., Chaari, M., Elhadef, K., Abdelhdi, C., Jlaiel, L., Mellouli, L., Ali, D. S., Elfalleh, W., Varzakas, T. H., et al. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107113 · Cited by 10 · see citing works

Bioprocessing of Spent Coffee Grounds as a Sustainable Alternative for the Production of Bioactive Compounds

Luna, K. A., Aguilar, C. N., Ramírez‐Guzmán, N., Ruíz, H. A., Martínez‐Hernández, J. L., & Chávez‐González, M. L. (2025) · Fermentation · doi:10.3390/fermentation11070366 · Cited by 6 · see citing works

Valorization of spent coffee grounds as an antimicrobial agent and variation of its potential according to solvent extraction and microbial strain: a multivariate comparative study

Aalam, Z., Khtira, A., Joine, M., Akbib, N., Gharby, S., & Sakar, E. H. (2024) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-024-06316-4 · Cited by 5 · see citing works

Chemical profiling, antioxidant, and antimicrobial activity of spent coffee grounds aqueous extract and its use to enhance antioxidant, microbiological, and sensorial properties of shrimp under storage

Aalam, Z., Kamli, T. E., & Sakar, E. H. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117171 · Cited by 5 · see citing works

Impact of roasting levels and brewing cycles on bioactive compounds in spent coffee grounds

Maiyah, N., Kerdpiboon, S., KERR, W. L., Klaypradit, W., Smithisukul, C., & Supapvanich, S. (2026) · Food Chemistry X · doi:10.1016/j.fochx.2026.103661 · Cited by 6 · see citing works

Molecular Insights on Coffee Components as Chemical Antioxidants

Hernández‐Ayala, L. F., Guzmán‐López, E. G., Pérez‐González, A., Reina, M., & Galano, A. (2024) · Journal of the Mexican Chemical Society · doi:10.29356/jmcs.v68i4.2238 · Cited by 7 · see citing works

New Therapeutic Approaches against Inflammation and Oxidative Stress in Neurodegeneration

Buoso, E., Biundo, F., & Attanzio, A. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9824350 · Cited by 5 · see citing works

Role of red beetroot in bread for reducing mycotoxin risks: Bioavailability of beetroot polyphenols and betalains with ochratoxin a, aflatoxin B1 and zearalenone in Caco-2 cells

Llorens, P., Ana, J.-G., Pakkanen, H. K., Carlos, M. J., Vehniäinen, E., & Cristina, J. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.142036 · Cited by 5 · see citing works

Effect of Solvent Fractionation and Lactic Acid Fermentation on Coffee Cherry Pulp Phenolic Compounds

On, J. H., Oh, B.-M., Oh, H. H., Jeong, D., & Kim, Y. (2023) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2023.52.3.291 · Cited by 4 · see citing works

Upcycling Coffee Waste into Sustainable Nano Zerovalent Iron for Environmental Contaminant Remediation: Characterization, Applicability and Cytotoxicity

Fernandes, F., de Freitas, M. A. R., Pinho, C., Oliveira, A. I., Delerue-Matos, C. M., & Grosso, C. (2025) · Nanomaterials · doi:10.3390/nano15231788 · Cited by 3 · see citing works

Polyphenolic Profile and Antioxidant Capacity of Coffee Silverskin Extracts: Insights from HPLC and GC-MS Analyses and Protective Effect in Schwann-like Cells

Damato, M., Garofalo, N., Schipa, L., Musarò, D., Anzilli, A., Corbo, F., Quarta, A. L., Maffia, M., & Ragusa, A. (2026) · Antioxidants · doi:10.3390/antiox15020172 · Cited by 3 · see citing works

Non-edible onion skin waste as a source of bioactive agents for functional foods development: Chemical composition and multifunctional bioactivity

Trigueros, E., Benito-Román, Ó., Oliveira, A. P., Videira, R. A., Pinto, E., Andrade, P. B., Sanz, M. T., & Beltrán, S. (2025) · Food Chemistry X · doi:10.1016/j.fochx.2025.102794 · Cited by 2 · see citing works

Sustainable utilization of spent coffee grounds in low-moisture meat analogs

Jung, H. G., Han, Y., & Gu, B. (2025) · Food Science and Preservation · doi:10.11002/fsp.2025.32.1.77 · Cited by 4 · see citing works

Morning Antioxidants: Molecular Insights on the Chemistry of Coffee ComponentsPreprint

Hernández‐Ayala, L. F., Pérez‐González, A., Reina, M., Guzmán‐López, E. G., & Galano, A. (2023) · Preprints.org · doi:10.20944/preprints202306.2138.v1 · Cited by 2 · see citing works

Extraction and LC–MS characterization of bioactive compounds from spent coffee grounds

Firdaus, R. M., Ishak, N. A. I. M., Aroua, M. K., & Gew, L. T. (2026) · Discover Food · doi:10.1007/s44187-026-00840-0 · Cited by 1 · see citing works

Functional Chewing Gum Enriched with Spent Coffee Grounds Extract: Chemical Characteristics and Antimicrobial Potential Against Oral Bacteria

Mansour, H. M. M., Hafez, E. E., El-Naggar, M. N., Alsonpaty, H. S. A., Ali, S. A., Abd-Elnoor, A. V., Abdellatef, A. A., Shaltout, O. E., Allam, M. G., & Abdo, E. M. (2026) · Foods · doi:10.3390/foods15040640 · Cited by 1 · see citing works

Therapeutic Effects of Spent Ground Coffee Oil on Nociception, Anxiety- and Depression-Like Behaviors, and Inflammatory Mechanisms in a CFA-Induced Intraplantar Inflammation Model in Mice

