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Cited by 23Gut microbiota and healthOral microbiology and periodontitis researchGastrointestinal motility and disorders

Systems to model the personalized aspects of microbiome health and gut dysbiosis

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Matthewman, Cristina, Narin, Alexandra, Huston, Hannah, Hopkins, Christopher Edward·2023·Molecular Aspects of Medicine
DOI 10.1016/j.mam.2022.101115
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Abstract

The human gut microbiome is a complex and dynamic microbial entity that interacts with the environment and other parts of the body including the brain, heart, liver, and immune system. These multisystem interactions are highly conserved from invertebrates to humans, however the complexity and diversity of human microbiota compositions often yield a context that is unique to each individual. Yet commonalities remain across species, where a healthy gut microbiome will be rich in symbiotic commensal biota while an unhealthy gut microbiota will be experiencing abnormal blooms of pathobiont bacteria. In this review we discuss how omics technologies can be applied in a personalized approach to understand the microbial crosstalk and microbial-host interactions that affect the delicate balance between eubiosis and dysbiosis in an individual gut microbiome. We further highlight the strengths of model organisms in identifying and characterizing these conserved synergistic and/or pathogenic host-microbe interactions. And finally, we touch upon the growing area of personalized therapeutic interventions targeting gut microbiome.

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  • Patterning of microbiota through molecular, sequencing, and bioinformatic approaches enables a more sensitive and personalized evaluation of nutritional status, complementing traditional anthropometric, biochemical, and clinical methods.

    “Patterning of microbiota through molecular, sequencing, and bioinformatic approaches enables a more sensitive and personalized evaluation of nutritional status, complementing traditional anthropometric, biochemical, and clinical methods [64].”

    From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [64]

    The Introduction (page unavailable) says sequencing and other omics approaches reveal individual microbiome variability and contribute to personalized medicine. It does not say they provide a more sensitive evaluation of nutritional status or that they complement traditional anthropometric, biochemical, and clinical methods; searches for nutritional-status assessment and those methods found no supporting passage. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Matthewman, C., Narin, A., Huston, H., & Hopkins, C. E.
Affiliations
Life Extension Foundation (US)
Corresponding author
Hopkins, Christopher Edward
ORCID
Venue
Molecular Aspects of Medicine
Publisher
Elsevier BV
Published
2023-06
Volume
91
Pages
101115
ISSN
0098-2997 (ISSN-L)
DOI
10.1016/j.mam.2022.101115
OpenAlex
W4295203592
Cited by
23
References
16
Citations by year
2026: 1 · 2025: 14 · 2024: 2 · 2023: 4 · 2022: 2
FWCI
0.57
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Aspects of Medicine (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
gut microbiota, gut dysbiosis, eubiosis, host-microbe interactions, pathobionts, commensal bacteria, model organisms, omics technologies
MeSH terms
Gastrointestinal Microbiome, Bacteria, Humans, Immune System, Microbiota, Dysbiosis

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