Lins, E., Cubas, A. L. V., de Oliveira, B. H., Medeiros, E. B., Mathias, K., Kraus, S. I., Martins, D. F., Mack, J. M., Piovezan, A. P., Petronilho, F. C., et al. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06069-3 · Cited by 1 · see citing works

Antioxidants in a Morning Cup: Molecular Insights on Coffee ComponentsPreprint

Hernández‐Ayala, L. F., Pérez‐González, A., Reina, M., Guzmán‐López, E. G., & Galano, A. (2023) · Preprints.org · doi:10.20944/preprints202306.1794.v1 · Cited by 1 · see citing works

Exploration of potential antioxidant and antibacterial activities of Lampung robusta coffee ethanolic extracts

Iqbal, M., & Triyandi, R. (2024) · AIP conference proceedings · doi:10.1063/5.0208216

VPLYV RÔZNYCH SPÔSOBOV PRÍPRAVY KÁVY NA ANTIOXIDAČNÉ VLASTNOSTI KÁVOVÉHO LÓGRU / THE INFLUENCE OF DIFFERENT COFFEE PREPARATION METHODS ON THE ANTIOXIDANT PROPERTIES OF SPENT COFFEE GROUNDS

Kotianová, D., Pencák, T., Slámová, D., Đorđević, Đ., & Tremlová, B. (2024) · Konference o jakosti potravin a potravinových surovin / Conference on Food Quality and Safety · doi:10.11118/978-80-7509-996-9-0180

Extraction and characterization of bioactive compounds from coffee by-products: physicochemical and LC-MS analysisPreprint

Firdaus, R. M., Ishak, N. A. I. M., Aroua, M. K., & Gew, L. T. (2025) · Research Square · doi:10.21203/rs.3.rs-7024028/v1

OLEJ Z KÁVOVEJ USADENINY AKO ADITÍVUM V BIODEGRADOVATEĽNÝCH OBALOCH: HODNOTENIE CHEMICKÝCH ZMIEN CHROMATOGRAFICKOU METÓDOU / SPENT COFFEE GROUND OIL AS AN ADDITIVE IN BIODEGRADABLE PACKAGING: CHEMICAL CHANGES EVALUATED BY CHROMATOGRAPHIC METHOD

Kotianová, D., Pencák, T., Đorđević, Đ., & Tremlová, B. (2025) · Konference o jakosti potravin a potravinových surovin / Conference on Food Quality and Safety · doi:10.11118/978-80-7701-048-1-0141

Caffeine Alleviates Oxidative Damage of Retinal Pigment Epithelium Cells

Liu, H., Zhang, W., Xiong, Y., Yang, M., Long, H., Gong, C., & Li, S. (2025) · Journal of Ophthalmology · doi:10.1155/joph/6121757

Kahve posası kaynaklı lignin nanoparçacıklar: metilen mavisi taşınımı ve fotodinamik özelliklerinin değerlendirilmesi

Kolcuk, Ş., & Akkurt, M. G. (2026) · Gazi Üniversitesi Mühendislik-Mimarlık Fakültesi Dergisi · doi:10.17341/gazimmfd.1777501

Metabolic composition and bioactive potential of extracts from cocoa and coffee by-products: a systematic review

León-Inga, A. M., Cala, M. P., Arroyo, M. C., Sánchez‐Camargo, A. D. P., & Fernández-Niño, M. (2026) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2026.2728440

Inflammatory Burden Shapes Antioxidant Adaptation and Immunometabolic Remodeling in LPS-Activated BV-2 Microglial Cells

Barbalace, M. C., Rinaldi, I., Mantini, M., Zallocco, L., Ronci, M., Cintio, F. D., Attanzio, A., Prata, C., Malaguti, M., Hrelia, S., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27208981

Dichamanetin attenuates hydrogen peroxide-induced cytotoxicity in retinoic acid (RA) -differentiated human neuroblastoma (SH-SY5Y) cells

Zainuddin, M.-S., Wei, A. C., Bhuvanendran, S., & Azman, A. S. (2026) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-026-00842-y

Potential neuroprotective effect of spent coffee grounds extracts against neurodegeneration

Freschi, M., Angeloni, S., Pasquale, M., Beghelli, D., Caprioli, G., Gianni, S., Silvana, H., & Cristina, A. (2022) · Unicam Scientific Publications (University of Camerino)

Neuroprotective and antioxidant effects of fermented spent coffee ground fractions against Alzheimer's-related oxysterol 27-hydroxycholesterol in SH-SY5Y neuronal cells

Arancibia‐Díaz, A., Trujillo-Fernández, S., Astudillo‐Castro, C., Vergara‐Castro, M., Soto‐Maldonado, C., Córdova, A., Zúñiga‐Hansen, M. E., Vega-Letter, A. M., Fuentes, P., & Altamirano, C. (2026) · Food Chemistry · doi:10.1016/j.foodchem.2026.149435 · Cited by 1 · see citing works

Chemical characterization and biological activities of spent coffee ground and coffee silverskin: possible reuse as nutraceuticals and ingredients for fertilizer products

Caprioli, G., Angeloni, S., Nzekoue, F. K., Maggi, F., Mustafa, A. M., Navarini, L., Vittori, S., & Sagratini, G. (2022) · Unicam Scientific Publications (University of Camerino)

Development of antioxidant from spent coffee ground and its appication

Paidech, C., & Borompichaichartkul, C. (2023) · doi:10.58837/chula.the.2023.953

Polyphenolic Extracts from Spent Coffee Grounds Prevent H2O2-Induced Oxidative Stress in Centropomus viridis Brain Cells

Leyva‐López, N., Peraza-Arias, M., Ávalos-Soriano, A., Hernández, C., Lizárraga-Velázquez, C. E., & Heredia, J. B. (2021) · Molecules · doi:10.3390/molecules26206195 · Cited by 9 · see citing works